BLEEDING DISORDERS Simple complement:

Size: px
Start display at page:

Download "BLEEDING DISORDERS Simple complement:"

Transcription

1 BLEEDING DISORDERS Simple complement: 1. Select the statement that describe the thrombocytopenia definition: A. Marked decrease of the Von Willebrandt factor B. Absence of antihemophilic factor A C. Disorder of platelet function D. Absence of antihemophilic factor B E. Reduced platelet count 2. Select the statement that describe the Von Willebrandt disease definition: A. Megakaryopoiesis disorder B. It s a mixt coagulopathy C. It s a mixt disorder of primary and secondary hemostasis D. Disorder of platelet function E. Marked decrease of the coagulation factor VIII 3. Select the most characteristic manifestation for the Von Willebrandt disease: A. Massive bleeding B. Hematomas C. Mixt type of bleeding D. Hemarthroses E. Vascular purpura 4. Select the treatment recommendation for primary hemostasis disorders: A. Fresh frozen plasma B. Native plasma C. Trental D. Drugs that decrease viscosity of the blood 5. Select the diagnostic test that is NOT used to confirm thrombocytopenia diagnosis: A. Myelogram B. Assessment of the levels of anti-platelet antibodies C. Platelet count D. Skin bleeding time test E. Coagulation tests 6. Select the manifestation that is NOT characteristic for Hemorrhagic vasculitis (Henoch's disease) in children: A. Acute onset B. Polyorganic lesions C. Maculopapular cutaneous symptoms D. Hematomas E. Recurrent evolution 7. Select the treatment method that is NOT indicated for patients with Disseminated Intravascular Coagulation Syndrome: A. Fibrinogen B. Fresh frozen plasma C. Symptomatic therapy D. Fibrinolytic preparations E. Antithrombins 8. Select the most characteristic manifestation for thrombocytopenia: A. Hematoma

2 B. Petechial - macular C. Mixt D. Vascular purpura E. Angioma 9. Select the most important diagnostic criteria for Disseminated Intravascular Coagulation Syndrome in children: A. Assessment of the platelet aggregation B. Assessment of the fibrin degradation product (FDPs, fibrin split products) C. Assessment of the platelet adhesion D. Assessment of the plasma fibrinogen level E. Appreciation of plasma toleration to heparin 10. Choose the treatment that is NOT indicated in hemophilia treatment: A. Fresh frozen plasma B. Cryoprecipitate C. Fibrinogen D. Lyophilized factor VIII E. Lyophilized factor IX 11. Choose the diagnostic test that is NOT indicated for thrombocytopathy diagnosis: A. Appreciation of hereditary character of disease B. Determination of morphologic structure of platelets C. Determination of platelet count D. Appreciation of fibrinolytic function E. Evaluation of platelet factors 12. In a child with marked hemorrhagic syndrome and reduced platelet count the following drugs were administered. Choose the indication that is NOT correct: A. Aminocapronic acid for local hemostasis B. Fibrin sponge C. Subcutaneous administration of heparin D. Corticosteroids Multiple complement : 1. Hemophilia is characterized by the followings: A. Massive hemorrhages B. Prolonged bleeding time C. Prolonged coagulation time E. Petechiae and ecchymosis 2. Von Willebrand disease is characterized by the followings symptoms: A. Gingival bleeding B. Epistaxis C. Menorrhagia E. Petechiae and ecchymosis 3. The following diagnostic tests are characteristic for hemophilia : A. Prolonged bleeding time B. Prolonged coagulation time C. Prolonged partially activated thromboplastin time D. Increased prothrombin time

3 E. Decreased platelet count 4. Select characteristic features for hemophilia C (factor XI deficiency): A. The most frequent coagulation disorder B. The most easy form of hemophilia traits C. The most severe form of hemophilia traits D. The clinical form with the most severe complications E. Represents 1-2 % out of the total number of coagulation disorder 5. Select clinical symptoms characteristic for thrombocytopenia: A. Gingival hemorrhages B. Epistaxis C. Hematomas D. Ecchymosis E. Menorrhagia 6. Select diagnostic tests characteristic for Disseminated Intravascular Coagulation: A. Prolonged aptt B. Prolonged PT C. Increase in fibrinfibrinogen split products D. Increased platelet count E. Increased fibrinogen 7. Conditions known to trigger Disseminated Intravascular Coagulation include: A. Endothelial damage (eg, endotoxin, virus) B. Tissue necrosis (eg, burns) C. Diffuse ischemic injury (eg, shock, hypoxia acidosis) D. It is hereditary disorder E. Food allergens 8. Signs of Disseminated Intravascular Coagulation may include: A. Signs of shock B. Diffuse bleeding tendency (eg, hematuria, melena, purpura, petechiae, persistent oozing from needle punctures or other invasive procedures) C. Evidence of thrombotic lesions (eg, major vessel thrombosis, purpura fulminans) E. End-organ dysfunction 9. Select treatment indications for platelet function disorders: A. Corticosteroids (prednisone) B. Antiplatelet drugs (antiaggregant) C. Desmopressin acetate D. Fresh frozen plasma 10. Select treatment indications for hemophilia: A. Direct transfusions of blood B. Recombinant factor VIII C. Fresh frozen plasma D. Cryoprecipitate 11. Select treatment indications for thrombocytopenia: A. Prednisone B. Local hemostasis C. Fresh frozen plasma D. Splenectomy in circumstances of life-threatening bleeding

4 12. Select symptoms typical for Henoch-Schönlein Purpura: A. Purpuric cutaneous rash B. Migratory polyarthritis or polyarthralgias C. Intermittent abdominal pain D. Leukocytosis E. Nephritis 13. Enumerate first-line clotting tests: A. Activated partial thromboplastin time (APTT) B. Prothrombin time (PT) C. Platelet function analysis D. Platelet count E. Standardized skin bleeding time (BT) 14. Decrease of the platelet count in children leads to: A. Coagulation disorders B. Increase of the blood vessels permeability C. Platelet function disorder D. Increased blood vessels fragility E. Increasing of serum anticoagulant potential

5

HENOCH SCHÖNLEIN PURPURA (VASCULAR PURPURA, ANAPHYLACTOID PURPURA) IN CHILDREN Single choice tests (SC)

HENOCH SCHÖNLEIN PURPURA (VASCULAR PURPURA, ANAPHYLACTOID PURPURA) IN CHILDREN Single choice tests (SC) HENOCH HÖNLEIN PURPURA (VAULAR PURPURA, ANAPHYLACTOID PURPURA) IN CHILDREN Single choice tests () 1. Choose the type of bleeding characteristic for the Henoch Schönlein purpura (vascular purpura, anaphylactoid

More information

HEME 10 Bleeding Disorders

HEME 10 Bleeding Disorders HEME 10 Bleeding Disorders When injury occurs, three mechanisms occur Blood vessels Primary hemostasis Secondary hemostasis Diseases of the blood vessels Platelet disorders Thrombocytopenia Functional

More information

Coagulation Disorders. Dr. Muhammad Shamim Assistant Professor, BMU

Coagulation Disorders. Dr. Muhammad Shamim Assistant Professor, BMU Coagulation Disorders Dr. Muhammad Shamim Assistant Professor, BMU 1 Introduction Local Vs. General Hematoma & Joint bleed Coagulation Skin/Mucosal Petechiae & Purpura PLT wound / surgical bleeding Immediate

More information

Bleeding Disorders. Dr. Mazen Fawzi Done by Saja M. Al-Neaumy Noor A Mohammad Noor A Joseph Joseph

Bleeding Disorders. Dr. Mazen Fawzi Done by Saja M. Al-Neaumy Noor A Mohammad Noor A Joseph Joseph Bleeding Disorders Dr. Mazen Fawzi Done by Saja M. Al-Neaumy Noor A Mohammad Noor A Joseph Joseph Normal hemostasis The normal hemostatic response involves interactions among: The blood vessel wall (endothelium)

More information

Haemostasis & Coagulation disorders Objectives:

Haemostasis & Coagulation disorders Objectives: Haematology Lec. 1 د.ميسم مؤيد علوش Haemostasis & Coagulation disorders Objectives: - Define haemostasis and what are the major components involved in haemostasis? - How to assess the coagulation status?

More information

Bleeding Disorders: (Hemorrhagic Diatheses) Tests used to evaluate different aspects of hemostasis are the following:

Bleeding Disorders: (Hemorrhagic Diatheses) Tests used to evaluate different aspects of hemostasis are the following: Bleeding Disorders: (Hemorrhagic Diatheses) Excessive bleeding can result from: 1. Increased fragility of vessels. 2. Platelet deficiency or dysfunction. 3. Derangement of coagulation. 4. Combinations

More information

Bleeding disorders. Hemostatic failure: Inappropriate and excessive bleeding either spontaneous or in response to injury.

Bleeding disorders. Hemostatic failure: Inappropriate and excessive bleeding either spontaneous or in response to injury. 1 Bleeding disorders Objectives: 1. Discuss briefly the physiology of hemostasis. 2. Define the mechanisms of thrombocytopenia and the relative bleeding risk at any given platelet count. 3. Be able to

More information

Approach to bleeding disorders &treatment. by RAJESH.N General medicine post graduate

Approach to bleeding disorders &treatment. by RAJESH.N General medicine post graduate Approach to bleeding disorders &treatment by RAJESH.N General medicine post graduate 2 Approach to a patient of bleeding diathesis 1. Clinical evaluation: History, Clinical features 2. Laboratory approach:

More information

Disseminated Intravascular Coagulation (DIC) Seminar. Ron Kopilov 4 th year Medical Student, Tel Aviv University Internal Medicine A 8.3.

Disseminated Intravascular Coagulation (DIC) Seminar. Ron Kopilov 4 th year Medical Student, Tel Aviv University Internal Medicine A 8.3. Disseminated Intravascular Coagulation (DIC) Seminar Ron Kopilov 4 th year Medical Student, Tel Aviv University Internal Medicine A 8.3.2012 1 Our plan: Understand the pathophysiology Identify risk factors

More information

Disseminated Intravascular Coagulation. M.Bahmanpour MD Assistant professor IUMS

Disseminated Intravascular Coagulation. M.Bahmanpour MD Assistant professor IUMS به نام خدا Disseminated Intravascular Coagulation M.Bahmanpour MD Assistant professor IUMS Algorithm for Diagnosis of DIC DIC Score factor score Presence of known underlying disorder No= 0 yes=2 Coagolation

More information

L iter diagnostico di laboratorio nelle coagulopatie congenite emorragiche

L iter diagnostico di laboratorio nelle coagulopatie congenite emorragiche L iter diagnostico di laboratorio nelle coagulopatie congenite emorragiche Armando Tripodi Angelo Bianchi Bonomi Hemophilia and Thrombosis Center Dept. of Clinical Sciences and Community Health University

More information

Easy Bleeding General Presentation

Easy Bleeding General Presentation Easy Bleeding General Presentation It is not uncommon for children to bleed and bruise after experiencing trauma. However, a child may also have an underlying coagulopathy, which results in easy and possibly

More information

Dr. MUBARAK ABDELRAHMAN MD PEDIATRICS AND CHILD HEALTH Assistant Professor FACULTY OF MEDICINE -JAZAN

Dr. MUBARAK ABDELRAHMAN MD PEDIATRICS AND CHILD HEALTH Assistant Professor FACULTY OF MEDICINE -JAZAN Dr. MUBARAK ABDELRAHMAN MD PEDIATRICS AND CHILD HEALTH Assistant Professor FACULTY OF MEDICINE -JAZAN The student should be able:» To identify the mechanism of homeostasis and the role of vessels, platelets

More information

Approach to disseminated intravascular coagulation

Approach to disseminated intravascular coagulation Approach to disseminated intravascular coagulation Khaire Ananta Shankarrao 1, Anil Burley 2, Deshmukh 3 1.MD Scholar, [kayachikitsa] 2.Professor,MD kayachikitsa. 3.Professor and HOD,Kayachikitsa. CSMSS

More information

Haemorrhagic Disorders. Dr. Bashar Department of Pathology Mosul Medical College

Haemorrhagic Disorders. Dr. Bashar Department of Pathology Mosul Medical College Haemorrhagic Disorders Dr. Bashar Department of Pathology Mosul Medical College Hemorrhagic Disorders These include Disorders of platelets. Disorders of blood vessels. Disorders of coagulation & fibrinolysis.

More information

EDUCATIONAL COMMENTARY DISSEMINATED INTRAVASCULAR COAGULATION

EDUCATIONAL COMMENTARY DISSEMINATED INTRAVASCULAR COAGULATION EDUCATIONAL COMMENTARY DISSEMINATED INTRAVASCULAR COAGULATION Educational commentary is provided through our affiliation with the American Society for Clinical Pathology (ASCP). To obtain FREE CME/CMLE

More information

Disseminated intravascular coagulation (DIC) Dr. Klara Vezendi Szeged University Transfusiology Department

Disseminated intravascular coagulation (DIC) Dr. Klara Vezendi Szeged University Transfusiology Department Disseminated intravascular coagulation (DIC) Dr. Klara Vezendi Szeged University Transfusiology Department Disseminated intravascular coagulation (DIC, consumptive coagulopathy) is a clinicopathologic

More information

Dr. Rai Muhammad Asghar Associate Professor Head of Pediatric Department Rawalpindi Medical College

Dr. Rai Muhammad Asghar Associate Professor Head of Pediatric Department Rawalpindi Medical College Dr. Rai Muhammad Asghar Associate Professor Head of Pediatric Department Rawalpindi Medical College AN APPROACH TO BLEEDING DISORDERS NORMAL HEMOSTASIS After injury, 3 processes halt bleeding Vasoconstriction

More information

Approach To A Bleeding Patient

Approach To A Bleeding Patient ABDUL MAJEED, RAHUL RAJEEV REVIEW ARTICLE INTRODUCTION Hemostasis is the process of forming clots in the walls of damaged blood vessels and preventing blood loss while maintaining blood in a fluid state

More information

Platelet Disorders. By : Saja Al-Oran

Platelet Disorders. By : Saja Al-Oran Platelet Disorders By : Saja Al-Oran Introduction The platelet arise from the fragmentation of the cytoplasm of megakaryocyte in the bone marrow. circulate in the blood as disc-shaped anucleate particles

More information

Document Title: Hemostasis: Platelet and Coagulation Disorders. Author(s): Joseph H. Hartmann (University of Michigan), DO 2012

Document Title: Hemostasis: Platelet and Coagulation Disorders. Author(s): Joseph H. Hartmann (University of Michigan), DO 2012 Project: Ghana Emergency Medicine Collaborative Document Title: Hemostasis: Platelet and Coagulation Disorders Author(s): Joseph H. Hartmann (University of Michigan), DO 2012 License: Unless otherwise

More information

Congenital bleeding disorders

Congenital bleeding disorders Congenital bleeding disorders Overview Factor VIII von Willebrand Factor Complex factor VIII von Willebrand factor (vwf) complex circulate as a complex + factor IX intrinsic pathway Platelets bind via

More information

John Davidson Consultant in Intensive Care Medicine Freeman Hospital, Newcastle upon Tyne

John Davidson Consultant in Intensive Care Medicine Freeman Hospital, Newcastle upon Tyne John Davidson Consultant in Intensive Care Medicine Freeman Hospital, Newcastle upon Tyne Overview of coagulation Testing coagulation Coagulopathy in ICU Incidence Causes Evaluation Management Coagulation

More information

ACQUIRED COAGULATION ABNORMALITIES

ACQUIRED COAGULATION ABNORMALITIES ACQUIRED COAGULATION ABNORMALITIES ACQUIRED COAGULATION ABNORMALITIES - causes 1. Liver disease 2. Vitamin K deficiency 3. Increased consumption of the clotting factors (disseminated intravascular coagulation

More information

Bleeding Disorders HOPE Maram Al-anbar

Bleeding Disorders HOPE Maram Al-anbar Bleeding Disorders HOPE Maram Al-anbar 9-9 - 2014 ^^ Attention Please ^^ We ( correction team of pediatric package^hope/2010^ ) had decided to make one lecture of bleeding disorders in place of the two

More information

Hematologic Disorders. Assistant professor of anesthesia

Hematologic Disorders. Assistant professor of anesthesia Preoperative Evaluation Hematologic Disorders Dr M.Razavi Assistant professor of anesthesia Anemia Evaluation needs to consider the extent and type of surgery, the anticipated blood loss, and the patient's

More information

BLEEDING (PLATELET) DISORDER. IAP UG Teaching slides

BLEEDING (PLATELET) DISORDER. IAP UG Teaching slides BLEEDING (PLATELET) DISORDER 1 APPROACH The initial set of questions should establish the following: (1) the most common site and type of bleeding (e.g., mucocutaneous versus articular or deep muscle),

More information

This slide belongs to iron lecture and it is to clarify the iron cycle in the body and the effect of hypoxia on erythropoitein secretion

This slide belongs to iron lecture and it is to clarify the iron cycle in the body and the effect of hypoxia on erythropoitein secretion This slide belongs to iron lecture and it is to clarify the iron cycle in the body and the effect of hypoxia on erythropoitein secretion Topics of today lectures: Hemostasis Meaning of hemostasis Mechanisms

More information

General approach to the investigation of haemostasis. Jan Gert Nel Dept. of Haematology University of Pretoria 2013

General approach to the investigation of haemostasis. Jan Gert Nel Dept. of Haematology University of Pretoria 2013 General approach to the investigation of haemostasis Jan Gert Nel Dept. of Haematology University of Pretoria 2013 Clinical reasons to investigate haemostasis Investigating a clinically suspected bleeding

More information

INHERITED COAGULOPATHY

INHERITED COAGULOPATHY Disorder Etiology Pathophysiology and Presentation Lab Findings and Diagnosis Treatment INHERITED COAGULOPATHY HEMOPHILIA A and B Hemophilia A: deficiency in XIII (85%) Hemophilia B: deficiency in IX (15%)

More information

Effective Date: Approved by: Laboratory Director, Jerry Barker (electronic signature)

Effective Date: Approved by: Laboratory Director, Jerry Barker (electronic signature) 1 of 5 Policy #: 702 (PHL-702-05) Effective Date: 9/30/2004 Reviewed Date: 8/1/2016 Subject: TRANSFUSION GUIDELINES Approved by: Laboratory Director, Jerry Barker (electronic signature) Approved by: Laboratory

More information

LAMA SHATAT TTP, ITP, DIC

LAMA SHATAT TTP, ITP, DIC TTP, ITP, DIC Reduction in platelet number (thrombocytopenia) constitutes an important cause of generalized bleeding. A count less than 100,000 platelets/μl is generally considered to constitute thrombocytopenia.

More information

Bleeding and Thrombotic Disorders. Kristine Krafts, M.D.

Bleeding and Thrombotic Disorders. Kristine Krafts, M.D. Bleeding and Thrombotic Disorders Kristine Krafts, M.D. Bleeding and Thrombotic Disorders Bleeding disorders von Willebrand disease Hemophilia A and B DIC TTP/HUS ITP Thrombotic disorders Factor V Leiden

More information

MASSIVE TRANSFUSION DR.K.HITESH KUMAR FINAL YEAR PG DEPT. OF TRANSFUSION MEDICINE

MASSIVE TRANSFUSION DR.K.HITESH KUMAR FINAL YEAR PG DEPT. OF TRANSFUSION MEDICINE MASSIVE TRANSFUSION DR.K.HITESH KUMAR FINAL YEAR PG DEPT. OF TRANSFUSION MEDICINE CONTENTS Definition Indications Transfusion trigger Massive transfusion protocol Complications DEFINITION Massive transfusion:

More information

Bleeding and Haemostasis. Saman W.Boskani HDD, FIBMS Maxillofacial Surgeon

Bleeding and Haemostasis. Saman W.Boskani HDD, FIBMS Maxillofacial Surgeon Bleeding and Haemostasis Saman W.Boskani HDD, FIBMS Maxillofacial Surgeon 1 Beeding Its escaping or extravasation of blood contents from blood vessels Types: - Arterial - Venous - Capillary Differences

More information

Appendix 3 PCC Warfarin Reversal

Appendix 3 PCC Warfarin Reversal Appendix 3 PCC Warfarin Reversal Reversal of Warfarin and Analogues 1. Principle of Procedure Guidelines for the Reversal of Oral-anticoagulation in the Event of Life Threatening Haemorrhage Prothrombin

More information

Blood Lecture Test Questions Set 2 Summer 2012

Blood Lecture Test Questions Set 2 Summer 2012 Blood Lecture Test Questions Set 2 Summer 2012 1. Leukocytes are attracted to a site of injury or disease by: a. diapedesis b. chemotaxis c. leukocytosis d. heparin e. leukomotosis 2. Leukocytes leave

More information

Introduction to coagulation and laboratory tests

Introduction to coagulation and laboratory tests Introduction to coagulation and laboratory tests Marc Jacquemin Special Haemostasis Laboratory Center for Molecular and Vascular Biology University of Leuven Coagulation in a blood vessel: fibrin stabilises

More information

DISSEMINATED INTRAVASCULAR COAGULATION (DIC) Pichika Chantrathammachart MD Division of Hematology, Department of Medicine Ramathibodi Hospital

DISSEMINATED INTRAVASCULAR COAGULATION (DIC) Pichika Chantrathammachart MD Division of Hematology, Department of Medicine Ramathibodi Hospital DISSEMINATED INTRAVASCULAR COAGULATION (DIC) Pichika Chantrathammachart MD Division of Hematology, Department of Medicine Ramathibodi Hospital Disseminated intravascular coagulation (DIC) Disseminated

More information

DIC. Bert Vandewiele Fellow Critical Care 23 May 2011

DIC. Bert Vandewiele Fellow Critical Care 23 May 2011 DIC Bert Vandewiele Fellow Critical Care 23 May 2011 Dissiminated Intravascular Coagulopathie 11/3/2011 Dr. Bert Vandewiele 2 Dissiminated Intravascular Coagulopathie = Consumption coagulopathie = Defibrination

More information

LifeBridge Health Transfusion Service Sinai Hospital of Baltimore Northwest Hospital Center BQA Transfusion Criteria Version#2 POLICY NO.

LifeBridge Health Transfusion Service Sinai Hospital of Baltimore Northwest Hospital Center BQA Transfusion Criteria Version#2 POLICY NO. LifeBridge Health Transfusion Service Sinai Hospital of Baltimore Northwest Hospital Center BQA 1011.02 Transfusion Criteria Version#2 Department POLICY NO. PAGE NO. Blood Bank Quality Assurance Manual

More information

Blood products and plasma substitutes

Blood products and plasma substitutes Blood products and plasma substitutes Plasma substitutes Dextran 70 and polygeline are macromolecular substances which are metabolized slowly; they may be used to expand and maintain blood volume in shock

More information

Chapter 3 Diseases of the Blood and Bloodforming Organs and Certain Disorders Involving the Immune Mechanism D50-D89

Chapter 3 Diseases of the Blood and Bloodforming Organs and Certain Disorders Involving the Immune Mechanism D50-D89 Chapter 3 Diseases of the Blood and Bloodforming Organs and Certain Disorders Involving the Immune Mechanism D50-D89 Presented by Jennifer Kurkulonis 1 FOUR MAJOR TYPES OF BLOOD CELLS White blood cells

More information

Thursday, February 26, :00 am. Regulation of Coagulation/Disseminated Intravascular Coagulation HEMOSTASIS/THROMBOSIS III

Thursday, February 26, :00 am. Regulation of Coagulation/Disseminated Intravascular Coagulation HEMOSTASIS/THROMBOSIS III REGULATION OF COAGULATION Introduction HEMOSTASIS/THROMBOSIS III Regulation of Coagulation/Disseminated Coagulation necessary for maintenance of vascular integrity Enough fibrinogen to clot all vessels

More information

Topics of today lectures: Hemostasis

Topics of today lectures: Hemostasis Topics of today lectures: Hemostasis Meaning of hemostasis Mechanisms of hemostasis - Vascular contraction - Platelets plug - Blood coagulation (clotting) - Structure and functions of platelets - Blood

More information

Dental Management of Patients with Bleeding Disorders

Dental Management of Patients with Bleeding Disorders Dental Management of Patients with Bleeding Disorders Sandra D Amato-Palumbo, RDH, MPS Continuing Education Units: 3 hours Online Course: www.dentalcare.com/en-us/dental-education/continuing-education/ce319/ce319.aspx

More information

Major Haemorrhage Protocol. Commentary

Major Haemorrhage Protocol. Commentary Hairmyres Hospital Monklands Hospital Wishaw General Hospital Major Haemorrhage Protocol Commentary N.B. There is a separate NHSL protocol for the Management of Obstetric Haemorrhage Authors Dr Tracey

More information

The LaboratoryMatters

The LaboratoryMatters Laboratory Medicine Newsletter for clinicians, pathologists & clinical laboratory technologists. A Initiative. HEMOSTASIS AND THE LABORATORY This issue highlights: Primary Hemostasis Screening Tests Case

More information

Coagulation, Haemostasis and interpretation of Coagulation tests

Coagulation, Haemostasis and interpretation of Coagulation tests Coagulation, Haemostasis and interpretation of Coagulation tests Learning Outcomes Indicate the normal ranges for routine clotting screen and explain what each measurement means Recognise how to detect

More information

Chapter 19. Hemostasis

Chapter 19. Hemostasis Chapter 19 Hemostasis Hemostasis Hemostasis is the cessation of bleeding stopping potentially fatal leaks important in small blood vessels not effective in hemorrhage excessive bleeding from large blood

More information

HAEMORRHAGIA Bleeding

HAEMORRHAGIA Bleeding HAEMORRHAGIA Bleeding Cassification Size Location pathomechanism Hematoma: external or may be enclosed within a tissue petechial rash (spot) : 1-2 mm hemorrhages into skin, mucous membranes, or serosal

More information

COAGULATIONS. Dr. Hasan Fahmawi, MRCP(UK), FRCP(Edin)

COAGULATIONS. Dr. Hasan Fahmawi, MRCP(UK), FRCP(Edin) COAGULATIONS Dr. Hasan Fahmawi, MRCP(UK), FRCP(Edin) Haemostasis-blood must be maintained in a fluid state in order to function as a transport system, but must be able to solidify to form a clot following

More information

Guidelines for Shared Care Centres and Community Staff

Guidelines for Shared Care Centres and Community Staff Reference: CG1410 Written by: Dr Jeanette Payne Peer reviewer Dr Jenny Welch Approved: February 2016 Approved by D&TC: 8th January 2016 Review Due: February 2019 Intended Audience This document contains

More information

Easy bruising vs Coagulopathy

Easy bruising vs Coagulopathy Easy bruising vs Coagulopathy Sept. 19, 2015 Lakehead Summer School Chris Hillis, MD MSc FRCPC hillis@hhsc.ca @HemeHillis Aim & Objectives Aim: To increase comfort in detecting non-pathologic bleeding

More information

Blood Transfusion Guidelines in Clinical Practice

Blood Transfusion Guidelines in Clinical Practice Blood Transfusion Guidelines in Clinical Practice Salwa Hindawi Director of Blood Transfusion Services Associate Professor in Haematology and Transfusion Medicine King Abdalaziz University, Jeddah Saudi

More information

BLEEDING DISORDERS. JC Opperman 2012

BLEEDING DISORDERS. JC Opperman 2012 BLEEDING DISORDERS JC Opperman 2012 Primary and Secondary Clotting Laboratory Tests Routine screening tests Prothrombin time (PT) (INR) increased in neonates (12-18 sec) Partial thromboplastin time (PTT)

More information

HAEMORRHAGIA Bleeding

HAEMORRHAGIA Bleeding HAEMORRHAGIA Bleeding Cassification Size Location pathomechanism Hematoma: external or may be enclosed within a tissue petechiae : 1-2 mm hemorrhages into skin, mucous membranes, or serosal surfaces increased

More information

Prothrombin Complex Concentrate- Octaplex. Octaplex

Prothrombin Complex Concentrate- Octaplex. Octaplex Prothrombin Complex Concentrate- Concentrated Factors Prothrombin Complex Concentrate (PCC) 3- factor (factor II, IX, X) 4-factor (factors II, VII, IX, X) Activated 4-factor (factors II, VIIa, IX, X) Coagulation

More information

Transfusion Medicine Best Practices: Indications for Blood Components

Transfusion Medicine Best Practices: Indications for Blood Components Transfusion Medicine Best Practices: 1.0 Policy Statements 1.1 Regional Health Authorities (RHAs) shall develop policies, processes and procedures for ordering, distribution, storage, transfusion and administration

More information

Coagulation an Overview Dr.Abdolreza Abdolr Afrasiabi Thal assem a & Heamophili hilia G ene i tic R esearc C en er Shiraz Medical Medic University

Coagulation an Overview Dr.Abdolreza Abdolr Afrasiabi Thal assem a & Heamophili hilia G ene i tic R esearc C en er Shiraz Medical Medic University In The Name God Coagulation an Overview Dr.Abdolreza Afrasiabi Thalassemia & Heamophilia Genetic Research hcenter Shiraz Medical University Bleeding Clotting Hemostasis Review of platelet function Platelets

More information

Bleeding, Coagulopathy, and Thrombosis in the Injured Patient

Bleeding, Coagulopathy, and Thrombosis in the Injured Patient Bleeding, Coagulopathy, and Thrombosis in the Injured Patient June 7, 2008 Kristan Staudenmayer, MD Trauma Fellow UCSF/SFGH Trauma deaths Sauaia A, et al. J Trauma. Feb 1995;38(2):185 Coagulopathy is Multi-factorial

More information

Sysmex Educational Enhancement and Development No

Sysmex Educational Enhancement and Development No SEED Coagulation Sysmex Educational Enhancement and Development No 2 2016 An approach to the bleeding patient The purpose of this newsletter is to provide an overview of the approach to the bleeding patient

More information

Hemostatic System - general information

Hemostatic System - general information PLATELET DISORDERS Hemostatic System - general information Normal hemostatic system vessel wall circulating blood platelets blood coagulation and fibrynolysis Bleeding Diathesis inherited or acquired defects

More information

Approach to bleeding

Approach to bleeding Approach to bleeding By Assoc. Prof. Darintr Sosothikul, MD Pediatric Hematology-Oncology division, King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University The mechanism of

More information

Hematology Review. CCRN exam. The Coagulation Cascade. The Coagulation Cascade. Components include: Intrinsic pathway Extrinsic pathway Common pathway

Hematology Review. CCRN exam. The Coagulation Cascade. The Coagulation Cascade. Components include: Intrinsic pathway Extrinsic pathway Common pathway CCRN exam Hematology Review CCRN Review October 2013 Department of Critical Care Nursing Hematology is 2% of the exam Focus on coagulation cascade, DIC, and HIT Anatomy of the hematologic system Bone marrow

More information

Guidelines for the management of warfarin reversal in adults

Guidelines for the management of warfarin reversal in adults SharePoint Location Clinical Policies and Guidelines SharePoint Index Directory General Policies and Guidelines Sub Area Haematology and Transfusion Key words (for search purposes) Warfarin, Bleeding Central

More information

Hemostasis. Learning objectives Dr. Mária Dux. Components: blood vessel wall thrombocytes (platelets) plasma proteins

Hemostasis. Learning objectives Dr. Mária Dux. Components: blood vessel wall thrombocytes (platelets) plasma proteins Hemostasis Learning objectives 14-16 Dr. Mária Dux Components: blood vessel wall thrombocytes (platelets) plasma proteins Hemostatic balance! procoagulating activity anticoagulating activity 1 Thrombocytes

More information

SECTION XIX HEMATOLOGIC AND ONCOLOGIC DISEASE AND DYSFUNCTION CHAPTER 170 COAGULATION DISORDERS IN THE INTENSIVE CARE UNIT OVERVIEW OF COAGULATION

SECTION XIX HEMATOLOGIC AND ONCOLOGIC DISEASE AND DYSFUNCTION CHAPTER 170 COAGULATION DISORDERS IN THE INTENSIVE CARE UNIT OVERVIEW OF COAGULATION SECTION XIX HEMATOLOGIC AND ONCOLOGIC DISEASE AND DYSFUNCTION CHAPTER 170 COAGULATION DISORDERS IN THE INTENSIVE CARE UNIT ROBERT I. PARKER This chapter focuses on various pathophysiologic conditions associated

More information

There are two main causes of a low platelet count

There are two main causes of a low platelet count Thrombocytopenia Thrombocytopenia is a condition in which a person's blood has an unusually low level of platelets Platelets, also called thrombocytes, are found in a person's blood along with red blood

More information

Hemodynamic Disorders, Thrombosis, and Shock. Richard A. McPherson, M.D.

Hemodynamic Disorders, Thrombosis, and Shock. Richard A. McPherson, M.D. Hemodynamic Disorders, Thrombosis, and Shock Richard A. McPherson, M.D. Edema The accumulation of abnormal amounts of fluid in intercellular spaces of body cavities. Inflammation and release of mediators

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Index Note: Page numbers of article titles are in boldface type. A Acute lung injury (ALI) transfusion-related, 363 372. See also Transfusion-related acute lung injury (TRALI) ALI. See Acute lung injury

More information

GUIDELINES FOR THE TRANSFUSION OF BLOOD COMPONENTS

GUIDELINES FOR THE TRANSFUSION OF BLOOD COMPONENTS CHILDREN S HOSPITALS AND CLINICS OF MINNESOTA Introduction: GUIDELINES FOR THE TRANSFUSION OF BLOOD COMPONENTS These guidelines have been developed in conjunction with the hospital Transfusion Committee.

More information

Physiology of. The Blood hemostasis. By prof. Israa f. jaafar

Physiology of. The Blood hemostasis. By prof. Israa f. jaafar Physiology of The Blood hemostasis By prof. Israa f. jaafar Learning objectives Understand the Platelet structure and function Explane the Platelet production Understand the phases of hemostasis: vascular

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Note: Page numbers of article titles are in boldface type. A Abdominal tumors, in children, 530 531 Alkalinization, in tumor lysis syndrome, 516 Allopurinol, in tumor lysis syndrome, 515 Anaphylaxis, drug

More information

Medical Surgical Review Handout- Hematology/Oncology 2016

Medical Surgical Review Handout- Hematology/Oncology 2016 Medical Surgical Review Handout- Hematology/Oncology 2016 Overview Blood circulates in the cardiovascular system o Carries oxygen to the cells o Carries waste away from the cells Functions of blood o Transportation:

More information

General Pathology. Hemorrhage (Web)

General Pathology. Hemorrhage (Web) General Pathology Hemorrhage (Web) Paul Hanna Feb 2015 Hemorrhage escape of blood from the cardiovascular system may be external or internal Hemorrhage Causes Trauma Sepsis, viruses or toxins Coagulation

More information

Hemostasis and. Blood Coagulation

Hemostasis and. Blood Coagulation Hemostasis and Blood Coagulation Events in Hemostasis The term hemostasis means prevention of blood loss. Whenever a vessel is severed or ruptured, hemostasis is achieved by several mechanisms: (1) vascular

More information

Primary Exam Physiology lecture 5. Haemostasis

Primary Exam Physiology lecture 5. Haemostasis Primary Exam Physiology lecture 5 Haemostasis Haemostasis Body s response for the prevention and cessation of bleeding. Broadly consists of: Primary Haemostasis - vascular spasm and platlet plug formation

More information

CLINICAL FELLOWSHIP PROGRAM IN COAGULATION

CLINICAL FELLOWSHIP PROGRAM IN COAGULATION CLINICAL FELLOWSHIP PROGRAM IN COAGULATION The Department of Pathology and Laboratory Medicine University of Alberta, Faculty of Medicine and Dentistry and Alberta Health Services CLINICAL FELLOWSHIP IN

More information

MANAGEMENT OF COMMON BLEEDING DISORDERS. Auro Viswabandya Department of Haematology, CMC, Vellore

MANAGEMENT OF COMMON BLEEDING DISORDERS. Auro Viswabandya Department of Haematology, CMC, Vellore MANAGEMENT OF COMMON BLEEDING DISORDERS Auro Viswabandya Department of Haematology, CMC, Vellore BLOOD CLOT : PRIMARY HAEMOSTASIS (Platelets) + SECONDARY HAEMOSTASIS (Coagulation Factors) HAEMOSTATIC DISORDERS

More information

Chapter 46. Care of the Patient with a Blood or Lymphatic Disorder

Chapter 46. Care of the Patient with a Blood or Lymphatic Disorder Chapter 46 Care of the Patient with a Blood or Lymphatic Disorder All items and derived items 2015, 2011, 2006 by Mosby, Inc., an imprint of Elsevier Inc. All rights reserved. Components of the Blood Red

More information

QUESTIONS OF HEMATOLOGY AND THEIR ANSWERS

QUESTIONS OF HEMATOLOGY AND THEIR ANSWERS QUESTIONS OF HEMATOLOGY AND THEIR ANSWERS WHAT IS TRUE AND WHAT IS FALSE? Questions 1 Iron deficiency anemia a) Is usually associated with a raised MCV. b) The MCH is usually low. c) Is most commonly due

More information

FELINE HEMATOLOGY Inherited and Acquired Bleeding Disorders Marjory Brooks DVM, D.ACVIM

FELINE HEMATOLOGY Inherited and Acquired Bleeding Disorders Marjory Brooks DVM, D.ACVIM FELINE HEMATOLOGY Marjorie Brooks, D.V.M. Diplomate, A.C.V.I.M. Comparative Hematology Laboratory N.Y.S. Department of Health WCL&R P. O. Box 509 Albany, NY 12201 f / b - f / i 3 FELINE HEMATOLOGY Inherited

More information

Pathophysiology. Tutorial 3 Hemodynamic Disorders

Pathophysiology. Tutorial 3 Hemodynamic Disorders Pathophysiology Tutorial 3 Hemodynamic Disorders ILOs Recall different causes of thrombosis. Explain different types of embolism and their predisposing factors. Differentiate between hemorrhage types.

More information

Hemostasis and thrombosis in patients with liver disease. Ton Lisman, Dept Surgery, UMC Groningen, The Netherlands

Hemostasis and thrombosis in patients with liver disease. Ton Lisman, Dept Surgery, UMC Groningen, The Netherlands Hemostasis and thrombosis in patients with liver disease Ton Lisman, Dept Surgery, UMC Groningen, The Netherlands Importance of the liver in hemostasis Synthesis of Coagulation factors Fibrinolytic proteins

More information

Heme (Bleeding and Coagulopathies) in the ICU

Heme (Bleeding and Coagulopathies) in the ICU Heme (Bleeding and Coagulopathies) in the ICU General Topics To Discuss Transfusions DIC Thrombocytopenia Liver and renal disease related bleeding Lack of evidence in managing critical illness related

More information

Blood coagulation and fibrinolysis. Blood clotting (HAP unit 5 th )

Blood coagulation and fibrinolysis. Blood clotting (HAP unit 5 th ) Blood coagulation and fibrinolysis Blood clotting (HAP unit 5 th ) Vessel injury Antithrombogenic (Favors fluid blood) Thrombogenic (Favors clotting) 3 Major systems involved Vessel wall Endothelium ECM

More information

THROMBOSIS AND BLEEDING

THROMBOSIS AND BLEEDING THROMBOSIS AND BLEEDING Klara Gadó MD. PhD. Senior Professor of Internal Medicine Semmelweis University, Budapest What is thrombosis? formation of a blood clot in a blood vessel Blood can not flow Organ

More information

TRANSFUSION GUIDELINES FOR CARDIOTHORACIC UNIT 2006

TRANSFUSION GUIDELINES FOR CARDIOTHORACIC UNIT 2006 TRANSFUSION GUIDELINES FOR CARDIOTHORACIC UNIT 2006 CTU blood product transfusion guidelines 2006 1 Summary of guidelines RED CELLS (10-15ml/kg) This applies to ward patients / icu patients who are stable.

More information

Agent Dose MoA/PK/Admin Adverse events Disadvantages Protamine Heparin: 1mg neutralizes ~ 100 units Heparin neutralization in ~ 5 min

Agent Dose MoA/PK/Admin Adverse events Disadvantages Protamine Heparin: 1mg neutralizes ~ 100 units Heparin neutralization in ~ 5 min Nanik (Nayri) Hatsakorzian Pharm.D/MPH candidate 2014 Touro University College of Pharmacy CA Bleeding Reversal Agents Agent Dose MoA/PK/Admin Adverse events Disadvantages Protamine Heparin: 1mg neutralizes

More information

Thrombocytopenic purpura. Haemophilia. Thrombocytopenic purpura Hemorrhagic diathesis

Thrombocytopenic purpura. Haemophilia. Thrombocytopenic purpura Hemorrhagic diathesis Thrombocytopenic purpura. Haemophilia. Thrombocytopenic purpura (idiopathic thrombocytopenic purpura, Verlgofa disease) and hemophilia (A, B, C) belong to the group of hemorrhagic diseases and syndromes

More information

12 Dynamic Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization

12 Dynamic Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization Table of Contents: PART I: Molecular and Cellular Basis of Hematology 1 Anatomy and Pathophysiology of the Gene 2 Genomic Approaches to Hematology 3 Regulation of Gene Expression, Transcription, Splicing,

More information

Transfusion Requirements and Management in Trauma RACHEL JACK

Transfusion Requirements and Management in Trauma RACHEL JACK Transfusion Requirements and Management in Trauma RACHEL JACK Overview Haemostatic resuscitation Massive Transfusion Protocol Overview of NBA research guidelines Haemostatic resuscitation Permissive hypotension

More information

Chapter 19 Blood Lecture Outline

Chapter 19 Blood Lecture Outline Chapter 19 Blood Lecture Outline Cardiovascular system Circulatory system Blood 1. distribution 2. regulation 3. protection Characteristics: ph 7.4 38 C 4-6 L Composition: Plasma Formed elements Erythrocytes

More information

Hemorrhage http://www.docstoc.com/docs/106382628/hematocrit-plasma-andserum http://www.cdha.nshealth.ca/system/files/hemolysis.jpg http://www.pxbiovision.com/science/science/science/preanalyticalphase_files/

More information

MANAGEMENT OF COAGULOPATHY AFTER TRAUMA OR MAJOR SURGERY

MANAGEMENT OF COAGULOPATHY AFTER TRAUMA OR MAJOR SURGERY MANAGEMENT OF COAGULOPATHY AFTER TRAUMA OR MAJOR SURGERY 19th ANNUAL CONTROVERSIES AND PROBLEMS IN SURGERY Thabo Mothabeng General Surgery: 1 Military Hospital HH Stone et al. Ann Surg. May 1983; 197(5):

More information

UNIT VI. Chapter 37: Platelets Hemostasis and Blood Coagulation Presented by Dr. Diksha Yadav. Copyright 2011 by Saunders, an imprint of Elsevier Inc.

UNIT VI. Chapter 37: Platelets Hemostasis and Blood Coagulation Presented by Dr. Diksha Yadav. Copyright 2011 by Saunders, an imprint of Elsevier Inc. UNIT VI Chapter 37: Platelets Hemostasis and Blood Coagulation Presented by Dr. Diksha Yadav Hemostasis: Prevention of Blood Loss Vascular constriction Formation of a platelet plug Formation of a blood

More information

Surgical and Postsurgical Bleeding

Surgical and Postsurgical Bleeding Chapter 56 Surgical and Postsurgical Bleeding Pouya J. Benyamini and Danny M. Takanishi, Jr. Introduction It is crucial that clinicians who provide care to surgical patients understand the dynamic interplay

More information

Wheater: Part 1: Thrombosis, embolism and infarction. Laboratory assignment: C601/C602 Histopathology manual, hemodynamic unit.

Wheater: Part 1: Thrombosis, embolism and infarction. Laboratory assignment: C601/C602 Histopathology manual, hemodynamic unit. Pathology C 601 Hemodynamic Derangements Assignment page. Reading: Robbins: Chapter 4 Clinical Lab Source: - Protime (PT) Know about INR - Activated partial thrmboplastin time (APTT) - Activated coagulation

More information

DIC. Disseminated intravascular coagulation, is a life threatening pathological process in which clotting factors are abnormally activated.

DIC. Disseminated intravascular coagulation, is a life threatening pathological process in which clotting factors are abnormally activated. Miss. kamlah 1 DIC Disseminated intravascular coagulation, is a life threatening pathological process in which clotting factors are abnormally activated. Resulting in wide spread of clot formation in the

More information