NobelActive Inventor s perspective on this new direction for implants

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1 NobelActive Inventor s perspective on this new direction for implants Nobel Biocare launches a unique new implant with revolutionary features due to the advanced design of its implant body NobelActive. For the clinician, NobelActive is indicated for all positions, but is especially effective in regions of diminished bone quality or quantity, due to its bone-condensing capability, capacity for shorter drilling protocols, and ability to change direction on insertion. On the patient side, NobelActive offers a solution for difficult treatment situations and provides for quicker treatments, shorter healing times, and less invasive procedures. The inventors of this radical design are Prof. Nitzan Bichacho and Drs. Ophir Fromovich, Benny Karmon, and Yuval Jacoby. For first-hand insight, Prof. Bichacho shares his experiences in developing and using NobelActive. Before being sold to Nobel Biocare, this implant design has undergone more than three years of study 1 and has been placed thousands of times, with equal more often better results than traditional implants, claims Prof. Nitzan Bichacho, There is no doubt the system will benefit even further from the enhancements introduced by Nobel Biocare. Prof. Bichacho refers to the well-proven TiUnite 2 surface and grooves Groovy 3,4 on the implant threads. The TiUnite surface has been documented to improve osseointegration, promote soft tissue seal around the implant, and increase the esthetic result of implant rehabilitations. The NobelActive implant has a variable thread profile that becomes wider vertically and shorter horizontally, from bottom to top; the core of the implant forms condensing lines, unlike the linear profile as is the case with contemporary tapered implants. NobelActive implant system NobelActive Inventor Final v2.1.doc 1 of 1

2 Easier insertion and greater initial stability In the apical region, the implant has a pronounced tapered body with sharp threads, which facilitates its insertion into minimally prepared sites. The apical region is followed by a sequence of variable thread units that allow easy insertion and gradual bone condensing, resulting in excellent initial implant stability especially in very low bone density. The implant has a spiral tap extending along more than half of the implant length. This tap substantially increases the penetration of the implant. The coronal region, adjacent to the threaded collar is tapered coronally, in all but the narrowest of implant diameters, allowing elastic relapse of the bone over the implant head. Furthermore, a groove has been machined at the lower part of the thread flank and two circumferential grooves have been placed around the implant neck. Grooves enhance the stability of the implant, because bone forms faster to threads with grooves than without. All NobelActive implants feature TiUnite on the threads and collars, which produces better osseointegration and Immediate Function characteristics. 5,6 Multicenter studies on the NobelActive implant are currently ongoing and show excellent results in support of bone remodeling, as well as implant- and soft tissue stability. 7,8 Fewer drilling steps The complete NobelActive design produces a self-drilling, maneuverable, conical implant: a double corkscrew form, with a narrow core and sharp horizontal threads, which often requires less site preparation and minimizes bone and soft tissue trauma. This design also offers trained clinicians the ability to reorient a NobelActive implant during insertion, when necessary. These implants can be placed like any contemporary tapered implant, says Prof. Bichacho, The ability to redirect it on insertion is an added feature that makes it possible to place an implant and load it in sites with limited or diminished bone quantity. In areas of limited bone, the clinician is able to begin insertion of a NobelActive implant at an angle where more bone exists; during final torquing, of the implant is redirected to the desired final position. The NobelActive system lineup consists of internal (2-piece) configuration, in 3.5, 4.3, 5.0mm implant diameters and 10, 11.5, 13, 15mm lengths, and are applicable in all indications. Fig. 1 Extraction of tooth and preparation of the fresh socket follows regular procedures NobelActive Inventor Final v2.1.doc 2 of 2

3 Fig. 2 Penetration of the palatal wall in the apical third of the socket, with the Twist Drill w Tip 2mm Fig. 3 Drilling continues while gradually changing the direction to a more vertical direction Fig. 4 Insertion begins at the same angle as initial drilling Figs. 5 and 6 Insertion continues while gradually changing the angle until final optimal position is achieved NobelActive Inventor Final v2.1.doc 3 of 3

4 Training and pre-launch NobelActive is a sophisticated implant and Nobel Biocare recommends that even experienced implant clinicians attend a NobelActive training course. Therefore in 2007, Nobel Biocare initiated a pre-launch of NobelActive and offered special training courses for clinicians interested in using this implant. The official launch of NobelActive, including a full spectrum of training courses, occurred on May 15, Important information regarding Nobel Biocare solutions Nobel Biocare strongly recommends caregivers always go through special training before undertaking a new treatment method. Furthermore, clinicians should always work with an experienced colleague the first few times they employ a new treatment method. Nobel Biocare has a global network of mentors available for this purpose. Nobel Biocare provides a wide range of courses for various levels of knowledge. For more information, please visit References: 1 Karmon, B. Survival rate around SPI and SFB dental implants in single tooth replacement and immediate (within 24h) functional loading. Multicenter retrospective clinical study with SPI / SFB implants of Alpha Bio, Inc Schüpbach P, Glauser R, Rocci A, Matignoni M, Sennerby L, Lundgren AK, Gottlow J. The human bone-oxidized titanium implant interface: A microscopic, scanning electron microscopic, back-scatter scanning electron microscopic and energy-dispersive X-ray study of clinically retrieved implants. Clin Implant Dent Relat Res 2005; 7 (Suppl 1): Hall J, Miranda-Burgos P, Sennerby L. Stimulation of directed bone growth at oxidized implants by macroscopic grooves: an in vivo study. Clin Implant Dent Relat Res 2005; 7 (Suppl 1): Miranda-Burgos P, On the influence of micro-and macroscopic surface modifications on bone integration of titanium implants. Doctoral thesis. Department of Biomaterials Institute for Clinical Sciences, Sahlgrenska Academy at Göteborg University and the Department of Oral and Maxillofacial Surgery, Lund University Hospital. Göteborg Schüpbach, op. cit. pp Balshi SF, Wolfinger GJ, Balshi TJ. A prospective study of immediate functional loading, following the Teeth in a Day protocol: a case series of 55 consecutive edentulous maxillas. Clin Implant Dent Relat Res 2005; 7: Calandriello R, Tomatis M. Immediate function of single implants using Brånemark System: Prospective one year report of final restorations. Appl Osseointegration Res 2004;4: Calandriello R, Tomatis M, Vallone R, Rangert B, Gottlow J. Immediate occlusal loading of single lower molars using Brånemark System Wide Platform TiUnite implants: An interim report of a prospective, open-ended clinical multi-center study. Clin Implant Dent Relat Res 2003;5 (suppl 1): Calandriello R, Tomatis M. Simplified treatment of the atrophic posterior maxilla via immediate/early function and tilted implants: a prospective 1-year clinical study. Clin Implant Dent Relat Res 2005; 7 (Suppl 1): Chiapasco M, Gatti C. Immediate loading of dental implants placed in revascularized fibula free flaps: a clinical report on 2 consecutive patients. Int J Oral Maxillofac Implants 2004; 19: da Cunha HA, Francischone CE, Filho HN, de Oliveira RC. A comparison between cutting torque and resonance frequency in the assessment of primary stability and final torque capacity of standard and TiUnite single-tooth implants under immediate load. Int J Oral Maxillofac Implants 2004; 19: Glauser R, Ruhstaller P, Windisch S, Zembic A, Lundgren AK, Gottlow J, Hämmerle CHF. Immediate occlusal loading of Brånemark System TiUnite implants placed in predominantly soft bone: 4-year results of a prospective clinical study. Clin Implant Dent Relat Res 2005; 7 (Suppl 1): NobelActive Inventor Final v2.1.doc 4 of 4

5 Maló P, Rangert B, Nobre M. All-on-4 immediate-function concept with Brånemark System implants for completely edentulous maxillae: a 1-year retrospective clinical study. Clin Implant Dent Relat Res 2005; 7 (Suppl 1): Olsson M, Urde G, Andersen JB, Sennerby L. Early loading of maxillary fixed cross-arch dental prostheses supported by six or eight oxidized titanium implants: Results after 1 year of loading, case series. Clin Implant Dent Relat Res 2003;5 (suppl 1): Östman PO, Hellman M, Sennerby L. Direct implant loading in the edentulous maxilla using a bone density-adapted surgical protocol and primary implant stability criteria for inclusion. Clin Implant Dent Relat Res 2005; 7 (Suppl 1): Rocci A, Martignoni M, Gottlow J. Immediate loading of Brånemark System with TiUnite and machined surfaces in the posterior mandible: A randomized, open-ended trial. Clin Implant Dent Relat Res 2003;12 (suppl 1): Vanden Bogaerde L, Pedretti G, Dellacasa P, Mozzati M, Rangert B. Early function of splinted implants in the maxillae and posterior mandibles using Brånemark System TiUnite implants: An 18-month prospective clinical multicenter study. Clin Implant Dent Relat Res 2003; 5 (Suppl 1): Vanden Bogaerde L, Rangert B, Wendelhag I. Immediate/early function of Brånemark System TiUnite implants in fresh extraction sockets in the maxillae and posterior mandibles: an 18-month prospective clinical study. Clin Implant Dent Relat Res 2005; 7 (Suppl 1): van Steenberghe D, Glauser R, Blombäck U, Andersson M, Schutyser F, Pettersson A, Wendelhag I. A computed tomographic scanderived customized surgical template and fixed prosthesis for flapless surgery and immediate loading of implants in fully edentulous maxillae: a prospective multicenter study. Clin Implant Dent Relat Res 2005; 7 (Suppl 1): Villa R, Rangert B. Early loading of interforaminal implants immediately installed after extraction of teeth presenting endodontic and periodontal lesions. Clin Implant Dent Relat Res 2005; 7 (Suppl 1): Clinical evaluation of Nobel Biocare SFB and CFB Implants. Multicenter study in 13 centers. Clinical Research Department, Nobel Biocare Services AG, Evaluation of Nobel Biocare CFB Implants in Extraction Sites. Multicenter study in 7 centers, Clinical Research Department, Nobel Biocare Services AG, NobelActive Inventor Final v2.1.doc 5 of 5

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