REGENERATION BY DESIGN

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1 REGENERATION BY DESIGN ALLOGRAFT, XENOGRAFT, PUTT Y & BIOACTIVE GLASS FOR BONE REGENERATION INSTRUMENTS FOR COLLECTING BONE BARRIER MEMBRANES FOR GUIDED REGENERATION

2 GUIDED IMPLANT TREATMENT Wide Selection Of Allograft Materials RegenerOss Allograft Broad selection of cadaveric-derived bone from the University of Miami Tissue Bank: a comprehensive tissue bank that conducts screening, recovery, autopsies, processing and packaging for all donor tissue. Aseptically processed for maximum regenerative properties without destruction of the biological properties of the tissue. All donor tissues receive multiple screening and cultures to ensure that the tissues are pathogen-free. The Following Are Common Applications For Allograft Tissue: Sinus floor elevation Peri-implant defects Ridge augmentation and reconstruction Other osseous defects such as apicoectomies and tumor resection As a graft extender Harvesting And Preparation By: University Of Miami Tissue Bank

3 RegenerOss Allograft Putty & Putty Plus Mineralized Mineralized and Demineralized Bone Matrix (DBM) in a sterilized lecithin fatty acid carrier Plant-based (derived from soybeans - no residual soy proteins) Provides excellent graft containment Highly resistant to irrigation Available in 3 volumes: 0.5cc, 1cc and 2cc 2 year shelf-life RegenerOss Allograft Putty RegenerOss Allograft Putty Plus Mineralized Contains 40% by weight DBM for optimal handling Moldable, non-toxic, lecithin carrier resists movement under irrigation Osteoinductivity of every lot is validated by a cell proliferation assay Intended For Use In Small Defects, Such As: Peri-implant, root re-section or apicoectomy defects Localized ridge augmentation A graft extender Contains 48% by weight DBM (28% Cortical and 20% cancellous chips) for optimal handling and bone regeneration Moldable, non-toxic, lecithin carrier that is highly resistant to irrigation Osteoinductivity of every lot is validated by a cell proliferation assay Ergonomic design features a smaller diameter syringe with a curved tip to treat hard-to-reach defects Intended For Use In Small Defects, Such As: Peri-implant, root re-section or apicoectomy defects Manufactured By: Interpore Cross Localized ridge augmentation A graft extender Periodontal defects Cystic defects Manufactured By: LifeLink Tissue Bank (AATB Certified)

4 GUIDED IMPLANT TREATMENT An Assortment Of Bone Graft Substitutes Endobon Xenograft Granules Bovine-derived hydroxyapatite that has been fully deproteinated for safety An essentially non-resorbable material that is ideally suited for regeneration of defects when effective space maintenance is required Osseoconductive due to the interconnecting micro and macro pores for bony integration, which facilitate graft stability and vascular ingrowth New easy to open dishes and value packs for sterility and value Endobon Xenograft Granules Are Indicated For Dental And/Or Oral Surgical Procedures, Such As: Filling defects after resection, cystectomy, apicoectomy or other defects in the alveolar ridge or wall Peri-implant defects Alveolar ridge augmentation, including aesthetic contouring defects Extraction socket grafting Sinus elevation Manufactured By: France Sarl Biogran Bioactive Glass Bioactive glass (silica gel surrounded by a calcium phosphate shell) with a µm particle size range that stimulates bone by providing a protective environment for osteogenesis 100% synthetic and completely resorbable through the krebs cycle Effective when preservation of sockets or a ridge is desired Indications: Periodontal defects Alveolar ridge augmentation Bony defects Alveolar ridge reconstruction Manufactured By:

5 Barrier Membranes For Guided Bone Regeneration OsseoGuard Resorbable Collagen Membranes Resorbable collagen membranes made with highly purified, bovine-derived collagen sourced from closed, New Zealand and Australian herds (OsseoGuard) and U.S. herds (OsseoGuard Flex ) Resorption profile of both membranes long enough to be well suited for GBR procedures Two different levels of drapability so that you can choose the membrane that best meets your needs OsseoGuard OsseoGuard Flex Slightly stiffer, more space maintaining handling characteristics. Indications*: Localized ridge augmentation / future implant site preparation Peri-implant bone defects Bone regeneration after root resection Coverage of sinus window and sinus membrane perforations Manufactured By: Collagen Matrix, Inc., Oakland, NJ Less extrinsic crosslinking for a higher degree of flexibility. Indications*: Peri-implant defects in immediate or delayed extraction sockets Localized ridge augmentation Alveolar ridge reconstruction Filling of bone defects GBR in dehiscence defects GTR in periodontal defects Manufactured By: Collagen Matrix, Inc., Oakland, NJ *Suggested indications due to differences in handling characteristics.

6 GUIDED IMPLANT TREATMENT Instrumentation For Augmentation Safescraper TWIST Bone Collector Unique design provides 160 cutting area to effectively harvest up to 5cc of cortical bone and facilitates access to difficult posterior regions Bone is contained in a sterile, exclusive chamber Lateral opening system provides device stability for easy retrieval of harvested bone Manufactured By: META Advanced Medical Technology Whatever The Regenerative Need, Has The Solution! Graft Type Autograft Harvest Allograft* Xenograft Product Safescraper TWIST RegenerOss Allograft* RegenerOss Allograft Putty* RegenerOss Allograft Putty Plus Endobon Xenograft Granules* Synthetic Biogran Resorbable Collagen Membrane OsseoGuard Membrane OsseoGuard Flex Membrane* *Not available in all markets.

7 Ordering Information Description Item No. RegenerOss Allograft Cancellous, Partially Demineralized 0.5cc µm RDCA205 Cancellous, Partially Demineralized 1cc µm RDCA210 Cancellous, Partially Demineralized 0.5cc µm RDCA305 Cancellous, Partially Demineralized 1cc µm RDCA310 Cancellous, Partially Demineralized 0.5cc µm RDCA505 Cancellous, Partially Demineralized 1cc µm RDCA510 Cortical, Partially Demineralized 0.5cc µm RDCO205 Cortical, Partially Demineralized 1cc µm RDCO210 Cortical, Partially Demineralized 0.5cc µm RDCO305 Cortical, Partially Demineralized 1cc µm RDCO310 Cortical, Partially Demineralized 0.5cc µm RDCO505 Cortical, Partially Demineralized 1cc µm RDCO510 Cancellous, Mineralized 0.5cc µm RMCA205 Cancellous, Mineralized 1cc µm RMCA210 Cancellous, Mineralized 0.5cc µm RMCA305 Cancellous, Mineralized 1cc µm RMCA310 Cancellous, Mineralized 0.5cc µm RMCA505 Cancellous, Mineralized 1cc µm RMCA510 Cortical, Mineralized 0.5cc µm RMCO205 Cortical, Mineralized 1cc µm RMCO210 Cortical, Mineralized 0.5cc µm RMCO305 Cortical, Mineralized 1cc µm RMCO310 Cortical, Mineralized 0.5cc µm RMCO505 Cortical, Mineralized 1cc µm RMCO510 Cancellous, Mineralized 2cc µm RMCA220 Cancellous, Mineralized 2cc µm RMCA320 Cancellous, Mineralized 2cc µm RMCA520 Cortical, Mineralized 2cc µm RMCO220 Cortical, Mineralized 2cc µm RMCO320 Cortical, Mineralized 2cc µm RMCO520 Cancellous, Partially Demineralized 2cc µm RDCA220 Cancellous, Partially Demineralized 2cc µm RDCA320 Cancellous, Partially Demineralized 2cc µm RDCA520 Cortical, Partially Demineralized 2cc µm RDCO220 Cortical, Partially Demineralized 2cc µm RDCO320 Cortical, Partially Demineralized 2cc µm RDCO520 Cancellous, Partially Demineralized, Irradiated 0.5cc µm RDCA305r Cancellous, Partially Demineralized, Irradiated 1cc µm RDCA310r Cortical, Partially Demineralized, Irradiated 0.5cc µm RDCO205r Cortical, Partially Demineralized, Irradiated 0.5cc µm RDCO305r Cortical, Partially Demineralized, Irradiated 1cc µm RDCO310r Cancellous, Mineralized, Irradiated 0.5cc µm RMCA205r Cancellous, Mineralized, Irradiated 0.5cc µm RMCA305r Cortical, Mineralized, Irradiated 0.5cc µm RMCO305r Cancellous, Partially Demineralized, Irradiated 2cc µm RDCA320r Cortical, Partially Demineralized, Irradiated 2cc µm RDCO320r Cancellous, Mineralized, Irradiated 1cc µm RMCA310r Cortical, Mineralized, Irradiated 1cc µm RMCO310r Dura Mater Patch (Membrane) 4 x 5cm 0655* Fascia Lata Patch (Membrane) 4 x 5cm 0716* Description Item No. RegenerOss Allograft (Cont d) Right Hemi Mandible 0630* Left Hemi Mandible 0631* Full Mandible 0632* Iliac Crest Strip Small 0055* Iliac Crest Strip Medium 0473* lliac Crest Strip Large 0056* Mineralized Cancellous Powder 10cc µm 1454* Demineralized Cancellous Powder 10cc µm 1462* Demineralized Cortical Powder 10cc µm 1465* Dental M&M Block Small 1507* Dental M&M Block, Irradiated Small 1523* Dental M&M Block Medium 1491* Dental M&M Block, Irradiated Medium 1522* Dental M&M Block Large 1508* Dental M&M Block, Irradiated Large 1565* RegenerOss Allograft Putty 0.5cc Syringe ROAP05 1cc Syringe ROAP10 2cc Syringe ROAP20 RegenerOss Allograft Putty Plus Mineralized 0.5cc Syringe ROAPM05 1cc Syringe ROAPM10 2cc Syringe (Four 0.5cc syringes) Value Pack! ROAPM20 Endobon Xenograft Granules µm 0.5ml ROX µm 1ml ROX µm 2ml ROX µm 2ml ROXLG µm 5ml ROXLG µm 8ml ROXLG80 OsseoGuard Membrane Resorbable Collagen Membrane 15mm x 20mm OG1520 Resorbable Collagen Membrane 20mm x 30mm OG2030 Resorbable Collagen Membrane 30mm x 40mm OG3040 OsseoGuard Flex Membrane Resorbable Collagen Membrane 15mm x 20mm OGF1520 Resorbable Collagen Membrane 20mm x 30mm OGF2030 Resorbable Collagen Membrane 30mm x 40mm OGF3040 Biogran Mixing Cup (750mg) & Syringe 1-Pack Mixing Cups (500mg) 7-Pack Mixing Cups (750mg) 7-Pack Mixing Cups (1500mg) 7-Pack Safescraper TWIST Disposable Cortical Bone Collector 3-Pack Straight 3598 Disposable Cortical Bone Collector 3-Pack Curved 3987 R. Quétin Bone-Mill Stainless Steel Bone Grinder QBM001 *Not available in all regions.

8 WANT TO FACILITATE RE-GROWTH OF BONE AND SOFT TISSUE? CONSIDER REGENERATIVE OPTIONS Not Available In All Markets. Please Contact Your Local BIOMET 3i Sales Representative For Availability Or Visit BIOMET 3i EC REP 4555 Riverside Drive Palm Beach Gardens, FL Outside The U.S.: Fax: BIOMET 3i Europe, Middle East & Africa WTC Almeda Park, Ed. 1, Planta 1ª Pl. de la Pau, s/n 08940, Cornellà de Llobregat (Barcelona) Spain Phone: Fax: Join Us Follow Us Watch Us Download It All trademarks herein are the property of BIOMET 3i LLC unless otherwise indicated. This material is intended for clinicians only and is not intended for patient distribution. This material is not to be redistributed, duplicated, or disclosed without the express written consent of BIOMET 3i. For additional product information, including indications, contraindications, warnings, precautions, and potential adverse effects, see the product package insert and the BIOMET 3i Website. Biogran, OsseoGuard, OsseoGuard Flex and RegenerOss are registered trademarks of BIOMET 3i. Providing Solutions One Patient At A Time is a trademark of BIOMET 3i LLC. Endobon is a registered trademark of BIOMET Deutschland GmbH. Safescraper is a registered trademark of META Advanced Medical Technology BIOMET 3i LLC. REV C 02/13

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