BLEEDING DISORDERS Simple complement:
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1 BLEEDING DISORDERS Simple complement: 1. Select the statement that describe the thrombocytopenia definition: A. Marked decrease of the Von Willebrandt factor B. Absence of antihemophilic factor A C. Disorder of platelet function D. Absence of antihemophilic factor B E. Reduced platelet count 2. Select the statement that describe the Von Willebrandt disease definition: A. Megakaryopoiesis disorder B. It s a mixt coagulopathy C. It s a mixt disorder of primary and secondary hemostasis D. Disorder of platelet function E. Marked decrease of the coagulation factor VIII 3. Select the most characteristic manifestation for the Von Willebrandt disease: A. Massive bleeding B. Hematomas C. Mixt type of bleeding D. Hemarthroses E. Vascular purpura 4. Select the treatment recommendation for primary hemostasis disorders: A. Fresh frozen plasma B. Native plasma C. Trental D. Drugs that decrease viscosity of the blood 5. Select the diagnostic test that is NOT used to confirm thrombocytopenia diagnosis: A. Myelogram B. Assessment of the levels of anti-platelet antibodies C. Platelet count D. Skin bleeding time test E. Coagulation tests 6. Select the manifestation that is NOT characteristic for Hemorrhagic vasculitis (Henoch's disease) in children: A. Acute onset B. Polyorganic lesions C. Maculopapular cutaneous symptoms D. Hematomas E. Recurrent evolution 7. Select the treatment method that is NOT indicated for patients with Disseminated Intravascular Coagulation Syndrome: A. Fibrinogen B. Fresh frozen plasma C. Symptomatic therapy D. Fibrinolytic preparations E. Antithrombins 8. Select the most characteristic manifestation for thrombocytopenia: A. Hematoma
2 B. Petechial - macular C. Mixt D. Vascular purpura E. Angioma 9. Select the most important diagnostic criteria for Disseminated Intravascular Coagulation Syndrome in children: A. Assessment of the platelet aggregation B. Assessment of the fibrin degradation product (FDPs, fibrin split products) C. Assessment of the platelet adhesion D. Assessment of the plasma fibrinogen level E. Appreciation of plasma toleration to heparin 10. Choose the treatment that is NOT indicated in hemophilia treatment: A. Fresh frozen plasma B. Cryoprecipitate C. Fibrinogen D. Lyophilized factor VIII E. Lyophilized factor IX 11. Choose the diagnostic test that is NOT indicated for thrombocytopathy diagnosis: A. Appreciation of hereditary character of disease B. Determination of morphologic structure of platelets C. Determination of platelet count D. Appreciation of fibrinolytic function E. Evaluation of platelet factors 12. In a child with marked hemorrhagic syndrome and reduced platelet count the following drugs were administered. Choose the indication that is NOT correct: A. Aminocapronic acid for local hemostasis B. Fibrin sponge C. Subcutaneous administration of heparin D. Corticosteroids Multiple complement : 1. Hemophilia is characterized by the followings: A. Massive hemorrhages B. Prolonged bleeding time C. Prolonged coagulation time E. Petechiae and ecchymosis 2. Von Willebrand disease is characterized by the followings symptoms: A. Gingival bleeding B. Epistaxis C. Menorrhagia E. Petechiae and ecchymosis 3. The following diagnostic tests are characteristic for hemophilia : A. Prolonged bleeding time B. Prolonged coagulation time C. Prolonged partially activated thromboplastin time D. Increased prothrombin time
3 E. Decreased platelet count 4. Select characteristic features for hemophilia C (factor XI deficiency): A. The most frequent coagulation disorder B. The most easy form of hemophilia traits C. The most severe form of hemophilia traits D. The clinical form with the most severe complications E. Represents 1-2 % out of the total number of coagulation disorder 5. Select clinical symptoms characteristic for thrombocytopenia: A. Gingival hemorrhages B. Epistaxis C. Hematomas D. Ecchymosis E. Menorrhagia 6. Select diagnostic tests characteristic for Disseminated Intravascular Coagulation: A. Prolonged aptt B. Prolonged PT C. Increase in fibrinfibrinogen split products D. Increased platelet count E. Increased fibrinogen 7. Conditions known to trigger Disseminated Intravascular Coagulation include: A. Endothelial damage (eg, endotoxin, virus) B. Tissue necrosis (eg, burns) C. Diffuse ischemic injury (eg, shock, hypoxia acidosis) D. It is hereditary disorder E. Food allergens 8. Signs of Disseminated Intravascular Coagulation may include: A. Signs of shock B. Diffuse bleeding tendency (eg, hematuria, melena, purpura, petechiae, persistent oozing from needle punctures or other invasive procedures) C. Evidence of thrombotic lesions (eg, major vessel thrombosis, purpura fulminans) E. End-organ dysfunction 9. Select treatment indications for platelet function disorders: A. Corticosteroids (prednisone) B. Antiplatelet drugs (antiaggregant) C. Desmopressin acetate D. Fresh frozen plasma 10. Select treatment indications for hemophilia: A. Direct transfusions of blood B. Recombinant factor VIII C. Fresh frozen plasma D. Cryoprecipitate 11. Select treatment indications for thrombocytopenia: A. Prednisone B. Local hemostasis C. Fresh frozen plasma D. Splenectomy in circumstances of life-threatening bleeding
4 12. Select symptoms typical for Henoch-Schönlein Purpura: A. Purpuric cutaneous rash B. Migratory polyarthritis or polyarthralgias C. Intermittent abdominal pain D. Leukocytosis E. Nephritis 13. Enumerate first-line clotting tests: A. Activated partial thromboplastin time (APTT) B. Prothrombin time (PT) C. Platelet function analysis D. Platelet count E. Standardized skin bleeding time (BT) 14. Decrease of the platelet count in children leads to: A. Coagulation disorders B. Increase of the blood vessels permeability C. Platelet function disorder D. Increased blood vessels fragility E. Increasing of serum anticoagulant potential
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