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1 Supplementary Online Content Karimkhani C, Boyers LN, Prescott L, et al. Global Burden of Skin Disease in 2010 and Skin Disease Systematic Reviews and Protocols in Cochrane Database of Systematic Reviews. Published online May 7, JAMA Dermatology. doi: /jamadermatol etable 1. Terms entered into search query for other skin and subcutaneous category with GBD 2010 ICD-10 code definitions etable 2. Titles for all reviews and protocols included for the 15 skin conditions studied by GBD 2010 and associated Cochrane Group responsible for publication etable 3. titles generated from search of 15 skin conditions studied by GBD 2010 in The Cochrane Database of Systematic Reviews etable 4. Titles for all reviews and protocols included for the other skin and subcutaneous category studied by GBD 2010 and associated Cochrane Group responsible for publication etable 5. titles generated from search of GBD 2010 other skin and subcutaneous category in The Cochrane Database of Systematic Reviews This supplementary material has been provided by the authors to give readers additional information about their work.

2 2 etable 1. Terms entered into search query for other skin and subcutaneous category with GBD 2010 ICD-10 code definitions a GBD other skin and subcutaneous category (ICD-10 code) Pediculosis and phthiriasis (B85) Abstract/project terms supporting inclusion pediculosis phthiriasis Myiasis (B87) Other infestations (B88) Pilonidal cyst with and without abscess (L05.0 and L05.9) Pemphigus (L10) Other acantholytic disorders (L11) Pemphigoid (L12) Other bullous disorders (L13) Lichen simplex chronicus and prurigo (L28) Other dermatitis (L30) Pityriasis rosea (L42) myiasis acariasis tungiasis or sandflea scarabiasis or arthropod hirudiniasis or leech ichthyoparasitism vandellia cirrhosa, linguatulosis porocephaliasis skin infestation mites skin parasites pilonidal cyst pemphigus keratosis follicularis acantholytic dermatosis acantholytic pemphigoid bullous or bulla epidermolysis bullosa dermatitis herpetiformis subcorneal pustular dermatitis bullous bulla lichen simplex chronicus prurigo nummular dermatitis dyshidrosis cutaneous autosensitization infective dermatitis erythema intertrigo pityriasis alba pityriasis rosea

3 3 Lichen planus (l42) Other papulosquamous disorders (L44) Erythema multiforme (L51) Erythema nodosum (L52) Other erythematous conditions (L53) Sunburn (L55) Other acute skin changes due to ultraviolet radiation (L56) Skin changes due to chronic exposure to nonionizing radiation (L57) Radiodermatitis (L58) Other disorders of skin and subcutaneous tissue related to radiation (L59) Nail disorder (L60) Androgenic alopecia (L64) Other nonscarring hair loss (L65) lichen planus pityriasis rubra pilaris lichen nitidus lichen striatus lichen ruber moniliformis infantile papular acrodermatitis or Giannotti-Crosti papulosquamous erythema multiforme Stevens Johnson erythema nodosum toxic erythema erythema annulare centrifugum erythema marginatum chronic figurate erythema sunburn drug phototoxic drug photoallergic photocontact dermatitis solar urticaria polymorphous light eruption acute and UV or ultraviolet actinic keratosis actinic reticuloid cutis rhomboidalis nuchae poikiloderma of Civatte cutis laxa senilis actinic granuloma nonionizing radiation wrinkles chronic and UV or ultraviolet tanning radiodermatitis erythema ab igne dermatitis ab igne nail ingrowing onycholysis onychogryphosis Beau lines yellow nail syndrome androgenic alopecia telogen effluvium anagen effluvium alopecia mucinosa nonscarring

4 4 Cicatricial alopecia (scarring hair loss) (L66) Hair color and hair shaft abnormalities (L67) Hypertrichosis (L68) Rosacea (L71) Follicular cysts of skin and subcutaneous tissue (L72) Other follicular disorders (L73) Eccrine sweat disorders (L74) apocrine sweat disorder (L75) Vitiligo (L80) Other disorders of pigmentation (L81) Seborrhoeic keratosis (L82) hair loss alopecia pseudopelade lichen planopilaris folliculitis decalvans perifolliculitis capitis abscedens folliculitis ulerythematosa reticulate cicatricial scarring hair loss alopecia trichorrhexis nodosa hair color hair shaft hirsutism hypertrichosis polytrichia rosacea perioral dermatitis rhinophyma cyst follicular epidermal trichilemmal steatocystoma acne keloid pseudofolliculitis barbae hidradenitis suppurativa eccrine sweat miliaria anhydrosis apocrine sweat bromhidrosis chromhidrosis apocrine miliaria vitiligo hyperpigmentation chloasma freckles café au lait spots leukoderma hypopigmentation [excluding vitiligo] pigmented purpuric dermatosis iron pigmentation tattoo pigmentation seborrhoeic keratosis

5 5 Acanthosis nigricans (L83) Corns and callosities (L84) Other epidermal thickening (L85) Transepidermal elimination disorders (L87) Atrophic disorders of skin (L90) Hypertrophic disorders of skin (L91) Granulomatous disorders of skin and subcutaneous tissue (L92) (L93) Other localized connective tissue disorders (L94) L95: Vasculitis limited to skin, not elsewhere classified (L95) acanthosis nigricans corn callous (acquired) icthyosis keratoderma (acquired)keratosis xerosis cutis epidermal thickening keratosis follicularis et parafollicularis in cutem penetrans reactive perforating collagenosis elastosis perforans serpiginosa transepidermal lichen sclerosis anetoderma atrophoderma acrodermatitis chronica atrophicans adherent scar cicatrix striae atrophicae hypertrophic scar keloid granuloma annulare necrobiosis lipoidica granuloma faciale eosinophilic granuloma of skin foreign body granuloma and skin discoid cutaneous and lupus local and lupus localized scleroderma morphea linear scleroderma calcinosis cutis sclerodactyly Gottron papules poikiloderma vasculare atrophicans ainhum livedoid vascultitis erythema elevatum diutinum vasculitits and skin a Specific ICD-10 and ICD-9 codes used by GBD 2010 for the other skin and subcutaneous category are published in: Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Supplementary appendix to: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study The Lancet Dec 13; 380:

6 6 etable 2: Titles for all reviews and protocols included for the 15 skin conditions studied by GBD 2010 and associated Cochrane Group responsible for publication Skin Condition Review or Protocol (P) Title Cochrane Group Dermatitis Oral H1 antihistamines as monotherapy for eczema Dermatitis Probiotics for treating eczema Dermatitis Topical pimecrolimus for eczema Dermatitis Interventions to reduce Staphylococcus aureus in the management of atopic eczema Dermatitis Chinese herbal medicine for atopic eczema Dermatitis Oral evening primrose oil and borage oil for eczema Dermatitis Dietary exclusions for established atopic eczema Dermatitis Psychological and educational interventions for atopic eczema in children Dermatitis Dietary supplements for established atopic eczema Dermatitis Prebiotics in infants for prevention of allergy Neonatal Group Dermatitis Probiotics in infants for prevention of allergic disease and food Neonatal Group hypersensitivity Dermatitis Formulas containing hydrolysed protein for prevention of allergy Neonatal Group and food intolerance in infants Dermatitis Soy formula for prevention of allergy and food intolerance in Neonatal Group infants Dermatitis Maternal dietary antigen avoidance during pregnancy or lactation, or both, for preventing or treating atopic disease in the child Pregnancy and Childbirth Group Dermatitis Topical cyclosporine for atopic keratoconjunctivitis Eyes and Vision Group Dermatitis Topical Vitamin A, or its derivatives, for treating and preventing napkin dermatitis in infants Dermatitis Disposable nappies for preventing napkin dermatitis in infants Dermatitis Interventions for preventing occupational irritant hand dermatitis Dermatitis House dust mite reduction and avoidance measures for treating eczema (P) Dermatitis Interventions for hand eczema (P) Dermatitis Specific allergen immunotherapy for the treatment of atopic eczema (P) Dermatitis Topical tacrolimus for atopic dermatitis (P) Dermatitis Emollients for eczema (P) Dermatitis Different strategies for using topical corticosteroids for established eczema (P) Dermatitis Interventions for seborrhoeic dermatitis (P) Dermatitis Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp (P) Minocycline for acne vulgaris: efficacy and safety Laser resurfacing for facial acne scars Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne Menstrual Disorders and Insulin sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome Statins for women with polycystic ovary syndrome not actively trying to conceive Subfertility Group Menstrual Disorders and Subfertility Group Menstrual Disorders and Subfertility Group

7 7 Skin Condition Review or Protocol (P) Title Cochrane Group Combined oral contraceptive pills for treatment of acne Fertility Regulation Group Complementary therapies for acne vulgaris (P) Oral isotretinoin for acne (P) Light therapies for acne (P) Ovarian surgery for symptom relief in women with polycystic ovarian syndrome (P) Interventions to reduce Staphylococcus aureus in the management of atopic eczema Interventions for impetigo Interventions of cellulitis and erysipelas Antibiotics for treating scrub typhus Interventions for the prevention of recurrent erysipelas and cellulitis (P) Interventions for cutaneous molluscum contagiosum Topical treatments for cutaneous warts Medical interventions for high grade vulval intraepithelial neoplasia Interventions for anal canal intraepithelial neoplasia Vaccines for preventing herpes zoster in older adults Vaccines for post exposure prophylaxis against varicella (chickenpox) in children and adults Menstrual Disorders and Subfertility Group Infectious Diseases Group Acute Respiratory Infections Group Acute Respiratory Infections Group Interventions for prevention of herpes simplex labialis (cold sores on the lips) (P) Interventions for treatment of herpes simplex labialis (cold sores on the lips) (P) Management of herpes zoster ophthalmicus in people with HIV HIV/AIDs Group infection (P) Urticaria Histamine H2 receptor antagonists for urticaria Urticaria H1-antihistamines for chronic urticaria (P) Fungal skin Topical treatments for fungal infections of the skin and nails of the foot Fungal skin Oral treatments for fungal infections of the skin of the foot Fungal skin Systemic antifungal therapy for tinea capitis in children Fungal skin Oral potassium iodide for the treatment of sporotrichosis Skin Condition Review or Protocol (P) Title Cochrane Group Fungal skin Oral antifungal medication for toenail onychomycosis (P) Fungal skin Topical antifungal treatments for tinea cruris and tinea corporis (P)

8 8 Pharmacological interventions for pruritus in adult palliative care patients Pain, Palliative, and Supportive Care Group Anaesthesia Group Drugs for the prevention and treatment of pruritus in patients receiving neuraxial opioids (P) Scabies Interventions for treating scabies Infectious Diseases Group Scabies Treatment of close contacts of people with scabies for preventing re infestation or spread of infestation in contacts (P) Occupational Safety and Health Group Alopecia areata Interventions for alopecia areata Cellulitis Interventions for cellulitis and erysipelas Cellulitis Interventions for the prevention of recurrent erysipelas and cellulitis (P) Support surfaces for pressure ulcer prevention Wounds Group Wound cleansing for pressure ulcers Wounds Group Pressure relieving devices for treating heel pressure ulcers Wounds Group Therapeutic ultrasound for pressure ulcers Wounds Group Risk assessment tools for the prevention of pressure ulcers Wounds Group Support surfaces for treating pressure ulcers Wounds Group Repositioning for treating pressure ulcers Wounds Group Electromagnetic therapy for treating pressure ulcers Wounds Group Nutritional interventions for preventing and treating pressure ulcers Wounds Group Dressings and topical agents for preventing pressure ulcers Wounds Group Massage therapy for preventing pressure ulcers (P) Wounds Group Hydrocolloid dressings for treating pressure ulcers (P) Wounds Group Topical phenytoin for treating pressure ulcers (P) Wounds Group Phototherapy for treating pressure ulcers (P) Wounds Group Repositioning for pressure ulcer prevention in adults (P) Wounds Group Melanoma Surgical excision margins for primary cutaneous melanoma Melanoma Statins and fibrates for preventing melanoma Melanoma Chemoimmunotherapy versus chemotherapy for metastatic malignant melanoma Melanoma Systemic treatments for metastatic cutaneous melanoma Melanoma Interferon alpha for the adjuvant treatment of cutaneous melanoma Melanoma Interventions for melanoma in situ, including lentigo maligna (P) Melanoma Sentinel lymph node biopsy followed by lymph node dissection for early cutaneous melanoma (P) Psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis Psoriasis Interventions for nail psoriasis Psoriasis Topical treatments for chronic plaque psoriasis Psoriasis Interventions for guttate psoriasis Skin Condition Review or Protocol (P) Title Cochrane Group Psoriasis Narrow band ultraviolet B phototherapy versus broad band ultraviolet B or psoralen ultraviolet A photochemotherapy for psoriasis Psoriasis Interventions for chronic palmoplantar pustulosis Psoriasis Interventions for treating psoriatic arthritis Musculoskeletal Group Psoriasis Anti-TNF agents for paediatric psoriasis (P)

9 9 Psoriasis Oral fumaric acid esters for psoriasis (P) Psoriasis Methotrexate for psoriasis (P) Psoriasis Topical treatments for scalp psoriasis (P) Non-melanoma Interventions for non metastatic squamous cell carcinoma of the skin cancer skin Non-melanoma Interventions for cutaneous Bowen's disease skin cancer Non-melanoma Interventions for preventing non melanoma skin cancers in highrisk skin cancer groups Non-melanoma Interventions for basal cell carcinoma of the skin skin cancer Non-melanoma skin cancer Mohs micrographic surgery versus surgical excision for periocular basal cell carcinoma Eyes and Vision Group Non-melanoma skin cancer Selenium for preventing cancer Gynaecological Group Leprosy Interventions for skin changes caused by nerve damage in leprosy Leprosy Interventions for erythema nodosum leprosum Leprosy Decompressive surgery for treating nerve damage in leprosy Cochrane Neuromuscular Disease Group Leprosy Corticosteroids for treating nerve damage in leprosy Cochrane Neuromuscular Disease Group

10 10 etable 3: titles generated from search of 15 skin conditions studied by GBD 2010 in The Cochrane Database of Systematic Reviews Searched Skin Review or Protocol (P) Condition Dermatitis Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilization without Discrepancy after Consensus Review Dermatitis Dermatitis Optimal duration of exclusive breastfeeding Psychological interventions for parents of children and adolescents with chronic illness Dermatitis Tartrazine exclusion for allergic asthma Dermatitis Gold as an oral corticosteroid sparing agent in stable asthma Testosterone for peri and postmenopausal women Dehydroepiandrosterone for systemic lupus Lifestyle changes in women with polycystic ovary syndrome Skin patch and vaginal ring versus combined oral contraceptives for contraception Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility Danazol for heavy menstrual bleeding Danazol for uterine fibroids Corticosteroids for treating optic neuritis Progestagens and anti-progestagens for pain associated with endometriosis Interventions for melasma Interventions for rosacea Gonadotrophin-releasing hormone analogues for endometriosis: bone mineral density

11 11 Searched Skin Condition Review or Protocol (P) Anti-inflammatory treatment for carditis in acute rheumatic fever without Discrepancy after Consensus Review Quadriphasic versus monophasic oral contraceptives for contraception Danazol for pelvic pain associated with endometriosis Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis Different classes of antibiotics given to women routinely for preventing infection at caesarean section Topical ointment for preventing infection in preterm infants Skin preparation with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion Antibiotic prophylaxis for preventing burn wound infection Antibiotics to reduce post-tonsillectomy morbidity Antibiotics for acute maxillary sinusitis Additional anti-gram-positive antibiotic treatment for febrile neutropenic cancer patients Percutaneous lines for delivering intravenous antibiotics in people with cystic fibrosis Early versus delayed dressing removal after primary closure of clean and cleancontaminated surgical wounds Antistreptococcal interventions for guttate and chronic plaque psoriasis Searched Skin Condition Review or Protocol (P) without Discrepancy after Consensus

12 12 Minocycline for acne vulgaris: efficacy and safety Review Quinolones for uncomplicated acute cystitis in women Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section Face washing promotion for preventing active trachoma Dietary exclusions for established atopic eczema Teicoplanin versus vancomycin for proven or suspected infection Interventions for treating leg ulcers in people with sickle cell disease Removal of nail polish and finger rings to prevent surgical infection Vaccines for post-exposure prophylaxis against varicella (chickenpox) in children and adults Vaccines for preventing anthrax Umbilical cord antiseptics for preventing sepsis and death among newborns Routine perineal shaving on admission in labour De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock Early versus late pre-intensive care unit admission broad spectrum antibiotics for severe sepsis in adults Gauze and tape and transparent polyurethane dressings for central venous catheters Searched Skin Condition Review or Protocol (P) Antibiotics / anti-inflammatories for reducing acute inflammatory episodes in lymphoedema of the limbs without Discrepancy after Consensus Review

13 13 Interventions for chronic blepharitis Mupirocin ointment for preventing Staphylococcus aureus infections in nasal carriers Interventions for the management of dry mouth: non-pharmacological interventions Interventions for guttate psoriasis Infant position in neonates receiving mechanical ventilation Dietary exclusions for established atopic eczema Physical interventions to interrupt or reduce the spread of respiratory viruses Antibiotics for acute maxillary sinusitis Immunotherapy for advanced renal cell cancer Urticaria Urticaria Prebiotics in infants for prevention of allergy Maternal dietary antigen avoidance during pregnancy or lactation, or both, for preventing or treating atopic disease in the child Urticaria Soy formula for prevention of allergy and food intolerance in infants Urticaria Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth Urticaria Oral H1 antihistamines as monotherapy for eczema Fungal skin Fungal skin Topical ointment for preventing infection in preterm infants Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants Searched Skin Condition Fungal skin Review or Protocol (P) Additional anti-gram-positive antibiotic treatment for febrile neutropenic cancer patients Interventions for treating cholestasis in pregnancy without Discrepancy after Consensus Review Methotrexate for primary biliary cirrhosis

14 14 Horse chestnut seed extract for chronic venous insufficiency Ursodeoxycholic acid for primary biliary cirrhosis Colchicine for primary biliary cirrhosis Cyclosporin A for primary biliary cirrhosis Combined spinal-epidural versus epidural analgesia in labour Phlebotonics for haemorrhoids Laxatives for the treatment of hemorrhoids Drug therapy for preventing post-dural puncture headache Pain management for women in labour: an overview of systematic reviews Bezafibrate for primary biliary cirrhosis Azathioprine for primary biliary cirrhosis Linezolid versus vancomycin for skin and soft tissue infections Different antibiotic regimens for treating asymptomatic bacteriuria in pregnancy Topical interventions for genital lichen sclerosus Local anaesthetic wound infiltration and abdominal nerves block during caesarean section for postoperative pain relief D-penicillamine for primary biliary cirrhosis Searched Skin Condition Review or Protocol (P) Patient controlled opioid analgesia versus conventional opioid analgesia for postoperative pain without Discrepancy after Consensus Review Neuromodulators for pain management in rheumatoid arthritis Rituximab for relapsing-remitting multiple sclerosis Pressure-relieving interventions for treating diabetic foot ulcers

15 15 Honey as a topical treatment for wounds Compression for preventing recurrence of venous ulcers Effectiveness of organisational infrastructures to promote evidence-based nursing practice Endovenous thermal ablation for healing venous ulcers and preventing recurrence Therapeutic ultrasound for venous leg ulcers Hyperbaric oxygen therapy for chronic wounds Dressings for healing venous leg ulcers Autologous platelet-rich plasma for treating chronic wounds Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus Aloe vera for treating acute and chronic wounds Silver based wound dressings and topical agents for treating diabetic foot ulcers Enteral tube feeding for older people with advanced dementia Searched Skin Condition Review or Protocol (P) Negative pressure wound therapy for skin grafts and surgical wounds healing by primary intention without Discrepancy after Consensus Review Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in non surgical wounds Surgery for deep venous incompetence Compression stockings for the initial treatment of varicose veins in patients without venous ulceration Rofecoxib for osteoarthritis Compression therapy for treating stage I and

16 16 II (Widmer) post-thrombotic syndrome Injection sclerotherapy for varicose veins Pre-operative traction for hip fractures in adults Hospital nurse staffing models and patient and staff-related outcomes Infant position in neonates receiving mechanical ventilation Melanoma Interventions for preventing non-melanoma skin cancers in high-risk groups Melanoma Selenium for preventing cancer Melanoma Psychosocial interventions to improve quality of life and emotional wellbeing for recently diagnosed cancer patients Melanoma Thymic peptides for treatment of cancer patients Melanoma Mistletoe therapy in oncology Melanoma Cryotherapy for liver metastases Searched Skin Condition Psoriasis Review or Protocol (P) Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis) without Discrepancy after Consensus Review Psoriasis Effect of cyclosporine on blood pressure Psoriasis Non-melanoma skin cancer Non-melanoma skin cancer Tumour necrosis factor alpha blocking agents for induction of remission in ulcerative colitis Psychosocial interventions to improve quality of life and emotional wellbeing for recently diagnosed cancer patients Topical interventions for genital lichen sclerosus

17 17 etable 4: Titles for all reviews and protocols included for the other skin and subcutaneous category studied by GBD 2010 and associated Cochrane Group responsible for publication Skin Condition Review or Protocol (P) Title Cochrane Group Pediculosis Interventions for treating head lice (P) Infectious Diseases Group Pemphigus Interventions for pemphigus vulgaris and pemphigus foliaceus Pemphigoid Interventions for mucous membrane pemphigoid and epidermolysis bullosa acquisita Pemphigoid Interventions for bullous pemphigoid Pityriasis rosea Interventions for pityriasis rosea Lichen planus Interventions for erosive lichen planus affecting mucosal sites Lichen planus Interventions for treating oral lichen planus Oral Health Group Lichen planus Interventions for cutaneous lichen planus (P) Toxic epidermal Interventions for toxic epidermal necrolysis necrolysis Actinic Interventions for actinic keratoses Keratosis Polymorphic Interventions for polymorphic light eruption (P) light eruption Other skin changes due to chronic exposure to nonionizing radiation Interventions for photodamaged skin Radiodermatitis Homeopathic medicines for adverse effects of cancer treatments Pain, Palliative, and Supportive Care Group Radiodermatitis Interventions for preventing and managing radiation-induced skin reactions in cancer patients (P) Ingrowing nail Interventions for ingrowing toenails Androgenic Interventions for female pattern hair loss alopecia Hirsutism Cyproterone acetate for hirsutism Menstrual Disorders and Subfertility Group Hirsutism Hirsutism Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne Insulin sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome Menstrual Disorders and Subfertility Group Menstrual Disorders and Subfertility Group Hirsutism Laser and photoepilation for unwanted hair growth Hirsutism Statins for women with polycystic ovary syndrome not actively Menstrual trying to conceive Disorders and Hirsutism Hirsutism Ovarian surgery for symptom relief in women with polycystic ovarian syndrome (P) Interventions for hirsutism excluding laser and photoepilation therapy (P) Subfertility Group Menstrual Disorders and Subfertility Group

18 18 Skin Condition Review or Protocol (P) Title Cochrane Group Rosacea Interventions for rosacea Hidradenitis Interventions for hidradenitis suppurativa (P) suppurativa Eccrine sweat Interventions for excessive sweating of unknown cause (P) disorder unspecified Vitiligo Interventions for vitiligo Chloasma Interventions for melasma Lichen Topical interventions for genital lichen sclerosus sclerosus Hypertrophic Silicone gel sheeting for preventing and treating hypertrophic and Wounds Group scar keloid scars Drugs for discoid lupus Interventions for cutaneous disease in systemic lupus (P) Localized scleroderma (morphea) Interventions for morphea (P)

19 19 etable 5: titles generated from search of GBD 2010 other skin and subcutaneous category in The Cochrane Database of Systematic Reviews Searched Skin Condition (ICD-10 code) Androgenic alopecia (L64) Review or Protocol (P) 5-alpha-reductase inhibitors for prostate cancer prevention without Discrepancy after Consensus Review Hirustim (L68.0) Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding Hirsutism (L68.0) Hirsutism (L68.0) Hirsutism (L68.0) Hirustism (L68.0) Hirsutism (L68.0) Vitiligo (L80) Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome Danazol for uterine fibroids Lifestyle changes in women with polycystic ovary syndrome Quadriphasic versus monophasic oral contraceptives for contraception Acupuncture for polycystic ovarian syndrome Selenium supplementation for Hashimoto's thyroiditis (L93) (L93) (L93) (L93) (L93) (L93) (L93) (L93) Dehydroepiandrosterone for systemic lupus Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus Treatment for lupus nephritis Minocycline for acne vulgaris: efficacy and safety Chloroquine as a steroid sparing agent for asthma Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis Ketanserin for Raynaud's phenomenon in progressive systemic sclerosis Belimumab for systemic lupus (P) Searched Skin Review or Protocol (P)

20 20 Condition (ICD-10 code) (L93) (L93) Disease modifying immunosuppressant drugs for juvenile-onset systemic lupus (P) Herbal medicines for systemic lupus (P) without Discrepancy after Consensus Review