Work Place Carcinogens Solar Radiation and Skin Cancer. November 2013 Dr Mark Foley

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1 Work Place Carcinogens Solar Radiation and Skin Cancer November 2013 Dr Mark Foley

2 Overview Work place carcinogens and skin cancer Who is a risk? Screening and Self skin exam Common skin cancers

3 Many work place hazards that cause Solar radiation Skin Cancer UV radiation from welders Tar (coal, soot, mineral oils) Arsenic

4 Sun exposure is a work place carcinogen

5 Who is at risk?

6

7 Who is at risk? Every outdoor worker Especially fair skin and poor protection

8 Office worker on lunch break

9 Office worker on lunch break Fair skin and poor protection!

10 Who is at risk? Every outdoor worker Especially fair skin and poor protection Sun burns and total UV exposure Potentially every indoor worker Pattern of sun exposure work and home? UVA

11 Who is at risk? Every outdoor worker Especially fair skin and poor protection Sun burns and total UV exposure Potentially every indoor worker Pattern of sun exposure work and home? UVA Retired out door workers Lag time from exposure to development

12 So every worker with poor UV protection is at risk..not just during their working life but a life-long risk which becomes greater in later life..

13 Skin checks Every worker should be taught and preform regular self examination Regular skin checks for outdoor workers, especially those with fair skin and or poor protection. Clinician: Knowledge of vast variation in skin cancer presentation. Check head to toe, not just sun exposed skin. Ideally with dermatoscopy.

14

15 Why is sun exposure a work place carcinogen? Chronic sun exposure Sun damage Actinic Keratosis SCC Lentigo maligna

16 Why is sun exposure a work place carcinogen? Chronic sun exposure Sun damage Actinic Keratosis SCC Lentigo maligna Intermittent sun exposure Melanomas BCC

17

18 Common Skin Cancers

19 Reminder of epidermal structure UVB UVA

20

21 Epidermis Dermis Fat

22

23 BCC

24 Melanoma

25 AK/SCCi/SCC

26 K/SCCi/SCC BCC Melanoma

27 Where do they occur

28

29

30

31

32 When do they occur? BCC s, SCC s and Melanoma risk all increases with age Different onset ages.

33 Melanoma Age specific rates

34

35 Basal Cell Carcinoma Squamous Cell Carcinoma

36 BCC s common in under 35 Dramatic increased rate 35+ Intermittent sun exposure Mainly sun exposed sites

37 SCC s Uncommon under 40 Dramatic increase in 50 s Chronic sun exposure Sun exposed sites

38 Melanoma Rare under 14 yrs age Dramatic increase 50 s Intermittent sun exposure Sun protected sites

39 So Far UV light damages DNA, if not repaired this is one factor in causing skin cancer Different age and body site profiles Work sun exposure is a significant risk factor. Long lead time from exposure to development of sun damage and skin cancer.

40 Solar induced DNA damage & gene suppression Implications for prevention Minimisation of sun exposure to reduce life time accumulation of UV radiation. Implications for surveillance Risk extends well beyond leaving a job or retiring

41 Skin Cancers - clinical

42 Solar Keratosis / Actinic Keratosis Sun damage, sun spots Considered Pre-malignant

43 Epidermis AK lower 1/3 SCCi full thickness SCCi AK

44 AK and SCCi therefore have similar naked eye features Different dermatoscopy features

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