DTI and MR spectroscopy study in the auditory neural pathway of paediatric congenital sensorineural hearing loss patients

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1 DTI and MR spectroscopy study in the auditory neural pathway of paediatric congenital sensorineural hearing loss patients Poster No.: B-0528 Congress: ECR 2015 Type: Authors: Keywords: DOI: Scientific Paper C. X. Wu, W. Zheng; Shantou/CN Neuroradiology brain, Ear / Nose / Throat, MR physics, MR- Spectroscopy, MR-Diffusion/Perfusion, Technology assessment /ecr2015/B-0528 Any information contained in this pdf file is automatically generated from digital material submitted to EPOS by third parties in the form of scientific presentations. References to any names, marks, products, or services of third parties or hypertext links to thirdparty sites or information are provided solely as a convenience to you and do not in any way constitute or imply ECR's endorsement, sponsorship or recommendation of the third party, information, product or service. ECR is not responsible for the content of these pages and does not make any representations regarding the content or accuracy of material in this file. As per copyright regulations, any unauthorised use of the material or parts thereof as well as commercial reproduction or multiple distribution by any traditional or electronically based reproduction/publication method ist strictly prohibited. You agree to defend, indemnify, and hold ECR harmless from and against any and all claims, damages, costs, and expenses, including attorneys' fees, arising from or related to your use of these pages. Please note: Links to movies, ppt slideshows and any other multimedia files are not available in the pdf version of presentations. Page 1 of 8

2 Purpose To evaluate possible changes in microstructure and metabolism in the auditory neural pathway, in children with sensorineural hearing loss (SNHL), by using diffusion tensor imaging and MR spectroscopy. Methods and materials Eighty-eight SNHL children (41 females, 47 males, 1-14 years of age; mean age 5 years) and thirty-one normal hearing subjects (17 females, 14 males, 1-10 years of age; mean age 3.7 years) were studied by conventional MR imaging, DTI and MRS. SNHL patients were divided into two groups: group A >3-years old (n=43) and group B #3- years old (n=45). Two DTI parameters, FA and ADC, were measured in the superior temporal gyrus (STG) and auditory radiation. Regions of interest for metabolic changes measurements were located inside the STG.Image of the ROIs (bilaterally) of the auditory radiation(figure1) and STG (Figure2) are depicted in the picture, respectively. Images for this section: Fig. 2: Image of the ROIs (bilaterally) of the auditory radiation(figure2) are depicted in the picture. Page 2 of 8

3 Fig. 1: Image of the ROIs (bilaterally) of the STG (Figure1) are depicted in the pictures. Page 3 of 8

4 Results Compared with healthy individuals, SNHL individuals displayed decreased FA values in the auditory radiation and STG. A statistically significant reduction (p<0.05) in FA of auditory radiation was observed in group A and group B. And in group A, NAA/CR ratio and FA values in the STG were also significantly decreased (p<0.05).(table1,2) Images for this section: Fig. 2: Image of the ROIs (bilaterally) of the auditory radiation(figure2) are depicted in the picture. Page 4 of 8

5 Table 1: TABLE 1. Summary of the diffusion indices (mean and SEM) at the STG and auditory radiation for the SNHL and control groups. TABLE 2#MR spectroscopic values (mean and SEM) at the STG for the SNHL and control groups. Page 5 of 8

6 Conclusion DTI and MRS can evaluate microstructural alterations and metabolite concentration changes in the auditory neural pathway that are not detectable by conventional MR imaging. Due to the lack of sound stimulus, children with SNHL might undergo myelin developmental delay in the auditory neural pathway and have metabolite concentrations changes in the auditory cortex, which might be associated with the effect of cochlear implantation. Personal information References 1.Chang, Y., Lee, S.-H., Lee, Y.-J., Hwang, M.-J., Bae, S.-J., Kim, M.-N., Lee, J., Woo, S., Lee, H., Kang, D.-S., Auditory neural pathway evaluation on sensorineural hearing loss using diffusion tensor imaging. NeuroReport. 15, Chang, Y., Lee, H.R., Paik, J.S., Lee, K.Y., Lee, S.H., Voxel-wise analysis of diffusion tensor imaging for clinical outcome of cochlear implantation: retrospective study. Clin Exp Otorhinolaryngol. 5 Suppl 1, S Hong, P., Jurkowski, Z.C., Carvalho, D.S., Preoperative cerebral magnetic resonance imaging and white matter changes in pediatric cochlear implant recipients. Int J Pediatr Otorhinolaryngol. 74, Jonas, N.E., Ahmed, J., Grainger, J., Jephson, C.G., Wyatt, M.E., Hartley, B.E., Saunders, D., Cochrane, L.A., MRI brain abnormalities in cochlear implant candidates: how common and how important are they? Int J Pediatr Otorhinolaryngol. 76, Lin, Y., Wang, J., Wu, C., Wai, Y., Yu, J., Ng, S., Diffusion tensor imaging of the auditory pathway in sensorineural hearing loss: changes in radial diffusivity and diffusion anisotropy. J Magn Reson Imaging. 28, Migirov, L., Wolf, M., Magnet removal and reinsertion in a cochlear implant recipient undergoing brain MRI. ORL J Otorhinolaryngol Relat Spec. 75, Moon, I.J., Kim, E.Y., Park, G.Y., Jang, M.S., Kim, J.H., Lee, J., Chung, W.H., Cho, Y.S., Hong, S.H., The clinical significance of preoperative brain magnetic resonance imaging in pediatric cochlear implant recipients. Audiol Neurootol. 17, Page 6 of 8

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