2018 INNOVATORS WORKSHOP on Personalized and Precision Orthodontics: Bridging the Biology-Technology Gap in Orthodontics & Craniofacial Care

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1 2018 INNOVATORS WORKSHOP on Personalized and Precision Orthodontics: Bridging the Biology-Technology Gap in Orthodontics & Craniofacial Care September 12-16, 2018 Scottsdale, Arizona Organized by the Consortium for Orthodontic Advances in Science and Technology (COAST) Committee Members: Dr. David Covell Jr., University at Buffalo, Buffalo NY Dr. Sylvia Frazer-Bowers, University of North Carolina at Chapel Hill, Chapel Hill NC Dr. Sarandeep Huja, Medical University of South Carolina, Charleston SC Dr. Laura Iwasaki, University of Missouri Kansas City, Kansas City MO Dr. Sunil Kapila, University of California San Francisco, San Francisco CA Dr. Jeff Nickel, University of Missouri Kansas City, Kansas City MO Wednesday, September 12 th, :00 p.m. 9:00 p.m. Conference Registration 6:00 p.m. 7:00 p.m. Welcome Reception 7:00 p.m. 9:00 p.m. DINNER Thursday, September 13 th, 2018 Session 1: 8:00AM 11:30AM 8:00AM - 8:45AM Theme: Biology and Environment- relevance to therapeutic Outcomes Keynote Speaker: Dr. Laura Iwasaki, University of Missouri Kansas City Mechanobehavior as a predictor of growth and degeneration of the TMJ

2 8:50AM 9:10AM Dr. Lina Moreno-Uribe, University of Iowa Genetics of malocclusions- results from a multicenter collaboration Dr. Seth Weinberg, University of Pittsburgh Genetics of facial soft tissues Dr. Hee Soo Oh, University of the Pacific Mechanobiology and Craniofacial Growth Dr. Sunita Ho, University of California San Francisco Biomechanics and Mechanobiology of Alveolar Bone Dr. Sue Herring, University of Washington Mechanobiology of bone and suture results from animal models 11:00AM 11:20AM Dr. William Giannobile, University of Michigan Image-based, fiber building scaffolds: a platform for regenerating tissue interfaces 11:30- Noon Noon 1:15PM General Lunch, and 1. Limited Registration MEET THE EXPERTS- Drs. PAOLO CATTANEO (Arrhaus University) AND SID VORA (University of British Columbia): Getting your 3D Imaging Research Into High Gear Agenda Topics: 1. Current updates on software and how to access programs; 2. Opportunities for inter-institutional collaborations in Europe and North America, 3. Sources of funding and strategies for accessing funding. 2. Limited Registration Career Development Workshop- With Drs. Laura Iwasaki (UMKC), Sunil Kapila (UCSF), and Saran Huja (MUSC)(Topic: It s a business deal: the facts of life of university employment, and how to keep your sanity while maintaining productivity)- Agenda Topics: 1. Negotiating your first job; 2. management strategies; 3. Start-up funds and how to calculate what you need; 3. The 10 Year Cycle - constantly reinvent yourself over an entire career. Thursday, September 13 th, 2018 Session 2: 1:30PM 5:00PM 1:30PM 2:15PM 2:20PM 2:40PM 2:45PM 3:05PM Theme: Application of Bioinformatics in Craniofacial Research Keynote Speaker: Dr. George Wehby, University of Iowa Academic Achievement of Children with Oral Clefts Dr. Veersathpurush Allareddy, University of Iowa Data mining for clinical outcomes research Dr. Shankar Rengasamy Venugopalan, University of Missouri Kansas City De novo genetic changes in craniofacial anomalies

3 3:10PM 3:30PM 3:35PM 3:55PM 4:15PM 5:00PM Dr. Sylvia Frazier-Bowers, University of North Carolina Molecular genetics of eruption and eruption failure Dr. Sompop Bencharit, Virginia Commonwealth University Update in research and methods in proteomics and bioinformatics 5:00 p.m. 6:00 p.m. Manuscript Submission- Q&A Session with Scientific Advisory Board 6:00PM 7:15PM DINNER 7:30PM-9:00 Poster Session 1 9:00 Social Hour Friday, September 14 th, 2018 Session 3: 8:00AM 11:30AM 8:00AM - 8:45AM 8:50AM 9:10AM 11:00AM 11:20AM Noon 1:15PM Theme: Regeneration with and For Orthodontic Treatment Facilitators: Drs. Covell and Huja Keynote Speaker: Dr. Paul H. Krebsbach, University of California Los Angeles Stem cells in orthodontic therapies Dr. Laurie Gower, University of Florida Biomimetic Processing for Fabricating Hard Tissues Structures Dr. Mary MacDougall, University of British Columbia Regenerating teeth: what have we achieved so far? Dr. Andrew Jheon, University of California San Francisco "Alterations in osteoclasts in utero leads to changes in adult mouse jaws" Dr.Ayman Al Dayeh, University of Tennessee Understanding the suture biology effects of bone anchored mini-plates Dr. Ching Ko, University of North Carolina Orthodontic biomechanics and bone tissue engineering Dr. Wellington Rody, University of Florida Clastic cell mechanisms in alveolar bone remodeling: Translating bench side information into clinical applications General Lunch, and 1. Limited Registration MEET THE EXPERTS- Drs. PAOLO CATTANEO

4 (Arrhaus University) AND SID VORA (University of British Columbia): Getting your 3D Imaging Research Into High Gear Agenda Topics: 1. Current updates on software and how to access programs; 2. Opportunities for inter-institutional collaborations in Europe and North America, 3. Sources of funding and strategies for accessing funding. 2. Limited Registration MEET THE EXPERTS- Drs. Luigi Gallo (University of Zurich) AND Hai Yao (Clemson University/MUSC): Recording Biological Signals: the future of real-time analysis of biobehaviors Agenda Topics: 1. Getting help from bioengineering- the need for pattern recognition algorithms; 2. Real-time data transmission using BlueTooth technology and secure server storage; 3. The future of phones and apps in personalized medicine Friday, September 14 th, 2018 Session 4: 1:30PM 3:30PM 1:30PM 1:50PM 2:00PM 2:20PM Theme: Regeneration with and For Orthodontic Treatment Facilitators: Drs. Covell and Huja Dr. Shannon Holliday, University of Florida Exosome identification in tooth movement models Dr. Emily Farrow, Children s Mercy Hospital Kansas City, Missouri Next generation sequencing to study craniofacial disorders 2:30PM 2:50PM 3:00PM 3:30PM 4:00PM 7:00PM 7:00PM- 8:00 PM Dr. Alex Robling, University of Indiana Osteocyte and mechanical loading Facilitators: Drs. Covell and Huja Planned Social Event(s) Dinner 8:00PM- 9:00PM Poster Session 1 9:00PM Social Hour Saturday, September 15 th, 2018 Session 5: 8:00AM 11:55AM 8:00AM-8:45 AM Theme: Technology in Precision Orthodontics Facilitators: Drs. Nickel and Iwasaki Keynote Speaker: Dr. Hitesh Kapadia, Seattle Children s Hospital Novel applications of DO in presurgical infant orthopedics and nonsurgical management of midface hypoplasia

5 8:50AM 9:10AM 10:55AM 11:15AM 11:25AM 11:55AM Dr. Walter Renne, Medical University of South Carolina Digital Dentistry: integrating virtual realities across disciplines Dr. Paolo Cantaneo, Arrhaus University, Denmark 3-D Superimposition of Craniofacial Imaging- The European Perspective Dr. Sid Vora, University of British Columbia 3-D Superimposition of Craniofacial Imaging- The North American Perspective Dr. Marila Yatabe, University of Michigan 3-D Superimposition of Craniofacial Imaging- the utility of multicenter collaborations across continents and oceans Dr. Tung Nguyen, University of North Carolina 3-D Superimposition of Craniofacial Imaging- Post-surgical changes in the craniofacial complex Dr. Ahmed Ghoneima, University of Indianna 3D superimposition of digital models Facilitators: Drs. Huja and Frazier-Bowers 12 NOON 1:15PM 1. Limited Registration MEET THE EXPERTS- Drs. Luigi Gallo (University of Zurich) AND Hai Yao (Clemson University/MUSC): Recording Biological Signals: the future of real-time analysis of biobehaviors Agenda Topics: 1. Getting help from bioengineering- the need for pattern recognition algorithms; 2. Real-time data transmission using BlueTooth technology and secure server storage; 3. The future of phones and apps in personalized medicine 2. Limited Registration Career Development Workshop- With Drs. Laura Iwasaki (UMKC), Sunil Kapila (UCSF), and Saran Huja (MUSC)(Topic: It s a business deal: the facts of life of university employment, and how to keep your sanity while maintaining productivity)- Agenda Topics: 1. Negotiating your first job; 2. management strategies; 3. Start-up funds and how to calculate what you need; 3. The 10 Year Cycle - constantly reinvent yourself over an entire career. Saturday, September 15 th, 2018 Session 6: 1:30PM 6:00PM 1:30PM 1:50PM 2:00PM 2:20PM Technology in Precision Orthodontics Facilitators: Drs. Nickel and Iwasaki Dr. Nada Souccar, University of Alabama 3D facial analyses Dr. Dogyoon Kim, Ohio State University Interpretation of bone tissue properties from CBCT images

6 2:30PM 2:50PM 3:00PM 3:20PM 3:30PM- 4:00PM 4:00PM 7:00PM 7:00PM- 8:00 PM Dr. Snehlata Oberoi, University of California San Francisco Digital health devices to improve compliance and monitoring of appliance wear Dr. Sean Edwards, University of Michigan Virtual Treatment Planning for Craniofacial Surgeries Facilitators: Drs. Covell and Iwasaki Planned Social Event Dinner 8:00PM- 9:00PM Poster Session 2 9:00PM Social Hour Sunday, September 16 th, 2018 Session 7: 8:00AM 11:45AM 8:00AM-8:45 AM 8:50AM 9:10AM 10:55AM- 11:30AM 11:30AM 11:50AM Muscle, Joint, and Airway: Growth, Function, and Pain Facilitators: Drs. Frazier-Bowers and Huja Keynote Speaker: Dr. Scott Conley, University at Buffalo Airway function and the role of the orthodontic intervention Ms. Linda D'Onofrio, Oregon Health and Sciences University Speech pathology and craniofacial growth Dr. Hai Yao, Clemson University/Medical University of South Carolina Automation algorithms for characterizing behavior via pattern recognition Dr. Yoly Gonzalez, University at Buffalo Anxiety, depression, somatization and muscle duty factors Dr. Luigi Gallo, University of Zurich Real-time ecological recording of homeostatic status Dr. Jeff Nickel, University of Missouri Kansas City Nocturnal sympathetic and parasympathetic tone and masticatory muscle duty factors Facilitators: Drs. Frazier-Bowers and Huja Concluding Remarks, Circulation of Outline for Position Paper, Official

7 Closing of COAST 2018 Innovators Workshop: Scientific Advisory Board 12 NOON Lunchboxes to go END OF CONFERENCE For additional information contact: FASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD

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