Relieving pain. Winning patronage. Retaining patients.

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1 KaVo HealOzone Relieving pain. Winning patronage. Retaining patients. Thorough and painless caries treatment and prophylaxis is possible in every dental practice.

2 How important is caries prophylaxis and caries treatment for you and your practice? Finally pain-free: Ozone caries treatment for dentists who are committed and highly patient-oriented Afford yourself and your patients pain-free caries treatment with KaVo HealOzone. You will find there is less stress for both you and your patients who will be glad to come back to you for treatment and ensure loyal patronage of your practice. Marketing suggestion: Beating pain with high-tech. Minimally invasive caries treatment A patient magnet Supported by informational and educational materials for the patients in your locality, use KaVo HealOzone to set your practice apart with a clear and positive statement. "That's the dentist who gives high-tech painfree caries treatment." The word will get around fast. And we'll help you spread it. Always the trendsetter be: Ozone is the treatment of choice for the experienced practitioner applying a clear prophylactic concept. As a trendsetter, you are constantly open to new ideas and technologies. Your strategy has always been one of caries prophylaxis and systematic therapy, right? KaVo HealOzone lets you stride in a completely new therapeutic direction: A pharmacological approach to the management and treatment of caries. Not only can HealOzone be used for caries treatment, but it is also effective for disinfecting surfaces treated the conventional way. It is also suited for orthodontics, endodontics and for treating hypersensitivities, aphthae and herpes, too. Sustainable healing without drilling Tooth-preserving, painless caries treatment of roots, fissures and proximal caries Remineralisation and hardening within 4-12 weeks Root canal disinfection (endodontics): full endodontic treatment in just one session Disinfection of cavity or preparation before placing dental restorations 100% disinfection of all surfaces where a vacuum seal can be achieved No free ozone enters the oral cavity or airways (vacuum sealed) No known side effects with our patented delivery system

3 Fulfil an age-old patient dream: Eradicate caries painlessly. I didn't become a dentist to inflict pain. Whenever and wherever possible, I aim to alleviate pain and stress for my patients, and for myself, too. Patients who are happy to come back Modern curative methods that are less onerous on both the patient and treating practitioner in equal measure. With KaVo HealOzone, you will notice that a burden is removed from your shoulders in multiple ways. Indeed, you will treat caries at an earlier stage. Without needles, without probing, without drilling. And you will eradicate fissures and proximal caries gently but thoroughly nevertheless. This will ensure that your patients are happy to return for their regular check-ups. Even when caries is detected, treatment is always pain-free. Non-invasive or minimally interventive combined with thoroughness: It's in your hands! Sustainable and thorough caries treatment without anxiety for your patients. No matter whether you utilise KaVo HealOzone to enhance disinfection of mechanically treated diseased sites or you decide to administer the full treatment with KaVo HealOzone, you will notice the difference it makes. KaVo HealOzone treatment is free of pain, vibrations, needles and probing. Free of all those things that previously caused constant anxiety and tension. Put an end to all that: Your patients will thank you. Life Ein long Leben healthy lang gesunde Zähne teeth

4 Your results are unbeatable? Now you have support. Our prophylaxis concept is logical and proven. Naturally, I treat with the most up-to-date procedures and technologies. Progressive: The spot-on alternative to drilling that is gentle to dentin and enamel and lowers the stress factor. Don't just stop caries, but intentionally leave previously diseased, ozonised tooth substance in situ to become remineralised and hardened again within 4 to 12 weeks. And that's not the only thing revolutionary about KaVo's HealOzone treatment. Your patients rely on you. And they know you employ curative dental procedures systematically and pragmatically If you have to drill, then you know exactly why. When you utilise ozone treatment for specific indications, you do so knowing your patients' trust equally in you and this modern procedure and they have good reason to do so! And when you employ KaVo HealOzone to complement the use of your conventional, more familiar methods, then you are utilising the aspects of each procedure that you value for good reasons and that expands the likelihood of you making your good results even better. Diagnosing caries: KaVo HealOzone treats the diseased portions of the tooth under a vacuum (treatment time seconds) Situation before the ozone treatment. 60 seconds' disinfection with ozone Situation 12 weeks after the ozone treatment. Caries are reversed and the texture of the treated site is of a markedly harder consistency High-tech without drilling Treatment of deep caries, while previously diseased material is preserved and re-hardens Incipient and large pit and fissure caries, reliably detected with DIAGNOdent Endodontics root canal disinfection: Orthodontics: before attaching brackets, when adjusting the wires Full prophylactic treatment Therapy of hypersensitivities, herpes, aphthae Root canal disinfection: Ozone penetrates into the entire root canal system down to the very last corner

5 Discover the patient magnet of the 21st century: KaVo HealOzone I continually keep up-to-date on new therapeutic modalities to ensure revenues for my dental practice, and enable me to offer my patients more attractive options. There is nothing that attracts patients more than dental treatments, free from anxiety and pain. Take away the pain and patients of every age will even be happy to pay a little more. Above and beyond that, a modern procedure like KaVo HealOzone will help you set yourself apart in the market. And the word will spread at lightening speed. Pain-free, gentle, thorough." "High-tech looks." "Stands out in the crowd." When you use KaVo HealOzone, all these kinds of recommendations by your pleasantly surprised patients will recommend you and your practice. Invoicing example with a turnover of 180 per day. Assumed annual earnings over 200 workdays One-time investment costs Annual material requirements (ampoules, silicone cups, filters) Servicing costs Your additional earnings with an amortisation within one year and without any depreciation for wear and tear 36,000 13,804 3, ,552 Added revenues right from the start: On average, five caries treatments are carried out daily in European dental practices. This calculation is based on three treatments a day. You are a practitioner who patients prefer to go to, and whom they recommend to others You lower your patients' resistance to checkups when they no longer feel anxious about the results of their exams. Educate your patients about this novel innovative technology. We have prepared helpful information material just for this purpose. You can display it in your waiting room or send it with your mailings. Complete fissure disinfection before sealing approx. 120 Herpes/aphthae approx. 20 The costs per tooth vary from 25 to 60 Prices calculated on the basis of the practice's costs per minute factor You will work profitably with daily sales of as little as 90 Ask us about our leasing and financing offers! This is what patients think about KaVo HealOzone 100 % of the patients treated with KaVo HealOzone would submit to repeat treatment 99 % were delighted about the treatment 97 % will recommend to others the KaVo HealOzone treatment they received from their dentist All data are reference values from applied practice. All prices are stated in euros.

6 Numerous international studies speak for themselves. Whether non-invasive or minimally interventive: Risk-free, tooth preserving, long-term efficacy. 1. The efficacy of ozone on carious diseases without cavity formation in permanent molars. A controlled-prospective clinical study. CLINICAL RELEVANCE: Within a period up to 3 months, the application of ozone gas for incipient carious diseases without cavity formation reversed and/or slowed the progression of the carious disease process in patients at a high risk for carious diseases. 2. Clinical reversal of root caries through the use of ozone in an 18-month controlled double-blind trial with a randomly allocated control group. CONCLUSIONS: Leathery non-cavitated primary root caries can be predictably arrested non-operatively with ozone and remineralising products. This treatment regime is an effective alternative to conventional "drilling and filling" 3. Efficacy of root canal disinfection with ozone and calcium hydroxide ozone was highly effective against Enterococcus faecalis. Root canal preparation and irrigation with NaOCl or CHX promoted disinfection efficacy even more significantly. The application of gaseous ozone in combination with chemomechanical preparation thus appears to provide sufficient disinfection of root canals infected with Enterococcus faecalis in vitro. 4. Efficacy of a single ozone application in reducing bacteria in patients with deep caries in deciduous teeth A single ozone application led to a reduction... of caries-inducing pathogenic microorganisms in the superficial layers of untreated carious dentine. Longer application times did not lead to any greater efficacy. Karin Christine Huth, DDS, Ekaterini Paschos, DDS Prof. Korbinian Brand, MD Prof. Reinhard Hickel, DDS. Published in: Am J Dent, 2005 Aug;18(4):223-8.: J. Holmes, UKSmiles Dental Practice, 3 Old Row Court, Rose Street, Wokingham, Berkshire, RG40 1XZ, United Kingdom Published in: Gerodontology 2003 Dec; 20(2): J. Noetzel 1), J. Nonhoff 1), J. Wagner 2), S. Baraliakos 1), K. Neumann 3) and A. M. Kielbassa 1) 1) Policlinic for Conservative Dentistry and Periodontology, Clinic and Policlinics for Dento-Maxillo-Facial Surgery, Campus Benjamin Franklin, Charité - University Medical School, Berlin (Universitätsmedizin Berlin) 2) Medical Institute for Infectious Diseases, Campus Benjamin Franklin, Charité University Medical School, Berlin (Universitätsmedizin Berlin) 3) Institute for Medical Informatics, Biometrics and Epidemiology, Campus Mitte, Charité - University Medical School, Berlin (Universitätsmedizin Berlin) Published in: DZZ - Supplement 2005 Special edition, Zahnmedizin Interdisziplinär, 26 to 30 Oct. 2005, ICC Berlin, Abstract 391 M. J. Wicht 1), R. Haak 1), S. Kneist 2), M. J. Noack 1), 1) Policlinic for Conservative Dentistry and Periodontology, University of Cologne 2) Biology Laboratories, ZZMK, FSU Jena Published in: DZZ - Supplement 2005 Special edition, Zahnmedizin Interdisziplinär, 26 to 30 Oct. 2005, ICC Berlin, Abstract 322 Validated method, proven mechanism of action The study by Baysan, published in 2002, is a good example for the empirical proof of efficacy of the procedure. It proved that KaVo HealOzone can be used to reliably stop root caries progression. Four groups of root caries were compared: I. Not treated II. Treated with ozone alone III. Treated with ozone followed by sealant IV. Treated with sealant alone The follow-up examinations were performed using the electrical carious monitor (ECM), using DIAGNOdent and a clinical index over a three-month period. The values in groups II - IV improved after one and three months, respectively. The values in the untreated control group I worsened compared to baseline. Ozone can consequently be used as a non-invasive treatment modality for treating root caries. The 12-month follow-up examination confirmed this result. KaVo HealOzone provides added benefits in the treatment of pit and fissure caries: The sterilising effect of ozone at the fissure itself before sealing improved the bond at the sealant-tooth interface (Celeberti and Lussi, 2006). Tooth 36 X-ray finding of 9 Mar X-ray finding: Root filled on 21 Mar X-ray finding: 1-year follow-up X-ray finding: 2-year follow-up on 11 Mar HealOzone s broad spectrum of indications Pit and fissure caries: Significant successes demonstrated in prophylaxis and treatment of open carious lesions Cervical caries: Achieves valuable preservation of tissues in especially sensitive areas, treatment of hypersensitive cervical areas Root canal treatment: Complete root canal (endodontic) treatment possible in a single session Orthodontics: Reliable disinfection and prevention Soft tissue treatment: A 20-second exposure proves effective against aphthae and herpes X-ray finding: 3-year follow-up on 6 Apr. 2006

7 Thoroughly and painlessly Caries-free in just a few steps. With high-tech Ozone generator Differential pressure sensor Air dryer cartridge Atmospheric air is drawn in Moisture trap Ozone neutraliser Vacuum pump 1. Air dryer with automatic humidity sensor ensures that air humidity is stable and that the ozone concentration within the silicone cup remains steady 2. Differential pressure sensor registers leaks and activates the ozone generator 3. Safe Closed-system ozone generator generates ozone from atmospheric oxygen 4. Ozone concentration of 2100 ppm at a flow rate of ~ 100 x/s in the vacuum-tight silicone cup 5. Moisture trap prevents moisture from contaminating the ozone neutraliser 6. Ozone neutraliser reduces O 3 to O 2 and releases neutral air into the practice environment 7. Vacuum pump low pressure to prevent ozone from leaking out of the system. Ozone: 2100 ppm Flow rate: 100 x/s Easy to use, easy to explain. HealOzone, the talented all-rounder for everyday use. Ozone is one of the most effective oxidants available. Ozone quickly kills bacteria including carious pathogens, as well as viruses and fungi. It also disinfects wounds and stops bleeding. KaVo HealOzone generates its active principle from the oxygen in the atmospheric air. The vacuum created under the silicone tooth cup sucks ozone to the site to be treated. After the required treatment time, all the ozone is aspirated off and broken back down into oxygen again. Immediately after this treatment, the dentist initiates remineralisation of the now disinfected area. When given a special kit, the patient can continue this remineralisation treatment themself at home for a while afterwards. Simply safer. No free ozone whatsoever enters the oral cavity or airways. Ozone is highly effective against microorganisms. The system ensures 100% protection of the oral cavity and the airways. No ozone is generated or pumped to the diseased fissure, Standardised cleaning (PROPHYflex and KaVo Pearls) and drying Extended fissures Clinical diagnostics (with an index, e.g. CSI) Disinfection with HealOzone (applied for seconds) Then: Etching + conditioning of surfaces and fissures Light curing lesion or into root canal, until a vacuum is created and detected under the silicone cup. Appropriately sized cups are available for the different tooth sizes and shapes. Laser fluorescence measurement (with DIAGNOdent pen); Then: Selective, minimally invasive extension of fissures (RONDOflex, KEY Laser) Finalised extended fissure sealing (X Flow, Dentsply)

8 Help your patients discover a new groundbreaking caries therapy. Your patients desire pain-free treatment. Tell them about the amazing possibilities. Research has shown that in most cases, with good preparation and careful explanation, patients are willing to pay for a pain free treatment option. Use every opportunity to educate your patients in the benefits of HealOzone. Most patients accept that nowadays any up-to-date, quality-oriented dentistry will virtually always entail a personal financial commitment, with most dental cover only reimbursing for the minimum standard of care. We will support you in educating your patients accordingly. Free informational and educational materials and convincing arguments to support you and your practice Patient brochure to hand out or display in your waiting room Educational poster Informational DVD with supporting sales arguments for you and your dental team Audio CD for waiting room Note pads with scheduling reminders Information bulletins on the topic of caries treatment with KaVo HealOzone for your regular patient address Have your practice listed on the the website platform for interested patients willing to pay extra for quality dental care Tooth loss Bridges Removable dentures Implants The use of HealOzone as supportive measure in restorative dentistry Prevention in healthy teeth Monitoring Professional teeth cleaning Fissure sealing Fluoridation Use of HealOzone in prophylaxis as preventive measure Tooth decay Fillings Crowns Endodontic treatment Use of HealOzone for disinfection in invasive/conservative dentistry Initial lesion Monitoring Professional teeth cleaning Extended fissure sealing: cured with HealOzone Use of HealOzone in minimalintervention dentistry with curative indication

9 Mat.-Nr /06 en We reserve the right to make technical modifications. Slight colour differences are due to the printing process. Copyright KaVo Dental GmbH. KaVo Dental GmbH I D Biberach/Riß I Tel I Fax I

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