MCL 30. MCL 30 Dermablate Fractional Er:YAG (with MICROSPOT EXTENSION SET) EN 1

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1 MCL 30 MCL 30 Dermablate Fractional Er:YAG (with MICROSPOT EXTENSION SET) 1

2 The third generation of the Dermablate series MCL 29 Dermablate Dermablate D1 MCL 30 Dermablate MCL29, the first Er:YAG laser for Dermatology, was introduced in 1996.

3 Specifications Wavelength: Power: Puls energy: 2,940 nm max. 12 W; voltage 230; 100; 120 V max. 1.5 J Fluence: 2 10 J/cm² (Ablation, limited) J/cm² (Ablation, without fluence filter) 1 J/cm² in thermal mode J/cm² (MicroSpot) Frequency: 1 / 4 / 8 / 10 / 15 Hz in ablation mode 20 Hz in thermal mode Spot size: 1 6 mm with VarioTEAM handpiece (Ablation, thermal mode) 13x13 mm with MicroSpot handpiece (Fractional, 169 MicroSpots with Ø 250 µm and 5% cover rate) Laser class: 4

4 Evidence of clinical success 1990: First clinical trials by R. Kaufmann et al. 1996: First Er:YAG Laser in dermatology introduced by Asclepion MCL 29 Dermablate by Asclepion-Meditec, more than 800 systems worldwide Germany: the Dermablate has became a standard tool for dermatologists in the treatment of a wide range of cutaneous lesions advantages of the Erbium laser compared to CO 2 lasers: - precise and safe ablation - very limited thermal damage (necrotic zone 30µm/70µm) - superficial treatments possible as well as deep ablation - reduced risk of scarring and pigmentation changes - many treatments require no anaesthesia - short healing process, little side effects

5 USPs Integrated suction system VarioTEAM handpiece Subablative mode (coagulation mode) Adjustable internal filter system Sterilizable distance holder Most homogenious beam profile Thermal mode Unbeaten reliability Fast amortisation Ugradeable with super fractional extension set (SFE)

6 Integrated filter system 1 filter - set contains: 1 HEPA filter 1 active coal filter 3 pre-filter sufficiant for 30 hours active use

necessary Cost reduction Patents: US 6 162 218 DE 197 106 76 with VarioSpot-Technology Spot

7 VarioTEAM handpiece VarioTEAM handpiece (Ablation) with TEAM-Technology (Total Evacuation of Ablated Material) Very effective smoke evacuation Lowest smell nuisance No assistance necessary Cost reduction Patents: US DE with VarioSpot-Technology Spot size from 1 to 6 mm (adjustable in 1mm steps) Automatic spot size detection Automatic fluence adaption

8 Ablation in µm Ablation vs. Coagulation Ablation vs. Fluence - Different Mechanism of Er:YAG - Ablation Koagulation Fluence in J/cm 2 linear correlation constant ablation depth of 5 µm per 1 J/cm² (above ablation treshhold) Thermal Mode Specs: 1 J/cm², 20 Hz, N = 5... coagulation zone up to 400 µm depth (with single impulse up to 40 µm) Recommended parameters 5 6 J/cm² conservative 7 8 J/cm² normal 9 10 J/cm² aggressive treatment

9 Other Advantages FLUENCE directly adjustable: Easy to use No difficult calculation between energy and spot size Flat-Top-Profile: most homogenious spot ablation fractional

10 Other Advantages Modern design + Easy handling + Mobility

Absorption Coefficient [cm -1 ] Laser Selective absorption High absorbtion in water 100000 10000 Low absorbtion in melanin and hemoglobine 1000 100 Protein Desoxy-Hemoglobin Water

11 Absorption Coefficient [cm -1 ] Laser Selective absorption High absorbtion in water Low absorbtion in melanin and hemoglobine Protein Desoxy-Hemoglobin Water Selective thermolysis (effective targeting and low side effects) Oxy-Hemoglobin Melanin Scattering Wavelength [nm]

12 Indications Removal of dermal and epidermal lesions: epidermal naevi, seborrhoic ceratoses, warts, naevuscellnaevus, hypertrophic scars, acne scars, xanthelasma, rhynophym, wrinkles, lentigines, actinic keratoses, syringoma full skin resurfacing soft laser peel skin refreshing New fractional laser therapy By soft and precise ablation.

13 Epidermal naevus By courtesy of Dr. R. Hartmann, Blaustein, Germany

14 Xanthelasma By courtesy of Dr. R. Hartmann, Blaustein, Germany

15 Lentigo senilis By courtesy of Prof. Dr. E. Haneke, Wuppertal, Germany

16 Skin resurfacing By courtesy of Dres. Hadravek and Salsicky, Plzen, CZ

17 Full skin resurfacing By courtesy of D. Fleming, M.D., Brisbane, Australia

18 Full skin resurfacing By courtesy of D. Fleming, M.D., Brisbane, Australia

19 Perioral ablation By courtesy of D. Fleming, M.D., Brisbane, Australia

20 Freckles By courtesy of D. Fleming, M.D., Brisbane, Australia

21 Seborrhoic ceratoses 3 weeks after treatment By courtesy of Dr. Paul Wood, Proderma, Bad Homburg, Germany

22 Dermal / epidermal Naevus 6 months after treatment By courtesy of Dr. Paul Wood, Proderma, Bad Homburg, Germany

23 Verruca seborrhoica pigmentosa 6 months after treatment By courtesy of Dr. W. Petrow, Bonn, Germany

24 Verruca seborrhoica pigmentosa 6 months after treatment By courtesy of Dr. W. Petrow, Bonn, Germany

25 Dermal NCN 6 months after treatment By courtesy of Dr. W. Petrow, Bonn, Germany

26 Milia By courtesy of Dr. M. Fuchs, Dr. Samimi-Fard, Germany

27 Syringoma By courtesy of Dr. M. Fuchs, Dr. Samimi-Fard, Germany

29 MicroSpot Superfractional Extension Set

30 MicroSpot Superfractional Extension Set

31 MicroSpot Superfractional Extension Set

32 MicroSpot Superfractional Extension Set

33 MicroSpot Superfractional Extension Set

$MicroSpot Superfractional Extension Set involvement of the whole epidermis in the$

34 MicroSpot Superfractional Extension Set involvement of the whole epidermis in the healing process Formation of heat shock proteins deep in the dermis Resulting in neocollagenesis

35 MicroSpot Superfractional Extension Set

36 MicroSpot Superfractional Extension Set

37 MicroSpot Superfractional Extension Set

38 MicroSpot Superfractional Extension Set

39 MicroSpot Superfractional Extension Set

40 MicroSpot Superfractional Extension Set

41 MicroSpot Superfractional Extension Set

42 MicroSpot Superfractional Extension Set

43 MicroSpot Superfractional Extension Set

44 MicroSpot Superfractional Extension Set

45 MicroSpot Superfractional Extension Set

46 MicroSpot Superfractional Extension Set

47 MicroSpot Superfractional Extension Set

48 MicroSpot Superfractional Extension Set

49 MicroSpot Superfractional Extension Set

50 MicroSpot Superfractional Extension Set

51 MicroSpot Superfractional Extension Set

$MicroSpot Superfractional Extension Set new designed and patented handpiece automatic suction and lens cleaning cooling outlets integrated in$

52 MicroSpot Superfractional Extension Set new designed and patented handpiece automatic suction and lens cleaning cooling outlets integrated in distance holders maintenance free Microlens technology with 169 fractional spots per shot Up to 20 Hz (quickest fractional technology available)

$MicroSpot Superfractional$ after one day after two days

53 MicroSpot Superfractional Extension Set immediately after one day after two days after Parameter: Handpiece 13 13mm Fluence J/cm² Micro Pulse 3 4 Pass 1 3 three days after By courtesy of Dr. Daniel, Cassuto, Milano, Italy

$MicroSpot Superfractional Extension Set 2 treatment$ $2, cover rate 15% and 4 shots on the same fractional$

54 MicroSpot Superfractional Extension Set 2 treatment within 4 weeks, each treatment with 2 passes, 10 J/cm 2, cover rate 15% and 4 shots on the same fractional spots, 2 months By courtesy of Dr. Daniel, Cassuto, Milano, Italy

$MicroSpot Superfractional Extension Set 2 treatment$ $cover rate 10% and 4 shots on the same fractional$

55 MicroSpot Superfractional Extension Set 2 treatment within weeks, each treatment with 2 passes, 10 J/cm 2, cover rate 10% and 4 shots on the same fractional spots, 2 months By courtesy of Dr. Daniel, Cassuto, Milano, Italy

$MicroSpot Superfractional Extension Set Post$ $cover rate 15% and 4 shots on the same fractional$

56 MicroSpot Superfractional Extension Set Post traumatic scar, 1 treatment, 2 passes, 10 J/cm 2, cover rate 15% and 4 shots on the same fractional spots By courtesy of Dr. Daniel, Cassuto, Milano, Italy

$MicroSpot Superfractional$ of Dr.

57 MicroSpot Superfractional Extension Set By courtesy of Dr. Feller-Heppt, University Hospital, Mannheim, Germany

$MicroSpot Superfractional$ $on the same fractional spots, 1$ and 7 days By courtesy of Dr.

58 MicroSpot Superfractional Extension Set Single treatment, 20 J/cm 2, 10 % cover rate, 3 shots on the same fractional spots, 1 and 7 days By courtesy of Dr. Feller-Heppt, University Hospital, Mannheim, Germany

$MicroSpot Superfractional Extension Set$ $rate, 3 shots on the same fractional$ spots, 1 and 7 days By courtesy of Dr.

59 MicroSpot Superfractional Extension Set Periorbital treatment only (forehead): single treatment, 20 J/cm 2, 10 % cover rate, 3 shots on the same fractional spots, 1 and 7 days By courtesy of Dr. Feller-Heppt, University Hospital, Mannheim, Germany

$MicroSpot Superfractional Extension$ $fractional By courtesy of Prof.$

60 MicroSpot Superfractional Extension Set BEFORE AFTER 3 treatments MCL 30 Dermablate 126 J/cm², 13x13 mm fractional By courtesy of Prof. Kabir Sardana, Delhi

$MicroSpot Superfractional Extension Set$ $126 J/cm², 13x13 mm fractional 2 treatments,$

61 MicroSpot Superfractional Extension Set BEFORE AFTER 2 treatments MCL 30 Dermablate 126 J/cm², 13x13 mm fractional 2 treatments, 2 Passes By courtesy of Prof. Kabir Sardana, Delhi

$MicroSpot Superfractional Extension Set$ $162 J/cm², 13x13 mm fractional 3 treatments,$

62 MicroSpot Superfractional Extension Set BEFORE AFTER 3 treatments MCL 30 Dermablate 162 J/cm², 13x13 mm fractional 3 treatments, 3 Passes By courtesy of Prof. Kabir Sardana, Delhi

63 Bibliography Er:YAG-Laser Dermal lesions 1. Khatri KA. Ablation of cutaneous lesions using an erbium:yag laser. J Cosmet Laser Ther 2003; 5: Kaufmann R, Beier C. Erbium YAG laser therapy of skin lesions. Med Laser Appl 2001;16: Doi H, Ogawa Y, Hatoko M. Treatment of melanin-induced benign dermal lesions by an Erbium-YAG laser system. J Plast Reprod Surg 2000; 0: Wollina U, Konrad H, Karamfilov T. Treatment of common warts and actinic keratosis by Er:YAG laser. J Cutan Laser Ther 2001;3: Beier C, Kaufmann R. Efficacy of erbium:yag laser ablation in Darier disease and Hailey-Hailey disease. Arch Dermatol. 1999; 135(4): Aesthetic lesions (Skin Resurfacing) 1. Jasin ME. Achieving superior resurfacing results with the Erbium:YAG laser. Arch Facial Plast Surg 2002; 4: Perez MI, Bank DE. Facial skin resurfacing with the Erbium:YAG laser: new findings. Cosmetic Dermatology 1998;5: Khatri KA, Machado A, Magro C, Davenport S. Laser peel: facial rejuvenation with a superficial erbium:yag laser treatment. J Cutaneous Laser Ther 2000;2: Khatri KA, Ross V, Grevelink JM, Magro CM, Andersson RR. Comparison of erbium:yag and carbon dioxide lasers in resurfacing of facial rhytids. Arch Dermatol 1999;135(4):391-7

64 MCL 30 Dermablate: cleared, approved and registered worldwide FDA CE KFDA Thai-FDA SFDA PPAD USA Europe Korea Thailand China Taiwan Made in Germany

MCL31 Dermablate - Er:YAG Laser -

MCL31 Dermablate - Er:YAG Laser - Technology Made in Germany For more than 35 years, Asclepion has been operating on the medical laser market. As the company is based in Jena, famous through the world