Clinical Investigation II (Other Diseases and Safety) August 20, 2017, 9:30 12:00
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1 Clinical Investigation II (Other Diseases and Safety) August 20, 2017, 9:30 12:00
2 Panel members Chairman: Ge LIN The Chinese University of Hong Kong Co-Chairman: Wei-Jen CHENG Chang Gung Memorial Hospital, Taoyuan Panelist: Chuan-jian LU Guangdong Provincial Hospital of Chinese Medicine
3 layout of presentation session No. Abs Presenter/ Corresponding author 1 65 Hsiao-Wei CHEN / Jiun-Liang CHEN Title Region Oral Utilization Pattern of Traditional Chinese Medicine among Late Stage Chronic Kidney Disease Patients: A Hospital-Based Retrospective Observational Study 2 73 Lei WAN Chinese herbal medicine as a therapeutic agent for inhibiting myopia progression 3 68 Zhi-Qin ZHOU Citrus intake decreases risk of incident type 2 diabetes: a systematic review and meta-analysis 4 69 Jian MA / Ge LIN Development of biomarkers for clinical diagnosis of pyrrolizidine alkaloid-induced liver injury 5 71/72 Wei-Jen CHENG The utilization of traditional Chinese medicine for patients with polycystic ovary syndrome in Taiwan: Implications from Chang Gung research database 6 74/75 You-hua WANG Effects of Kuoxin Decoction on Dilated Cardiomyopathy 7 78 Siu-wai LEUNG Is Dengzhanxixin injection more effective than nitrates in treating angina pectoris? A metaanalysis of randomized controlled trials 8 79 Chuan-jian LU Oral Chinese medicine PSORI-CM01 plus calcipotriol betamethasone ointment for Psoriasis Vulgaris: A feasibility pilot study for a randomized controlled trial 9 87 Jian-wen GUO Removing Blood Stasis Therapy in Treating Ultraacute Intracerebral Hemorrhage: A Multi-center Controlled Randomized Clinical Trial Zehuai WEN Comparative effectiveness research of Chinese herb injections for activating blood circulation for stroke: a network meta-analysis Taoyuan Taichung Chong Qing Hong Kong Taoyuan Shanghai Macau Guangdong Guangdong Guangdong No No
4 General Information Total: 25 (from 21 research groups) Hospital-based retrospective study: 16 --Observation, data analysis, literature review Clinical practice: 8 --Clinical trial, use of TCMs for different diseases Clinical diagnosis of herb-induced hepatotoxicity: 1 --Novel biomarker for diagnosis of pyrrolizidine alkaloid (PA)-containing herbs induced hepatotoxicity
5 Hospital-based retrospective study v Importance of authenticated database Database in Chang Gung Memorial Hospital v Chronic kidney disease, ~5% TCM (8,459 patients within ). Jia-wei-xiaoyao-san (~36%), Bu-yang-huan-wu-tang (~33%) v Polycystic ovary syndrome, ~8% TCM (57,713 patients within ). Zou- Gui-Wan was most commonly used
6 Safety v Diagnosis of pyrrolizidine alkaloid (PA)- containing herb-induced hepatotoxicity v A novel mechanism-based biomarker has been developed and currently applied for the confirmative diagnosis of PA-induced liver injury (PA-ILI) in Zhongshan hospital, Shanghai, China
7 Development of mechanismbased biomarker H H 3 C CH 2 OH H 3 C OAc O O H 3 C H 2 C CH 2 O O H N O Ri ddelliine (Retronecine-type) [P450] Oxidation O O [P450] Oxidative N-demethylation CH 3 O O N CH 3 Clivorine (Otonecine-type) O CH 2 N Pyrrolic ester Toxic metabolite Nu N u N C H 2 -Nu Pyrrole-protein adducts in liver & blood pyrrole-protein adducts potential biomarker Nu: Nucleophlic biological macromolecules (i.e. proteins) Hepatotoxicity Lin G. et al. J. Hepatol. 2011, 54,
8 Suggested guidance of diagnosis of acute PA-ILI DILI patients Herbal ingested No Herbal hepatotoxicity Not PA related DILI 2 Seattle Score <2 Herb-induced HSOS Unlikely PA related DILI Recommend blood biomarker test No PA-ILI Not PA related Blood biomarker test if needed Gao, et al. DDDT. 2015
9 Challenges/problems/future development v Establishment of database with detailed information, including ADRs v Toxicity of herbal medicines -- development of specific biomarker and other diagnostic methods
10
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