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1 acne hasn t changed ISolaz has ISOLAZ 2: THE FIRST CHOICE IN ACNE THERAPY

2 Finally. An effective ACNE solution. Bring CPR rescue to acne sufferers. Isolaz Acne Therapy uses the power of technology to provide a clinically safe, effective and comfortable solution to fight the root causes of acne: C leanse the pores purify FROM THE INSIDE OUT REPLENISH THE SKIN More than 60 million people around the globe suffer from Acne¹. Do you have an effective solution? Isolaz 2 further enhances non-systemic acne treatments: Proven, programmed treatment settings Disposable, single-use tips Modern design Ergonomic handpiece ¹ Acne-resource.org, American Dermatologist Association

3 Meet patient demand. Millions of acne sufferers worldwide will spend an estimated $3.02 billion on acne therapy in 2016¹. Stand out from the crowd by offering them a solution that works. BEFORE Photographs courtesy of N. Fenline, CME, LE POST 21 TREATMENTS After my first treatment, I noticed a huge change to my skin and now I wish I d had the Isolaz treatment done sooner. Naomi, Isolaz Patient BEFORE 3 MONTHS POST 6 TREATMENTS Photographs courtesy of Solta Medical Aesthetic Center Isolaz has been a real game-changer for teens with acne. Many of these kids simply want their acne to go away over-night, and become impatient and frustrated with traditional acne therapies. A series of 2 to 3 Isolaz treatments can do wonders for teen inflammatory and comedonal acne, with significant improvement in as little as 2 weeks. I have even treated both of my teenage children with Isolaz, and thankfully the treatments did wonders for their acne. Michael Kaminer, MD, Dermatologist BEFORE Photographs courtesy of N. Fenline, CME, LE BEFORE Photographs courtesy of K. Tadashi, M.D. POST 12 TREATMENTS POST 4 TREATMENTS ¹ Global Data: Acne-Drug Pipeline Analysis and Market Forecasts to 2016

4 The science and technolgy behind Isolaz. The Isolaz system harnesses the dual power of Photopneumatic energy, by combining vacuum with the proven benefits of Intense Pulsed Light (IPL), to treat acne effectively. This combined technology followed by enhanced topical application, targets the root causes of acne for reliable results. CLEANSE: Pneumatics (vacuum) manipulates and stretches the skin, cleansing the pores and removing sebaceous material. PURIFY: Broadband light delivers heat and light to treat the lesion, reducing oil production, killing bacteria and purifying the pores. REPLENISH: Profusion, with the help of vacuum power, gives you the ability to enhance topical application. Cleanse Purify Replenish A special treatment tip uses vacuum to gently lift acne impurities helping extract dirt, blackheads, dead cells and excess oil from the pores. Broadband light is applied, helping to destroy acne causing bacteria and to reduce sebum production. With Profusion technology, vacuum gently stretches the skin cells, allowing the application of topical products into the intercellular spaces in the skin. The vacuum is released, having helped enhance topical product application for improved overall treatment outcomes.

5 Profusion meets the challenges of topical application. The cells of the stratum corneum block the majority of topically applied skin care products, leading to poor depth of penetration, slower absorption times and not enough topical reaching the target. Without Profusion With Profusion With Profusion With Profusion, vacuum spreads the skin cells to allow for (and assist with) the application of topical therapies into the intercellular spaces, for improved overall treatment outcomes. Photo courtesy of Professor Guillermo Aguilar, PhD et al. University of California, Riverside; Pig skin confocal microscopy The Isolaz Advantage While most acne therapies only address one or two root causes of acne, Isolaz attacks multiple causes, effectively shutting down the pathway to active acne. The Isolaz Difference Efficient use of broadband light. Vacuum pulls the skin closer to the light source to safely and effectively deliver the energy to the target Mechanical pore cleansing. Vacuum helps to evacuate any sebaceous blockages and dislodge follicular ostia Topical Application. Vacuum spreads skin cells to enhance the application of topical therapies into the intercellular spaces The Isolaz Solution Treatments are quick, comfortable and get results without the potential of harsh systemic side effects and complications. Typical treatment course is 4-6 weeks * with visible improvements as early as after the first treatment. * Dependent on clinical end points and patient s condition

6 Stay ahead with cutting-edge technology. Proven Results Clinical Studies Show: 88% clearance of papular, pustular, nodular and inflammatory acne¹ Immediate drying and flattening of lesions within hours post treatment¹ Significant decrease in number of acne lesions (spots, pimples, pustules, etc)² Decrease in the amount of oil production, starting after the first treatment² Non-responders to orals (including isotretinoin), topicals and lasers had over a 75% reduction in lesions within two months² Patient satisfaction You re not putting anything on the skin except water and the device. You re not putting anything in the patients mouth, so there s no potential risk of irritation from benzoyl peroxide or retinoic acid and there s no potential side effects from antibiotics. They like the fact that it s painless. They like the fact that they see the improvement while they re in the office. And then a day later, we get calls from patients saying Wow! These spots look better right away. They never do that when you prescribe tetracycline. Jeffrey Dover, MD, Dermatologist ¹ Multi-Center data presented to the FDA, July Aesthera Corporation. ² Shamban, Ava T., MD. Photopneumatic (PPx) Pore-Cleansing Acne Treatment: A Breakthrough Treatment Option for Non-Responders to Acne Therapies. White Paper. August 2006

7 Don t take our word for it. Patients tell their story: Christine The case I have had acne for about 16 years. I was 12 years old when it started and have always been very self-conscious about it. I love my skin now The tries I have tried so many thing over the years: Proactiv, (didn t have lasting results and dried out my skin), prescriptions from my dermatologist, and several brands of face washes and products. Nothing really seemed to work for me. The solution I wanted to find something that worked for the long term. Then I tried Isolaz. The process was painless and super easy. It was once a week for 5 weeks. I noticed improvements after about 3 weeks. I was so excited to wake up in the morning and not dread looking in the mirror. I love my skin now. It is smooth and acne free. I even love those days that you just don t have time for makeup! After the first treatment, I felt my skin was glowing. Natalie Isolaz was great! It helped my self-esteem. I m excited to take pictures now! Tracey I feel more confident with clear skin. My skin looks better and my make-up goes on nicer!! Carla

8 Solta Medical, Inc Industrial Blvd., Hayward, CA Indications for use include the treatment of mild to moderate acne, including pustular acne, comedonal acne and mild to moderate inflammatory acne (acne vulgaris) in all skin types (Fitzpatrick I-VI). Side effects are generally mild and may include redness, swelling and mild discomfort during treatment. Potential risks include, blistering, scarring, infection, bruising, pigmentary changes, skin fragility around the treatment area and superficial erosion of the treated area. MK 3291A 2013 Solta Medical and its logo and Isolaz are trademarks of Solta Medical, Inc. All rights reserved. Other names and brands may be claimed as the property of others.

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