Dental Research Journal

Size: px
Start display at page:

Download "Dental Research Journal"

Transcription

1 Dentl Reserch Journl Originl Article The role of cyclosporine A on the periodontl tissues Mllpp Jysheel 1, Dhoom Singh Meht 1 1 Deprtment of Periodontology, Bpuji Dentl College nd Hospitl, Dvngere, Krntk, Indi ABSTRACT Received: Novemer 2012 Accepted: My 2013 Address for correspondence: Dr. M. Jysheel, Deprtment of Periodontology, Bpuji Dentl College nd Hospitl, Dvngere , Krntk, Indi. E-mil: Jysheel6@ gmil.com Bckground: Cyclosporin A (CsA) is known immunosuppressive gent nd cn e considered s lifesving drug in the orgn trnsplnttion cses. However, it is ssocited with mny side-effects on different tissues nd ody orgns including the periodontl tissues. The present niml study ws undertken to evlute the effects of CsA trgeting the tissue trid of periodontl tissues, i.e., gingiv, lveolr one nd cementum in rts. Mterils nd Methods: Twelve 6-week-old mle Wistr rts weighing g were considered for the cse-control study in rts. The rts were divided into 2 groups: (1) CsA (test) group (2) Sline (control) group nd were dministered the sme sucutneously dily once for 45 dys. Impressions were tken nd study csts were prepred on weekly sis for the morphometric nlysis. At the end of 45 dys, rts were scrificed nd specimens were nlyzed for histomorphometric nlysis. CsA nd sline groups were nlyzed to test of ssocition using the Student t-test t 99% confidence intervl. Results: The morphometric exmintion showed significnt gingivl overgrowth in the CsA group, wheres no such growth in the sline group. Similrly, on histomorphometric nlysis, there ws significnt loss of lveolr one in CsA group s compred with control. Furthermore, there ws lrge mount of cementum formtion ccompnied y insertion of new connective tissue fiers especilly in the cervicl region of the tooth in CsA group rts. Conclusion: CsA trgets the periodontl tissues (gingiv, lveolr one nd cementum) in different pttern. Its role in cementogenesis cn e utilized for periodontl regenertion, if its locl ppliction is testified nd verified in the future niml studies. Key Words: Alveolr one loss, cyclosporin A, gingivl overgrowth, new cementum formtion INTRODUCTION Cyclosporin A (CsA) is one of the sic immunosuppressive drugs widely used to prevent orgn trnsplnt rejection nd for the tretment of other immune diseses, such s Behçet s disese, rheumtoid rthritis, systemic lupus erythemtosus, Crohn s disese, ulcertive colitis nd insulin dependent dietes mellitus. The side-effects of Access this rticle online Wesite: http//:drj.mui.c.ir CsA therpy include gingivl overgrowth (GO), nephrotoxicity, heptotoxicity nd one loss. [1] Periodontium is trget tissue for cyclosporine therpy wherein it trgets specilly the tissue of the periodontium (gingiv, lveolr one nd cementum) in very unique wy. Though CsA hs negtive impct on gingiv (overgrowth) nd lveolr one (one loss), [2] it stimultes cementum formtion on the root surfces. [3] The CsA-induced GO hs een reported in oth niml models [4,5] nd humn clinicl cses. [6] The prevlence of CsA-induced GO, which ffects the qulity-of-life of ptients, rnges from 8% to 70% with men prevlence of 35%. [6] Bone loss is cliniclly importnt prolem ffecting 6% to 15% of ptients in 1 st yer fter orgn trnsplnttion. An incresed lveolr one destruction t periodontl sites ws found in rts 802 Dentl Reserch Journl / Novemer 2013 / Vol 10 / Issue 6

2 fter CsA exposure. [7] This phenomenon of incresed lveolr one loss my e relted to the current concept of osteoimmunology wherein there is n incresed recognition of the interctions etween cells of immune nd skeletl systems. [8] There is ccumulting evidence tht CsA hs negtive impct on one metolism in humn, [9-11] lthough the current literture regrding the effect of CsA on lveolr one is controversil nd indequte. Dentl cementum is minerlized tissue covering the root dentin nd plys key role in the ttchment of the tooth to the surrounding structures. This ttchment occurs y mens of functionl insertion of periodontl collgen fiers into the new cementum (NC). In recent niml study, it ws oserved tht the cyclosporine fed rts showed NC deposition on the root surfces with functionlly inserting collgen fiers. [3,12] The NC is deposited on the firillr extrinsic fier cementum, minly on the cervicl third of roots s irregulr lyers, spurs of vrious sizes nd shpes or in oth configurtions. [3] There re severl studies in the literture investigting the role of CsA on the periodontl tissue trid on the individul sis. [4-8,12-14] However, on literture serch nd to the est of our knowledge, there is no such study, in which the impct of CsA on ll the three periodontl trget tissues were investigted simultneously. Hence, the present cse-control niml study ws undertken to investigte the effect of cyclosporine therpy to mesure the GO morphometriclly nd evlute the lveolr one loss nd NC formtion histologiclly in Wistr rts. MATERIALS AND METHODS Selection of rts nd cre Twelve mle Wistr rts, ge 6 weeks nd weighing pproximtely g were used for this cse-control niml study. Rts were housed in polypropylene cges using husk s their edding nd kept in the niml house of the JJM Medicl College, Dvngere. The niml house temperture ws mintined t 24 C nd light cycle (12 h light nd 12 h drk). Rts were fed with stndrd commercil lortory diet nd wter d liitum. Hndling of the rts ws crried out s per the guidelines given y Ntionl Centre for Lortory Animl Sciences. The ethicl pprovl ws otined from the Ethicl Committee of JJM Medicl College, Dvngere. CsA dministrtion After 1 week of cclimtiztion in the niml house, the rts were rndomly divided into two groups: six rts in ech group. The control group rts were injected with norml sline 10 mg/kg ody weight/ dy sucutneously nd test groups with 10 mg/kg ody weight/dy of CsA sucutneously for period of 45 dys. CsA ws procured from Novrtis Indi nd ws injected using tuerculin syringe. The rts were weighed once week in order to djust the dose of CsA. After the injections, the rts were given free ccess to food nd wter. Assessment of GO Impression mking nd preprtion of stone models To record the gingivl chnges in the mndiulr nterior region, impressions were mde prior to strt of the study with customized crylic trys nd stone csts were poured to serve s seline. The procedure ws crried out t the end of 45 dys nd stone csts were poured. Gingivl dimensions on the cst were mesured. Morphometric mesurement of GO The gingivl dimensions in the region of mndiulr incisors were mesured nd recorded [Figure 1]. Buccolingul dimension [BLi], mesiodistl dimension [MDi] nd verticl height dimensions [VHi] in the Figure 1: Gingivl dimension in () sline treted rts () cyclosporin A treted rts Dentl Reserch Journl / Novemer 2013 / Vol 10 / Issue 6 803

3 region of the interdentl ppill ws recorded s previously descried. [14] Assessment of lveolr one loss y histomorphometric nlysis Rts were scrificed t the end of the study period. The mndiles were crefully removed nd the sections involving the mndiulr molr teeth nd one were dissected out nd immeditely trnsferred into solution contining 10% neutrl formlin ( tissue fixtive gent) nd smples were sujected to histomorphometric nlysis. Morphometric nlysis To mesure the one loss morphometriclly, imges of the specimen were cptured using three chip chrge coupled deviceccd cmer ttched to stereomicroscope with 5 ojective. The mesurement ws crried out using the imge pro-plus softwre. The distnce ws mesured from the cusp tip to the crest of the lveolr one. Assessment of NC formtion Declcifiction procedure Declcifiction of the specimen ws crried out using the declcifying gent (formlin-nitric cid solution) nd this procedure ws crried out in room temperture of 37 C. Ech 100 ml solution consisted of formic cid-10 ml, Nitric cid-10 ml nd distilled wter-80 ml. The solution ws replced every 3 dys, wheres the completion of the declcifiction ws tested every dy using needle test. The test ws crried out the using shrp needle; when the needle penetrtes the one without ny pressure it confirms the end of declcifiction process (pproximtely 30 dys). After the declcifiction ws crried out, the specimen ws wshed first in tp wter overnight, then in the following order; 70% lcohol for 30 min, 80% lcohol for 1 h, 90% lcohol for 2 h, solute lcohol for overnight nd finlly treted with chloroform for 2 h. Tissues were emedded in prffin wx nd cut into slices in the thickness of 5 micron using hrd-tissue microtome. Tissue sections were sujected to H nd E stining nd viewed under stereomicroscope. Sttisticl nlysis Sttisticl nlysis ws performed; CsA nd sline groups were nlyzed to test of ssocition using Student t-test t 99% confidence intervl. RESULTS In the present niml study, the morphometric nlysis showed no GO in the sline treted rts [Figure 1] where s significnt (P < 0.001) increse in gingivl dimensions in oth mxillry nd mndiulr regions in the CsA treted rts [Figure 1]. Furthermore in CsA treted rts, the incresed size of the gingiv (oth mrginl nd interdentl ppill) produced distem formtion etween mndiulr nterior teeth. The chnge in the gingivl dimension etween CsA treted nd sline treted rts ws sttisticlly significnt with the P vlue of < [Tle 1]. Morphometric evlution of the dissected mndiulr re reveled significnt mount of lveolr one loss in the CsA group rts when compred to the sline treted rts [Figure 2]. However, some res lso showed concomitnt lveolr one formtion nd resorption. On histologicl exmintion, the lveolr one resorption s mesured from the cusp tip to the lveolr crest ws found to e sttisticlly significnt (P < 0.01) [Figure 3] in the CsA treted rts s compred with sline treted rts. Such resorption sites were more pronounced nd frequently seen in the CsA treted specimen thn in the sline treted specimen [Figure 4]. The histologicl exmintion lso reveled drkly stined thick lyer of mssive NC on the root surfces in the CsA treted rts s compred to sline treted rts. Acellulr type of cementum covered the coronl root dentin of the mndiulr first molrs of CsA group rts, wheres cellulr cementum ws more evident on the Tle 1: Chnge in the gingivl dimension (in millimeters) etween sline treted nd CsA treted rts with stndrd devition nd P vlue from t test Sl. no Gingivl dimension in sline treted rts (mesured in millimeter) Gingivl dimension in CsA treted (mesured in millimeter) Bli Mdi Vhi Bli Mdi Vhi Averge SD t-test P vlue CsA: Cyclosporin A 804 Dentl Reserch Journl / Novemer 2013 / Vol 10 / Issue 6

4 Figure 2: Morphometric ssessment of lveolr one level () no chnge in sline treted rts () reduced in cyclosporin A treted rts Figure 3: Grph showing lveolr one loss in cyclosporin A treted nd sline treted rts Figure 5: Thickness of new cementum () no chnge in sline treted rts () incresed in cyclosporin A treted rts Figure 4: Histologicl ssessment of lveolr one level () no chnge in sline treted rts () reduced in cyclosporin A treted rts mesured in microns Figure 6: Grph showing new cementum formtion in cyclosporin A treted nd sline treted rts picl third of roots. In some segments, the cementum consisted of two or more lyers; the externl lyer showed strited structure nd presented suggestive imges of inclusion of collgen fiers originting from the underlying connective tissue. The djcent gingivl connective tissue ws composed of lrge mounts of dense collgen undles inserting into the NC [Figure 5]. The cementolsts were situted close to the cementum surfce in the periodontl ligment nd constituted ovoid or round, plump cells with sophilic cytoplsm. These cells were present singly or in groups of up to 4 cells. The cementocytes were present in the cementl lcuns. In the sline treted rts, norml thickness of cementum ws seen without ny oservle increse in the thickness of the cementum. In the CsA treted rts, the men increse in the thickness of cementum ws found to e μ s compred to sline treted rts (4.733 μ). The difference etween these two groups ws sttisticlly significnt with the P vlue of < [Figure 6]. Dentl Reserch Journl / Novemer 2013 / Vol 10 / Issue 6 805

5 DISCUSSION Jysheel nd Meht: Cyclosporin A trgeting periodontl tissues Though the role of cyclosporine A on the individul periodontl tissues hs een evluted in severl niml nd humn studies, the ssessment of its effects on ll the three periodontl tissues (gingiv, lveolr one nd cementum) in single experimentl study mkes it unique from other studies. In the present morphometric nd histologicl nlysis on rts, CsA ws found to ct differentilly on ll three periodontl trget tissues: GO, lveolr one loss nd NC formtion, fter n experimentl period of 45 dys. These findings support the oservtions mde y other uthors in their ddressing this issue. [4-8,12-14] The CsA-induced GO hs een oserved in vrious niml models [4,5] nd humn clinicl studies. [6] In the present morphometric ssessment of the drug induced GO model, cliniclly evident increse in the dimensions of gingiv with significnt chnge in the morphology ws oserved in the CsA group rts s compred to the sline treted rts, in 45 dy experimentl period. Though the exct mechnism is not cler, it hs een proposed tht the drug cts directly or indirectly on the growth nd function of oth gingivl firolsts nd collgen fiers through its ltertion in vrious growth fctors nd cytokines. [15] The potent CsA effect on TGF-β trnscription nd secretion hs een oserved in vitro in humn T lymphocytes, mouse proximl tuulr cell lines nd tuule-interstitil firolsts nd in vivo in mouse nd rt kidneys. [16] It is possile tht CsA cts through similr pthwy of development nd regression of CsA-induced GO during tretment. There re evidences to show tht CsA cuses incresed one turnover, with higher resorption thn formtion, resulting in one loss. [7,9,10,17] CsA-induced osteopeni hs een reported to e ssocited with n incresed incidence of one frctures. [17] Studies hve shown tht CsA therpy in rts hs lso cused incresed osteoclsi nd decresed one formtion t periodontl sites. [7] However in contrst to these findings, there re reports of significntly less lveolr one loss nd more one formtion in the experimentl periodontitis model in rts treted with CsA, iphsic effects of CsA on osteolst differentition nd one formtion ws oserved. [15-17] Studies hve postulted tht CsA exerts its osteopenic effect through the T-cell rther thn directly on one. [9] Other hypothesis my e tht, CsA medites its osteopenic effect y interfering in the cytokine ctivity on oth osteoclsts nd osteolsts t the one microenvironment; thus, influencing one remodeling. [17] One recent study suggested tht folic cid my hve protective effect on the CsA-induced lveolr one loss. [10] In the present morphometric nd histologicl study, evlution of the specimens reveled significnt mount of lveolr one loss in the CsA group rts s compred to control (sline) group; though, in some res, there ws lso n evidence of concomitnt formtion nd resorption of lveolr one. These results re in greement with the findings of erlier studies. [7,9,10,17] Cementum plys key role in the periodontl ttchment pprtus through the gingivl nd periodontl connective tissue fier insertion. However in periodontl disese, this ttchment pprtus including the cementum is dversely ffected owing to the inflmmtory process resulting in the suspect integrity nd stility of the tooth. Hence, one of the min ojectives of periodontl therpy includes the regenertion nd reformtion of these lost periodontl tissues including the cementum. The present histologicl study reveled lrge mount of NC formtion minly in the cervicl res with insertion of newly formed collgen fiers into it ut no such chnges were seen in the sline group [Figure 5]. The NC is chrcterized y (1) its lrge volume (2) irregulr outline (3) rther infrequent oservtions of incrementl outlines nd (4) presence of gloulr odies. Connective tissue djcent to the newly formed cementum shows densely pcked collgen fiers nd were seen to e functionlly inserting into the newly formed cementum. This finding ws in ccordnce with the oservtions mde in the previous studies. [12-14] However, present study stnds different in terms of providing oth quntittive nd qulittive dt of the CsA-induced NC formtion. TGF-β over-production due to CsA my e one of the mechnisms tht could explin the greter thickness of cementum formtion. [17] Another report demonstrted tht CsA my influence oth prolifertion nd differentition of humn periodontl ligment cells, which my ply n importnt role in the homeostsis of periodontl tissue. [1] Frequently, new ttchment requires NC formtion to replce disesed root surfces contminted with the cteril endotoxins, which re eliminted during periodontl therpy. The formtion nd regultion of NC in humns is not so cler. The connective tissue mtrix of cementum sequesters growth fctors such s the TGF-, firolst growth fctors nd cementum 806 Dentl Reserch Journl / Novemer 2013 / Vol 10 / Issue 6

6 derived growth fctor s well s ttery of other polypeptides, including osteopontin, one siloprotein- II nd cementum-specific ttchment protein, which medite cell dhesion nd spreding. These molecules ffect the migrtion, ttchment nd prolifertion of periodontl cells nd their mtrix synthesis nd more importntly, they mnifest cell specificity nd tissue specificity mong the sme cell type. The extrcellulr mtrix of cementum hs the potentil to regulte the differentition of precursor cells into cementolsts. Thus, cementum components re cple of providing informtionl signls for the recruitment, prolifertion nd differentition of periodontl cells nd regulte the regenertion of cementum s well s djcent periodontl components. [11,18] One of the experimentl studies demonstrted tht CsA dministrtion leds to the formtion of new cementum like islets (NCLI) inside the gingivl connective tissue. These islets were locted djcent to lood vessels ner the root surfces. NCLI were found to e engulfed y the multinucleted cells due to their loction ner the lood vessels. [19] Previous investigtions reveled tht NC formed during CsA dministrtion is mintined even fter suspension of the tretment. [20] There is potentil for future studies on different doses of CsA on gingiv, lveolr one nd NC. From this experimentl study, it cn e concluded tht periodontl regenertion, which is n ultimte gol of ny periodontl therpy cn e chieved through CsA induced cementogenesis. Since systemic dministrtion CsA t the clinicl level to chieve cementogenesis nd periodontl regenertion will e ethiclly unwrrnted nd uncceptle, further niml studies cn e conducted to ssess the effect of locl ppliction of CsA on the plned root surfces would result in cementogenesis nd periodontl regenertion. Hence within the limits of this experimentl study, it cn e concluded tht CsA in immunosuppressive dose on rts hs got its negtive effect on gingiv nd one, chrcterized y GO nd lveolr one loss. However, it hs lso got one positive effect on cementum where it cuses NC formtion with the insertion of new collgen fiers. When ll these effects of CsA re considered, it cn e concluded tht CsA hs its trget on periodontl tissue cusing GO, lveolr one loss nd NC formtion nd this could e new trid of CsA effects on periodontium. CONCLUSION CsA trgets the periodontl tissues (gingiv, lveolr one nd cementum) in different pttern. Its role in cementogenesis cn e utilized for periodontl regenertion if its locl ppliction is testified nd verified in the future niml studies. ACKNOWLEDGEMENTS We would like to cknowledge the help nd coopertion given y Dr. Ahmed Muji, Professor nd Hed, Deprtment of Orl Pthology nd Microiology for crrying out the histopthologicl work for this study. REFERENCES 1. Spolidorio LC, Spolidorio DM, Holzhusen M. Effects of long-term cyclosporin therpy on the periodontium of rts. J Periodontl Res 2004;39: Nieh S, Fu E, Chng HL, Wng SL, Wikesjö UM. Histopthologic ltertions of periodontium in cyclosporin-treted rts. Is the periodontium trget tissue for the drug? J Clin Periodontol 1996;23: Aynoglou CM, Lesty C. New cementum formtion induced y cyclosporin A: A histologicl, ultrstructurl nd histomorphometric study in the rt. J Periodontl Res 1997;32: Prhu A, Meht DS. A morphologic comprison of gingivl chnges influenced y cyclosporin nd tcrolimus in rts: An experimentl study. J Periodontol 2006;77: Cetinky BO, Acikgoz G, Keles GC, Ays B, Korkmz A. The effect of cyclosporin A on lveolr one in rts sujected to experimentl periodontl disese. Toxicol Pthol 2006;34: Afonso M, Bello Vde O, Shili JA, Sposto MR. Cyclosporin A-induced gingivl overgrowth in renl trnsplnt ptients. J Periodontol 2003;74: Fu E, Hsieh YD, Nieh S, Wikesjö UM, Liu D. Effects of cyclosporin A on lveolr one: An experimentl study in the rt. J Periodontol 1999;70: Murthy MB. Osteoimmunology Unleshing the concepts. J Indin Soc Periodontol 2011;15: Buchinsky FJ, M Y, Mnn GN, Rucinski B, Bryer HP, Romero DF, et l. T lymphocytes ply criticl role in the development of cyclosporin A-induced osteopeni. Endocrinology 1996;137: Mohmmdi A, Omrni L, Omrni LR, Kini F, Eshrghin A, Azizi Z, et l. Protective effect of folic cid on cyclosporineinduced one loss in rts. Trnspl Int 2012;25: Andrukhov O, Mtejk M, Rusch-Fn X. Effect of cyclosporin A on prolifertion nd differentition of humn periodontl ligment cells. Act Odontol Scnd 2010;68: Aynoglou CM. Evidence tht cyclosporin A dministrtion induces the formtion of new cementum-like islets inside the gingivl connective tissue. J Periodontl Res 1998;33: Dentl Reserch Journl / Novemer 2013 / Vol 10 / Issue 6 807

7 13. Spolidorio LC, Spolidorio DM, Holzhusen M, Nssr CA, Nssr PO. Cyclosporin A-induced new cementum formtion: A morphometric evlution in the peripicl region of rts. Brz Dent J 2007;18: Fu E, Nieh S, Chng HL, Wng SL. Cyclosporin A-induced gingivl overgrowth in rts: Mcroscopic nd microscopic oservtions. Int J Periodontics Restortive Dent 1996;16: Che HJ, H MS, Yun DH, Pe HO, Chung HT, Che SW, et l. Mechnism of cyclosporine-induced overgrowth in gingiv. J Dent Res 2006;85: Spolidorio LC, Spolidorio DM, Holzhusen M, Nssr PO, Nssr CA. Effects of long-term cyclosporin therpy on gingiv of rts Anlysis y stereologicl nd iochemicl estimtion. Brz Orl Res 2005;19: Yeo H, Beck LH, McDonld JM, Zyzfoon M. Cyclosporin A elicits dose-dependent iphsic effects on osteolst differentition nd one formtion. Bone 2007;40: Serkov N, Christins U. Trnsplnttion: Toxicokinetics nd mechnisms of toxicity of cyclosporine nd mcrolides. Curr Opin Investig Drugs 2003;4: Aynoglou CM. Phgocytosis of new cementum-like islets formed inside the gingivl connective tissue in cyclosporin-a treted rts. J Periodontl Res 1999;34: Aynoglou CM, Lesty C. Mintennce of new cementum formed during cyclosporin A dministrtion fter suspension of the tretment. J Periodontl Res 1997;32: How to cite this rticle: Jysheel M, Meht DS. The role of cyclosporine A on the periodontl tissues. Dent Res J 2013;10: Source of Support: We would like to thnk JJM medicl College, Dvngere, Indi for Animl House fcility nd Bpuji Dentl College & Hospitl, Dvngere, Indi for the Lortory fcility. Conflict of Interest: None declred. Announcement Android App A free ppliction to rowse nd serch the journl s content is now ville for Android sed moiles nd devices. The ppliction provides Tle of Contents of the ltest issues, which re stored on the device for future offline rowsing. Internet connection is required to ccess the ck issues nd serch fcility. The ppliction is comptile with ll the versions of Android. The ppliction cn e downloded from For suggestions nd comments do write ck to us. 808 Dentl Reserch Journl / Novemer 2013 / Vol 10 / Issue 6

Severe Gummy Smile with Class II Malocclusion Treated with LeFort I Osteotomy Combined with Horseshoe Osteotomy and Intraoral Vertical Ramus

Severe Gummy Smile with Class II Malocclusion Treated with LeFort I Osteotomy Combined with Horseshoe Osteotomy and Intraoral Vertical Ramus 2013 67 1 5560 Severe Gummy Smile with Clss II Mlocclusion Treted with LeFort I Osteotomy Comined with Horseshoe Osteotomy nd Introrl Verticl Rmus Osteotomy * 56 Shimo et l. Act Med. Okym Vol. 67, No.

More information

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE Swine Dy 22 Contents EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE B. J. Johnson, J. P. Kyser, J. D. Dunn, A. T. Wyln, S. S. Dritz 1, J.

More information

Effects of Fibrin Adhesive Material (Tissucol) Application on Furcation Defects in Dogs. Altan DOGAN1, Levent TANER1, Tiffin OYGUR2 and KOksal BALOS1

Effects of Fibrin Adhesive Material (Tissucol) Application on Furcation Defects in Dogs. Altan DOGAN1, Levent TANER1, Tiffin OYGUR2 and KOksal BALOS1 J. Nihon Univ. Sch. Dent., Vol. 34. 34-41. 1992 Effects of Firin Adhesive Mteril (Tissucol) Appliction on Furction Defects in Dogs Altn DOGAN1, Levent TANER1, Tiffin OYGUR2 nd KOksl BALOS1 (Received 19

More information

THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS

THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS John F. Ptience nd Doug Gillis SUMMARY

More information

Effect of supplemental fat from dried distillers grains with solubles or corn oil on cow performance, IGF-1, GH, and NEFA concentrations 1

Effect of supplemental fat from dried distillers grains with solubles or corn oil on cow performance, IGF-1, GH, and NEFA concentrations 1 Effect of supplementl ft from dried distillers grins with solules or corn oil on cow performnce, IGF-1, GH, nd NEFA concentrtions 1 Aigil Brtosh 2, Cody Wright 3, Aimee Wertz-Lutz 4, nd George Perry 5

More information

Study of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method

Study of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method Ksetsrt J. (Nt. Sci.) 48 : 729-739 (2014) Study of Stress Distriution in the Tii During Stnce Phse Running Using the Finite Element Method Thepwchr Ruchirh 1, Tumrong Puttpitukporn 1, * nd Siriporn Ssimontonkul

More information

Optimal sites for orthodontic mini-implant placement assessed by cone beam computed tomography

Optimal sites for orthodontic mini-implant placement assessed by cone beam computed tomography Originl Article Optiml sites for orthodontic mini-implnt plcement ssessed by cone bem computed tomogrphy Mon Mohmed Slh Fyed ; Pwel Pzer b ; Christos Ktsros c ABSTRACT Objectives: To determine (1) the

More information

Treatment of Generalised Aggressive Periodontitis: A 4-year Follow-up Case Report

Treatment of Generalised Aggressive Periodontitis: A 4-year Follow-up Case Report Tretment of Generlised Aggressive Periodontitis: A 4-yer Follow-up Cse Report Rui Fng LU 1, Li XU 1, Hun Xin MENG 1, Xing Hui FENG 1, Ki Ning LIU 1 Aggressive periodontitis comprises group of rre, often

More information

Correlation between periodontal soft tissue and hard tissue surrounding incisors in skeletal Class III patients

Correlation between periodontal soft tissue and hard tissue surrounding incisors in skeletal Class III patients Originl Article Correltion between periodontl soft tissue nd hrd tissue surrounding incisors in skeletl Clss III ptients Jeong-Ho Prk ; Ji-Yeon Hong b ; Hyo-Won Ahn c ; Su-Jung Kim d ABSTRACT Objectives:

More information

The effect of encapsulated butyric acid and zinc on performance, gut integrity and meat quality in male broiler chickens 1

The effect of encapsulated butyric acid and zinc on performance, gut integrity and meat quality in male broiler chickens 1 The effect of encpsulted utyric cid nd zinc on performnce, gut integrity nd met qulity in mle roiler chickens 1 Astrct This study evluted the impct of encpsulted utyric cid nd zinc (ButiPEARL Z) on performnce

More information

Journal of Hainan Medical University 2017; 23(2): Journal of Hainan Medical University.

Journal of Hainan Medical University 2017; 23(2): Journal of Hainan Medical University. Journl of Hinn Medicl University 2017; 23(2): 151-155 151 Journl of Hinn Medicl University http://www.hnykdxxb.com Reltionship between DEXA bone minerl density mesurement results nd serum cytokines s well

More information

Meat and Food Safety. B.A. Crow, M.E. Dikeman, L.C. Hollis, R.A. Phebus, A.N. Ray, T.A. Houser, and J.P. Grobbel

Meat and Food Safety. B.A. Crow, M.E. Dikeman, L.C. Hollis, R.A. Phebus, A.N. Ray, T.A. Houser, and J.P. Grobbel Met nd Food Sfety Needle-Free Injection Enhncement of Beef Strip Loins with Phosphte nd Slt Hs Potentil to Improve Yield, Tenderness, nd Juiciness ut Hrm Texture nd Flvor B.A. Crow, M.E. Dikemn, L.C. Hollis,

More information

Bioactive milk components to secure growth and gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM

Bioactive milk components to secure growth and gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM Bioctive milk components to secure growth nd gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM STSM Pigutnet FA1401 STSM 03/Septemer 30/Novemer/2017 (3 months) Host: Home: Thoms

More information

PROVEN ANTICOCCIDIAL IN NEW FORMULATION

PROVEN ANTICOCCIDIAL IN NEW FORMULATION PROVEN ANTICOCCIDIAL IN NEW FORMULATION Coxidin 100 microgrnulte A coccidiosttic dditive for roilers, chickens rered for lying nd turkeys Contins 100 g of monensin sodium per kg Aville s homogenous grnules

More information

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei

More information

308 nm excimer lamp in combination with topical tacrolimus: A retrospective study of its efficacy and safety in childhood vitiligo

308 nm excimer lamp in combination with topical tacrolimus: A retrospective study of its efficacy and safety in childhood vitiligo ORIGINAL ARTICLE 308 nm excimer lmp in comintion with topicl tcrolimus: A retrospective study of its efficcy nd sfety in childhood vitiligo BS Chndrshekr, N Shoh, P Deprtment of Dermtology, Cutis, Acdemy

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION Prentl doi:.8/nture57 Figure S HPMECs LM Cells Cell lines VEGF (ng/ml) Prentl 7. +/-. LM 7. +/-.99 LM 7. +/-.99 Fold COX induction 5 VEGF: - + + + Bevcizum: - - 5 (µg/ml) Reltive MMP LM mock COX MMP LM+

More information

27 June Bmnly L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION

27 June Bmnly L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION 27 June 1964 Bmnly MEDICAL JOURNAL L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION x 1,638.) FIG. 2.-Foci of sme tumour s in Fig. 1 contining vible tumour cells with scnty cytoplsm, reltively

More information

Check your understanding 3

Check your understanding 3 1 Wht is the difference etween pssive trnsport nd ctive trnsport? Pssive trnsport is the movement of prticles not requiring energy. Movement of prticles in ctive trnsport uses energy. 2 A gs tp in the

More information

Supplementary information for: Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage

Supplementary information for: Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage Supplementry informtion for: Low one mss nd chnges in the osteocyte network in mice lcking utophgy in the osteolst linege Mrilin Piemontese, Meld Onl, Jinhu Xiong, Li Hn, Jeff D. Thostenson, Mri Almeid,

More information

Thallium-201 chloride scintigraphy in soft tissue tumors

Thallium-201 chloride scintigraphy in soft tissue tumors 136 ORIGINAL Thllium-201 chloride scintigrphy in soft tissue tumors Hideki Otsuk, Kori Terzw, Nomi Morit, Yoichi Otomi, Shoichiro Tko, Seiji Iwmoto, Kyosuke Oski, Msfumi Hrd, nd Hiromu Nishitni Deprtment

More information

A FACTORIAL STUDY ON THE EFFECTS OF β CYCLODEXTRIN AND POLOXAMER 407 ON THE SOLUBILITY AND DISSOLUTION RATE OF PIROXICAM

A FACTORIAL STUDY ON THE EFFECTS OF β CYCLODEXTRIN AND POLOXAMER 407 ON THE SOLUBILITY AND DISSOLUTION RATE OF PIROXICAM IJRPC 20, (3) Chowdry et l. ISSN: 223 278 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Aville online t www.ijrpc.com Reserch Article A FACTORIAL STUDY ON THE EFFECTS OF β CYCLODEXTRIN AND

More information

Effect of Aqueous Extract of Carica papaya Dry Root Powder on Lactation of Albino Rats

Effect of Aqueous Extract of Carica papaya Dry Root Powder on Lactation of Albino Rats Effect of Aqueous Extrct of Cric ppy Dry Root Powder on Lcttion of Alino Rts G. Tosswnchuntr nd S. Aritjt Deprtment of Biology Fculty of Science Ching Mi University Ching Mi 50200 Thilnd Keywords: mmmry

More information

Finite Element Analysis of MOD Prosthetic Restored Premolars

Finite Element Analysis of MOD Prosthetic Restored Premolars Finite Element Anlysis of MOD Prosthetic Restored Premolrs LILIANA SANDU, FLORIN TOPALĂ, SORIN POROJAN School of Dentistry V. Beş University of Medicine nd Phrmcy 9 Revolutiei 1989 Blv., 300041 Timişor

More information

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess

More information

METHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY

METHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY METHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY 1.0 SCOPE AND APPLICATION 1.1 Method 4010 is procedure for screening solids such s soils, sludges, nd queous medi such s wste wter nd lechtes

More information

Shinhaeng Cho, Youngmoon Goh, Chankyu Kim, Haksoo Kim, Jong Hwi Jeong, Young Kyung Lim, Se Byeong Lee, Dongho Shin

Shinhaeng Cho, Youngmoon Goh, Chankyu Kim, Haksoo Kim, Jong Hwi Jeong, Young Kyung Lim, Se Byeong Lee, Dongho Shin Originl Article PMP Progress in Medicl Physics 28(4), Decemer 217 https://doi.org/1.14316/pmp.217.28.4.144 pissn 28-444, eissn 28-443 Dosimetric Impct of Ti Mesh on Proton Bem Therpy Shinheng Cho, Youngmoon

More information

Using Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids

Using Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids Using Pcloutrzol to Suppress Inflorescence Height of Potted Phlenopsis Orchids A REPORT SUBMITTED TO FINE AMERICAS Linsey Newton nd Erik Runkle Deprtment of Horticulture Spring 28 Using Pcloutrzol to Suppress

More information

Original Research. Lucitone 199 (P:M) 21 g:8 ml and DPI Heat cure 21 g:10 ml; Trevalon (P:M) 21 g:9 ml and Acrylyn-H 21 g:10 ml were

Original Research. Lucitone 199 (P:M) 21 g:8 ml and DPI Heat cure 21 g:10 ml; Trevalon (P:M) 21 g:9 ml and Acrylyn-H 21 g:10 ml were Received: 10 th Mrch 2014 Accepted: 2 nd June 2014 Conflict of Interest: None Source of Support: Nil Originl Reserch Comprison of Impct Strength nd Frcture Morphology of Different Het Cure Denture Acrylic

More information

Optimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality

Optimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality Optimistion of diets for Atlntic cod (Gdus morhu) roodstock: effect of rchidonic cid on egg & lrvl qulity Dr Gordon Bell, Ms. An Blnco, Dr Bill Roy, Dr Derek Roertson, Dr Jim Henderson nd Mr Richrd Prickett,

More information

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 : PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged

More information

Histologic and Biomechanical Studies of Tendon-To-Bone Healing After Autologous and Allogeneic Bone Transplants

Histologic and Biomechanical Studies of Tendon-To-Bone Healing After Autologous and Allogeneic Bone Transplants RTICLE Histologic nd iomechnicl Studies of Tendon-To-one Heling After Autologous nd Allogeneic one Trnsplnts Ming-Wei Li, 1 Xin-She Zhou 2, 3 Abstrct Objectives: Compre histologic nd biomechnicl differences

More information

The potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens

The potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens The potentil future of trgeted rdionuclide therpy: implictions for occuptionl exposure? Introduction: Trgeted Rdionuclide Therpy (TRT) Systemic tretment Molecule lbelled with rdionuclide delivers toxic

More information

WSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265;

WSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265; FINAL REPORT WTFRC Project # AH-1-5 WSU Project # 13C-355-3 Project title: PI: Orgniztion: Coopertors: of Sunburn in Apples with RAYNOX Lrry Schrder, Horticulturist WSU Tree Fruit Reserch nd Extension

More information

Restorative planning for hemisection surgery: a technique report

Restorative planning for hemisection surgery: a technique report CLINICAL REPORT 215 Sr Tit-Pour, Anthony Roerts, Ro Hrrison, Iin Chpple Restortive plnning for hemisection surgery: technique report KEY WORDS hemisection, lortory stges, restortion Hemisection surgery

More information

SYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT

SYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT Finl Arevited Clinicl Study Report Nme of Sponsor/Compny: Bristol-Myers Squi Ipilimum Individul Study Tle Referring to the Dossier (For Ntionl Authority Use Only) Nme of Finished Product: Yervoy Nme of

More information

Input from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer

Input from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer Input externl experts nd mnufcturer on the 2 nd drft project pln Stool DNA testing for erly detection of colorectl cncer (Project ID:OTJA10) All s nd uthor s replies on the 2nd drft project pln Stool DNA

More information

Extraction and Some Functional Properties of Protein Extract from Rice Bran

Extraction and Some Functional Properties of Protein Extract from Rice Bran Ksetsrt J. (Nt. Sci.) 40 : 209-214 (2006) Extrction nd Some Functionl Properties of Protein Extrct from Rice Brn Chockchi Theerkulkit*, Siree Chiseri nd Siriwt Mongkolknchnsiri ABSTRACT Rice brn protein

More information

Chronic high-sodium diet intake after weaning lead to neurogenic hypertension in adult Wistar rats

Chronic high-sodium diet intake after weaning lead to neurogenic hypertension in adult Wistar rats Chronic high-sodium diet intke fter wening led to neurogenic hypertension in dult Wistr rts 1 Pul Mglhães Gomes; 2 Rento Willin Mrtins Sá; 1 Giovn Lopes Aguir; 1 Milede Hnner Sriv Pes; 1 Andréi Crvlho

More information

Occlusal Status in Asian Male Adults:

Occlusal Status in Asian Male Adults: Originl Article Occlusl Sttus in Asin Mle Adults: Prevlence nd Ethnic Vrition Jen Soh ; Andrew Sndhm ; Yiong Huk Chn c Astrct: The purpose of this study ws to determine the occlusl sttus in young Asin

More information

A Study of Serological Markers of Hepatitis B and C Viruses in Istanbul, Turkey

A Study of Serological Markers of Hepatitis B and C Viruses in Istanbul, Turkey Originl Pper Med Princ Prct 2003;12:184 188 DOI: 10.1159/000070757 Received: Decemer 15, 2001 Revised: Decemer 21, 2002 A Study of Serologicl Mrkers of Heptitis B nd C Viruses in Istnul, Turkey S. Erden

More information

Bright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit

Bright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit Bright Futures Medicl Reference Tle 2 to 5 Dy (First Week) Visit Universl Action Metolic nd Verify documenttion of neworn metolic screening results, pproprite rescreening, nd needed follow-up. Document

More information

FERTILITY EFFECTS OF SODIUM FLUORIDE IN MALE MICE

FERTILITY EFFECTS OF SODIUM FLUORIDE IN MALE MICE 128 Fluoride Vol. 33 No. 3 128-134 2000 Reserch Report FERTILITY EFFECTS OF SODIUM FLUORIDE IN MALE MICE Ahmed Elbetieh, Hom Drmni, Ahmd S Al-Hiyst b Irbid, Jordn SUMMARY: Sexully mture mle Swiss mice

More information

Supplementary figure 1

Supplementary figure 1 Supplementry figure 1 Dy 8 post LCMV infection Vsculr Assoc. Prenchym Dy 3 post LCMV infection 1 5 6.7.29 1 4 1 3 1 2 88.9 4.16 1 2 1 3 1 4 1 5 1 5 1.59 5.97 1 4 1 3 1 2 21.4 71 1 2 1 3 1 4 1 5 1 5.59.22

More information

INFLUENCE OF DIFFERENT STRAINS AND WAYS OF INOCULATION ON THE RABBIT S RESPONSE TO EXPERIMENTAL INFECTION WITH PASTEURELLA MULTOCIDA

INFLUENCE OF DIFFERENT STRAINS AND WAYS OF INOCULATION ON THE RABBIT S RESPONSE TO EXPERIMENTAL INFECTION WITH PASTEURELLA MULTOCIDA Pthology nd Hygiene INFLUENCE OF DIFFERENT STRAINS AND WAYS OF INOCULATION ON THE RABBIT S RESPONSE TO EXPERIMENTAL INFECTION WITH PASTEURELLA MULTOCIDA Kulcsár G. 1, Fáián K. 1 *, Brn T. 1, Virág Gy.

More information

Hyperplastic dental follicle or peri-follicle fibrosis, is. Hyperplastic Dental Follicle Review of Literature and Report of Two Cases in One Family

Hyperplastic dental follicle or peri-follicle fibrosis, is. Hyperplastic Dental Follicle Review of Literature and Report of Two Cases in One Family Puliction Hyperplstic Dentl Follicle Review of Literture nd Report of Two Cses in One Fmily Chun Xio SUN 1, Crig RIRIE 1, Jeffrey M HENKIN 1 Hyperplstic dentl follicle is n extremely rre lesion. The prctitioner

More information

EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1

EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 Swine Dy 2001 Contents EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 C. W. Hstd, S. S. Dritz 2, J. L. Nelssen, M. D. Tokch, nd R. D. Goodbnd Summry Two trils were

More information

Effect of linear and random non-linear programming on environmental pollution caused by broiler production

Effect of linear and random non-linear programming on environmental pollution caused by broiler production Journl of Novel Applied Sciences Aville online t www.jnsci.org 24 JNAS Journl-24-3-/43-434 ISSN 2322-549 24 JNAS Effect of liner nd rndom non-liner progrmming on environmentl pollution cused y roiler production

More information

Dental Rehabilitation of Patients with Amelogenesis Imperfecta using Zirconia Crowns, Stainless Steel Crowns, and Composite Veneers: A Case Report

Dental Rehabilitation of Patients with Amelogenesis Imperfecta using Zirconia Crowns, Stainless Steel Crowns, and Composite Veneers: A Case Report Cse Report Print ISSN: 2321-6379 Online ISSN: 2321-595X DOI: 10.17354/ijss/2016/641 Dentl Rehilittion of Ptients with Amelogenesis Imperfect using Zirconi Crowns, Stinless Steel Crowns, nd Composite Veneers:

More information

The Dynamics of Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus

The Dynamics of Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus Chpter 2 The Dynmics of Vricell-Zoster Virus Epithelil Kertitis in Herpes Zoster Ophthlmicus The morphology of n individul VZV lesion reflects sequence of events triggered y the virus impct on cornel epithelil

More information

* * * * * liver kidney ileum. Supplementary Fig.S1

* * * * * liver kidney ileum. Supplementary Fig.S1 Supplementry Fig.S1 liver kidney ileum Fig.S1. Orlly delivered Fexrmine is intestinlly-restricted Mice received vehicle or Fexrmine (100mg/kg) vi per os (PO) or intrperitonel (IP) injection for 5 dys (n=3/group).

More information

The Effect of Substituting Sugar with Artificial. Sweeteners on the Texture and Palatability of Pancakes

The Effect of Substituting Sugar with Artificial. Sweeteners on the Texture and Palatability of Pancakes The Effect of Sustituting Sugr with Artificil NUTR 453 Sweeteners on the Texture nd Pltility of Pnckes Jmie Wldron, Rquel Reyes, nd Reecc Legi 1 I. Astrct The effects of replcing sugr with Stevi nd Splend

More information

ARTICLE. E. Pavlova 1, N. Atanassova 1, C. McKinnell 2, R.M. Sharpe 2 1 Institute of Experimental Morphology, Pathology and Anthropology with Museum,

ARTICLE. E. Pavlova 1, N. Atanassova 1, C. McKinnell 2, R.M. Sharpe 2 1 Institute of Experimental Morphology, Pathology and Anthropology with Museum, DOI:.554/5YRTIMB..3 OPPOSITE MODELS OF EXPRESSION OF ANDROGEN RECEPTOR (AR) AND RETINOIC ACID RECEPTOR-α (RAR-α) IN THE ONSET OF MALE GERM CELL DEVELOPMENT IN HORMONALLY MANIPULATED RATS E. Pvlov, N. Atnssov,

More information

EVALUATION OF EFFECT OF REUSED EDIBLE OILS ON VITAL ORGANS OF WISTAR RATS

EVALUATION OF EFFECT OF REUSED EDIBLE OILS ON VITAL ORGANS OF WISTAR RATS Originl Article Astrct : NUJHS Vol. I, No.4, Decemer 2011, ISSN 2249-7110 Nitte University Journl of Helth Science EVALUATION O EECT O REUSED EDIBLE OILS ON VITAL ORGANS O WISTAR RATS Shstry C.S., Ptel

More information

Agilent G6825AA MassHunter Pathways to PCDL Software Quick Start Guide

Agilent G6825AA MassHunter Pathways to PCDL Software Quick Start Guide Agilent G6825AA MssHunter Pthwys to PCDL Softwre Quick Strt Guide Wht is Agilent Pthwys to PCDL? Fetures of Pthwys to PCDL Agilent MssHunter Pthwys to PCDL converter is stnd-lone softwre designed to fcilitte

More information

Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression

Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression Online Sumissions:http://www.journltcm.com J Trdit Chin Med 2013 Octoer 15; 33(5): 674-681 info@journltcm.com ISSN 0255-2922 2013 JTCM. All rights reserved. EXPERIMENTAL STUDY TOPIC Effects of Sini Sn

More information

ENERGY CONTENT OF BARLEY

ENERGY CONTENT OF BARLEY ENERGY CONTENT OF BARLEY VARIATION IN THE DIETARY ENERGY CONTENT OF BARLEY Shwn Firbirn, John Ptience, Hnk Clssen nd Ruurd Zijlstr SUMMARY Formultion of commercil pig diets requires n incresing degree

More information

PHYSIOLOGICAL AND PROTEOMIC RESPONSES OF TOBACCO SEEDLINGS EXPOSED TO SILVER NANOPARTICLES

PHYSIOLOGICAL AND PROTEOMIC RESPONSES OF TOBACCO SEEDLINGS EXPOSED TO SILVER NANOPARTICLES PHYSIOLOGICAL AND PROTEOMIC RESPONSES OF TOBACCO SEEDLINGS EXPOSED TO SILVER NANOPARTICLES Rent Bi Deprtment of Biology, Fculty of Science, University of Zgre INTRODUCTION Nnoprticles (NPs) Silver nnoprticles

More information

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn

More information

Safety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA

Safety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA Sfety nd Tolerbility of Subcutneous Srilumb nd Intrvenous Tocilizumb in Ptients With RA Pul Emery, 1 Jun Rondon, 2 Anju Grg, 3 Hubert vn Hoogstrten, 3 Neil M.H. Grhm, 4 Ming Liu, 4 Nncy Liu, 3 Jnie Prrino,

More information

Arthroscopic Anatomy of Shoulder

Arthroscopic Anatomy of Shoulder Arthroscopic Antomy of Shoulder Murt Bozkurt, Mehmet Emin Simsek, nd Hlil İrhim Açr 2 2.1 Introduction In the lst 30 yers, shoulder rthroscopy hs ecome of greter importnce in the dignosis nd tretment of

More information

Prosthetic rehabilitation of a mandibular root amputated molar using single crown

Prosthetic rehabilitation of a mandibular root amputated molar using single crown Cse Report Prosthetic rehilittion of mndiulr root mputted molr using single crown Azm Sdt Mostfvi, Seyed Mehrn Flhchi Deprtment of Prosthodontics, Dentl Reserch Center, Fculty of Dentistry, Tehrn University

More information

Abstract ABSTRACT #69. Abstract. Introduction & Methods. Methods & Results. Results. Results & Conclusions

Abstract ABSTRACT #69. Abstract. Introduction & Methods. Methods & Results. Results. Results & Conclusions Effects of dietry β-glucn on Growth Performnce, Dirrhe, nd Gut Permeility of Wening Pigs Experimentlly Infected with Pthogenic E. coli Kwngwook Kim, Amy Ehrlich, Vivin Perng, Jennifer Chse, Helen Ryould,

More information

General Microscopic Changes

General Microscopic Changes Generl Microscopic Chnges 2 This chpter covers collection of microscopic chnges tht lck dignostic specificity ut occur in different specific diseses, s will ecome pprent in susequent chpters. Almost ll

More information

Modeling of the buccal and lingual bone walls of fresh extraction sites following implant installation

Modeling of the buccal and lingual bone walls of fresh extraction sites following implant installation Muricio G. Arújo Jn L. Wennström Jn Lindhe Modeling of the uccl nd lingul one wlls of fresh extrction sites following implnt instlltion Authors ffilitions: Muricio G. Arújo, Deprtment of Dentistry, Stte

More information

USE OF SORGHUM-BASED DISTILLERS GRAINS IN DIETS FOR NURSERY AND FINISHING PIGS

USE OF SORGHUM-BASED DISTILLERS GRAINS IN DIETS FOR NURSERY AND FINISHING PIGS Swine Dy 1996 USE OF SORGHUM-BASED DISTILLERS GRAINS IN DIETS FOR NURSERY AND FINISHING PIGS B. W. Senne, J. D. Hncock, I. Mvromichlis, S. L. Johnston, P. S. Sorrell, I. H. Kim, nd R. H. Hines Summry Two

More information

The RUTHERFORD-2 trial in heterozygous FH: Results and implications

The RUTHERFORD-2 trial in heterozygous FH: Results and implications The RUTHERFORD-2 tril in heterozygous FH: Results nd implictions Slide deck kindly supplied s n eductionl resource by Professor Derick Rl MD PhD Crbohydrte & Lipid Metbolism Reserch Unit University of

More information

Role of EP2 and EP4 receptor-selective agonists of prostaglandin E 2 in acute and chronic kidney failure

Role of EP2 and EP4 receptor-selective agonists of prostaglandin E 2 in acute and chronic kidney failure http://www.kidney-interntionl.org & 26 Interntionl Society of Nephrology originl rticle Role of EP2 nd EP4 receptor-selective gonists of prostglndin E 2 in cute nd chronic kidney filure S Vukicevic 1,

More information

Evaluation of the Masticatory Part and the Habitual Chewing Side by Wax Cube and Bite Force Measuring System (Dental Prescale )

Evaluation of the Masticatory Part and the Habitual Chewing Side by Wax Cube and Bite Force Measuring System (Dental Prescale ) J Jpn Prosthodont Soc 5:513-50, 008 ORIGINAL ARTICLE Evlution of the Mstictory Prt nd the Hitul Chewing Side y Wx Cue nd Bite Force Mesuring System (Dentl Prescle ) Mutsumi Tkhshi, DDS, Fumi Tkhshi, DDS,

More information

The Acute Time Course of Concurrent Activation Potentiation

The Acute Time Course of Concurrent Activation Potentiation Mrquette University e-publictions@mrquette Exercise Science Fculty Reserch nd Publictions Exercise Science, Deprtment of 1-1-2010 The Acute Time Course of Concurrent Activtion Potentition Luke Grceu Mrquette

More information

Debra A. Ignaut, R.N., B.S., C.D.E., and Haoda Fu, Ph.D.

Debra A. Ignaut, R.N., B.S., C.D.E., and Haoda Fu, Ph.D. Journl of Dietes Science nd Technology Volume 6, Issue 2, Mrch 2012 Dietes Technology Society TECHNOLOGY REPORT Comprison of Insulin Diluent Lekge Postinjection Using Two Different Needle Lengths nd Injection

More information

Not for Citation or Publication Without Consent of the Author

Not for Citation or Publication Without Consent of the Author Not for Cittion or Puliction Without Consent of the Author AN AUTOMATED SEX PHEROMONE TRAP FOR MONITORING ADULT CM AND OFM AND THE INFLUENCE OF TRAP COLOR ON MOTH AND NON-TARGET CAPTURES Brin L. Lehmn

More information

Radiographic evaluation of the technical quality of undergraduate endodontic competence cases in the Dublin Dental University Hospital: an audit

Radiographic evaluation of the technical quality of undergraduate endodontic competence cases in the Dublin Dental University Hospital: an audit Rdiogrphic evlution of the technicl qulity of undergrdute endodontic competence cses in the Dulin Dentl University Hospitl: n udit Précis: An udit exmining the technicl qulity of undergrdute endodontic

More information

Background Pears (Pyrus L.) are one of the leading cultivated fruit trees in China following apples and oranges in planting area and fruit yield.

Background Pears (Pyrus L.) are one of the leading cultivated fruit trees in China following apples and oranges in planting area and fruit yield. Nnjing Agriculturl University Potssium enhnces the sugr ssimiltion in leves nd fruit y regulting the expression of key genes involved in sugr metolism of Asin pers Cixi Dong, Chngwei Shen, Yngchun Xu College

More information

DR. MARC PAGÈS Project Manager R&D Biologicals - Coccidia Projects, HIPRA

DR. MARC PAGÈS Project Manager R&D Biologicals - Coccidia Projects, HIPRA DR. MARC PAGÈS Project Mnger R&D Biologicls - Coccidi Projects, HIPRA Dr. Mrc Pgès Bosch otined Microiology nd Genetics degree t the University of Brcelon in 1998. He otined his PhD working on the synptoneml

More information

Supplementary Materials. Viral delivery of mir-196a ameliorates the SBMA phenotype via the silencing of CELF2

Supplementary Materials. Viral delivery of mir-196a ameliorates the SBMA phenotype via the silencing of CELF2 Supplementry Mterils Virl delivery of mir-96 meliortes the SBMA phenotype vi the silencing of CELF2 Yu Miyzki, Hiroki Adchi, Mshis Ktsuno, Mkoto Minmiym, Yue-Mei Jing, Zhe Hung, Hideki Doi, Shinjiro Mtsumoto,

More information

Anti-Obesity Potential of Gallic Acid from Labisia pumila, through Augmentation of Adipokines in High Fat Diet Induced Obesity in C57BL/6 Mice

Anti-Obesity Potential of Gallic Acid from Labisia pumila, through Augmentation of Adipokines in High Fat Diet Induced Obesity in C57BL/6 Mice Advnces in Reserch 2(10): 556-570, 2014, Article no. AIR.2014.10.004 SCIENCEDOMAIN interntionl www.sciencedomin.org Anti-Oesity Potentil of Gllic Acid from Lisi pumil, through Augmenttion of Adipokines

More information

A Long-term Study on the Expansion Effects of the Cervical-pull Facebow With and Without Rapid Maxillary Expansion

A Long-term Study on the Expansion Effects of the Cervical-pull Facebow With and Without Rapid Maxillary Expansion Originl Article A Long-term Study on the Expnsion Effects of the Cervicl-pull Fcebow With nd Without Rpid Mxillry Expnsion Frederick A. Fenderson, DDS, MS ; Jmes A. McNmr Jr, DDS, PhD b ; Tizino Bccetti,

More information

Invasive Pneumococcal Disease Quarterly Report July September 2018

Invasive Pneumococcal Disease Quarterly Report July September 2018 Invsive Pneumococcl Disese Qurterly Report July Septemer Introduction Since 17 Octoer 2008, invsive pneumococcl disese (IPD) hs een notifile to the locl Medicl Officer of Helth under the Helth Act 1956.

More information

AR Rice Performance Trials (ARPT) Color as a Quality Indicator. Functional Property Analyses. Cause of Chalkiness in Rice Kernels

AR Rice Performance Trials (ARPT) Color as a Quality Indicator. Functional Property Analyses. Cause of Chalkiness in Rice Kernels Chlk, Color, n Milling Qulity Trens in AR Rice Performnce Tril Dt Srh Lnning, Rusty Butist, Terry Sieenmorgen, Pul Counce, n Amogh Amrekr 1 Inustry Allince Meeting Center for Excellence in Poultry Science

More information

Stability of anterior crossbite correction: A randomized controlled trial with a 2-year follow-up

Stability of anterior crossbite correction: A randomized controlled trial with a 2-year follow-up Originl Article Stbility of nterior crossbite correction: A rndomized controlled tril with 2-yer follow-up Ann-Pulin Wiedel ; Lrs Bondemrk b ABSTRACT Objective: To compre nd evlute the stbility of correction

More information

Consumer perceptions of meat quality and shelf-life in commercially raised broilers compared to organic free range broilers

Consumer perceptions of meat quality and shelf-life in commercially raised broilers compared to organic free range broilers Consumer perceptions of met qulity nd shelf-life in commercilly rised roilers compred to orgnic free rnge roilers C.Z. ALVARADO 1 *, E. WENGER 2 nd S. F. O KEEFE 3 1 Texs Tech University, Box 42141 Luock,

More information

Vitamin D and Mushrooms: Enrichment With Pulsed UV Light. Michael Kalaras Department of Food Science The Pennsylvania State University

Vitamin D and Mushrooms: Enrichment With Pulsed UV Light. Michael Kalaras Department of Food Science The Pennsylvania State University Vitmin D nd Mushrooms: Enrichment With Pulsed UV Light Michel Klrs Deprtment of Food Science The Pennsylvni Stte University Vitmin D Synthesis Source: http://vitmind.ucr.edu/imges/chem1.gif Vitmin D In

More information

distraction cleaning Peaks cages specifications

distraction cleaning Peaks cages specifications Peks cges specifictions We thnk for choosing Qulgenix Peks lumbr cges. 0Pwith α 8 00D8S Mteril 9 0D9S 9 be po Peks 0 - -8 0 0D0S resection with introduce remer 0DM remer 007RM Acute or chronic 0DM remer

More information

Influence of Chewing on Dental Health in Dogs

Influence of Chewing on Dental Health in Dogs 1 Influence of Chewing on Dentl Helth in Dogs S Bjone 1, W Brown 2, J. Billinghm 3, A. Hrris 3 nd P M c Genity 3 1 School of Psychology, University of New Englnd, Armidle, NSW, 2351, Austrli 2 Animl Science,

More information

Pulp response to dentine adhesives: A study on mature human pulps

Pulp response to dentine adhesives: A study on mature human pulps Originl Article Pulp response to dentine dhesives: A study on mture humn pulps Pntelis Kouros 1, Eugeni Koliniotou Koumpi 1, Eliseth Koulouzidou 1, Mri Helvtjoglu Antonides 1, Dimitrios Tzifs 2 Correspondence:

More information

TEMPLATE SYNTHESIS OF Cu AND Cu-Sn NANOPARTICLES USING CARBON FOAM AS A SUPPORT. Ivania MARKOVA-DENEVA, Tihomir PETROV, Ivan DENEV

TEMPLATE SYNTHESIS OF Cu AND Cu-Sn NANOPARTICLES USING CARBON FOAM AS A SUPPORT. Ivania MARKOVA-DENEVA, Tihomir PETROV, Ivan DENEV TEMPLATE SYNTHESIS OF Cu AND Cu-Sn NANOPARTICLES USING CARBON FOAM AS A SUPPORT Ivni MARKOVA-DENEVA, Tihomir PETROV, Ivn DENEV University of Chemicl Technology nd Metllurgy, 8, Kl. Ohridski lvd., Sofi,

More information

Comparison of three simple methods for the

Comparison of three simple methods for the J. clin. Pth. (1967), 2, 5 Comprison of three simple methods for the ssessment of 'free' thyroid hormone T. M. D. GIMLETTE1 From the Rdio-Isotope Lbortory, St. Thoms's Hospitl, London SYNOPSIS A dilysis

More information

Products for weaners Benzoic acid or the combination of lactic acid and formic acid

Products for weaners Benzoic acid or the combination of lactic acid and formic acid Products for weners Benzoic cid or the comintion of lctic cid nd formic cid Tril report no.: 490 Novemer, 000 Hnne Mrio, Lrs Egelund Olsen, Bent Borg Jensen 1 nd Nuri Miquel 1 The Ntionl Committee for

More information

Effect on Glycemic, Blood Pressure, and Lipid Control according to Education Types

Effect on Glycemic, Blood Pressure, and Lipid Control according to Education Types Originl Article http://dx.doi.org/10.4093/dmj.2011.35.6.580 pissn 2233-6079 eissn 2233-6087 D I A B E T E S & M E T A B O L I S M J O U R N A L Effect on Glycemic, Blood Pressure, nd Lipid Control ccording

More information

Supplementary Figure 1

Supplementary Figure 1 doi: 1.138/nture6188 SUPPLEMENTARY INFORMATION Supplementry Figure 1 c CFU-F colonies per 1 5 stroml cells 14 12 1 8 6 4 2 Mtrigel plug Neg. MCF7/Rs MDA-MB-231 * * MCF7/Rs-Lung MDA-MB-231-Lung MCF7/Rs-Kidney

More information

Hypoglycemic Activity of Polygala erioptera (Whole Plant) in Normal and Alloxan Induced Diabetic Rats

Hypoglycemic Activity of Polygala erioptera (Whole Plant) in Normal and Alloxan Induced Diabetic Rats Asin Journl of Chemistry Vol. 20, No. 1 (2008), 107-112 Hypoglycemic Activity of Polygl eriopter (Whole Plnt) in Norml nd Alloxn Induced Dibetic Rts G. SAMMAIAH* nd R.S. SRIVASTAVA Deprtment of Phrmceutics,

More information

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis Supplementry Informtion PDGF-BB secreted y preosteoclsts induces ngiogenesis during coupling with osteogenesis Hui Xie, Zhung Cui, Long Wng, Zhuying Xi, Yin Hu, Lingling Xin, Chngjun Li, Ling Xie, Jnet

More information

Celecoxib effectively inhibits the formation of joint adhesions

Celecoxib effectively inhibits the formation of joint adhesions EXPERIMENTAL AND THERAPEUTIC MEDICINE 6: 1507-1511, 2013 Celecoxib effectively inhibits the formtion of joint dhesions FENGFENG LI 1*, BIN HE 2*, SHEN LIU 1 nd CUNYI FAN 1 1 Deprtment of Orthopedics, Sixth

More information

Goal: Evaluate plant health effects while suppressing dollar spot and brown patch

Goal: Evaluate plant health effects while suppressing dollar spot and brown patch Newer Fungicide Products Alone nd In Rottion on Chicgo Golf Green Reserchers: Chicgo District Golf Assoc. Derek Settle, Tim Sibicky, nd Nick DeVries Gol: Evlute plnt helth effects while suppressing dollr

More information

Fundamentals of Spine MRI and Essential Protocols

Fundamentals of Spine MRI and Essential Protocols Fundmentls of Spine MRI nd Essentil Protocols A. C. Dougls-Akinwnde, MD Octoer 13, 2009 Fundmentls of Spine MRI Lerning Ojectives: 1. List the essentil sequences for Spine MRI exmintion 2. Discuss the

More information

Geographical influence on digit ratio (2D:4D): a case study of Andoni and Ikwerre ethnic groups in Niger delta, Nigeria.

Geographical influence on digit ratio (2D:4D): a case study of Andoni and Ikwerre ethnic groups in Niger delta, Nigeria. Journl of Applied Biosciences 27: 1736-1741 ISSN 1997 5902 Geogrphicl influence on digit rtio (2D:4D): cse study of Andoni nd Ikwerre ethnic groups in Niger delt, Nigeri. Gwunirem, Isrel U 1 nd Ihemelndu,

More information

EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE

EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE Swine Dy 21 EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE J. M. DeRouchey, M. D. Tokch, J. L. Nelssen, R. D. Goodbnd, S. S. Dritz 1, J. C. Woodworth, M. J. Webster, B. W.

More information

Original Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract:

Original Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract: Fridpur Med. Coll. J. 214;9(2):61-67 Originl Article Nebuliztion by Isotonic Mgnesium Sulphte Solution with Provide Erly nd Better Response s Compred to Conventionl Approch ( Plus Norml Sline) in Acute

More information