BMP SYMPOSIUM Extended Clinical Applications of Recombinant Human Bone Morphogenetic Protein 2 (rhbmp-2) Robert E. Marx, DDS FEATURING CHAIRMAN

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1 BMP SYMPOSIUM 2010 FEBRUARY 12 13, 2010 SHERATON SAN DIEGO HOTEL AND MARINA FEATURING Extended Clinical Applications of Recombinant Human Bone Morphogenetic Protein 2 (rhbmp-2) CHAIRMAN Robert E. Marx, DDS Sponsored by SPEAKERS >> Joel S. Berger, DDS, MD >> Michael H. Carstens, MD >> Alan S. Herford, DDS, MD >> Ole T. Jensen, DDS, MS >> Jay P. Malmquist, DMD >> Robert E. Marx, DDS >> Peter K. Moy, DMD >> Daniel B. Spagnoli, DDS, PhD

2 BMP SYMPOSIUM 2010 INVITATION Dear Colleagues: It gives me great pleasure to invite you to attend the BMP Symposium 2010 on Extended Clinical Applications of Recombinant Human Bone Morphogenetic Protein 2 (rhbmp-2) in San Diego. After numerous animal and human research studies that first began in 1965, the US Food and Drug Administration cleared rhbmp-2 in combination with an acellular collagen sponge (rhbmp-2/acs) for two dental and oral and maxillofacial surgery indications (socket grafting and sinus augmentation) in March of In just 2 short years, it has met and even exceeded its clinical promise of bone regeneration without using the patient s own bone. Extended applications in horizontal and vertical ridge augmentations, ridge splitting, implant and inadequate graft salvage, alveolar clefts, orthognathic surgery, and continuity defects have shown that rhbmp-2/acs can replace autogenous grafting in many other applications, thereby providing reduced complication potential and morbidity for patients. The symposium is designed to present the specific indications, techniques, doses, comaterials, costs, and outcomes for these extended applications by the researchers and clinicians with the most thorough scientific and clinical experience using rhbmp-2/acs. This course should provide the necessary information and examples so that attendees can assess each of their own patients as to the potential advantages and limitations of using rhbmp-2/acs. I hope you will find the meeting an extraordinary learning opportunity and look forward to welcoming you in San Diego. Robert E. Marx, DDS PROGRAM CHAIRMAN COURSE GOALS >> Participants will be able to understand the expanding utility of rhbmp in jaw reconstructions. >> Participants will learn specific procedures for the regeneration of bone in defects of the jaws. >> Participants will be able to decide whether rhbmp is indicated in their individual patients. OBJECTIVES >> Participants will learn the appropriate dose of rhbmp for each indication. >> Participants will understand the role of scaffolds and tenting devices to achieve the best outcome when using rhbmp. >> Participants will learn the correct application of rhbmp through hands-on practice, lectures, and seminars. Disclaimer: In accordance with accreditation requirements, Quintessence Publishing Co Inc will disclose any financial interests or other relationship with the manufacturers of any commercial products and/or providers of commercial services discussed in an educational presentation.

3 GENERAL INFORMATION REGISTRATION Your registration fee includes admission to all symposium sessions and exhibits, daily meals (breakfast/ lunch/coffee break), and the welcome reception on Friday evening. Take advantage of specially reduced fees by registering in advance. REGISTRATION FEES By November 30, 2009 On or After December 1, 2009 Regular rate US $680 US $780 Resident rate* US $350 US $350 *Please submit verification of resident status with the registration form. HOW TO REGISTER Complete the enclosed registration form and do one of the following: > Register online at or > Mail your form and check (payable to Quintessence Publishing Co Inc) for the registration fee to Quintessence Publishing at the address indicated on the back, or > Fax your form with credit card information to Quintessence at > On-site registration will be accepted only on the basis of space availability and thus cannot be guaranteed. Early advance registration is strongly recommended. The deadline for registering for the symposium is January 31, CANCELLATIONS/REFUNDS Cancellations made in writing and received by Quintessence before January 31, 2010, will be refunded in full. For cancellations received on or after February 1, 2010, but before the start of the meeting, a cancellation fee of US $50 will be charged. No refunds will be made after the symposium begins on February 12, CONTINUING EDUCATION CREDITS Attendees of the symposium will receive up to 15 hours of CE credit. Quintessence Publishing Co Inc is an ADA CERP Recognized Provider. REGISTRATION DESK Your symposium packet will await you at the symposium registration desk, located in front of the Ballroom on the ground level of the hotel.the desk will open at 1:00 PM on Thursday, February 11, and 7:00 AM on Friday and Saturday. Please note that on-site registrations will be accepted only if room capacity allows. HOTEL RESERVATION Hotel rooms have been blocked for symposium participants at the Sheraton San Diego Hotel & Marina. Please make your reservations by the reservation cut-off date, January 11, Call the hotel reservation desk directly at Be sure to indicate the name of the symposium to receive the special meeting rate. Meeting Rate for Standard Single/Double: US $199 per night TECHNICAL EXHIBITS Technical exhibits will be held on Friday and Saturday during the symposium.visit the exhibits to observe the latest developments in regenerative products offered by the leading manufacturers. Exhibit hours are: Friday, February 12, 2010 Saturday, February 13, :00 AM 6:00 PM 6:30 AM 6:00 PM WELCOME RECEPTION The welcome reception will be held on Friday, February 12, from 6:30 PM to 8:00 PM.Take this opportunity to meet your colleagues and the distinguished speakers; renew old friendships and begin new ones.

4 PROGRAM SCHEDULE Friday, February 12, 2010 Breakfast with Exhibitors Welcome and Introduction 7:00 8:00 AM 8:00 8:15 AM >> The Science & History of BMP from Marshall Urist to the Clinical Arena Robert E. Marx 8:15 8:30 AM >> Sinus Augmentation Using rhbmp-2: Dosing, Space Maintainers, and Scaffolds Jay P. Malmquist Peter K. Moy 8:30 9:30 AM 9:30 10:30 AM Break with Exhibitors 10:30 11:00 AM >> Localized Horizontal and Vertical Ridge Augmentation Joel S. Berger 11:00 AM 12:00 PM Daniel B. Spagnoli 12:00 1:00 PM Lunch with Exhibitors 1:00 2:30 PM >> Bone Regeneration in Maxillary Alveolar Cleft Grafting Using rhbmp-2 Alan S. Herford Michael H. Carstens 2:30 3:30 PM 3:30 4:30 PM >> Case Discussion Sessions with Speakers * 4:30 6:00 PM Session A: Session B: Session C: Sinus Augmentation Ridge Augmentation Maxillary Alveolar J. Malmquist Cleft Grafting P. Moy J. Berger R. Marx D. Spagnoli A. Herford M. Carstens * In these special sessions, the speakers will present sample BMP reconstruction cases for problem solving, treatment planning, and discussion of specific techniques and applications. Participants are invited to bring their own cases for faculty and group discussion and assessment. >> Welcome Reception 6:30 8:00 PM

5 Saturday, February 13, 2010 Breakfast with Exhibitors 7:00 7:30 AM >> Use of rhbmp-2 for Maxillary Interpositional Grafting and Combined Buccopalatal Wall Defects Ole T. Jensen 7:30 8:30 AM >> Extended and Total Horizontal and Vertical Ridge Augmentations Robert E. Marx 8:30 9:30 AM Break with Exhibitors 9:30 10:00 AM >> Reconstruction of Mandibular Continuity Defects Using rhbmp-2 Robert E. Marx 10:00 11:00 AM Daniel B. Spagnoli 11:00 AM 12:00 PM Lunch with Exhibitors 12:00 1:30 PM >> Applications of rhbmp-2 in Orthognathic Surgery and Craniofacial Surgery Peter K. Moy 1:30 2:30 PM >> Salvaging the Inadequate Microvascular Fibula and Other Deficient Graft Outcomes Using rhbmp-2 Maxilla Daniel B. Spagnoli 2:30 3:00 PM Mandible Robert E. Marx 3:00 3:30 PM >> Case Discussion Sessions with Speakers * 3:30 5:00 PM Session A: Orthognathic Surgery and Interpositional Grafting O. Jensen J. Berger Session B: Orthognathic and Craniofacial Surgery M. Carstens P. Moy Session C: Continuity of Defect Reconstruction R. Marx D. Spagnoli

6 >> FREE BONUS BOOK As a special thank you from Quintessence Publishing Co Inc for your registration, a free copy of Dental and Craniofacial Applications of Platelet-Rich Plasma by Robert E. Marx and Arun K. Garg has been set aside for you. Pick it up with your registration materials at the opening of the meeting! This authoritative handbook explains PRP s biologic mechanism of action, the in-office procedure for developing PRP, and most important, its application and expected benefits in procedures such as implant placement, periodontal bone and soft tissue surgery, sinus lifts, jaw reconstructions, soft tissue facial augmentations, and facial cosmetic surgeries. 168 pp; 364 illus (mostly color); ISBN (B4322); US $98 (regular price) SYMPOSIUM REGISTRATION Mail or fax entire page to: Quintessence Publishing Co Inc 4350 Chandler Drive, Hanover Park, IL Fax: service@quintbook.com Please print.to register additional participants, please photocopy this form. Name Address City State Zip Country Fax Please check one: General practitioner Oral Surgeon Periodontist Other (please specify) By November 30, 2009 On or After December 1, 2009 Regular rate US $680 US $780 Resident rate* US $350 US $350 *Please submit verification of resident status with this registration form. Check enclosed (make payable to Quintessence Publishing Co Inc) Charge to: Visa, MasterCard, American Express, or Discover (circle one) Card no. Expires Signature >> SESSION PREFERENCES IMPORTANT! Please check the Case Discussion Sessions with Speakers you plan to attend (choose one for each day). Indicating your preference at this time does not obligate you to attend those sessions. Friday, February 12, 2010 Session A: Sinus Augmentation Session B: Ridge Augmentation Session C: Maxillary Alveolar Cleft Grafting Saturday, February 13, 2010 Session A: Orthognathic Surgery and Interpositional Grafting Session B: Orthognathic and Craniofacial Surgery Session C: Continuity of Defect Reconstruction >> HOTEL RESERVATION Sheraton San Diego Hotel & Marina Reserve by January 11, 2010 to receive the meeting rate: Standard Single/Double: US $199 per night Call the hotel reservation desk directly at Be sure to indicate the name of the symposium to receive the special meeting rate.

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