ORIGINAL ARTICLE Efficacy of testosterone gel in the treatment of erectile dysfunction in hypogonadal hemodialysis patients: a pilot study
|
|
- Todd Benson
- 5 years ago
- Views:
Transcription
1 (2010) 22, & 2010 Nature Publishing Group All rights reserved /10 $ ORIGINAL ARTICLE Efficacy of testosterone gel in the treatment of erectile dysfunction in hypogonadal hemodialysis patients: a pilot study Ö Cangüven 1, G Aykose 1, S Albayrak 1, C Goktas 1, R Horuz 1 and F Yencilek 2 1 Second Urology Clinic, Kartal Teaching and Research Hospital, Istanbul, Turkey and 2 Department of Urology, Yeditepe University, Istanbul, Turkey End-stage renal disease (ESRD) affects sexual function. The etiology of sexual dysfunction in ESRD is multifactorial and hypogonadism is not uncommon. In a cohort of 96 men with ESRD, scores on International Index of Erectile Function (IIEF) correlated with bioavailable testosterone (T; Po0.01). We further evaluated the effects of administration of T on ED in hypogonadal men on hemodialysis. Nine men with ED and hypogonadism (baseline bioavailable T o3.82 nmol l 1 ), received 5 g T-gel (1% (10 mg g 1 ) per day treatment for 6 months. The IIEF and frequency of sexual intercourse per week were used to assess treatment efficacy. T administration significantly increased serum T levels to the normal range, and was associated with statistically significant improvements of the scores of the IIEF domains (erectile function from 7.6±8.0 to 12.8±7.8; intercourse satisfaction from 3.4±4.5 to 4.8±3.1; orgasmic function from 4.8±3.1 to 3.4±2.9; sexual desire from 3.4±2.9 to 4.4±0.6; overall sexual satisfaction from 2.6±1.3 to 3.8±1.0). But scores of the IIEF did not normalize. Frequency of weekly sexual intercourse increased from 0.4±0.4 to 1.1±0.8 (Po0.05) after 6 months. There were no adverse effects. We conclude that restoring T levels to normal in men with ESRD improved scores on the IIEF and frequency of weekly sexual intercourse. (2010) 22, ; doi: /ijir ; published online 19 November 2009 Keywords: end-stage renal disease; erectile dysfunction; hypogonadism; testosterone Introduction Correspondence: Dr Ö Cangüven, Second Urology Clinic, Kartal Teaching and Research Hospital, Sakaci sokak Yildiz Apt. 42/5, Erenkoy Istanbul, Turkey. ocanguven@yahoo.com Received 30 July 2009; revised 6 October 2009; accepted 8 October 2009; published online 19 November 2009 Erectile dysfunction is a frequent occurrence in men with end-stage renal disease (ESRD). 1,2 Studies of patients with ESRD on hemodialysis (HD) have found that % of men have complaints of ED. 3 5 This shows that despite the improvements in the treatment of ESRD over the past decade, prevalence of ED remains high. Sexual dysfunction and hypogonadism begin before patients reach ESRD and are not corrected by HD therapy. 6 Hypogonadism leads not only to sexual dysfunction but also anemia, loss of lean body mass and altered bone metabolism. 2,7 9 It has been shown in men treated with HD that testosterone (T) concentrations inversely correlate with all-cause-related mortality, including cardiovascular disease. 10 So there are reasons to believe that low T levels affect general health of patients with ESRD. There have been a few studies addressing administration of T in HD patients. 7,11,12 Remarkably, in the study of Brockenbrough et al. 7 T administration of 100 mg of topical 1% T-gel for 6 months did not increase serum T levels and there was no effect on sexual function scores. But another study has shown that T transdermally administered daily as gel or patch resulted in a significant increase in serum T levels. 13 Lawrence et al. studied the effectiveness of T replacement with depot T injections in men with biochemically proven hypogonadism. 11 Only 3 of 27 patients benefited from T administration and the others had to use vacuum tumescence therapy to improve erectile function (EF). So, there is limited information on the efficacy of administration of T only in men on HD with lowerthan-normal serum T levels. The aim of this study was to evaluate the efficacy of administration of T on ED to hypogonadal ESRD patients on HD.
2 Methods This study prospectively evaluated 102 male patients with ESRD receiving HD treatment between March 2008 and October Patients were treated in a teaching hospital and in a private HD center. Patients were on chronic HD and had received treatment (mean of 12 dialysis hours per week with polysulphone membranes) for at least 6 months. Six patients were unwilling to participate or there were other factors making them unsuitable for this study. The inclusion criteria were having ED (assessed with the International Index of Erectile Function (IIEF) erectile function domain) and hypogonadism (based on levels of bioavailable T, as levels of sex hormone-binding globulin were strongly elevated). Patients who had undergone urogenital surgery or who had been treated with T earlier were excluded. Age, dialysis history and the number of weekly dialysis sessions of the patients were recorded. Coexisting diseases, use of medical drugs, urological complaints, were recorded. As another measure of sexual functioning the frequency of sexual intercourse per week was recorded as well. Each patient was asked to report the frequency of sexual intercourse per week in the last 4 weeks before the start of T treatment for baseline assessment and on days 30, 90 and 180 of the study. A total of 96 patients with a median age of 48 years (18 81 years) were initially considered eligible for the study. The patients were receiving HD treatment for ESRD for a median period of 4 years (6 months to 16 years). The etiology of the ESRD was glomerulonephritis, hypertensive nephropathy, diabetes mellitus, obstructive nephropathy and polycystic kidney disease in 22, 10, 9, 4 and 2 patients, respectively. Alport syndrome, amyloidosis and familial Mediterranean fever were the etiology in the other three patients. None of these patients had used or was using PDE5 inhibitors because of listlessness and lack of sexual appetite. Following physical examination, all patients were requested to fill out IIEF form of 15 questions (Qs). 14 The IIEF has five domains: EF (Q1 Q5 and Q15, total score 1 30), intercourse satisfaction (Q6 Q8, total score 0 15), orgasmic function (Q9 and Q10, total score 0 10), sexual desire (Q11 and Q12, total score 2 10) and overall sexual satisfaction (Q13 and Q14, total score 2 10). The EF domain consists of six questions (erection frequency, Q1; erection firmness, Q2; penetration ability, Q3; maintenance frequency, Q4; maintenance ability, Q5 and erection confidence, Q15). Subjects who scored o26 in this domain were considered to have ED. The score for each item ranges from 0 to 5 for questions 1 10, 0 meaning no sexual activity/no attempt to have sexual intercourse, and from 1 to 5 for questions The severity of ED was classified using five categories: no ED (EF score: 26 30), mild (EF score: 22 25), mild to moderate (EF score: 17 21), moderate (EF score: 11 16) and severe (EF score: 6 10). 15 At baseline complete blood count, serum creatinine, albumin, PSA, alanine aminotransferase and serum hormone levels including follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), total and free T, sex hormone binding globulin (SHBG) and intact parathyroid hormone were measured. Blood samples (8 ml) were obtained between 0800 and 0900 hours to minimize the confounding effects of diurnal variations in serum T. Serum (1 ml) from the blood taken from each sample was stored frozen at 18 1C until analyzed for measurement of SHBG. Autoanalyzer Immulite 2000 (DPC Diagnostic Products Corporation, Los Angeles, CA, USA) was used by using appropriate kit. Chemiluminescence was used as a method to measure levels of SHBG, LH, FSH, T, PSA and PRL. The SHBG-bound fraction of T is biologically virtually inactive because of the high binding affinity of SHBG for T, and therefore, bioavailable T, which includes free and weakly bound T to albumin, was calculated. Calculated bioavailable T levels were assessed using the formula presented by the International Society for the Study of the Aging Male (available at Patients with bioavailable T levels at screening of 3.82 nmol l 1 or less were considered hypogonadal. Of the 96 men initially selected for the study, 10 men eventually met the selection criteria of bioavailable T levels at screening of 3.82 nmol l 1 or less, and they were eligible for treatment with T-gel. However, before start of the T treatment, one patient suffered cardiovascular problems and had to be excluded from the prospective treatment group. So, nine men completed the research protocol. They had a stable relationship with a female sexual partner. As safety measures, patients with an abnormal digital rectal examination and/or a PSA level 42.5 ng ml 1 ) were excluded. Hematocrit levels o45 were a requirement for inclusion in the study. In addition to the monthly complete blood count and assessment of renal function variables, T levels were measured every month and SHBG and PSA levels were measured every 3 months. The patients were evaluated during monthly visits. To evaluate the potential changes in sexual functions, we requested the patients to fill out IIEF form on days 30, 90 and 180 of the study. After baseline measurements, each patient applied 5 g T-gel (1% (10 mg g 1 T), Testogel; Bayer Schering Pharma, Montrouge Cedex, France) per day to different application sites (right and left upper arm/shoulder and hairless abdominal area). Application sites alternated throughout the study. After application of the gel to the skin, the gel dried within a few minutes. Patients washed their hands thoroughly with soap and water after gel application. 141
3 142 Main outcome measures The scores on the different domains of the IIEF were used for assessment of sexual functioning of the hypogonadal ESRD patients before and after T-gel treatment. Also the frequency of weekly sexual intercourse was recorded and hormonal and hematological results in relation to bioavailable T were also recorded. Statistical analysis SPSS (Chicago, IL, USA) for Windows 10.0 statistics package program was used for statistical analysis of the data. Analysis of variance, Bonferroni test, Wilcoxon tests and Pearson s correlation analysis were used to analyze repeated measurements and Po0.05 was considered statistically significant. This clinical study was carried out in an academic institution and was approved by the institutional ethical review board. All patients gave informed consent in writing before participating in the study. Results Based on the IIEF scores, 15 ED was present in 90 of the total 96 patients initially selected for the study. The degree of ED was determined as mild, mild to medium, medium and severe in 15.70, 41.65, and 17.70% of patients, respectively. In six (6.25%) patients, there was no ED. The weekly sexual intercourse average was 1 (0 4) and was lower in men with more severe degrees of ED. There was no clear relationship of the degree of ED with respect to the various etiologies of ESRD. But in all of the diabetic patients medium and severe degrees of ED were found. On comparing of 86 men whose serum T was nmol l 1 with the men with serum T p3.82 nmol l 1, it was found that all domains of the IIEF and frequency of sexual intercourse were significantly better in the first group than in the latter group (Table 1; Po0.001). There was a statistically significant correlation between serum T levels and scores on the IIEF (Po0.01). The creatinine and hematocrit levels were not different. Hypogonadism, defined as bioavailable T levels (p3.82 nmol l 1 ), was found in 10 of the 90 patients with ED. The results of hypogonadal patients showed that there was a weak negative correlation between total T and age (r ¼ 0.296; Po0.01). Various degrees of ED were seen in these patients. The average weekly frequency of sexual intercourse per week 0.4±0.4 (once per 2.5 weeks) before T treatment in this group. In the patients defined as hypogonadal, IIEF sexual desire score (Po0.05) and the weekly sexual intercourse frequency (0.4±0.4) were significantly lower (Po0.05), compared with HD patients without hypogonadism (1.0±0.4). There was a weak positive correlation between the total of IIEF scores and the bioavailable T levels of the hypogonadal patients (r ¼ 0.406; Po0.05). There was also a weak positive correlation between the IIEF sexual desire scores and the bioavailable T levels of the hypogonadal patients (r ¼ 0.338; Po0.05). Using the methods described, 9 of the above 10 patients were eligible to be treated with T-gel in the study. Median HD period of the patients was 1.0±0.3 year. All nine patients completed the Table 1 Comparison of scores on IIEF between eugonadal and hypogonadal men with ESRD Eugonadal (n ¼ 86) Hypogonadal (n ¼ 9) IIEF Erectile function domain (1 30) 16.3± ±8.0 IIEF Intercourse satisfaction (0 15) 8.3± ±4.5* IIEF Orgasmic function (0 10) 5.9± ±3.5* IIEF Sexual desire (2 10) 4.9± ±0.7* IIEF Overall sexual satisfaction (2 10) 4.8± ±1.3* IIEF Total (5 75) 41.8± ±17.1* Frequency weekly sexual intercourse 1.3± ±0.4* SHBG (20 45 nmol l 1 ) 28.1± ±109.0* Total testosterone ( nmol l 1 ) 19.02± ±3.5* Bioavailable testosterone (43.8 nmol l 1 ) 10.3± ±0.5* Free testosterone ( nmol l 1 ) 0.6± ±0.1* Albumin ( g per 100 ml) 3.8± ±3.0 FSH ( miu ml 1 ) 8.1± ±23.9* LH (5 20 miu ml 1 ) 13.1± ±25.7 Prolactin ( ng ml 1 ) 47.3± ±43.3 PSA (0 2.5 ng ml 1 ) 1.04± ±0.44 Hematocrit (38 42%) 33.4± ±5.0 Creatinine ( mmol l 1 ) 935± ±212 Abbreviations: FSH, follicle-stimulating hormone; IIEF, International Index of Erectile Function; LH, luteinizing hormone; PSA, prostatespecific antigen; SHBG, sex hormone binding globulin. *Po0.05.
4 6-month study. After the first month, the T levels of the patients had increased to reference levels (Table 1). In the follow-up period, the T level of one patient exceeded (total T: 41.2 nmol l 1 ) normal physiological T values. In the evaluation of this patient, 1 week later, it was found that the T level was normal. It may well be that in this patient venous blood sampling occurred in an area where T-gel had been applied. This was also encountered in other studies administering T-gel. 16 No side effects requiring discontinuation of treatment were seen in any of the patients. None of the nine patients used any kind of PDE5 inhibitors. International Index of Erectile Function scores and the number of weekly sexual intercourse increased significantly over the first month (Po0.05; Table 2) and then reached a plateau. Scores of IIEF at 3 months were not different from those at 1 month, and scores of IIEF at 6 were not different from scores at 3 months or at 1 month. Although it would seem that IIEF sexual desire scores had declined at 6 months, the value at 6 months remained significantly higher than at baseline. Plasma levels of SHBG decreased profoundly on T administration. The levels of FSH and LH, which were higher than normal in the beginning, decreased significantly (Po0.05). The average PRL level in the treatment group was ng ml 1 (normal: ng ml 1 ). PRL levels were not different between the total population of patients and the treatment group. There was no statistical significant relation between the PRL level and IIEF scores. There was no statistically significant change in PRL levels with the T replacement treatment (P40.05). Hematocrit levels had increased with an average of 4.9% at the end of 6 months (Table 2). In one of the patients in the study group, a clinically relevant increase in PSA was detected. The pathological examination of the prostate biopsy performed on this patient showed no signs of malignancy. Discussion This study found that men with ESRD requiring HD have an impairment of sexual functioning. We found that there was a strong correlation between IIEF scores and bioavailable T in the whole cohort of 96 men, potentially suggesting that T levels are a factor in sexual dysfunction in men with ESRD. This correlation was weaker in the men with serum T in the hypogonadal range. We then analyzed the effects of administration of T to men treated with HD who had baseline levels of bioavailable T o3.82 nmol l 1 and IIEF scores qualifying them as having ED. Application of T-gel daily (5 mg per 24 h) consistently raised average serum total, free and bioavailable T concentrations to values in the mid-range for healthy young men. Normalization of serum T resulted in a significant increase in total and erectile function domain of IIEF scores. Then scores reached a plateau after 1 month and there were no significant further improvements when assessments were performed 3 and 6 months after initiation of T administration. Although the IIEF scores increased significantly in all patients, none of them attained an IIEF score of X26, regarded as normal erectile function. 143 Table 2 IIEF and laboratory data of hypogonadal ESRD male patients (n ¼ 9) before and 1, 3 and 6 months after T-gel treatment Baseline 1 Month 3 Months 6 Months IIEF Erectile function domain (1 30) 7.6± ±7.0* 11.8± ±7.8 IIEF Intercourse satisfaction (0 15) 3.4± ±3.6* 4.5± ±3.1 IIEF Orgasmic function (0 10) 2.6± ±2.8* 3.2± ±2.9 IIEF Sexual desire (2 10) 3.4± ±0.3* 4.4± ±1.0 IIEF Overall sexual satisfaction (2 10) 2.6± ±0.6* 3.7± ±1.0 IIEF Total (5 75) 20.0± ±14.5* 28.6± ±16.3 Frequency of weekly sexual intercourse 0.4± ±0.8* 1.2± ±1.1 SHBG (20 45 nmol l 1 ) 73.7± ±16.4* 30.7± ±13.4 Total testosterone ( nmol l 1 ) 10.0± ±4.7* 20.7± ±7.0 Bioavailable testosterone (43.8 nmol l 1 ) 3.3± ±5.7* 10.8± ±5.4 Free testosterone ( nmol l 1 ) 0.2± ±0.1* 0.5± ±0.1 Albumin ( g per 100 ml) 3.7± ± ± ±0.3 FSH ( miu ml 1 ) 23.3± ±5.7* 8.3± ±3.7 LH (5 20 miu ml 1 ) 25.3± ±6.9* 8.9± ±3.6 Prolactin ( ng ml 1 ) 62.8± ± ± ±36.8 PSA (0 2.5 ng ml 1 ) 0.756± ± ± ±0.476 Hematocrit (40 52%) 32.5± ± ±5.4* 35.8±4.8* Increase hematocrit (%) 0.2± ±1.1* 4.9±1.9* Creatinine ( mmol l 1 ) 946± ± ± ±150 Abbreviations: FSH, follicle-stimulating hormone; IIEF, International Index of Erectile Function; LH, luteinizing hormone; PSA, prostatespecific antigen; SHBG, sex hormone binding globulin. *Po0.05.
5 144 More importantly, T treatment led also to an increased sexual performance as shown by the significant increase in frequency of weekly intercourse. The pathogenesis of ED in ESRD patients is manifold and includes hormonal disturbances, zinc deficiency, medications, peripheral neuropathy, peripheral vascular disease and biochemical disturbances not corrected by HD. 1,6,8,17 Normal levels of T are of major significance for normal male sexual behavior and potency T monotherapy for the treatment of ED is very efficacious in men with hypogonadism when it is the sole cause of ED, but it is increasingly clear that it may also be beneficial in hypogonadal men with ED who have other pathologies, such as vascular disease and neuropathy. 20,21 In animal experimentation, experimental T deficiency caused significant reduction in trabecular smooth muscle and significant increase in connective tissue deposition concomitant with loss of erectile function. 20,22 These histological changes were partly reversible on normalization of T levels (for review see Saad et al. 18 and Shabsigh et al. 23 ). It is not clear in how far normalization of circulating T may be able to restore the histological damage to the corpus cavernosum in patients with ESRD. 1,24 In the ultrastructure of the corpora cavernosa in patients with ESRD treated with chronic HD, there are major changes in the structure of smooth muscle cells, with a reduction of dense bodies in the cytoplasm, and an increase of interstitial collagen fibers. 24 Apart from the impairment of the anatomical substrate of erection in patients with ESRD there are endocrine factors. Testosterone deficiency may have impact on endothelial dysfunction and therewith being an etiological factor in ED. 25 To elucidate the molecular mechanisms of hypogonadism in men with ESRD, Dunkel et al. 26 tested the capacity of serum from ESRD patients to inhibit recombinant human LH receptor activity. Using a cell line expressing functional human LH receptors, they found that adenosine monophosphate production was markedly inhibited by sera from the patients, compared to sera from healthy subjects. 26 However, the etiology of gonadal dysfunction remains largely unclear. A combination of primary testicular failure and secondary pituitary hypothalamic dysfunction has been implicated. 6,27 There is no evidence that low serum T concentrations in men on HD can be explained by clearance during HD. 13 Our patients had not tried PDE5 inhibitors. An earlier study indicated that is it rather sexual listlessness than lack of erectile function that prevents patients with ESRD from engaging in sexual activities. 28 But PDE5 inhibitors have been used to treat patients with ED on HD. 29 Seibel et al. 30 evaluated the efficacy and tolerance to oral sildenafil to treat ED in ESRD in patients on HD. An improvement in the score of all questions and domains of the IIEF was found except those related to sexual desire. 30 For the latter effect, addition of T might have been useful because sexual desire is exquisitely sensitive to the action of T. 31 Indeed, in a study using combination therapy of sildenafil with T for ED in patients on HD or after renal transplantation, all patients had a good response to the combination of T and sildenafil, particularly hypogonadal patients. 12 Our study restoring circulating plasma T to midnormal levels was reasonably successful. In the study by Lawrence et al. 11 administering depot injections, sexual function was fully restored in only three men (11.1%), and two gradually lost the response over 18 months. A total of 19 patients (70.3%) had partial responses, varying from an increased sense of well-being alone to restored sexual function apart from an impairment of the duration of penile erection. The patients in our study remained on HD for shorter time (1.0±0.3 years) than the participants of the study by Lawrence et al. (2.00±0.40 years). In our study the hematocrit level increased on average by 4.9% after 6 months. This might have led to a better general condition thus improving sexual functioning as well. This boost may be helpful in cases of severe anemia and may lead to a reduction in the use of erythropoietin. In this study this was, however, not the case. There are limitations to the design of our study that should be considered. The design was not double blind and placebo controlled and, therefore, it cannot be excluded that the effects of the T-gel were secondary to placebo effect. Further limitations of the study stem from the small number of participants, and relatively short follow-up period. We regard this study as a pilot study that hopefully leads to more studies including larger numbers of participants and longer duration. In conclusion, normalization of serum T levels after administration of T-gel was an effective treatment for ED in the present sample of nine hypogonadal patients with ESRD on HD. Scores on the IIEF did, however, not normalize and combination with PDE5 inhibitors might achieve better results. Longer-term studies with a larger number of participants are required to measure the effects of normalization of serum T levels in men with subnormal T receiving HD for ESRD. The assessment should also measure parameters of general vitality, mood and fatigue, which might be elements in the improvement of sexual functioning as well. Conflict of interest SHBG kits (L2KSH2) were provided free of charge by Bayer Schering Pharma. No further disclosures to be made.
6 References 1 Bellinghieri G, Santoro D, Mallamace A, Savica V. Sexual dysfunction in chronic renal failure. J Nephrol 2008; 21 (Suppl 13): S113 S Anantharaman P, Schmidt RJ. Sexual function in chronic kidney disease. Adv Chronic Kidney Dis 2007; 14: Rosas SE, Joffe M, Franklin E, Strom BL, Kotzker W, Brensinger C et al. Prevalence and determinants of erectile dysfunction in hemodialysis patients. Kidney Int 2001; 59: Ali ME, Abdel-Hafez HZ, Mahran AM, Mohamed HZ, Mohamed ER, El-Shazly AM et al. Erectile dysfunction in chronic renal failure patients undergoing hemodialysis in Egypt. Int J Impot Res 2005; 17: Cerqueira J, Moraes M, Glina S. Erectile dysfunction: prevalence and associated variables in patients with chronic renal failure. Int J Impot Res 2002; 14: Palmer BF. Sexual dysfunction in men and women with chronic kidney disease and end-stage kidney disease. Adv Ren Replace Ther 2003; 10: Brockenbrough AT, Dittrich MO, Page ST, Smith T, Stivelman JC, Bremner WJ. Transdermal androgen therapy to augment EPO in the treatment of anemia of chronic renal disease. Am J Kidney Dis 2006; 47: Johansen KL. Treatment of hypogonadism in men with chronic kidney disease. Adv Chronic Kidney Dis 2004; 11: Johansen KL. Testosterone metabolism and replacement therapy in patients with end-stage renal disease. Semin Dial 2004; 17: Carrero JJ, Qureshi AR, Parini P, Arver S, Lindholm B, Barany P et al. Low serum testosterone increases mortality risk among male dialysis patients. J Am Soc Nephrol 2009; 20: Lawrence IG, Price DE, Howlett TA, Harris KP, Feehally J, Walls J. Correcting impotence in the male dialysis patient: experience with testosterone replacement and vacuum tumescence therapy. Am J Kidney Dis 1998; 31: Chatterjee R, Wood S, McGarrigle HH, Lees WR, Ralph DJ, Neild GH. A novel therapy with testosterone and sildenafil for erectile dysfunction in patients on renal dialysis or after renal transplantation. J Fam Plann Reprod Health Care 2004; 30: Singh AB, Norris K, Modi N, Sinha-Hikim I, Shen R, Davidson T et al. Pharmacokinetics of a transdermal testosterone system in men with end stage renal disease receiving maintenance hemodialysis and healthy hypogonadal men. J Clin Endocrinol Metab 2001; 86: Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology 1999; 54: Swerdloff RS, Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM et al. Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. J Clin Endocrinol Metab 2000; 85: Lew-Starowicz M, Gellert R. The sexuality and quality of life of hemodialyzed patients ASED multicenter study. J Sex Med 2009; 6: Saad F, Grahl AS, Aversa A, Yassin AA, Kadioglu A, Moncada I et al. Effects of testosterone on erectile function: implications for the therapy of erectile dysfunction. BJU Int 2007; 99: Aversa A, Isidori AM, Greco EA, Giannetta E, Gianfrilli D, Spera E et al. Hormonal supplementation and erectile dysfunction. Eur Urol 2004; 45: Traish AM, Goldstein I, Kim NN. Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction. Eur Urol 2007; 52: Traish A, Kim N. The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and function. J Sex Med 2005; 2: Traish AM, Guay AT. Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence. J Sex Med 2006; 3: ; discussion Shabsigh R, Rajfer J, Aversa A, Traish AM, Yassin A, Kalinchenko SY et al. The evolving role of testosterone in the treatment of erectile dysfunction. Int J Clin Pract 2006; 60: Bellinghieri G, Santoro G, Santoro D, Lo Forti B, Savica V, Favazzi P et al. Ultrastructural changes of corpora cavernosa in men with erectile dysfunction and chronic renal failure. Semin Nephrol 2004; 24: Karakitsos D, Patrianakos AP, De Groot E, Boletis J, Karabinis A, Kyriazis J et al. Androgen deficiency and endothelial dysfunction in men with end-stage kidney disease receiving maintenance hemodialysis. Am J Nephrol 2006; 26: Dunkel L, Raivio T, Laine J, Holmberg C. Circulating luteinizing hormone receptor inhibitor(s) in boys with chronic renal failure. Kidney Int 1997; 51: Handelsman DJ, Liu PY. Androgen therapy in chronic renal failure. Baillieres Clin Endocrinol Metab 1998; 12: Toorians AW, Janssen E, Laan E, Gooren LJ, Giltay EJ, Oe PL et al. Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response. Nephrol Dial Transplant 1997; 12: Tas A, Ersoy A, Ersoy C, Gullulu M, Yurtkuran M. Efficacy of sildenafil in male dialysis patients with erectile dysfunction unresponsive to erythropoietin and/or testosterone treatments. Int J Impot Res 2006; 18: Seibel I, Poli De Figueiredo CE, Teloken C, Moraes JF. Efficacy of oral sildenafil in hemodialysis patients with erectile dysfunction. J Am Soc Nephrol 2002; 13: Bancroft J. The endocrinology of sexual arousal. J Endocrinol 2005; 186:
Sexual dysfunction of chronic kidney disease. Razieh salehian.md psychiatrist
Sexual dysfunction of chronic kidney disease Razieh salehian.md psychiatrist Disturbances in sexual function are a common feature of chronic renal failure. Sexual dysfunction is inversely associated with
More informationHypogonadism and testosterone replacement therapy in end-stage renal disease (ESRD) and transplant patients
Review Article Hypogonadism and testosterone replacement therapy in end-stage renal disease (ESRD) and transplant patients Grace Snyder, Daniel A. Shoskes Departments of Nephrology and Urology, Glickman
More information/04/ /0 Reprinted from Vol. 172, , August 2004 THE JOURNAL OF UROLOGY
0022-5347/04/1722-0658/0 Reprinted from Vol. 172, 658 663, August 2004 THE JOURNAL OF UROLOGY Printed in U.S.A. Copyright 2004 by AMERICAN UROLOGICAL ASSOCIATION DOI: 10.1097/01.ju.0000132389.97804.d7
More informationERECTILE DYSFUNCTION (ED) is the persistent
Transplantation Treatment of Erectile Dysfunction With Sildenafil Citrate in Renal Allograft Recipients: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial Raj K. Sharma, FASN, Narayan Prasad,
More informationSexual dysfunction in chronic renal failure
QUALITY OF LIFE JNEPHROL 2008; 21 (suppl 13): S113-S117 www.sin-italy.org/jnonline www.jnephrol.com Sexual dysfunction in chronic renal failure Guido Bellinghieri, Domenico Santoro, Agostino Mallamace,
More informationSponsored by. Schering. Sidney Glina
Sponsored by Schering Sidney Glina Testosterone and erectile dysfunction Sidney Glina Keywords Androgen Hormone replacement therapy Hypogonadism Impotence Testosterone Abstract The role of testosterone
More informationTHE RELEVANCE OF TESTOSTERONE THERAPY IN MANAGING PATIENTS WITH ERECTILE DYSFUNCTION
THE RELEVANCE OF TESTOSTERONE THERAPY IN MANAGING PATIENTS WITH ERECTILE DYSFUNCTION Aksam A. Yassin MD PhD EdD FEBU Professor of Urology & Human Sexuality Institute of Urology & Andrology, Segeberger
More informationTestosterone and PDE5 inhibitors in the aging male
Testosterone and PDE5 inhibitors in the aging male Francesco Romanelli Department of Experimental Medicine Medical Pathophysiology, Food Science and Endocrinology Section Sapienza University of Rome 3005
More informationAssessment of Erectile and Ejaculatory Function after Penile Prosthesis Implantation
www.kjurology.org DOI:.4/kju.2.5.3.22 Sexual Dysfunction/Infertility Assessment of Erectile and Ejaculatory Function after Penile Prosthesis Implantation Jang Ho Bae, Phil Hyun Song, Hyun Tae Kim, Ki Hak
More information6/14/2010. GnRH=Gonadotropin-Releasing Hormone.
Male Androgen Replacement Mitchell Sorsby, MD June 19, 2010. QUESTION # 1 Which of the following is not a symptom associated with low T levels? a) decreased libido b) erectile dysfunction c) depression
More informationSexual Dysfunction. Jae Il Kang, Byeong Kuk Ham, Mi Mi Oh, Je Jong Kim, Du Geon Moon. DOI: /kju
www.kjurology.org DOI:10.4111/kju.2011.52.6.416 Sexual Dysfunction Correlation between Serum Total Testosterone and the AMS and IIEF Questionnaires in Patients with Erectile Dysfunction with Testosterone
More informationHypogonadism 4/27/2018. Male Hypogonadism -- Definition. Epidemiology. Objectives HYPOGONADISM. Men with Hypogonadism. 95% untreated.
Male Hypogonadism -- Definition - Low T, Low Testosterone Hypogonadism -...a clinical syndrome that results from failure of the testes to produce physiological concentrations of testosterone due to pathology
More informationManaging Testosterone Deficiency: A Practical Guide. John Grantmyre MD Professor of Urology Dalhousie University
Managing Testosterone Deficiency: A Practical Guide John Grantmyre MD Professor of Urology Dalhousie University 1 2 Case Study #1 A 59-Year-Old Man with Erectile Dysfunction 3 Case History Robert is a
More informationErectile Dysfunction in Patients with Chronic Renal Failure
Clinical Urology Erectile Dysfunction in Patients with Chronic Renal Failure International Braz J Urol Vol. 33 (5): 673-678, September - October, 2007 Erectile Dysfunction in Patients with Chronic Renal
More informationTestosterone therapy in erectile dysfunction
The Aging Male 2004;7:312 318 Testosterone therapy in erectile dysfunction R. Department of Urology, Columbia University, New York, USA Key words: TESTOSTERONE, TESTOGEL 1, ERECTILE DYSFUNCTION, HYPOGONADISM,
More information/02/ /0 Vol. 168, , October 2002 THE JOURNAL OF UROLOGY
0022-5347/02/1684-1332/0 Vol. 168, 1332 1336, October 2002 THE JOURNAL OF UROLOGY Printed in U.S.A. Copyright 2002 by AMERICAN UROLOGICAL ASSOCIATION, INC. DOI: 10.1097/01.ju.0000028041.27703.da Original
More informationIC351 (tadalafil, Cialis): update on clinical experience
(2002) 14, Suppl 1, S57 S64 ß 2002 Nature Publishing Group All rights reserved 0955-9930/02 $25.00 www.nature.com/ijir IC351 (tadalafil, Cialis): update on clinical experience 1 * 1 Urological practice,
More informationInitial experience with linear focused shockwave treatment for erectile dysfunction: a 6-month follow-up pilot study
International Journal of Impotence Research (2014), 1 5 2014 Macmillan Publishers Limited All rights reserved 0955-9930/14 www.nature.com/ijir ORIGINAL ARTICLE Initial experience with linear focused shockwave
More informationIntroduction. Kanazawa, Ishikawa, Japan; 2 Ofuna Chuo Hospital, Ofuna, Kanagawa, Japan and 3 IUHW Hospital, Nasushiobara, Tochigi, Japan
(2009) 21, 207 212 & 2009 Nature Publishing Group All rights reserved 0955-9930/09 $32.00 www.nature.com/ijir ORIGINAL ARTICLE to male sexual dysfunction as measured by the International Index of Erectile
More informationGUIDELINES ON. Introduction. G.R. Dohle, S. Arver, C. Bettocchi, S. Kliesch, M. Punab, W. de Ronde
GUIDELINES ON Male Hypogonadism G.R. Dohle, S. Arver,. Bettocchi, S. Kliesch, M. Punab, W. de Ronde Introduction Male hypogonadism is a clinical syndrome caused by androgen deficiency. It may adversely
More informationCorporate Medical Policy Testosterone Pellet Implantation for Androgen Deficiency
Corporate Medical Policy Testosterone Pellet Implantation for Androgen Deficiency File Name: Origination: Last CAP Review: Next CAP Review: Last Review: testosterone_pellet_implantation_for_androgen_deficiency
More informationThe use of the simplified International Index of Erectile Function (IIEF-5) as a diagnostic tool to study the prevalence of erectile dysfunction
(2002) 14, 245 250 ß 2002 Nature Publishing Group All rights reserved 0955-9930/02 $25.00 www.nature.com/ijir The use of the simplified International Index of Erectile Function (IIEF-5) as a diagnostic
More informationSevere erectile dysfunction is a marker for hyperprolactinemia
(2001) 13, 176±182 ß 2001 Nature Publishing Group All rights reserved 0955-9930/01 $15.00 www.nature.com/ijir Severe erectile dysfunction is a marker for hyperprolactinemia AM Johri 1, JPW Heaton 1 * and
More informationTESTOSTERONE REPLACEMENT THERAPY. WHAT IS THE REAL RISK? WHAT TO DO IN PROSTATE CANCER?
TESTOSTERONE REPLACEMENT THERAPY. WHAT IS THE REAL RISK? WHAT TO DO IN PROSTATE CANCER? TESTOSTERONE REPLACEMENT THERAPY (TRT) Nuno Tomada, MD, PhD Department of Urology of Hospital S. João Faculty of
More informationHYPOGONADISM DEFINITION: PRODUCTION OF SEX HORMONES AND GERM CELLS IS INADEQUATE (ENDOCRINE SOCIETY)
HYPOGONADISM DEFINITION: PRODUCTION OF SEX HORMONES AND GERM CELLS IS INADEQUATE (ENDOCRINE SOCIETY) DEFECT OF THE REPRODUCTIVE SYSTEM THAT RESULTS IN LACK OF FUNCTION OF THE GONADS (Wikipedia) REDUCTION
More informationThe Role of Testosterone in the Sexual Function. Luiz Otavio Torres President Elect of ISSM Belo Horizonte - Brazil
The Role of Testosterone in the Sexual Function Luiz Otavio Torres President Elect of ISSM Belo Horizonte - Brazil Hormones and Sexual Function Paraventricular Nucleus Stimuli visual Sexual Desire Melatonine
More informationAdministration of Testosterone and its Rationale in the Treatment of Erectile Dysfunction
ORIGINAL ARTICLE Administration of Testosterone and its Rationale in the Treatment of Erectile Dysfunction *CATM Mowladad 1, HM Rafiqul 2, A Bakhtiar 3, KM Rahman 4, R Shofiqur 5 *1 Prof. Chowdhury ATM
More informationREVIEW The relationship between hypogonadism and erectile dysfunction
(2008) 20, 231 235 & 2008 Nature Publishing Group All rights reserved 0955-9930/08 $30.00 www.nature.com/ijir REVIEW The relationship between hypogonadism and erectile dysfunction TIS Hwang 1,2,3 and Y-C
More informationThe Centre for Men s Health
96 Harley Street (London) and Manchester All Enquiries - +44 (0)20 7486 2277 www.centreformenshealth.co.uk/ This leaflet provides information about: The Centre for Men s Health The conditions we treat:
More informationLow Energy Shockwaves for the Treatment of Erectile Dysfunction Y. Vardi, B. Appel, I Gruenwald
Low Energy Shockwaves for the Treatment of Erectile Dysfunction Y. Vardi, B. Appel, I Gruenwald Neuro-Urology Unit, Rambam Medical Center & the Technion Faculty of Medicine Haifa, Israel 3 crucial questions
More informationEfficacy and Safety of Linear Focused Shockwaves for Erectile Dysfunction (RENOVA) A Second Generation Technology
Efficacy and Safety of Linear Focused Shockwaves for Erectile Dysfunction (RENOVA) A Second Generation Technology Y. Reisman, MD, PhD. 1, A. Hind, MD. 2, A. Varaneckas, MD. 3, I. Motil, MD. 4 1 Men's Health
More informationDaily vs. on-demand PDE-5 inhibitors for management of erectile dysfunction following treatment for prostate cancer
Daily vs. on-demand PDE-5 inhibitors for management of erectile dysfunction following treatment for prostate cancer Lead author: Nancy Kane Regional Drug & Therapeutics Centre (Newcastle) February 2018
More informationDiagnosis and Clinical Evaluation of Hypogonadism in Adult Patients with Obesity and Diabetes
Diagnosis and Clinical Evaluation of Hypogonadism in Adult Patients with Obesity and Diabetes Adrian Dobs, M.D., M.H.S. Professor of Medicine and Oncology The Johns Hopkins University School of Medicine
More informationLONG-TERM POTENCY AFTER IODINE-125 RADIOTHERAPY FOR PROSTATE CANCER AND ROLE OF SILDENAFIL CITRATE
ADULT UROLOGY CME ARTICLE LONG-TERM POTENCY AFTER IODINE-125 RADIOTHERAPY FOR PROSTATE CANCER AND ROLE OF SILDENAFIL CITRATE RUPESH RAINA, ASHOK AGARWAL, KUSH K. GOYAL, CHERYL JACKSON, JAMES ULCHAKER,
More informationA dro r gen e R e R p e lac a e c m e e m n e t t T her e a r p a y Androgen Replacement Therapy in the Aging O j b ecti t ve v s Male
Androgen Replacement Therapy in the Aging Male Thomas J. Walsh, MD, MS Department of Urology University of California, San Francisco Objectives 1. List 3 effects of androgens on normal male physiology.
More informationDiagnosis and management of sexual dysfunction. Dr Chris Simpson Consultant Psychiatrist
Diagnosis and management of sexual dysfunction Dr Chris Simpson Consultant Psychiatrist What are we talking about? Male Erectile dysfunction Premature ejaculation Delayed ejaculation Sexual aversion Paraphilia
More informationAndroderm patch, AndroGel packets and pump, Axiron solution, First- Testosterone, First-Testosterone MC, Fortesta gel, Testim gel, Vogelxo
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.30.31 Subject: Testosterone Topical Page: 1 of 9 Last Review Date: September 23, 2016 Testosterone topical
More informationTestosterone Treatment: Myths Vs Reality. Fadi Al-Khayer, M.D, F.A.C.E
Testosterone Treatment: Myths Vs Reality Fadi Al-Khayer, M.D, F.A.C.E The Biological Functions of Testosterone in Men Testosterone is essential to the musculoskeletal and metabolic systems throughout a
More informationWhat Is the Low T Syndrome? Is Testosterone Supplementation Safe?
What Is the Low T Syndrome? Is Testosterone Supplementation Safe? UCSF Osher Mini Medical School March 7, 2018 Dolores Shoback, MD Staff Physician SF-VAMC Professor of Medicine, UCSF No disclosures or
More informationTestosterone Therapy in Men with Hypogonadism
Testosterone Therapy in Men with Hypogonadism (Endocrine Society 2018 Guideline) Ngwe Yin, MD Assistant Clinical Professor of Medicine, UCSF Fresno Medical Education Program Disclosures None Objective
More informationLONG-TERM EFFECT OF SILDENAFIL CITRATE ON ERECTILE DYSFUNCTION AFTER RADICAL PROSTATECTOMY: 3-YEAR FOLLOW-UP
ADULT UROLOGY LONG-TERM EFFECT OF SILDENAFIL CITRATE ON ERECTILE DYSFUNCTION AFTER RADICAL PROSTATECTOMY: 3-YEAR FOLLOW-UP RUPESH RAINA, MILTON M. LAKIN, ASHOK AGARWAL, RAKESH SHARMA, KUSH K. GOYAL, DROGO
More informationISSM QUICK REFERENCE GUIDE ON TESTOSTERONE DEFICIENCY FOR MEN
International Society for Sexual Medicine - www.issm.info ISSM QUICK REFERENCE GUIDE ON TESTOSTERONE DEFICIENCY FOR MEN Version: September 2015 What is testosterone deficiency? Testosterone deficiency
More informationIndex. urologic.theclinics.com. Note: Page numbers of article titles are in boldface type.
Note: Page numbers of article titles are in boldface type. A Acquired hypogonadism, prevalence of, 165 167 primary, 165 secondary, 167 Adipose tissue, as an organ, 240 241 Adrenal hyperplasia, congenital,
More informationA Proposed Study of Hyperbaric Oxygen Therapy Following Radical Prostatectomy: Effects on Erectile Dysfunction
A Proposed Study of Hyperbaric Oxygen Therapy Following Radical Prostatectomy: Effects on Erectile Dysfunction Anthony J. Bella MD, FRCSC Division of Urology, Department of Surgery and Department of Neuroscience
More informationMALE SEXUAL DYSFUNCTION. Urology Division, Surgery Department Medical Faculty, University of Sumatera Utara
MALE SEXUAL DYSFUNCTION Urology Division, Surgery Department Medical Faculty, University of Sumatera Utara DEFINITION The inability to achieve a satisfactory sexual relationship May involve : - inadequacy
More informationSexual dysfunction in men with diabetes
Article Sexual dysfunction in men with diabetes Lesley Mills Citation: Mills L (2015) Sexual dysfunction in men with diabetes. Journal of Diabetes Nursing 19: 332 8 Article points 1. Sexual dysfunction
More informationMen Getting Older Will Testosterone Keep Him Young?
Men Getting Older Will Testosterone Keep Him Young? Alvin M. Matsumoto, M.D. Associate Director, GRECC V.A. Puget Sound Health Care System Professor, Department of Medicine Division of Gerontology and
More informationTadalafil: a novel treatment for erectile dysfunction
European Heart Journal Supplements (22) 4 (Supplement H), H24 H31 Tadalafil: a novel treatment for erectile dysfunction F. Giuliano 1 and L. Varanese 2 1 Department of Urology, AP-HP, Centre Hospitalier
More informationEffects of testosterone on erectile function: implications for the therapy of erectile dysfunction
Mini Reviews SAAD et al. Effects of testosterone on erectile function: implications for the therapy of erectile dysfunction Farid Saad, Anca S. Grahl 1, Antonio Aversa 2, Aksam A. Yassin 3,4, Atez Kadioglu
More informationEndocrine Update Mary T. Korytkowski MD Division of Endocrinology University of Pittsburgh
Endocrine Update 2016 Mary T. Korytkowski MD Division of Endocrinology University of Pittsburgh Disclosure of Financial Relationships Mary Korytkowski MD Honoraria British Medical Journal Diabetes Research
More information/03/ /0 Vol. 170, , July 2003 THE JOURNAL OF UROLOGY. Printed in U.S.A. Copyright 2003 by AMERICAN UROLOGICAL ASSOCIATION
0022-5347/03/1701-0159/0 Vol. 170, 159 163, July 2003 THE JOURNAL OF UROLOGY Printed in U.S.A. Copyright 2003 by AMERICAN UROLOGICAL ASSOCIATION DOI: 10.1097/01.ju.0000072524.82345.6d COMPARISON OF SATISFACTION
More informationOver the past decade, androgen replacement
J. Andrew Hoover, MD; Jeffrey T. Kirchner, DO, FAAFP Department of Family and Community Medicine, Lancaster General Hospital, Pa jhoover4@lghealth.org The authors reported no potential conflict of interest
More informationGUIDELINES ON MALE HYPOGONADISM
GUIDELINES ON MALE HYPOGONADISM (Text update March 2015) G.R. Dohle (Chair), S. Arver, C. Bettocchi, T.H. Jones, S. Kliesch, M. Punab Introduction Male hypogonadism is a clinical syndrome caused by androgen
More informationEAU GUIDELINES ON MALE HYPOGONADISM
EAU GUIDELINES ON MALE HYPOGONADISM (Limited text update March 2017) G.R. Dohle (Chair), S. Arver, C. Bettocchi, T.H. Jones, S. Kliesch Introduction Male hypogonadism is a clinical syndrome caused by androgen
More informationPoint-Counterpoint: Late Onset Hypogonadism (LOH)
Point-Counterpoint: Late Onset Hypogonadism (LOH) We are Under-diagnosing and Treating Men with LOH LOH is a Non-existent Disease ~ Robert E. Donohue, MD Late Onset Hypogonadism LOH: underdx. & undertx
More informationThe clinical importance of testosterone in men with type 2 diabetes
22 The clinical importance of testosterone in men with type 2 diabetes GEOFF HACKETT Although the association of low testosterone with type 2 diabetes is well established, testosterone levels are not routinely
More informationTestosterone Therapy in Men An update
Testosterone Therapy in Men An update SANDEEP DHINDSA Associate Professor of Medicine Director, Division of Endocrinology and Metabolism, Saint Louis University, St. Louis, MO Presenter Disclosure None
More informationGP guide to testosterone replacement therapy in men
GP guide to testosterone replacement therapy in men SPL Mike Kirby FRCP Professor Mike Kirby describes how the diagnosis and treatment of test - osterone deficiency in primary care can lead to improved
More informationTestim 1 Gel: Review of Clinical Data
European Urology Supplements European Urology Supplements 4 (2005) 24 30 Testim 1 Gel: Review of Clinical Data Tom A. McNicholas* Department of Urology, Lister Hospital, Corey s Mill Lane, Stevenage, Hertfordshire
More informationAssociated factors and prevalence of erectile dysfunction in hemodialysis patients
ORIGINAL ARTICLE Vol. 40 (1): 44-55, January - February, 2014 doi: 10.1590/S1677-5538.IBJU.2014.01.07 Associated factors and prevalence of erectile dysfunction in hemodialysis patients Márcio Rodrigues
More informationERECTILE DYSFUNCTION DIAGNOSIS
ERECTILE DYSFUNCTION DIAGNOSIS Head of Andrology and Sexual Medicine Dep.of Urology and Nefrology Hospital Virgen del Rocío ANDROMEDI. Sexual Medicine SEVILLA. SPAIN General Secretary ESSM Natalio Cruz
More informationTestosterone levels in men with erectile dysfunction
Original Article TESTOSTERONE LEVELS IN MEN WITH ED MARTÍNEZ-JABALOYAS et al. Testosterone levels in men with erectile dysfunction JOSÉ M. MARTÍNEZ-JABALOYAS, ALFONSO QUEIPO-ZARAGOZÁ*, FRANCISCO PASTOR-HERNÁNDEZ,
More informationCorporate Medical Policy
Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: erectile_dysfunction 01/01/2019 n/a 01/01/2020 01/01/2019 Policy Effective April 1, 2019 Description of Procedure
More informationMANAGEMENT UPDATE , LLC MedReviews
MANAGEMENT UPDATE 2013 MedReviews, LLC rostate cancer is the most common cancer in men over the age of 50 years. 1 When patients undergo a radical prostatectomy (RP), there is a risk of postoperative erectile
More informationBIOCHEMICAL TESTS FOR THE INVESTIGATION OF COMMON ENDOCRINE PROBLEMS IN THE MALE
Authoriser: Moya O Doherty Page 1 of 7 BIOCHEMICAL TESTS FOR THE INVESTIGATION OF COMMON ENDOCRINE PROBLEMS IN THE MALE The purpose of this protocol is to describe common tests used for the investigation
More informationEAU GUIDELINES ON MALE HYPOGONADISM
EAU GUIDELINES ON MALE HYPOGONADISM (Text update March 2015) G.R. Dohle (Chair), S. Arver, C. Bettocchi, T.H. Jones, S. Kliesch, M. Punab Introduction Male hypogonadism is a clinical syndrome caused by
More informationEvaluation and Treatment of Primary Androgen Deficiency Syndrome in Male Patients
Evaluation and Treatment of Primary Androgen Deficiency Syndrome in Male Patients Jeff Unger, MD Director Chino Medical Group Diabetes and Headache Intervention Center Chino, California January 16, 2008
More informationCurrent Data and Considerations Novel Testosterone Formulations
Current Data and Considerations Novel Testosterone Formulations 1 Hypogonadism: Treatment Safety and Prostate Health 2 Monitoring for Testosterone Therapy DRE 1,2 PSA Parameter Voiding/IPSS 1,2 Hemoglobin
More informationORIGINAL ARTICLE Post-marketing surveillance study of the efficacy and safety of vardenafil among patients with erectile dysfunction in primary care
(2007) 19, 393 397 & 2007 Nature Publishing Group All rights reserved 0955-9930/07 $30.00 www.nature.com/ijir ORIGINAL ARTICLE Post-marketing surveillance study of the efficacy and safety of vardenafil
More informationErectile Dysfunction: A Primer for Primary Care Providers
Erectile Dysfunction: A Primer for Primary Care Providers Jeanne Martin, DNP, ANP-BC Objectives 1. Understand the definition, incidence and prevalence of Erectile Dysfunction in the U.S. 2. Understand
More informationMale Hypogonadism. Types and causes of hypogonadism. What is male hypogonadism? Symptoms. Testosterone production. Patient Information.
Patient Information English 31 Male Hypogonadism The underlined terms are listed in the glossary. What is male hypogonadism? Male hypogonadism means the testicles do not produce enough of the male sex
More informationRole of High-sensitivity C-reactive Protein as a Marker of Inflammation in Pre-dialysis Patients of Chronic Renal Failure
ORIGINAL ARTICLE JIACM 2009; 10(1 & 2): 18-22 Abstract Role of High-sensitivity C-reactive Protein as a Marker of Inflammation in Pre-dialysis Patients of Chronic Renal Failure N Nand*, HK Aggarwal**,
More informationA USER S GUIDE WHAT EVERY MAN NEEDS TO KNOW
A USER S GUIDE WHAT EVERY MAN NEEDS TO KNOW 1. Why men need to know more Good health is vital for a happy and full life. But, with work and family responsibilities, men often overlook their own health
More informationThe efficacy and safety of tadalafil: an update
Original Article C.C. CARSON et al. The efficacy and safety of tadalafil: an update C.C. CARSON, J. RAJFER, I. EARDLEY, S. CARRIER, J.S. DENNE, D.J. WALKER, W. SHEN and W.H. CORDELL Department of Surgery,
More informationErectile dysfunction
Erectile dysfunction Good Erectile Function Having good Erections => crucial for all men Because erections & the coitus they allow major pleasure brings self-confidence confirms his state of being a full
More informationCombining Testosterone and PDE5 Inhibitors in Erectile Dysfunction: Basic Rationale and Clinical Evidences
european urology 50 (2006) 940 947 available at www.sciencedirect.com journal homepage: www.europeanurology.com Review Sexual Medicine Combining Testosterone and PDE5 Inhibitors in Erectile Dysfunction:
More informationReview Article Penile Rehabilitation Therapy with PDE-V Inhibitors Following Radical Prostatectomy: Proceed with Caution
Advances in Urology Volume 2009, Article ID 852437, 4 pages doi:10.1155/2009/852437 Review Article Penile Rehabilitation Therapy with PDE-V Inhibitors Following Radical Prostatectomy: Proceed with Caution
More informationMinimal Clinically Important Differences in the Erectile Function Domain of the International Index of Erectile Function Scale
EUROPEAN UROLOGY 60 (2011) 1010 1016 available at www.sciencedirect.com journal homepage: www.europeanurology.com Platinum Priority Sexual Medicine Editorial by Andrea Salonia on pp. 1017 1019 of this
More informationProstate Biopsy Protocol in Active Surveillance for Prostate Cancer Causes ED. Con Man: Andrew McCullough May
Prostate Biopsy Protocol in Active Surveillance for Prostate Cancer Causes ED Con Man: Andrew McCullough May 12 2017 It may be particularly useful as an initial screening instrument in a general practice
More informationASSESSMENT OF SEXUAL FUNCTION IN PATIENTS UNDERGOING VASECTOMY USING THE INTERNATIONAL INDEX OF ERECTILE FUNCTION
Clinical Urology International Braz J Urol Official Journal of the Brazilian Society of Urology POST-VASECTOMY SEXUAL FUNCTION Vol. 31 (5): 452-458, September - October, 2005 ASSESSMENT OF SEXUAL FUNCTION
More informationPREVALENCE OF PROSTATE CANCER AMONG HYPOGONADAL MEN WITH PROSTATE-SPECIFIC ANTIGEN LEVELS OF 4.0 ng/ml OR LESS
ADULT UROLOGY PREVALENCE OF PROSTATE CANCER AMONG HYPOGONADAL MEN WITH PROSTATE-SPECIFIC ANTIGEN LEVELS OF 4.0 ng/ml OR LESS ABRAHAM MORGENTALER AND ERNANI LUIS RHODEN ABSTRACT Objectives. To determine
More informationfor ED and LUTS/BPH Pierre Sarkis, M.D. Assistant Professor Fellow of the European Board of Urology
Tadalafil 5 mg once daily for ED and LUTS/BPH Pierre Sarkis, M.D. Assistant Professor Fellow of the European Board of Urology Why this conference? Not promotional but educational The pharmacist regularly
More informationavanafil 50mg, 100mg, 200mg tablets (Spedra ) SMC No. (980/14) A. Menarini Farmaceutica Internazionale SRL.
avanafil 50mg, 100mg, 200mg tablets (Spedra ) SMC No. (980/14) A. Menarini Farmaceutica Internazionale SRL. 07 August 2015 The Scottish Medicines Consortium (SMC) has completed its assessment of the above
More informationAlternative management of hypogonadism Tamoxifen. Emmanuele A. Jannini, MD Tor Vergata University of Rome ITALY
Alternative management of hypogonadism Tamoxifen Emmanuele A. Jannini, MD Tor Vergata University of Rome ITALY eajannini@gmail.com What hypogonadism is? What hypogonadism is? It is an empty glass The two
More informationCanadian Undergraduate Urology Curriculum (CanUUC): Erectile Dysfunction
Canadian Undergraduate Urology Curriculum (CanUUC): Erectile Dysfunction Last reviewed July 2014 Objectives 1. Define erectile dysfunction 2. List and classify the risk factors for erectile dysfunction
More informationImprovement in Pittsburgh Symptom Score Index After Initiation of Peritoneal Dialysis
Advances in Peritoneal Dialysis, Vol. 24, 2008 Matthew J. Novak, 1 Heena Sheth, 2 Filitsa H. Bender, 1 Linda Fried, 1,3 Beth Piraino 1 Improvement in Pittsburgh Symptom Score Index After Initiation of
More informationHypogonadism and Sexual Dysfunction in Male Cancer Survivors Receiving Chronic Opioid Therapy
Vol. 26 No. 5 November 2003 Journal of Pain and Symptom Management 1055 Clinical Note Hypogonadism and Sexual Dysfunction in Male Cancer Survivors Receiving Chronic Opioid Therapy Arun Rajagopal, MD, Rena
More informationRecognizing and Managing Testosterone Deficiency
Recognizing and Managing Testosterone Deficiency J. Bruce Redmon, M.D. Professor Division of Endocrinology Departments of Medicine and Urologic Surgery Disclosure Information I have no financial relationships
More informationLate onset hypogonadism
Late onset hypogonadism Farrukh Javid Male Menopause Clinical AND biochemical syndrome Testosterone levels decline by 0.4-3% per year after the age of 30, as opposed to the more rapid decline that occurs
More informationTreatment Strategy for Non-Responders to PDE5 Inhibitors
pissn: 2287-4208 / eissn: 2287-4690 World J Mens Health 2013 April 31(1): 31-35 http://dx.doi.org/10.5534/wjmh.2013.31.1.31 Review Article Treatment Strategy for Non-Responders to PDE5 Inhibitors Nam Cheol
More informationThe New England Journal of Medicine
The New England Journal of Medicine Copyright, 199, by the Massachusetts Medical Society VOLUME 33 M AY 14, 199 NUMBER ORAL IN THE TREATMENT OF ERECTILE DYSFUNCTION IRWIN GOLDSTEIN, M.D., TOM F. LUE, M.D.,
More informationTestosterone Replacement in Adults. John A. Seibel, MD, FACP, MACE
Testosterone Replacement in Adults John A. Seibel, MD, FACP, MACE Disclosures None! *Privately Authenticated Definition of Male Hypogonadism inadequate gonadal function, as manifested by deficiencies in
More informationPenile Implant Should be Offered Early
Penile Implant Should be Offered Early Landon Trost, MD Assistant Professor in Urology Mayo Clinic, Rochester, MN SMSNA AUA May 16 th, 2015 2013 MFMER slide-1 Clear Indications for Penile Implants Men
More informationChapter 15 ENDOCRINE AND METABOLIC IMPAIRMENT
Chapter 15 ENDOCRINE AND METABOLIC IMPAIRMENT Introduction This chapter provides criteria used to rate permanent impairment resulting from endocrine disorders and disorders of metabolism. The endocrine
More informationAssessment of female sexual dysfunction: review of validated methods
FERTILITY AND STERILITY VOL. 77, NO. 4, SUPPL 4, APRIL 2002 Copyright 2002 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Assessment
More informationAndrogen deficiency. Dr Rakesh Iyer Staff Specialist in Endocrinology Calvary hospital
Androgen deficiency Dr Rakesh Iyer Staff Specialist in Endocrinology Calvary hospital Outline Pathological androgen deficiency - Background, causes, interpretation - Indications for treatment Androgen
More informationERECTION HARDNESS: A UNIFYING FACTOR FOR DEFINING RESPONSE IN THE TREATMENT OF ERECTILE DYSFUNCTION
ERECTION HARDNESS: A UNIFYING FACTOR FOR DEFINING RESPONSE IN THE TREATMENT OF ERECTILE DYSFUNCTION JOHN P. MULHALL, LAURENCE A. LEVINE, and KLAUS-PETER JÜNEMANN ABSTRACT The extensive sildenafil citrate
More informationErectile Dysfunction (ED) after Radiotherapy (RT) for Prostate Cancer. William M. Mendenhall, MD
Erectile Dysfunction (ED) after Radiotherapy (RT) for Prostate Cancer William M. Mendenhall, MD Meta-Analysis of Probability of Maintaining Erectile Function after Treatment of Localized Cancer Treatment
More information25 mg oestradiol implants--the dosage of first choice for subcutaneous oestrogen replacement therapy?
Research Subcutaneous estrogen replacement therapy. Jones SC. Journal of Reproductive Medicine March, 2004; 49(3):139-142. Department of Obstetrics and Gynecology, Keesler Medical Center, Keesler Air Force
More informationOral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction
(2000) 12, Suppl 1, S75±S80 ß 2000 Macmillan Publishers Ltd All rights reserved 0955-9930/00 $15.00 www.nature.com/ijir Oral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of
More information