Index. Note: Page numbers of article titles are in boldface type.

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1 Index Note: Page numbers of article titles are in boldface type. A Alginate, tooth-shaped, for constructs, encapsulated pulp cells in, Antibiotic paste, triple, change in root length and width in use of, 631 Antibiotic pills and pastes, Apical bone, failure to heal, 635 Apical papilla, stem cells from, 555 Autologous fibrin matrix, in regenerative endodontic procedures, 619, 620, 621 B Bacteria, pulpal regeneration and, 591 Bioactive materials, in pulp capping, Bioceramics, as implant materials, 505 Blood clot revascularization, 617 within root canal, 579, 580 Bone grafts, in regenerative therapy, 539 Bone morphogenetic protein, 567 C Calcium hydroxide, as antimicrobial agent, 615, 616 in pulp capping, 527 Cardiac muscle, mesenchymal stem cells for therapy of, 661 Caries, pulp response to, , 524 pulpal and periradicular response to, Cell homing, dental pulp-dentin regeneration by, Cell-reprogramming techniques, Chitosan, 645 Computed tomography, cone beam, in assessment of regenerative endodontic procedures, Construct(s), and scaffolds, used to regenerate dental tissue, dental tissue, 581, 583 generation of, 579 steps in use of, 578 in tissue regeneration, steps in use of, 578 periodontal, scaffolds to create, stem cell survival in, 581, 584 periodontal ligament, 582 tissue engineered, in dental treatment in future, 585 survival of stem cells in, 584 tooth-shaped alginate, encapsulated pulp cells in, Dent Clin N Am 56 (2012) doi: /s (12) /12/$ see front matter ª 2012 Elsevier Inc. All rights reserved. dental.theclinics.com

2 692 Index D Deciduous teeth, human exfoliated, stem cells from, Dental follicle precursor cells, Dental pulp. See Pulp. Dental pulp-dentin regeneration, by cell homing, Dental tissue, and supporting structures, regeneration of, constructs and scaffolds employed to regenerate, regeneration of, 578 definition of, 579 history of, steps to use constructs in, 578 tissue injury and, 592 Dental treatment, in future, tissue engineered constructs in, 585 Dentin-pulp regeneration, cellular events in, in young permanent tooth, 656 molecular events in, translational opportunities for, Dentinogenesis, reparative, importance of, 595 Discoloration, caused by minocycline, 634 E Endodontic procedures, regenerative, access and disinfection for, American Association of Endodontists protocol considerations for, and tissue engineering, 609, bone healing and tooth retention following, 633 case selection for, 615 clinical concerns in, clinical considerations for, clinically successful, case studies of, , 613 commitment to, 609 cone beam computed tomography in assessment of, , 633 early case study protocols in, early outcomes of, 628 follow-up of, future protocols in, goals of, 610 histology from animal studies, informed consent for, 615 major effort of, 678 outcomes of, case reports of, 630 potential complications/undesired outcomes of, pulp repair and regeneration and, recent outcomes of, signaling molecules for, effects and interactions of, 564 stimulating, scaffolds, and seals in, , 620, 621 terminology in, 610 trauma literature on,

3 Index 693 Endodontics, definition of, 640 inflammation-regeneration in, 684 nonsurgical, causes and incidences of failure of, 640 pulp tissue engineering in, Epithelial-mesenchymal transition, induced stemness by, Ethylenediamine tetraacetic acid, 593, , 617 F Fibroblast growth factor, 568 G Glass ionomer and adhesives, in pulp capping, 528 Growth factor(s), and signaling pathways, 683 effects of, on dental stem/progenitor cells, fibroblast, 568 insulin-like, nerve, 569 platelet-derived, 566 vascular endothelial growth factor, 568 H Hyaluronic acid, 645 I Immunomodulatory therapies, using mesenchymal stem cells, for systemic diseases, Induced pluripotent stem cells, and dental pluripotentlike stem cells, 556 Inflammation-regeneration, in endodontics, 684 Insulin-like growth factor, L Liver, mesenchymal stem cell-mediated generation therapy for, 662 M Mesenchymal stem cells, 551 allogeneic versus autologous, dental, dental tissue engineering using, 655 direct pulp capping using, in periodontal ligament regeneration, 658 pulp revitalization using, pulp tissue engineering using, tissue engineering of dental structures and periodontium using, derivation from many tissues, 652 for oral and systemic diseases, therapeutic potential of, for therapy of cardiac muscle, 661 function of, effects on aging, 665 immunomodulatory therapies using, for systemic diseases,

4 694 Index Mesenchymal (continued) in bone marrow tissues, 652 in skin wound closure, in vitro induction of, toward different cell lineages, 653, 654 in vitro transdifferentiation potential of, in different cell types, 659, 660 induced stemness by epithelial transition with, isolation, identification, and differentiation of, life span of, morphology of, 652 regenerative therapies using, for systemic diseases, therapies using, challenges and future directions in, to mediate generation therapy of liver, 662 to mediate therapy of pancreatic b-cells, types of, phenotypic comparison of, 653 Mineral trioxide aggregate, 591, 593, 641 in pulp capping, Minocycline, discoloration caused by, 634 Molar development, schematic of, 500, 501 Multiple sclerosis, immunomodulatory therapy using mesenchymal stem cells in, 664 N Nanofiber scaffolds, 646 Nanostructured films, and self-assembled peptides, 508 Nerve growth factor, 569 Niches, stem cells and, 682 Nondental tissues, regeneration of, NOTCH signaling proteins, O Odontoblast cell secretion, during reparative dentinogenesis, 597 3D Organ printing, 505 Organ/tissue engineering, key components of, 508 P Pancreatic b-cells, mesenchymal stem cell-mediated therapy of, Peptides, self-assembled, nanostructured films and, 508 Periodontal defect, bone graft for treatment of, 539 Periodontal disease, , Periodontal ligament, regeneration of, mesenchymal stem cells in, 658 stem cells from, 679 Periodontal ligament constructs, 582 Periodontitis, apical, treatment with bone allograft material and resorbable membrane, 541 Periodontium, and dental structures, tissue engineering of, mesenchymal stem cells in, Periradicular disease, guided tissue regeneration in, management and treatment options in, 530, 531

5 Index 695 Platelet-derived growth factor, 566 Platelet-rich plasma, in regenerative endodontic procedures, 619, 620, 621 Polyglycolic acid, 645 Protein(s), bone morphogenetic, 567 NOTCH signaling, Pulp, natural regenerative potential of, harvesting of, regeneration of, bacteria and, 591 creation of conducive environment for, inflammatory and immune challenges to, microbial challenges to, response to caries, , 524 stem cells from, in regenerative engineering, 585 vascularization of, 683 Pulp capping, direct, mesenchymal stem cells in, materials of, newer materials for, 591 Pulp capping procedure, direct, 527, 528 indirect, 525 Pulp constructs, Pulp-dentin complex, main roles of, 680 stem cells to repair, 681 Pulp/dentin regeneration, cells to be used for, scaffolding material for, Pulp repair and regeneration, regenerative endodontics and, Pulp revascularization, clinical studies of, Pulp revitalization, mesenchymal stem cells in, Pulp tissue engineering, in endodontics, Pulpal injury, endodontic repair versus regeneration in, 538 periodontal repair versus regeneration in, R Regenerative endodontics. See Endodontic procedures, regenerative. Regenerative therapy, bone grafts in, 539 growth and differentiation factors in, 543 guided tissue regeneration for, stem cells in, Restorative materials, in regenerative dentistry, 598 Rheumatoid arthritis, immunomodulatory therapy using mesenchymal stem cells in, Root canal, blood clot revascularization within, 579, 580 treatment of, 640 S Scaffold(s), and constructs, used to regenerate dental tissue, choice of, 681 composed of extracellular matrix proteins, 580, 581 for dental regeneration, types of, 580, 581 in new tissue-engineering approaches, 591, 618

6 696 Index Scaffold(s) (continued) materials for, 503 nanofiber, 646 naturally derived, 505 physical properties of, 581 stem cells for, 681 structure of, 581, 582 synthetic, , to create periodontal constructs, stem cell survival in, 581, 584 Signaling molecules, for regenerative endodontics, effects and interactions of, 564 mechanism of action and pulp-dentin complex regeneration, 565 Signaling pathways, growth factors and, 683 Skin wound closure, mesenchymal stem cells in, Sodium hypochlorite, 593, 597 Stem cell and biomaterials research, in dental tissue engineering and regeneration, Stem cells, and niches, 682 dental, 552, 553 and their sources, dental follicle, 679 dental pluripotentlike, and induced pluripotent stem cells, 556 dental/progenitor, effects of growth factors on, dental pulp, embryonic, for scaffolds, 681 from apical papilla, 555, 679, 680 from human exfoliated deciduous teeth, general characterisitcs of, 550 in pulp, in regenerative medicine, 585 in regenerative therapy, 539 in tissue regeneration, 498 induced pluripotent, 502 and dental pluripotentlike stem cells, 556 mesenchymal. See Mesenchymal stem cells. origin of, 679 periodontal ligament, 679 somatic or adult, 499, 500 storage of, 553 survival in tissue engineered constructs, 584 to repair pulp-dentin complex, 681 undifferentiated, selective removal of, 502 Stromal cell-derived factor 1, 569 Systemic diseases, mesenchymal stem cells for immunomodulatory therapies using, mesenchymal stem cells in regenerative therapy for, Systemic lupus erythematosus, immunomodulatory therapy using mesenchymal stem cells in, 663 T Tissue engineering, and regeneration, stem cell and biomaterials research in, approaches in, past and present, 496

7 Index 697 goal of, 496 in regenerative endodontics, 609 key element of, 577 mesenchymal stem cells in, 655, regenerative endodontics and, scaffolds in, Tissue injury, and regeneration of dental tissue, 592 Tissue regeneration, guided, regenerative therapy in, stem cells in, 498 Tooth injury, mild versus intense, cellular sequences of events in, Transdifferentiation, Transforming growth factor ß, Trioxide aggregate, mineral, 591, 593, 641 in pulp capping, V Vascular endothelial growth factor, 568 Vascularization of dental pulp, 683 Vital pulp therapy, indirect, pulp exposure in, 526 W Wound closure, skin, mesenchymal stem cells in, Wound healing, natural, and tissue environment, 591