Symbios Xenograft Granules Porcine Bone Graft Material
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1 Symbios Xenograft Granules Porcine Bone Graft Material USX-1607_Symbios Highlight Brochure.indd :12
2 Symbios Xenograft Granules Porcine bone graft material Symbios Xenograft Granules is a porcine bone mineral indicated for periodontal, oral and maxillofacial surgery. The use of Symbios Xenograft Granules may be considered when autogenous bone is not indicated or is insufficient in quantity to fulfill the needs of the proposed surgical procedure. Highly porous carbonate apatite particles 1 Natural pore structure for cell conduction 1 High intra- and inter-particle space for osteoconduction and new bone deposition 1 The anorganic bone matrix of Symbios Xenograft Granules has an interconnecting macro- and microscopic pore structure that supports the formation and ingrowth of new bone. 88% void space for bone ingrowth 1 High porosity Natural carbonate apatite Rough surface texture USX-1607_Symbios Highlight Brochure.indd :12
3 Magnification 6x USX-1607_Symbios Highlight Brochure.indd :12
4 Tackle bony defects Symbios Xenograft Granules is intended for periodontal, oral and maxillofacial surgery. Symbios Xenograft Granules: SEM pictures shows interconnecting pores and the rough surface which favors the cell adhesion 2 Sinus floor elevation Ridge augmentation Socket preservation Infrabony periodontal defects Apicoectomy Cystectomy Filling of periodontal and peri-implant defects in conjunction with products intended for Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR) Magnification x50 Magnification x75 Bio-Oss Magnification x50 Magnification x75 Symbios Xenograft Granules has statistically significant higher volume fill capacity than Bio-Oss USX-1607_Symbios Highlight Brochure.indd :12
5 Features Interconnecting macro- and microscopic pore structure à Benefits Supports vascularization, bone ingrowth and nutrition 6 Highly porous with 88% to 95% empty space à More space for new bone deposition Rough surface texture à Facilitates cell adhesion and bone ingrowth 2 3, 4, 5 Carbonate apatite à Aids remodeling of the healing bone Granules hold together upon hydration Available in a jar or syringe in two different particle sizes and in a range of volumes à à Ease of handling and placement in the defect site Greater clinician choice Symbios Xenograft Granules provide more intra- and inter-particle space for osteoconductivity and new bone deposition than Bio-Oss 1 Properties Symbios Xenograft Granules Particle size ( mm) Particle size ( mm) % Void space Particle size ( mm) 2.86 ± 0.13 cm 3 /g 4.35 ± 0.34 cm 3 /g 88% 95% Bio-Oss 2.13 ± 0.08 cm 3 /g 2.91 ± 0.08 cm 3 /g 78% 88% % Void space Particle size ( mm) USX-1607_Symbios Highlight Brochure.indd :12
6 Clinical Cases Sinus floor elevation with Symbios Xenograft Granules, Shankar Iyer, D.D.S., M.D.S., USA hydration with sterile saline or patient s blood Lateral window sinus floor elevation Filling the defect with porcine mineral bone grafting material Socket preservation with Symbios Xenograft Granules, Barry P. Levin, D.M.D., USA Patient s pre-operative PA The residual extraction sockets are obturated with a composite, particulate graft composed of equal parts Freeze Dried Bone Allograft & Porcine bone graft material. PerioDerm* (thin, mm) is trimmed and adapted via a tissue punch over the healing abutment and utilized as a membrane (GBR) and soft tissue thickening material USX-1607_Symbios Highlight Brochure.indd :12
7 Symbios Xenograft Granules ORDER NO. PARTICLE SIZE VOLUME mm 0.5 cc (0.5 ml) mm 1.0 cc (1.0 ml) Symbios Xenograft Granules Syringe* ORDER NO. PARTICLE SIZE VOLUME mm 0.25 cc (0.25 ml) mm 0.5 cc (0.5 ml) mm 2.0 cc (2.0 ml) mm 4.0 cc (4.0 ml) mm 1.0 cc (1.0 ml) mm 2.0 cc (2.0 ml) References 1 Li ST, Chen HC, Yuen D. Isolation and Characterization of a Porous Carbonate Apatite From Porcine Cancellous Bone. Science, Technology, Innovation, Aug. 2014: Deligianni DD, Katsala ND, Koutsoukos PG, Missirlis YF, Effect of Surface Roughness of Hydroxyapatite on Human Bone Marrow Cell Adhesion, Proliferation, Differentiation and Detachment Strength. Elsevier Biomaterials 22 (2001) Spense G., Patel N., Brooks R., Rushton N Carbonate Substituted Hydroxyapatite: Resorption by Osteoclasts Modifies the OsteoblasticResponse. Journal of Biomedical Materials Research Part A Ellies LG, Carter JM, Natiella JR, Featherstone JDB, Nelson DGA Quantitative Analysis of Early In Vivo Tissue Response to Synthetic Apatite Implants. J Biomed Mater Res 22: Landi E., Celotti G., Logroscino G., Tampieri A Carbonated Hydroxyapatite as Bone Substitute. Journal of theeuropean Ceramic Society 23: Frank M. Klenke, Yuelian Liu, Huipin Yuan, Ernst B. Hunziker,Klaus A. Siebenrock, Willy Hofstetter. Impact of pore size on the vascularization and osseointegration of ceramic bone substitutes in vivo. Journal of Biomedical Materials Research Part A, 2007, Symbios Xenograft Granules is manufactured by Collagen Matrix, Inc. Bio-Oss is a registered trade mark of Geistlich Pharma AG. * Not yet available in all countries. Please contact your sales representatives for availability USX-1607_Symbios Highlight Brochure.indd :12
8 About Dentsply Sirona Implants Dentsply Sirona Implants offers comprehensive solutions for all phases of implant therapy, including Ankylos, Astra Tech Implant System and Xive implant lines, digital technologies, such as Atlantis patient-specific CAD/CAM solutions and Simplant guided surgery, Symbios regenerative solutions, and professional and business development programs, such as STEPPS. Dentsply Sirona Implants creates value for dental professionals and allows for predictable and lasting implant treatment outcomes, resulting in enhanced quality of life for patients. About Dentsply Sirona Dentsply Sirona is the world s largest manufacturer of professional dental products and technologies, with a 130-year history of innovation and service to the dental industry and patients worldwide. Dentsply Sirona develops, manufactures, and markets a comprehensive solutions offering including dental and oral health products as well as other consumable medical devices under a strong portfolio of world class brands. As The Dental Solutions Company, Dentsply Sirona s products provide innovative, high-quality and effective solutions to advance patient care and deliver better, safer and faster dentistry. Dentsply Sirona s global headquarters is located in York, Pennsylvania, and the international headquarters is based in Salzburg, Austria. The company s shares are listed in the United States on NASDAQ under the symbol XRAY. Visit for more information about Dentsply Sirona and its products. Dentsply Sirona does not waive any right to its trademarks by not using the symbols or USX Dentsply Sirona. All rights reserved THE DENTAL SOLUTIONS COMPANY USX-1607_Symbios Highlight Brochure.indd :12
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