Pathology of the skin. Dr Fónyad László, 1sz. Patológiai és Kísérleti Rákkutató Intézet, SE
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1 Pathology of the skin Dr Fónyad László, 1sz. Patológiai és Kísérleti Rákkutató Intézet, SE
2 The skin Biggest organ Kb. 1.8 nm Kb. 10 kg Most frequent site for tumor development (BCC)
3 Pathology of the skin Inflammatory diseases - dermatosis Epidermal changes Melanocytic changes Skin appendageal changes Dermal changes Limphoproliferative changes
4 Pathology of the skin Clinical Macula Papula Bullae Purpura Pustule... Histology Hyperkeratosis Parakeratosis Acanthosis Spongiosis Psoriasiform hyperplasia Lichenoid inflammation...
5 Pathology of the skin Inflammatory diseases - dermatosis Epidermal changes Melanocytic changes Skin appendageal changes Dermal changes Limphoproliferative changes
6 dermatosis
7 dermatosis Spongiotic pattern Acanthotic pattern Lichenoid pattern Vesiculobullous pattern Acantholytic pattern Granulomatous pattern Vasculopathic pattern Ekzema (atopic, contact, allergic) Lichen simplex chronicus, Psoriasis Lichen sclerosus, Lichen planus Bullosus pemphigoid, gestation pemphigoid, pepmphigus vulgaris, cicatricial pepmphigoid Hailey-Hailey, Darier Crohn's Zoon vulvitis Aphthous ulcers Behcet's
8 dermatosis Spongiotic pattern Acanthotic pattern Lichenoid pattern Vesiculobullous pattern Acantholytic pattern Granulomatous pattern Vasculopathic pattern Ekzema (atopic, contact, allergic) Lichen simplex chronicus, Psoriasis Lichen sclerosus, Lichen planus Bullosus pemphigoid, gestation pemphigoid, pepmphigus vulgaris, cicatricial pepmphigoid Hailey-Hailey, Darier Crohn's Zoon vulvitis Aphthous ulcers Behcet's
9 Spongiotic pattern - ekzema Allergic contact dermatitis Irritant contact dermatitis Atopic dermatitis Drug induced ekzema Stasis dermatitis Acut Subacute Chronic
10 Spongiotic pattern - ekzema Constantly changing histology - acute Preserved stratum corneum Intercellular edema Spongiotic microvesicules +/- Papilláry edema +/- SPVI lymphocytes, eosinophils Phelps RG, Miller MK, Singh F. The varieties of "eczema": clinicopathologic correlation. Clin Dermatol Mar-Apr;21(2):
11 Spongiotic pattern - ekzema Constantly changing histology - subacute Parakeratosis Spongiosis Acanthosis Papilláris edema -/mild SPVI lymphocytes, eosinophils Phelps RG, Miller MK, Singh F. The varieties of "eczema": clinicopathologic correlation. Clin Dermatol Mar-Apr;21(2):
12 Spongiotic pattern - ekzema Constantly changing histology - chronic compact hyperkeratosis Parakeratosis -/minimal Acanthosis Minimal spongiosis Superficialis dermal fibrosis Mild SPVI ly/eos Phelps RG, Miller MK, Singh F. The varieties of "eczema": clinicopathologic correlation. Clin Dermatol Mar-Apr;21(2):
13 Acanthotic pattern - psoriasis
14 Acanthotic pattern - psoriasis Classic Well demarcated erythematous non-puritic plaques covered by fine, loosely adherent, silvery-white scales Auspitz-sign, Koebner-phenomen Guttate After Streptococcal infection Might result in Classic psoriasis Pustular Systemic signs/symptoms, high fever
15 Acanthotic pattern - psoriasis Parakeratosis Regular acanthosis Neutrophils in stratum corneumban/epidermis Loss of granulár layer Suprapapillary plate thinning Dilated tortous vessels in the papillary dermis Dermal infl. wo. eosinophils
16 Acanthotic pattern - psoriasis
17 Acanthotic pattern - lichen simplex chronicus (LSC) Not a real entity Reaction to repetitive minor trauma (eg. scratching) Indurated Erythemal Scaly Hyperpigmented (later could be hypopigmented!) Usu. soliter
18 Acanthotic pattern - lichen simplex chronicus (LSC)
19 Acanthotic pattern - lichen simplex chronicus (LSC) compact hyperkeratosis Parakeratosis -/focal Irregular acanthosis prominent granular layer Vertical streaks of dermal collagen Mild inflammation
20 lichenoid pattern - lichen planus
21 lichenoid pattern - lichen planus Chronic, T-cell mediated dermatosis Cutan Wrist, elbow Mucosal Oral, genital Destructive
22 lichenoid pattern - lichen planus small papules Poorly demarcated Extremely itchy
23 lichenoid pattern - lichen planus Inflammatory Dermatopathology - Billings Compakt hyperkeratosis No parakeratosis Hypergranulosis Band like inflammation Basal vacuolisation Dyskeratotic keratinocytes Saw-tooth DE-junction No Eos.
24 dermatosis Spongiotic pattern Acanthotic pattern Lichenoid pattern Ekzema Lichen simplex chronicus, Psoriasis Lichen planus
25 Pathology of the skin Inflammatory diseases - dermatosis Epidermal changes Melanocytic changes Skin appendageal changes Dermal changes Limphoproliferative changes
26 Epidermal changes Benign Seborrheic keratosis Premalignant Actinic keratosis In situ scc. Malignant BCC SCC
27 Epidermal changes Benign Seborrheic keratosis Premalignant Actinic keratosis In situ scc. Malignant BCC SCC
28 Epidermal changes - actinic keratosis
29 Pathology of the skin Inflammatory diseases - dermatosis Epidermal changes Melanocytic changes Skin appendageal changes Dermal changes Limphoproliferative changes
30 Melanocytás elváltozások
31 Melanocytic lesions Acquired nevi Dysplastic nevi Melanoma
32 Melanocytic lesions - melanoma etiology UV, dysplastic nevus syndrome Skin - NRAS, BRAF activating mutations Mucosa - ckit activating mutations PTEN ts. loss ABCDE-rule
33 Melanocytic lesions - melanoma types SSM Nodular Lentigo maligna, lentigo maligna melanoma...
34 Melanocytic lesions - melanoma Melanoma Breslow Clark Sentinel node Atypical metastatic sites
35 Pathology of the skin Inflammatory diseases - dermatosis Epidermal changes Melanocytic changes Skin appendageal changes Dermal changes Limphoproliferative changes
36 Appendageal lesions, cysts Follicular lesion Cysts Benign tumors Malignant tumors Sebaceus lesions Benign tumors Malignant tumors Eccrine lesions Benign tumors Malignant tumors
37 Bőrfüggelékek elváltozásai, cysták Follicular lesions Cysts Epidermal cyst Trichilemmal cyst
38 Bőrfüggelékek elváltozásai, cysták Szőrtüsző eredetű elváltozások Cysták Epidermoid cysta Trichilemmalis cysta
39 Pathology of the skin Inflammatory diseases - dermatosis Epidermal changes Melanocytic changes Skin appendageal changes Dermal changes Limphoproliferative changes
40 Dermal lesions (soft tissue tumors) Adipous tumors Fibrous tumors Neuroectodermal tumors Smooth muscle tumors Striated muscle tumors Vascular tumors Cartilage/bone forming tumors Others...
41 Dermal lesions (soft tissue tumors) Adipous tumors Fibrous tumors - dermatofibroma Neuroectodermal tumors Smooth muscle tumors Striated muscle tumors Vascular tumors Cartilage/bone forming tumors Others...
42 Dermal lesions - dermatofibroma dermatofibroma
43 KÖSZÖNÖM A FIGYELMET! Dr Fónyad László, 1sz. Patológiai és Kísérleti Rákkutató Intézet, SE
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