Versatile grafting Solutions
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1 Versatile grafting Solutions
2 A Canadian company serving Canadian dentists since 1997 Here s why your colleagues are calling us for their bone regeneration needs Founded in 1997 Citagenix has been providing product to dental and orthopedic clinicians to regenerate bone. 100% privately owned Canadian company whose management and field force have an average of over 20 years of experience and are one of the most knowledgeable and experienced teams in this industry. We are experts in this field with a proven track record, making us a valuable resource for our customers. Citagenix is fully licensed by Health Canada as a Medical Device Establishment (Class I to IV) as well as under the CTO Regulations to import and distribute human tissues and is ISO13485 and ISO9001 certified. Citagenix is the premiere Canadian provider of bone grafting and surgical products. Using our experience and expertise, we work with dentists and orthopedic surgeons to filter through the wide variety of bone regeneration products available today to select the best solution in order for them to obtain their desired surgical outcomes. Our head office is located in Laval, Quebec. Citagenix has expanded its international activities in the recent years. With distribution partners in 25 countries and growing, we are increasing our international reach annually. Along with our knowledge and expertise, our international activities have made Citagenix a valuable partner to global companies with similar approach to servicing these markets. We believe in creating lifelong relationships with health care innovators and providers across North America and around the world. To maintain our position as market leaders and innovators, Citagenix is constantly looking for new technologies and innovative products within our field of expertise to serve you better. 100% Canadian owned company serving Canadian clinicians and hospitals since 1997 Call us, we are looking forward to fulfilling your needs! Citagenix... Innovative solutions; better outcomes
3 Three key elements of bone regeneration Scaffolds Allograft chips or synthetic granules provide the osteoconductive elements to encourage the attachment of osteogenic precursor cells. Scaffold maintains volume of the defect site while anchoring surrounding cells. Signals Proven osteoinductive properties of BMPs in demineralized bone stimulates the growth of new bone. Cells Patient s own osteoblasts, osteoclasts and mesenchymal stem cells integrate with the graft material. key elements of bone regeneration Particulate Demineralized Bone Matrix (DBM) consists of a highly dense matrix of Type-I Collagen and naturally occurring growth factors, with limited accessibility. Natural Plant Derived Carrier Carboxymethylcellulose (CMC) Cancellous Chips
4 Demineralized Bone Matrix (DBM) Putty + CMC C-Graft Putty is a demineralized bone matrix in a CMC carrier. Features & Benefits Quality products Excellent handling Great pricing Ready to use Room temperature storage Open bore syringes E-beam sterilization Double sealed blister packaging Common applications Sockets Preservation Extraction site repair Implant dehiscence defects Sinus lift procedures Moderate localized ridge defects Available in 0.3 cc Available syringe sizes: 0.3 cc 0.5 cc 1 cc 3 cc syringes IN VITRO DBM + CMC
5 Ridge Split with Implants Ridge Split & Grafting using C-Graft Putty This patient was complaining of pain when wearing lower dentures. The previous treatment plan had partial dentures anchored by single implants using ERA attachments due to cost. The new treatment plan included multiple implants and ridge split with grafting due to resorption. C-Graft Putty was used. NATURAL PLANT DERIVED CARRIER Carboxymethyl cellulose (CMC) Natural, odourless, tasteless & nontoxic High viscosity and malleable Widely used in medical preparations
6 Demineralized Bone Matrix Putty + CMC + Cancellous bone chips C-Blast Putty is a composite graft product that combines osteoinductive and osteoconductive elements in a CMC carrier. Features & Benefits Quality products Excellent handling Great pricing Ready to use Room temperature storage Open bore syringes E-beam sterilization Double sealed blister packaging Common applications Sockets Preservation Extraction site repair Implant dehiscence defects Sinus lift procedures Moderate localized ridge defects Available in 0.3 cc Available syringe sizes: 0.3 cc 0.5 cc 1 cc 3 cc syringes DBM + + Cancellous CMC
7 Sinus elevation NATURAL PLANT DERIVED CARRIER Carboxymethyl cellulose (CMC) Natural, odourless, tasteless & nontoxic High viscosity and malleable Widely used in medical preparations
8 Eclipse Synthetic resorbable bone substitute Synthetic resorbable bone substitute that uses the mineral building blocks naturally found in human bone. Eclipse goes a step beyond with its unique combination of micro and macroporosity technology. Granules: 80 % ß-tcp - 20 % HA Putty: 40 % ß-tcp - 60 % HA Common applications Ridge preservation Extraction site repair Sinus lifts Ridge augmentation Osseous defects Periodontal defects Eclipse may be used alone or mixed with DBM Putty for osteoinductive potential. Granules available in vials or syringes. Putty available in syringes. Micro
9 Eclipse Granules and Eclipse Putty Synthetic Resorbable Bone Substitutes 80 % ß-tcp calcium and phosphate ion release 20 % HA scaffold effect for osteoblastic activity 70 % overall porosity 2/3 macroporosity 1/3 microporosity Putty 40 % ß-tcp calcium and phosphate ion release 60 % HA scaffold effect for osteoblastic activity 70 % overall porosity Eclipse micropores assure interconnectivity of the porous network, allowing diffusion of biological fluids throughout the graft. These fluids are necessary for the dissolution of the ß-tcp causing the liberation and precipitation of calcium and phosphate ions. This initial step creates large specific surfaces able to catch and absorb the proteins and growth factors of the patient. Then Eclipse macropores allow cells and tissue to colonize into the core of the implant resulting in bone formation through the natural osseous substitution process. Microporosity + Macroporosity = Controlled Bioactivity => Resorption & Substitution vial syringe Macro Granules (0.5 to 1.0 mm) Granules (1.0 to 2.0 mm).25 cc.5 cc 1 cc.5 cc 1.0 cc 2 cc Putty cc 1.0 cc
10 Irradiated bone particulates, a natural scaffold for bone regeneration Raptos allograft mineralized bone grafts offer an osteoconductive platform for bone regeneration and Raptos demineralized particles offer an osteoinductive boost. Used either alone or as part of a composite bone graft, allograft bone particulates supply a natural framework facilitating the attachment of osteogenic precursor cells. Features & Benefits Osteoconductive scaffold Remodels completely to host bone Mineralized graft material Common applications Mineralized component in a composite graft As a graft extender Osseous defects Raptos particles may be used alone or mixed with DBM Putty for osteoinductive potential. Raptos Bone blocks Raptos bone blocks are available in convenient sizes and shapes. Our cortico-cancellous blocks and wedge combine the stability of a cortical surface with the porosity of a cancellous surface for osteointegration. Raptos demineralized sponge block can be compressed once rehydrated to adapt easily to the defect site. 7x7x10 mm Wedge 6x6x10 mm Block 6x12x12 mm Block 6x12x20 mm Block Raptos bone blocks can be drilled for screw fixation and can be trimmed according to surgical needs. 10x10x10 mm Sponge Block
11 Safety information Each donor is thoroughly evaluated using medical/social history questions, medical records, blood tests, culture results, physical examination and autopsy reports (when performed). This process is used to ensure the donor is suitable for donation by allowing to recognize and exclude potential diseases or medical conditions that are unacceptable. Specific lab tests are performed for Syphilis, Hepatitis B and C, HIV and other viruses. All of the donor chart information is evaluated by individuals trained in tissue banking, prior to the processing of the tissue. Tissue grafts are rinsed and soaked in various solutions to minimize transmission of bacteria and viruses. Processing and packaging of the tissue are performed using aseptic technique and occur in a clean room. As an added margin of safety, a low dose gamma irradiation after final packaging of the musculoskeletal grafts is utilized. AATB accredited source and mandatory CTO registered with Health Canada. Vials Granule size µm µm µm µm Syringes Granule size µm µm CAnCellOUs.5 cc 1 cc 2 cc CAnCellOUs.25cc.5 cc 1 cc COrTiCAl.5 cc 1 cc 2 cc.5 cc 1 cc.5 cc 1 cc 2 cc 1 cc 2 cc COrTiCAl COrTiCO- CAnCellOUs.5 cc 1 cc 2 cc COrTiCO- CAnCellOUs DeMinerAliZeD DeMinerAliZeD.25cc.5 cc 1 cc.25cc.5 cc 1 cc.25cc.5 cc 1 cc 1 cc 1 cc 1 cc 1 cc
12 Raptos Allograft Cancellous, cortical, corticocancellous and demineralized irradiated bone particulates that offer an osteoconductive scaffold for bone regeneration. C-Graft Putty Demineralized bone matrix in CMC - a natural, plant derived, carrier for superior handling. C-Blast Putty A composite graft product that combines osteoinductive DBM and osteoconductive cancellous particles in CMC - a natural, plant derived carrier for superior handling. Eclipse Synthetic Granules Synthetic resorbable bone substitute that uses the mineral building blocks naturally found in human bone. Granules: 80%ß-tcp - 20%HA Putty: 40% ß-tcp - 60% HA Regenerative properties dbm CMC dbm CC CMC Characteristics Osteoconductive scaffold Remodels completely to host bone Mineralized graft material DBM with natural CMC carrier Excellent handling Great pricing Ready to use Open bore syringe Osteoinductive and osteoconductive Demineralized Bone Matrix (DBM) with Cancellous Bone and CMC carrier Excellent handling Great pricing Open bore syringe Macro and Micro pores allow complete remodeling Completely remodels to host bone while preserving volume (12-18 months**) Applications Mineralized component in a composite graft As a graft extender Osseous defects Periodontal defects Extraction site repair Implant site development Sinus lift procedures Coronal defects around immediate implants Sockets Preservation Extraction site repair Implant dehiscence defects Sinus lift procedures Moderate localized ridge defects Ridge preservation Extraction site repair Sinus lifts Ridge augmentation Osseous defects Periodontal defects Mixing options May be used alone or mixed with DBM Putty for osteoinductive potential. May be used alone or mixed with Raptos allograft bone and/or Eclipse synthetic bone. May be used alone or mixed with cortical bone (Raptos) in larger defect sites. May be used alone or mixed with DBM Putty for osteoinductive potential. Citagenix Inc., 1111 Autoroute Chomedey, Laval, QC H7W 5J8 T Citagenix.com info@citagenix.com
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