Ophthalmology Drug Development Pipeline Review, 2016

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1 Ophthalmology Drug Development Pipeline Review, 2016

2 Ophthalmology Drug Development Pipeline Review, 2016 BioPortfolio has been marketing business and market research reports from selected publishers for over fifteen years. BioPortfolio offers a personal service to our customers with dedicated research managers who will work with you to source the best report for your needs. Based in the UK, BioPortfolio is well positioned to coordinate our customers' orders sourced from over 50 global report publishers. We are pleased to present details of this report to assist your buying decision and administrative process. You will find easy-to-use How To Buy information on the last page of this document. We look forward to being of service to you. If you have bulk and/or recurring requirements, please get in touch - we can liaise with publishers to obtain sample pages and negotiate discounts on your behalf. Phone: +44 (0) or reportstore@bioportfolio.com 2

3 Ophthalmology Drug Development Pipeline Review, 2016 Ophthalmology Drug Development Pipeline Review, 2016 Summary Ophthalmology disorders are associated with the eyes and visual system. If left untreated, serious long-term comorbidities such as diabetes, and particularly blindness, can arise. Although there are a number of treatments approved in ophthalmology, there are currently no curative therapies for any of these indications. In particular, there are strong unmet needs within age-related macular degeneration and glaucoma, which can lead to blindness if not adequately treated. Although there is a high degree of failure and uncertainty within the R&D of pharmaceuticals, there is a great deal of interest in ophthalmology development. Overall, there are over 700 products in active development in the ophthalmology therapy area, making it one of the largest therapy area pipelines. Although two thirds of products in development for ophthalmology disorders are at the Discovery or Preclinical stage of development, the number of drugs in the pipeline is very high, creating strong potential for a blockbuster drug to enter the market. The report provides comprehensive information on the pipeline development landscape for glaucoma, agerelated macular degeneration, diabetic retinopathy, diabetic macular edema and keratoconjunctivitis sicca (dry eye), from Discovery through to the Pre-Registration stage. This includes an analysis of products by stage of development, molecular target, mechanism of action (MoA), route of administration (RoA) and molecule type. A list of all products in development is provided, including dormant and discontinued projects. Finally, the report provides an overview of key players involved in the development of products in this area, and outlines recent updates and press releases in the field. Scope - Which companies are the most active within the pipeline for ophthalmology? - Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication? - To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies? - What are the most important R&D milestones and data publications to have occurred in ophthalmology? Reasons to buy - Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication. - Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline 3

4 program in each indication, and a comprehensive picture of recent updates and milestones for each. - Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these. - Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration. Additional Details Publisher : GBI Research Reference : Number of Pages : 633 Report Format : PDF Publisher Information : 4

5 Table Of Contents for Ophthalmology Drug Development Pipeline Review, Table of Contents1 Table of Contents 41.1 List of Tables 51.2 List of Figures 132 Introduction Ophthalmology Therapeutics Report Coverage 153 Therapeutics Development by Stage Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma 264 Therapeutics under Development by Companies Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma 505 Therapeutics under Investigation by Universities/Institutes Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma 586 Pipeline Products Glance Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma 727 Products under Development by Companies Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma 1028 Products under Investigation by Universities/Institutes Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma 1119 Companies Involved in Therapeutics Development Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma Therapeutics Assessment Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma Recent Pipeline Updates Age Related Macular Degeneration Diabetic Retinopathy Dormant Projects Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma Discontinued Products Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma Product Development Milestones Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema Keratoconjunctivitis sicca (Dry Eye) Glaucoma Appendix Research Methodology Secondary Research Contact Us Disclaimer 633 5

6 List Of Tables in Ophthalmology Drug Development Pipeline Review, List of Tables Table 1: Number of Products under Development for Age Related Macular Degeneration 18 Table 2: Number of Products under Development for Age Related Macular Degeneration Comparative Analysis 19 Table 3: Number of Products under Development for Diabetic Retinopathy 20 Table 4: Number of Products under Development for Diabetic Retinopathy Comparative Analysis 21 Table 5: Number of Products under Development for Diabetic Macular Edema 22 Table 6: Number of Products under Development for Diabetic Macular Edema Comparative Analysis 23 Table 7: Number of Products under Development for Keratoconjunctivitis sicca (Dry Eye) 24 Table 8: Number of Products under Development for Keratoconjunctivitis sicca (Dry Eye) Comparative Analysis 25 Table 9: Number of Products under Development for Glaucoma, H Table 10: Number of Products under Development for Glaucoma Comparative Analysis, H Table 11: Number of Products under Development by Companies 29 Table 12: Number of Products under Development by Companies (Contd..1) 30 Table 13: Number of Products under Development by Companies (Contd..2) 31 Table 14: Number of Products under Development by Companies (Contd..3) 32 Table 15: Number of Products under Development by Companies (Contd..4) 33 Table 16: Number of Products under Development by Companies (Contd..5) 34 Table 17: Number of Products under Development by Companies (Contd..6) 35 Table 18: Number of Products under Development by Companies (Contd..7) 36 Table 19: Number of Products under Development by Companies (Contd..8) 37 Table 20: Number of Products under Development by Companies (Contd..9) 38 Table 21: Number of Products under Development by Companies 39 Table 22: Number of Products under Development by Companies (Contd..1) 40 Table 23: Number of Products under Development by Companies (Contd..2) 41 Table 24: Number of Products under Development by Companies 43 Table 25: Number of Products under Development by Companies (Contd..1) 44 Table 26: Number of Products under Development by Companies (Contd..2) 45 6

7 Table 27: Number of Products under Development by Companies 47 Table 28: Number of Products under Development by Companies (Contd..1) 48 Table 29: Number of Products under Development by Companies (Contd..2) 49 Table 30: Number of Products under Development by Companies, H Table 31: Number of Products under Development by Companies, H (Contd..1) 52 Table 32: Number of Products under Development by Companies, H (Contd..2) 53 Table 33: Number of Products under Development by Companies, H (Contd..3) 54 Table 34: Number of Products under Development by Companies, H (Contd..4) 55 Table 35: Number of Products under Investigation by Universities/Institutes 56 Table 36: Number of Products under Investigation by Universities/Institutes 57 Table 37: Number of Products under Investigation by Universities/Institutes 57 Table 38: Number of Products under Investigation by Universities/Institutes 58 Table 39: Number of Products under Investigation by Universities/Institutes, H Table 40: Comparative Analysis by Late Stage Development 60 Table 41: Comparative Analysis by Clinical Stage Development 61 Table 42: Comparative Analysis by Early Stage Development 62 Table 43: Comparative Analysis by Unknown Stage Development 63 Table 44: Comparative Analysis by Clinical Stage Development 64 Table 45: Comparative Analysis by Early Stage Development 65 Table 46: Comparative Analysis by Unknown Stage Development 65 Table 47: Comparative Analysis by Late Stage Development 66 Table 48: Comparative Analysis by Clinical Stage Development 67 Table 49: Comparative Analysis by Early Stage Development 68 Table 50: Comparative Analysis by Unknown Stage Development 68 Table 51: Comparative Analysis by Late Stage Development 69 Table 52: Comparative Analysis by Clinical Stage Development 70 Table 53: Comparative Analysis by Early Stage Development 71 Table 54: Comparative Analysis by Unknown Stage Development 71 Table 55: Comparative Analysis by Late Stage Development, H Table 56: Comparative Analysis by Clinical Stage Development, H Table 57: Comparative Analysis by Early Stage Development, H

8 Table 58: Comparative Analysis by Unknown Stage Development, H Table 59: Products under Development by Companies 76 Table 60: Products under Development by Companies (Contd..1) 77 Table 61: Products under Development by Companies (Contd..2) 78 Table 62: Products under Development by Companies (Contd..3) 79 Table 63: Products under Development by Companies (Contd..4) 80 Table 64: Products under Development by Companies (Contd..5) 81 Table 65: Products under Development by Companies (Contd..6) 82 Table 66: Products under Development by Companies (Contd..7) 83 Table 67: Products under Development by Companies (Contd..8) 84 Table 68: Products under Development by Companies (Contd..9) 85 Table 69: Products under Development by Companies (Contd..10) 86 Table 70: Products under Development by Companies (Contd..11) 88 Table 71: Products under Development by Companies 90 Table 72: Products under Development by Companies (Contd..1) 91 Table 73: Products under Development by Companies (Contd..2) 92 Table 74: Products under Development by Companies (Contd..3) 93 Table 75: Products under Development by Companies 94 Table 76: Products under Development by Companies (Contd..1) 95 Table 77: Products under Development by Companies (Contd..2) 96 Table 78: Products under Development by Companies 98 Table 79: Products under Development by Companies (Contd..1) 99 Table 80: Products under Development by Companies (Contd..2) 100 Table 81: Products under Development by Companies (Contd..3) 101 Table 82: Products under Development by Companies, H Table 83: Products under Development by Companies, H (Contd..1) 103 Table 84: Products under Development by Companies, H (Contd..2) 104 Table 85: Products under Development by Companies, H (Contd..3) 105 Table 86: Products under Development by Companies, H (Contd..4) 106 Table 87: Products under Development by Companies, H (Contd..5) 107 Table 88: Products under Investigation by Universities/Institutes 108 8

9 Table 89: Products under Investigation by Universities/Institutes 109 Table 90: Products under Investigation by Universities/Institutes 110 Table 91: Products under Investigation by Universities/Institutes 110 Table 92: Products under Investigation by Universities/Institutes, H Table 93: Age Related Macular Degeneration Pipeline by AC Immune SA 112 Table 94: Age Related Macular Degeneration Pipeline by Achillion Pharmaceuticals, Inc. 112 Table 95: Age Related Macular Degeneration Pipeline by Aciont Inc. 113 Table 96: Age Related Macular Degeneration Pipeline by AdAlta Pty Ltd. 113 Table 97: Age Related Macular Degeneration Pipeline by Adverum Biotechnologies, Inc. 114 Table 98: Age Related Macular Degeneration Pipeline by Aerie Pharmaceuticals, Inc. 114 Table 99: Age Related Macular Degeneration Pipeline by Aerpio Therapeutics, Inc. 115 Table 100: Age Related Macular Degeneration Pipeline by Alimera Sciences, Inc. 115 Table 101: Age Related Macular Degeneration Pipeline by Alkeus Pharmaceuticals, Inc. 116 Table 102: Age Related Macular Degeneration Pipeline by Allergan Plc 116 Table 103: Age Related Macular Degeneration Pipeline by Allinky Biopharma 117 Table 104: Age Related Macular Degeneration Pipeline by Alteogen Inc. 117 Table 105: Age Related Macular Degeneration Pipeline by Amakem NV 118 Table 106: Age Related Macular Degeneration Pipeline by Amarna Therapeutics B.V. 118 Table 107: Age Related Macular Degeneration Pipeline by Ampio Pharmaceuticals, Inc. 119 Table 108: Age Related Macular Degeneration Pipeline by Amyndas Pharmaceuticals LLC 119 Table 109: Age Related Macular Degeneration Pipeline by Apellis Pharmaceuticals, Inc. 120 Table 110: Age Related Macular Degeneration Pipeline by Apexigen, Inc. 120 Table 111: Age Related Macular Degeneration Pipeline by Applied Genetic Technologies Corporation 121 Table 112: Age Related Macular Degeneration Pipeline by Astellas Pharma Inc. 121 Table 113: Age Related Macular Degeneration Pipeline by Benitec Biopharma Limited 122 Table 114: Age Related Macular Degeneration Pipeline by BIOCAD 122 Table 115: Age Related Macular Degeneration Pipeline by Biokine Therapeutics Ltd. 123 Table 116: Age Related Macular Degeneration Pipeline by BioMAS Ltd. 123 Table 117: Age Related Macular Degeneration Pipeline by Biomics Biotechnologies Co., Ltd. 124 Table 118: Age Related Macular Degeneration Pipeline by Biophytis SAS 124 Table 119: Age Related Macular Degeneration Pipeline by Boehringer Ingelheim GmbH 125 9

10 Table 120: Age Related Macular Degeneration Pipeline by Caladrius Biosciences, Inc. 125 Table 121: Age Related Macular Degeneration Pipeline by Catalyst Biosciences, Inc. 126 Table 122: Age Related Macular Degeneration Pipeline by Cell Cure Neurosciences, Ltd. 126 Table 123: Age Related Macular Degeneration Pipeline by Charlesson LLC. 127 Table 124: Age Related Macular Degeneration Pipeline by Cipla Ltd. 127 Table 125: Age Related Macular Degeneration Pipeline by Clanotech AB 128 Table 126: Age Related Macular Degeneration Pipeline by Clearside BioMedical, Inc. 128 Table 127: Age Related Macular Degeneration Pipeline by Clonz Biotech Private Limited 129 Table 128: Age Related Macular Degeneration Pipeline by Coherus BioSciences, Inc. 129 Table 129: Age Related Macular Degeneration Pipeline by Colby Pharmaceutical Company 130 Table 130: Age Related Macular Degeneration Pipeline by Crinetics Pharmaceuticals, Inc. 130 Table 131: Age Related Macular Degeneration Pipeline by Critical Pharmaceuticals Limited 131 Table 132: Age Related Macular Degeneration Pipeline by Daiichi Sankyo Company, Limited 131 Table 133: Age Related Macular Degeneration Pipeline by Delenex Therapeutics AG 132 Table 134: Age Related Macular Degeneration Pipeline by Diffusion Pharmaceuticals Inc. 132 Table 135: Age Related Macular Degeneration Pipeline by Digna Biotech, S.L. 133 Table 136: Age Related Macular Degeneration Pipeline by Eleven Biotherapeutics Inc. 133 Table 137: Age Related Macular Degeneration Pipeline by Elsalys Biotech SAS 134 Table 138: Age Related Macular Degeneration Pipeline by Exonate Limited 134 Table 139: Age Related Macular Degeneration Pipeline by F. Hoffmann-La Roche Ltd. 135 Table 140: Age Related Macular Degeneration Pipeline by Foamix Pharmaceuticals Ltd. 135 Table 141: Age Related Macular Degeneration Pipeline by Formycon AG 136 Table 142: Age Related Macular Degeneration Pipeline by Gene Techno Science Co., Ltd. 136 Table 143: Age Related Macular Degeneration Pipeline by Genentech, Inc. 137 Table 144: Age Related Macular Degeneration Pipeline by GenSight Biologics S.A. 137 Table 145: Age Related Macular Degeneration Pipeline by GlaxoSmithKline Plc 138 Table 146: Age Related Macular Degeneration Pipeline by Grupo Ferrer Internacional, S.A. 138 Table 147: Age Related Macular Degeneration Pipeline by GTx, Inc. 139 Table 148: Age Related Macular Degeneration Pipeline by HanAll Biopharma Co., Ltd. 139 Table 149: Age Related Macular Degeneration Pipeline by Huabo Biopharm Co., Ltd. 140 Table 150: Age Related Macular Degeneration Pipeline by ico Therapeutics Inc

11 Table 151: Age Related Macular Degeneration Pipeline by Icon Bioscience, Inc. 141 Table 152: Age Related Macular Degeneration Pipeline by Iconic Therapeutics, Inc. 141 Table 153: Age Related Macular Degeneration Pipeline by Innovent Biologics, Inc. 142 Table 154: Age Related Macular Degeneration Pipeline by Intellect Neurosciences, Inc. 142 Table 155: Age Related Macular Degeneration Pipeline by International Stem Cell Corporation 143 Table 156: Age Related Macular Degeneration Pipeline by Ionis Pharmaceuticals, Inc. 143 Table 157: Age Related Macular Degeneration Pipeline by Jeil Pharmaceutical Co., Ltd. 144 Table 158: Age Related Macular Degeneration Pipeline by Johnson & Johnson 145 Table 159: Age Related Macular Degeneration Pipeline by Kadmon Corporation, LLC 146 Table 160: Age Related Macular Degeneration Pipeline by Kala Pharmaceuticals, Inc. 146 Table 161: Age Related Macular Degeneration Pipeline by Kodiak Sciences, Inc. 147 Table 162: Age Related Macular Degeneration Pipeline by LeadArtis S.L. 147 Table 163: Age Related Macular Degeneration Pipeline by M's Science Corporation 148 Table 164: Age Related Macular Degeneration Pipeline by Mabion SA 148 Table 165: Age Related Macular Degeneration Pipeline by MacuCLEAR, Inc. 149 Table 166: Age Related Macular Degeneration Pipeline by Mitotech S.A. 149 Table 167: Age Related Macular Degeneration Pipeline by Mitsubishi Tanabe Pharma Corporation 150 Table 168: Age Related Macular Degeneration Pipeline by Navigen Pharmaceuticals, Inc. 150 Table 169: Age Related Macular Degeneration Pipeline by Navya Biologicals Pvt Ltd 151 Table 170: Age Related Macular Degeneration Pipeline by Neovacs SA 151 Table 171: Age Related Macular Degeneration Pipeline by Neumedicines Inc. 152 Table 172: Age Related Macular Degeneration Pipeline by Neuroptis Biotech 152 Table 173: Age Related Macular Degeneration Pipeline by Neurotech Pharmaceuticals, Inc. 153 Table 174: Age Related Macular Degeneration Pipeline by Novartis AG 153 Table 175: Age Related Macular Degeneration Pipeline by Ocular Therapeutix, Inc. 154 Table 176: Age Related Macular Degeneration Pipeline by Ohr Pharmaceutical Inc. 154 Table 177: Age Related Macular Degeneration Pipeline by Omeros Corporation 155 Table 178: Age Related Macular Degeneration Pipeline by Ophthotech Corp. 155 Table 179: Age Related Macular Degeneration Pipeline by Orphagen Pharmaceuticals, Inc. 156 Table 180: Age Related Macular Degeneration Pipeline by Oxford BioMedica Plc 156 Table 181: Age Related Macular Degeneration Pipeline by PanOptica, Inc

12 Table 182: Age Related Macular Degeneration Pipeline by Pfenex Inc. 157 Table 183: Age Related Macular Degeneration Pipeline by Pfizer Inc. 158 Table 184: Age Related Macular Degeneration Pipeline by Precision Ocular Ltd 158 Table 185: Age Related Macular Degeneration Pipeline by Promedior, Inc. 159 Table 186: Age Related Macular Degeneration Pipeline by psivida Corp. 159 Table 187: Age Related Macular Degeneration Pipeline by QLT Inc. 160 Table 188: Age Related Macular Degeneration Pipeline by Quark Pharmaceuticals, Inc. 160 Table 189: Age Related Macular Degeneration Pipeline by Ra Pharmaceuticals, Inc. 161 Table 190: Age Related Macular Degeneration Pipeline by Regeneron Pharmaceuticals, Inc. 161 Table 191: Age Related Macular Degeneration Pipeline by RegenxBio Inc. 162 Table 192: Age Related Macular Degeneration Pipeline by Ribomic Inc. 162 Table 193: Age Related Macular Degeneration Pipeline by RXi Pharmaceuticals Corporation 163 Table 194: Age Related Macular Degeneration Pipeline by SanBio, Inc. 163 Table 195: Age Related Macular Degeneration Pipeline by Santen Pharmaceutical Co., Ltd. 164 Table 196: Age Related Macular Degeneration Pipeline by Sanwa Kagaku Kenkyusho Co., Ltd. 165 Table 197: Age Related Macular Degeneration Pipeline by SciFluor Life Sciences, LLC 165 Table 198: Age Related Macular Degeneration Pipeline by Sirnaomics, Inc. 166 Table 199: Age Related Macular Degeneration Pipeline by Stealth BioTherapeutics Inc. 166 Table 200: Age Related Macular Degeneration Pipeline by Sucampo Pharmaceuticals, Inc. 167 Table 201: Age Related Macular Degeneration Pipeline by Sumitomo Dainippon Pharma Co., Ltd. 167 Table 202: Age Related Macular Degeneration Pipeline by Sun Pharma Advanced Research Company Ltd. 168 Table 203: Age Related Macular Degeneration Pipeline by TRACON Pharmaceuticals, Inc. 169 Table 204: Age Related Macular Degeneration Pipeline by TWi Pharmaceuticals, Inc. 170 Table 205: Age Related Macular Degeneration Pipeline by Tyrogenex, Inc. 170 Table 206: Age Related Macular Degeneration Pipeline by VasGene Therapeutics, Inc. 171 Table 207: Age Related Macular Degeneration Pipeline by Wellstat Ophthalmics Corporation 171 Table 208: Age Related Macular Degeneration Pipeline by Xbrane Biopharma AB 172 Table 209: Diabetic Retinopathy Pipeline by Acucela Inc. 173 Table 210: Diabetic Retinopathy Pipeline by Aerie Pharmaceuticals, Inc. 173 Table 211: Diabetic Retinopathy Pipeline by Aerpio Therapeutics, Inc. 174 Table 212: Diabetic Retinopathy Pipeline by Antisense Therapeutics Limited

13 Table 213: Diabetic Retinopathy Pipeline by BCN Peptides, S.A. 175 Table 214: Diabetic Retinopathy Pipeline by Biomar Microbial Technologies 175 Table 215: Diabetic Retinopathy Pipeline by Charlesson LLC. 176 Table 216: Diabetic Retinopathy Pipeline by Coherus BioSciences, Inc. 176 Table 217: Diabetic Retinopathy Pipeline by Crinetics Pharmaceuticals, Inc. 177 Table 218: Diabetic Retinopathy Pipeline by Diffusion Pharmaceuticals Inc. 177 Table 219: Diabetic Retinopathy Pipeline by Dimerix Bioscience Pty Ltd 178 Table 220: Diabetic Retinopathy Pipeline by Dynamis Therapeutics, Inc. 178 Table 221: Diabetic Retinopathy Pipeline by EyeGene, Inc. 179 Table 222: Diabetic Retinopathy Pipeline by Foresee Pharmaceuticals, LLC

14 List Of Figures, Charts and Diagrams in Ophthalmology Drug Development Pipeline Review, List of Figures Figure 1: Number of Products under Development for Age Related Macular Degeneration 18 Figure 2: Number of Products under Development for Age Related Macular Degeneration Comparative Analysis 19 Figure 3: Number of Products under Development for Diabetic Retinopathy 20 Figure 4: Number of Products under Development for Diabetic Retinopathy Comparative Analysis 21 Figure 5: Number of Products under Development for Diabetic Macular Edema 22 Figure 6: Number of Products under Development for Diabetic Macular Edema Comparative Analysis 23 Figure 7: Number of Products under Development for Keratoconjunctivitis sicca (Dry Eye) 24 Figure 8: Number of Products under Development for Keratoconjunctivitis sicca (Dry Eye) Comparative Analysis 25 Figure 9: Number of Products under Development for Glaucoma, H Figure 10: Number of Products under Development for Glaucoma Comparative Analysis, H Figure 11: Number of Products under Development by Companies 28 Figure 12: Number of Products under Development by Companies 39 Figure 13: Number of Products under Development by Companies 42 Figure 14: Number of Products under Development by Companies 46 Figure 15: Number of Products under Development by Companies, H Figure 16: Number of Products under Investigation by Universities/Institutes 56 Figure 17: Number of Products under Investigation by Universities/Institutes 57 Figure 18: Number of Products under Investigation by Universities/Institutes, H Figure 19: Comparative Analysis by Late Stage Development 60 Figure 20: Comparative Analysis by Clinical Stage Development 61 Figure 21: Comparative Analysis by Early Stage Products 62 Figure 22: Comparative Analysis by Clinical Stage Development 64 Figure 23: Comparative Analysis by Early Stage Products 65 Figure 24: Comparative Analysis by Late Stage Development 66 Figure 25: Comparative Analysis by Clinical Stage Development 67 Figure 26: Comparative Analysis by Early Stage Products 68 14

15 Figure 27: Comparative Analysis by Late Stage Development 69 Figure 28: Comparative Analysis by Clinical Stage Development 70 Figure 29: Comparative Analysis by Early Stage Products 71 Figure 30: Comparative Analysis by Late Stage Development, H Figure 31: Comparative Analysis by Clinical Stage Development, H Figure 32: Comparative Analysis by Early Stage Products, H Figure 33: Comparative Analysis by Unknown Stage Development, H Figure 34: Assessment by Monotherapy Products 290 Figure 35: Number of Products by Top 10 Targets 292 Figure 36: Number of Products by Stage and Top 10 Targets 292 Figure 37: Number of Products by Top 10 Mechanism of Actions 300 Figure 38: Number of Products by Stage and Top 10 Mechanism of Actions 300 Figure 39: Number of Products by Top 10 Routes of Administration 306 Figure 40: Number of Products by Stage and Top 10 Routes of Administration 306 Figure 41: Number of Products by Top 10 Molecule Types 308 Figure 42: Number of Products by Stage and Top 10 Molecule Types 308 Figure 43: Assessment by Monotherapy Products 310 Figure 44: Number of Products by Top 10 Targets 311 Figure 45: Number of Products by Stage and Top 10 Targets 311 Figure 46: Number of Products by Top 10 Mechanism of Actions 315 Figure 47: Number of Products by Stage and Top 10 Mechanism of Actions 315 Figure 48: Number of Products by Top 10 Routes of Administration 319 Figure 49: Number of Products by Stage and Top 10 Routes of Administration 319 Figure 50: Number of Products by Top 10 Molecule Types 321 Figure 51: Number of Products by Stage and Top 10 Molecule Types 321 Figure 52: Assessment by Monotherapy Products 322 Figure 53: Number of Products by Top 10 Targets 324 Figure 54: Number of Products by Stage and Top 10 Targets 324 Figure 55: Number of Products by Top 10 Mechanism of Actions 328 Figure 56: Number of Products by Stage and Top 10 Mechanism of Actions 328 Figure 57: Number of Products by Routes of Administration

16 Figure 58: Number of Products by Stage and Routes of Administration 331 Figure 59: Number of Products by Molecule Types 333 Figure 60: Number of Products by Stage and Molecule Types 333 Figure 61: Assessment by Monotherapy Products 335 Figure 62: Number of Products by Top 10 Targets 336 Figure 63: Number of Products by Stage and Top 10 Targets 336 Figure 64: Number of Products by Top 10 Mechanism of Actions 342 Figure 65: Number of Products by Stage and Top 10 Mechanism of Actions 342 Figure 66: Number of Products by Top 10 Routes of Administration 349 Figure 67: Number of Products by Stage and Top 10 Routes of Administration 349 Figure 68: Number of Products by Molecule Types 351 Figure 69: Number of Products by Stage and Molecule Types 351 Figure 70: Assessment by Monotherapy Products, H Figure 71: Assessment by Combination Products, H Figure 72: Number of Products by Top 10 Targets, H Figure 73: Number of Products by Stage and Top 10 Targets, H Figure 74: Number of Products by Top 10 Mechanism of Actions, H Figure 75: Number of Products by Stage and Top 10 Mechanism of Actions, H Figure 76: Number of Products by Top 10 Routes of Administration, H Figure 77: Number of Products by Stage and Top 10 Routes of Administration, H Figure 78: Number of Products by Top 10 Molecule Types, H Figure 79: Number of Products by Stage and Top 10 Molecule Types, H

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