BCH Graduate Survey of Biochemistry
|
|
- Drusilla Edwards
- 5 years ago
- Views:
Transcription
1 BCH 5045 Graduate Survey of Biochemistry Instructor: Charles Guy Producer: Ron Thomas Director: Marsha Durosier Lecture 44 Slide sets available at:
2 David L. Nelson and Michael M. Cox LEHNINGER PRINCIPLES OF BIOCHEMISTRY Fifth Edition CHAPTER 14 Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway 2008 W. H. Freeman and Company
3 Glycolysis has yielded 4 ATPs and 2 NADH, but 2 ATPs were invested, thus the net ATP gain is 2. Still only a fraction of the free energy in glucose has been captured in ATP and NADH produced by glycolysis. Note the different free energy changes depending on which phosphoanhydride bond is hydrolyzed.
4 The three phosphates of ATP have a degree of electostatic repulsion which when relieved by a hydrolysis event and given the resonance stabilization of the free phosphate group results in a release of significant amounts of free energy that can be used to couple with a range of reactions to make them thermodynamically favorable under physiological conditions.
5 At standard conditions, the free energy content of PEP, 1,3-bisphosphoglycerate, phosphocreatine and ATP (AMP to PPi) are listed in order of most to least. Keep in mind that under physiological conditions and concentrations, the free energy content would be different. Find out what energy charge is and how it is calculated.
6 Glucose flux through glycolysis is tightly regulated to maintain ATP levels and metabolic intermediates used by other pathways at as constant concentration as possible. Regulation of the pathway includes allosteric effectors of hexokinase, PFK, and pyruvate kinase. The pathway is also regulated by glucagon, epinephrine and insulin through changes in gene expression. Warburg was the first to show that tumors operate glycolysis at a much higher rate than the related normal tissue. The reduction of oxidative phosphorylation with increased rate of aerobic glycolysis is known as the Warburg effect.
7 A 2004 survey of public databases EST revealed that the genes of the glycolysis pathway were overexpressed in 24 cancers accounting for more than 70% of human cancer cases. Genes most overexpressed, encoded glyceraldehyde-3-phosphate dehydrogenase, enolase 1, and also pyruvate kinase. Cancers with overexpression of the majority of the glycolysis genes included lymph node, prostate, and brain cancer while those with only some overexpressed genes included cancers of the cartilage and bone marrow (Altenberg and Greulich, 2004). In general, cancer cells produce large amounts of lactate resulting from aerobic glycolysis, but its role in cancer remains controversial. Some argue that rapid cell proliferation requires aerobic glycolysis. Pyruvate produced by glycolysis is converted to lactate by lactate dehydrogenase. Most of this lactate and also alanine is excreted from the cell as waste, and one byproduct of their generation is a robust production of NADPH. Glutamine is a source of alanine and can be converted into lactate which produces NADPH via the activity of NADP + -specific malate dehydrogenase (malic enzyme). Altenberg and Greulich (2004) Genomics 84,
8 Fig. 3 Metabolic pathways active in proliferating cells are directly controlled by signaling pathways involving known oncogenes and tumor suppressor genes. This schematic shows our current understanding of how glycolysis, oxidative phosphorylation, the pentose phosphate pathway, and glutamine metabolism are interconnected in proliferating cells. This metabolic wiring allows for both NADPH production and acetyl-coa flux to the cytosol for lipid synthesis. Key steps in these metabolic pathways can be influenced by signaling pathways known to be important for cell proliferation. Activation of growth factor receptors leads to both tyrosine kinase signaling and PI3K activation. Via AKT, PI3K activation stimulates glucose uptake and flux through the early part of glycolysis. Tyrosine kinase signaling negatively regulates flux through the late steps of glycolysis, making glycolytic intermediates available for macromolecular synthesis as well as supporting NADPH production. Myc drives glutamine metabolism, which also supports NADPH production. LKB1/AMPK signaling and p53 decrease metabolic flux through glycolysis in response to cell stress. Decreased glycolytic flux in response to LKB/AMPK or p53 may be an adaptive response to shut off proliferative metabolism during periods of low energy availability or oxidative stress. Tumor suppressors are shown in red, and oncogenes are in green. Key metabolic pathways are labeled in purple with white boxes, and the enzymes controlling critical steps in these pathways are shown in blue. Some of these enzymes are candidates as novel therapeutic targets in cancer. Malic enzyme refers to NADP + -specific malate dehydrogenase [systematic name (S)-malate:NADP + oxidoreductase (oxaloacetate-decarboxylating)]. From: Vander Heiden, Cantley and Thompson (2009) Science. 324:
9 Detection of cancerous tissue is possible with positron emission tomography (PET). 18 F- Labeled 2-fluoro-2- deoxyglucose (FdG) is used to identify where glucose is actively metabolized at dark spots which indicate regions of high glucose utilization.
10
11 When aerobic respiration is reduced by low oxygen levels, cells with active glycolysis and energy needs can reduce the level of pyruvate and at the same time regenerate NAD + to insure glycolysis is not NAD + limited.
12
13 Seven of the ten reactions of glycolysis are physiologically reversible and three are not under physiological conditions. What controls which direction a reaction will go? What about reactions 1, 3 and 10, can they be reversed?
CHAPTER 16. Glycolysis
CHAPTER 16 Glycolysis Net reaction of Glycolysis Converts: 1 Glucose Hexose stage 2 pyruvate - Two molecules of ATP are produced - Two molecules of NAD + are reduced to NADH Triose stage Glucose + 2 ADP
More informationBCH Graduate Survey of Biochemistry
BCH 5045 Graduate Survey of Biochemistry Instructor: Charles Guy Producer: Ron Thomas Director: Glen Graham Lecture 50 Slide sets available at: http://hort.ifas.ufl.edu/teach/guyweb/bch5045/index.html
More informationGlycolysis. Degradation of Glucose to yield pyruvate
Glycolysis Degradation of Glucose to yield pyruvate After this Lecture you will be able to answer: For each step of glycolysis: How does it occur? Why does it occur? Is it Regulated? How? What are the
More informationPhysiological Chemistry II Exam IV Dr. Melissa Kelley April 13, 2004
Name Write your name on the back of the exam Physiological Chemistry II Exam IV Dr. Melissa Kelley April 13, 2004 This examination consists of forty-four questions, each having 2 points. The remaining
More informationBCH Graduate Survey of Biochemistry
BCH 5045 Graduate Survey of Biochemistry Instructor: Charles Guy Producer: Ron Thomas Director: Glen Graham Lecture 45 Slide sets available at: http://hort.ifas.ufl.edu/teach/guyweb/bch5045/index.html
More informationCourse: PGPathshala-Biophysics Paper 3: THERMODYNAMICS OF LIVING SYSTEMS AND BIOENERGETICS Module 13: ENERGY GENERATION: GLYCOLYSIS
Course: PGPathshala-Biophysics Paper 3: THERMODYNAMICS OF LIVING SYSTEMS AND BIOENERGETICS Module 13: ENERGY GENERATION: GLYCOLYSIS Content Writer: Dr. Radhika Bakhshi, Shaheed Rajguru College of Applied
More informationGlucose is the only source of energy in red blood cells. Under starvation conditions ketone bodies become a source of energy for the brain
Glycolysis 4 / The Text :- Some Points About Glucose Glucose is very soluble source of quick and ready energy. It is a relatively stable and easily transported. In mammals, the brain uses only glucose
More informationEvidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells. Matthew G. Vander Heiden, et al. Science 2010
Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells Matthew G. Vander Heiden, et al. Science 2010 Introduction The Warburg Effect Cancer cells metabolize glucose differently Primarily
More informationBiochemistry. Metabolism
Biochemistry Metabolism 07.11.2017 27.11.2017 Gluconeogenesis Gerhild van Echten-Deckert Tel. 73 2703 E-mail: g.echten.deckert@uni-bonn.de www.limes-institut-bonn.de Gluconeogenesis Glycolysis 7 glycolytic
More informationChem Lecture 8 Carbohydrate Metabolism Part I: Glycolysis
Chem 352 - Lecture 8 Carbohydrate Metabolism Part I: Glycolysis Introduction Carbohydrate metabolism involves a collection of pathways. Glycolysis Hexoses 3-Carbon molecules Gluconeogenesis 3-Carbon molecules
More informationMajor Pathways in Carbohydrate Metabolism
Major Pathways in Carbohydrate Metabolism 70 Stage 1: Digestion of Carbohydrates In Stage 1, the digestion of carbohydrates Begins in the mouth where salivary amylase breaks down polysaccharides to smaller
More informationDr. Mohnen s notes on GLUCONEOGENESIS
Dr. Mohnen s notes on GLUCONEOGENESIS Note: Even though we did not get through all of these slides during lecture, I advise you to look them all through because they will be helpful to you as you learn
More informationGlycolysis Part 2. BCH 340 lecture 4
Glycolysis Part 2 BCH 340 lecture 4 Regulation of Glycolysis There are three steps in glycolysis that have enzymes which regulate the flux of glycolysis These enzymes catalyzes irreversible reactions of
More informationGlycolysis. Glycolysis Expectations. Glycolysis 10/20/2015. Chapter 16, Stryer Short Course. Memorize/learn Figure 16.1
Glycolysis Chapter 16, Stryer Short Course Glycolysis Expectations Memorize/learn Figure 16.1 Know overall reaction and stages Explain chemical/physiological purpose of each step Learn structures Reversible/Irreversible
More information(de novo synthesis of glucose)
Gluconeogenesis (de novo synthesis of glucose) Gluconeogenesis Gluconeogenesis is the biosynthesis of new glucose. The main purpose of gluconeogenesis is to maintain the constant blood Glc concentration.
More informationBCH 4054 Chapter 19 Lecture Notes
BCH 4054 Chapter 19 Lecture Notes 1 Chapter 19 Glycolysis 2 aka = also known as verview of Glycolysis aka The Embden-Meyerhoff Pathway First pathway discovered Common to almost all living cells ccurs in
More informationIn glycolysis, glucose is converted to pyruvate. If the pyruvate is reduced to lactate, the pathway does not require O 2 and is called anaerobic
Glycolysis 1 In glycolysis, glucose is converted to pyruvate. If the pyruvate is reduced to lactate, the pathway does not require O 2 and is called anaerobic glycolysis. If this pyruvate is converted instead
More informationGlycolysis. BCH 340 lecture 3 Chapter 8 in Lippincott 5 th edition
Glycolysis B 40 lecture hapter 8 in Lippincott 5 th edition All carbohydrates to be catabolized must enter the glycolytic pathway Glycolysis is degradation of glucose to generate energy (ATP) and to provide
More informationBiochemistry: A Short Course
Tymoczko Berg Stryer Biochemistry: A Short Course Second Edition CHAPTER 16 Glycolysis 2013 W. H. Freeman and Company Chapter 16 Outline Why is glucose such a prominent fuel in all life forms? 1. Glucose
More informationIntegration of Metabolism
Integration of Metabolism Metabolism is a continuous process. Thousands of reactions occur simultaneously in order to maintain homeostasis. It ensures a supply of fuel, to tissues at all times, in fed
More informationIII. Metabolism - Gluconeogenesis
Department of Chemistry and Biochemistry University of Lethbridge III. Metabolism - Gluconeogenesis Carl & Gertrude Cori Slide 1 Carbohydrate Synthesis Lactate, pyruvate and glycerol are the important
More informationBIOCHEMISTRY. Glycolysis. by Dr Jaya Vejayan Faculty of Industrial Sciences & Technology
BIOCHEMISTRY Glycolysis by Dr Jaya Vejayan Faculty of Industrial Sciences & Technology email: jayavejayan@ump.edu.my Chapter Description Overview This chapter is related to carbohydrate catabolism. It
More informationGLYCOLYSIS Generation of ATP from Metabolic Fuels
GLYCOLYSIS Generation of ATP from Metabolic Fuels - Catabolic process degradative pathway - Energy stored in sugars (carbohydrates) released to perform biological work - Transforms GLUCOSE to PYRUVATE
More informationIntegration Of Metabolism
Integration Of Metabolism Metabolism Consist of Highly Interconnected Pathways The basic strategy of catabolic metabolism is to form ATP, NADPH, and building blocks for biosyntheses. 1. ATP is the universal
More informationCarbohydrate Metabolism I
Carbohydrate Metabolism I Outline Glycolysis Stages of glycolysis Regulation of Glycolysis Carbohydrate Metabolism Overview Enzyme Classification Dehydrogenase - oxidizes substrate using cofactors as
More informationReview of Carbohydrate Digestion
Review of Carbohydrate Digestion Glycolysis Glycolysis is a nine step biochemical pathway that oxidizes glucose into two molecules of pyruvic acid. During this process, energy is released and some of it
More informationLink download full of Test Bank for Fundamentals of Biochemistry 4th Edition by Voet
Link download full of Test Bank for Fundamentals of Biochemistry 4th Edition by Voet http://testbankair.com/download/test-bank-for-fundamentals-ofbiochemistry-4th-edition-by-voet/ Chapter 16: Glycogen
More informationAhmad Ulnar. Faisal Nimri ... Dr.Faisal
24 Ahmad Ulnar Faisal Nimri... Dr.Faisal Fatty Acid Synthesis - Occurs mainly in the Liver (to store excess carbohydrates as triacylglycerols(fat)) and in lactating mammary glands (for the production of
More informationOVERVIEW OF THE GLYCOLYTIC PATHWAY Glycolysis is considered one of the core metabolic pathways in nature for three primary reasons:
Glycolysis 1 Supplemental Reading Key Concepts - Overview of the Glycolytic Pathway Glycolysis generates a small amount of ATP Preview of the ten enzyme-catalyzed reactions of glycolysis - Stage 1: ATP
More informationMetabolic engineering some basic considerations. Lecture 9
Metabolic engineering some basic considerations Lecture 9 The 90ties: From fermentation to metabolic engineering Recruiting heterologous activities to perform directed genetic modifications of cell factories
More informationCHE 242 Exam 3 Practice Questions
CHE 242 Exam 3 Practice Questions Glucose metabolism 1. Below is depicted glucose catabolism. Indicate on the pathways the following: A) which reaction(s) of glycolysis are irreversible B) where energy
More informationChemical Energy. Valencia College
9 Pathways that Harvest Chemical Energy Valencia College 9 Pathways that Harvest Chemical Energy Chapter objectives: How Does Glucose Oxidation Release Chemical Energy? What Are the Aerobic Pathways of
More informationnumber Done by Corrected by Doctor Nayef Karadsheh
number 13 Done by Asma Karameh Corrected by Saad hayek Doctor Nayef Karadsheh Gluconeogenesis This lecture covers gluconeogenesis with aspects of: 1) Introduction to glucose distribution through tissues.
More informationMETABOLISM Biosynthetic Pathways
METABOLISM Biosynthetic Pathways Metabolism Metabolism involves : Catabolic reactions that break down large, complex molecules to provide energy and smaller molecules. Anabolic reactions that use ATP energy
More informationMetabolism. Metabolic pathways. BIO 5099: Molecular Biology for Computer Scientists (et al) Lecture 11: Metabolic Pathways
BIO 5099: Molecular Biology for Computer Scientists (et al) Lecture 11: Metabolic Pathways http://compbio.uchsc.edu/hunter/bio5099 Larry.Hunter@uchsc.edu Metabolism Metabolism is the chemical change of
More informationReading Assignments. A. Energy and Energy Conversions. Lecture Series 9 Cellular Pathways That Harvest Chemical Energy. gasoline) or elevated mass.
Lecture Series 9 Cellular Pathways That Harvest Chemical Energy Reading Assignments Review Chapter 3 Energy, Catalysis, & Biosynthesis Read Chapter 13 How Cells obtain Energy from Food Read Chapter 14
More informationNAME KEY ID # EXAM 3a BIOC 460. Wednesday April 10, Please include your name and ID# on each page. Limit your answers to the space provided!
EXAM 3a BIOC 460 Wednesday April 10, 2002 Please include your name and ID# on each page. Limit your answers to the space provided! 1 1. (5 pts.) Define the term energy charge: Energy charge refers to the
More informationCellular Respiration. Overview of Cellular Respiration. Lecture 8 Fall Overview of Cellular Respiration. Overview of Cellular Respiration
Overview of Cellular Respiration 1 Cellular Respiration Lecture 8 Fall 2008 All organisms need ATP to do cellular work Cellular Respiration: The conversion of chemical energy of carbon compounds into another
More informationCellular Pathways That Harvest Chemical Energy. Cellular Pathways That Harvest Chemical Energy. Cellular Pathways In General
Cellular Pathways That Harvest Chemical Energy A. Obtaining Energy and Electrons from Glucose Lecture Series 12 Cellular Pathways That Harvest Chemical Energy B. An Overview: Releasing Energy from Glucose
More information0.40. Biochemistry of Carbohydrates
0.40 Biochemistry of Carbohydrates Biochemistry of Carbohydrates ATP ADP Glycolysis The Breakdown of Glucose Primary Energy Source of Cells Central Metabolic Pathway All Reactions Occur in Cytoplasm Two
More informationMetabolic Pathways and Energy Metabolism
Metabolic Pathways and Energy Metabolism Last Week Energy Metabolism - The first thing a living organism has got to be able to do is harness energy from the environment - Plants do it by absorbing sunlight
More informationBiochemistry: A Short Course
Tymoczko Berg Stryer Biochemistry: A Short Course First Edition CHAPTER 19 Harvesting Electrons from the Cycle 2013 W. H. Freeman and Company Chapter 19 Outline The citric acid cycle oxidizes the acetyl
More informationThis is an example outline of 3 lectures in BSC (Thanks to Dr. Ellington for sharing this information.)
This is an example outline of 3 lectures in BSC 2010. (Thanks to Dr. Ellington for sharing this information.) Topic 10: CELLULAR RESPIRATION (lectures 14-16) OBJECTIVES: 1. Know the basic reactions that
More informationCHAPTER 24: Carbohydrate, Lipid, & Protein Metabolism. General, Organic, & Biological Chemistry Janice Gorzynski Smith
CHAPTER 24: Carbohydrate, Lipid, & Protein Metabolism General, Organic, & Biological Chemistry Janice Gorzynski Smith CHAPTER 24: Carbohydrate, Lipid, & Protein Metabolism Learning Objectives: q Role in
More informationBiochemistry - I SPRING Mondays and Wednesdays 9:30-10:45 AM (MR-1307) Lecture 16. Based on Profs. Kevin Gardner & Reza Khayat
Biochemistry - I Mondays and Wednesdays 9:30-10:45 AM (MR-1307) SPRING 2017 Lecture 16 Based on Profs. Kevin Gardner & Reza Khayat 1 Catabolism of Di- and Polysaccharides Catabolism (digestion) begins
More informationMetabolism Energy Pathways Biosynthesis. Catabolism Anabolism Enzymes
Topics Microbial Metabolism Metabolism Energy Pathways Biosynthesis 2 Metabolism Catabolism Catabolism Anabolism Enzymes Breakdown of complex organic molecules in order to extract energy and dform simpler
More informationGlycolysis. Color index: Doctors slides Notes and explanations Extra information Highlights. Biochemistry Team 437
Glycolysis Color index: Doctors slides Notes and explanations Extra information Highlights Biochemistry Team 437 ﺑ ﺳ م ﷲ اﻟرﺣﻣن اﻟرﺣﯾم Objectives: Recognize glycolysis as the major oxidative pathway of
More informationChapter 9 Overview. Aerobic Metabolism I: The Citric Acid Cycle. Live processes - series of oxidation-reduction reactions. Aerobic metabolism I
n n Chapter 9 Overview Aerobic Metabolism I: The Citric Acid Cycle Live processes - series of oxidation-reduction reactions Ingestion of proteins, carbohydrates, lipids Provide basic building blocks for
More informationCarbohydrate. Metabolism
Carbohydrate Metabolism Dietary carbohydrates (starch, glycogen, sucrose, lactose Mouth salivary amylase Summary of Carbohydrate Utilization Utilization for energy (glycolysis) ligosaccharides and disaccharides
More informationTransport. Oxidation. Electron. which the en the ETC and. of NADH an. nd FADH 2 by ation. Both, Phosphorylation. Glycolysis Glucose.
Electron Transport Chain and Oxidation Phosphorylation When one glucose molecule is oxidized to six CO 2 molecules by way of glycolysiss and TCA cycle, considerable amount of energy (ATP) is generated.
More informationChapter 22. Before the class. 10 Steps of glycolysis. Outline. Can you tell the ten steps of glycolysis? Do you know how glucoses are
Chapter 22 Gluconeogenesis, Glycogen metabolism, and the Pentose Phosphate Pathway Reginald H. Garrett Charles M. Grisham 1 Before the class Can you tell the ten steps of glycolysis? Do you know how glucoses
More informationDr. DerVartanian is ill and will likely not be able to give lectures this week.
Dr. DerVartanian is ill and will likely not be able to give lectures this week. Today s slides will be put on-line today, and are designed to introduce you to glycolysis. You should use these slides, along
More informationMBioS 303 Recitation Introductory Biochemistry, Summer 2008 Practice Problem Set #7: General Metabolism Concepts, Glycolysis and the TCA Cycle
MBioS 303 Recitation Introductory Biochemistry, Summer 2008 Practice Problem Set #7: General Metabolism Concepts, Glycolysis and the TCA Cycle (1) Glucose 1-pohsphate is converted to fructose 6-phosphate
More information5.0 HORMONAL CONTROL OF CARBOHYDRATE METABOLISM
5.0 HORMONAL CONTROL OF CARBOHYDRATE METABOLISM Introduction: Variety of hormones and other molecules regulate the carbohydrates metabolism. Some of these have already been cited in previous sections.
More informationMULTIPLE CHOICE QUESTIONS
MULTIPLE CHOICE QUESTIONS 1. Which of the following statements concerning anabolic reactions is FALSE? A. They are generally endergonic. B. They usually require ATP. C. They are part of metabolism. D.
More informationBCH 4054 Chapter 23 Lecture Notes
BCH 4054 Chapter 23 Lecture Notes 1 Chapter 23 Gluconeogenesis Glycogen Metabolism Pentose Phosphate Pathway 2 Gluconeogenesis Humans use about 160 g of glucose per day, about 75% for the brain. Body fluids
More informationIntegration of Metabolism 1. made by: Noor M. ALnairat. Sheet No. 18
Integration of Metabolism 1 made by: Noor M. ALnairat Sheet No. 18 Data :24/11/2016 SLIDE 2: Metabolism Consist of Highly Interconnected Pathways The basic strategy of catabolic metabolism is to form ATP,
More informationCITRIC ACID CYCLE ERT106 BIOCHEMISTRY SEM /19 BY: MOHAMAD FAHRURRAZI TOMPANG
CITRIC ACID CYCLE ERT106 BIOCHEMISTRY SEM 1 2018/19 BY: MOHAMAD FAHRURRAZI TOMPANG Chapter Outline (19-1) The central role of the citric acid cycle in metabolism (19-2) The overall pathway of the citric
More informationChapter 13 Carbohydrate Metabolism
Chapter 13 Carbohydrate Metabolism Metabolism of Foods Food is broken down into carbohydrates, lipids, and proteins and sent through catabolic pathways to produce energy. Glycolysis glucose 2 P i 2 ADP
More informationChapter 24 Lecture Outline
Chapter 24 Lecture Outline Carbohydrate Lipid and Protein! Metabolism! In the catabolism of carbohydrates, glycolysis converts glucose into pyruvate, which is then metabolized into acetyl CoA. Prepared
More information3.2 Aerobic Respiration
3.2 Aerobic Respiration Aerobic Cellular Respiration Catabolic pathways Breaks down energy-rich compounds to make ATP Requires oxygen Occurs in different parts of the cell C 6 H 12 O 6 (s) + 6O 2 (g) 6CO
More informationPhotosynthesis in chloroplasts. Cellular respiration in mitochondria ATP. ATP powers most cellular work
Light energy ECOSYSTEM CO + H O Photosynthesis in chloroplasts Cellular respiration in mitochondria Organic molecules + O powers most cellular work Heat energy 1 becomes oxidized (loses electron) becomes
More informationAerobic Respiration. The four stages in the breakdown of glucose
Aerobic Respiration The four stages in the breakdown of glucose 1 I. Aerobic Respiration Why can t we break down Glucose in one step? (Flaming Gummy Bear) Enzymes gently lower the potential energy until
More informationGlycolysis. Intracellular location Rate limiting steps
Glycolysis Definition Fx Fate Site Intracellular location Rate limiting steps Regulation Consume ATP Subs level phosphoryla tion Key reactions control points Nb Oxidation of glucose to give pyruvate (
More informationLecture 34. Carbohydrate Metabolism 2. Glycogen. Key Concepts. Biochemistry and regulation of glycogen degradation
Lecture 34 Carbohydrate Metabolism 2 Glycogen Key Concepts Overview of Glycogen Metabolism Biochemistry and regulation of glycogen degradation Biochemistry and regulation of glycogen synthesis What mechanisms
More informationTumor Metabolism. Hypoxia-inducible factor (HIF)
Tumor Metabolism Kevin M. Brindle Department of Biochemistry, University of Cambridge Tennis Court Road, Cambridge CB2 1GA and Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson
More informationChapter 15 Glycolysis and The Pentose Phosphate Pathway
Principles of Biochemistry Fourth Edition Donald Voet Judith G. Voet harlotte W. Pratt hapter 15 Glycolysis and The Pentose Phosphate Pathway Page No. 47-490 Introduction Glucose: is major source of metabolic
More informationit s a specific enzyme, the mechanism is that the intermediate which is the thioester ( aldehyde, substrate ) is covalently bound to the enzyme.
Oxidation of glyceraldehyde 3 phosphate : glyceraldehyde 3 phosphate on carbon1 it s an aldehyde group, which is oxidized and converted to carboxylic group ( aldehyde - becomes carboxylic acid ) this is
More informationCellular Respiration Stage 1: (Glycolysis) AP Biology
Cellular Respiration Stage 1: (Glycolysis) What s the point? The point is to make! Glycolysis: Breaking down glucose glyco lysis (splitting sugar) glucose pyruvate 6C 2x 3C In the cytosol? Why does that
More informationCELLULAR GLYCOGEN Why Glycogen as an Energy Storage Molecule? Glycogenolysis NOT phosphorolysis
CHM333 LECTURE 29 & 30: 4/12 15/13 SPRING 2013 Professor Christine Hrycyna CELLULAR GLYCOGEN Why Glycogen as an Energy Storage Molecule? 1. Fat cannot be as rapidly mobilized in skeletal muscle. 2. Fat
More informationCHY2026: General Biochemistry UNIT 7& 8: CARBOHYDRATE METABOLISM
CHY2026: General Biochemistry UNIT 7& 8: CARBOHYDRATE METABOLISM Metabolism Bioenergetics is the transfer and utilization of energy in biological systems The direction and extent to which a chemical reaction
More informationYield of energy from glucose
Paper : Module : 05 Yield of Energy from Glucose Principal Investigator, Paper Coordinator and Content Writer Prof. Ramesh Kothari, Professor Dept. of Biosciences, Saurashtra University, Rajkot - 360005
More informationLecture Sixteen: METABOLIC ENERGY: [Based on GENERATION Chapter 15
Lecture Sixteen: METABOLIC ENERGY: [Based on GENERATION Chapter 15 AND STORAGE Berg, (Figures in red are for the 7th Edition) Tymoczko (Figures in Blue are for the 8th Edition) & Stryer] Two major questions
More informationWe must be able to make glucose
Biosynthesis of Carbohydrates Synthesis of glucose (gluconeogenesis) Glycogen Formation of pentoses and NADPH Photosynthesis We must be able to make glucose Compulsory need for glucose (above all the brain)
More informationPoints 1. Following is the overall reaction catalyzed by the Calvin-Benson cycle:
BCH 4054 February 22, 2002 HOUR TEST 2 NAME_ Points 1. Following is the overall reaction catalyzed by the Calvin-Benson cycle: CO 2 + 3ATP + 2NADPH 1/3 glyceraldehyde-3-p + 3ADP + 2NADP + Give the structures
More informationChapter 9. Cellular Respiration and Fermentation
Chapter 9 Cellular Respiration and Fermentation Energy flows into an ecosystem as sunlight and leaves as heat Photosynthesis generates O 2 and organic molecules, which are used in cellular respiration
More informationThe citric acid cycle Sitruunahappokierto Citronsyracykeln
The citric acid cycle Sitruunahappokierto Citronsyracykeln Ove Eriksson BLL/Biokemia ove.eriksson@helsinki.fi Metabolome: The complete set of small-molecule metabolites to be found in a cell or an organism.
More informationnumber Done by Corrected by Doctor Nayef Karadsheh
number 11 Done by حسام أبو عوض Corrected by Moayyad Al-Shafei Doctor Nayef Karadsheh 1 P a g e General Regulatory Aspects in Metabolism: We can divide all pathways in metabolism to catabolicand anabolic.
More informationBY: RASAQ NURUDEEN OLAJIDE
BY: RASAQ NURUDEEN OLAJIDE LECTURE CONTENT INTRODUCTION CITRIC ACID CYCLE (T.C.A) PRODUCTION OF ACETYL CoA REACTIONS OF THE CITIRC ACID CYCLE THE AMPHIBOLIC NATURE OF THE T.C.A CYCLE THE GLYOXYLATE CYCLE
More informationCase Study: Carbohydrate Metabolism. eating an early dinner the night before and skipping breakfast that morning, Sid goes to the
Student Name Biochemistry 4320 Case Study Part I 4 November 2013 Case Study: Carbohydrate Metabolism Sid is a high school student who has decided to start exercising before school. After eating an early
More informationChapter 9: Cellular Respiration Overview: Life Is Work. Living cells. Require transfusions of energy from outside sources to perform their many tasks
Chapter 9: Cellular Respiration Overview: Life Is Work Living cells Require transfusions of energy from outside sources to perform their many tasks Biology, 7 th Edition Neil Campbell and Jane Reece The
More informationGlycolysis Introduction to Metabolism Regulation of Metabolism Overview of Glycolysis Reactions of Glycolysis
Glycolysis Introduction to Metabolism Regulation of Metabolism Overview of Glycolysis Reactions of Glycolysis Suggested Reading: Lippincot s Ilustrated reviews: Biochemistry Glycolysis, an example of metabolic
More informationNotes CELLULAR RESPIRATION SUMMARY EQUATION C 6 H 12 O 6 + O 2. 6CO 2 + 6H 2 O + energy (ATP) STEPWISE REDOX REACTION
AP BIOLOGY CELLULAR ENERGETICS ACTIVITY #2 Notes NAME DATE HOUR SUMMARY EQUATION CELLULAR RESPIRATION C 6 H 12 O 6 + O 2 6CO 2 + 6H 2 O + energy (ATP) STEPWISE REDOX REACTION Oxidation: partial or complete
More information7 Pathways That Harvest Chemical Energy
7 Pathways That Harvest Chemical Energy Pathways That Harvest Chemical Energy How Does Glucose Oxidation Release Chemical Energy? What Are the Aerobic Pathways of Glucose Metabolism? How Is Energy Harvested
More informationBiol 219 Lec 7 Fall 2016
Cellular Respiration: Harvesting Energy to form ATP Cellular Respiration and Metabolism Glucose ATP Pyruvate Lactate Acetyl CoA NAD + Introducing The Players primary substrate for cellular respiration
More informationPart III => METABOLISM and ENERGY. 3.2 Glucose Catabolism 3.2a Glycolysis Pathway 3.2b Glycolysis Regulation 3.2c Fermentation
Part III => METABOLISM and ENERGY 3.2 Glucose Catabolism 3.2a Glycolysis Pathway 3.2b Glycolysis Regulation 3.2c Fermentation Section 3.2a: Glycolysis Synopsis 3.2a - Dietary starch (eg bread, rice and
More informationBiochemistry: A Short Course
Tymoczko Berg Stryer Biochemistry: A Short Course Second Edition CHAPTER 28 Fatty Acid Synthesis 2013 W. H. Freeman and Company Chapter 28 Outline 1. The first stage of fatty acid synthesis is transfer
More informationnumber Done by Corrected by Doctor
number 12 Done by Baraa Ayed Corrected by Mamoon Mohammad Alqtamin Doctor Nayef Karadsheh Lactate production 1 P a g e Advantages of producing lactate Lactate is produced anaerobically to meet the following
More informationHow Cells Release Chemical Energy. Chapter 7
How Cells Release Chemical Energy Chapter 7 7.1 Overview of Carbohydrate Breakdown Pathways All organisms (including photoautotrophs) convert chemical energy of organic compounds to chemical energy of
More informationCellular Respiration: Harvesting Chemical Energy
Chapter 9 Cellular Respiration: Harvesting Chemical Energy PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with
More informationTCA CYCLE (Citric Acid Cycle)
TCA CYCLE (Citric Acid Cycle) TCA CYCLE The Citric Acid Cycle is also known as: Kreb s cycle Sir Hans Krebs Nobel prize, 1953 TCA (tricarboxylic acid) cycle The citric acid cycle requires aerobic conditions!!!!
More informationMoh Tarek. Razi Kittaneh. Jaqen H ghar
14 Moh Tarek Razi Kittaneh Jaqen H ghar Naif Karadsheh Gluconeogenesis is making glucose from non-carbohydrates precursors. Although Gluconeogenesis looks like Glycolysis in many steps, it is not the simple
More informationCARBOHYDRATE METABOLISM
Note (Study Glycolysis, fermentation and their regulation, Gluconeogenesis and glycogenolysis, Metabolism of galactose, TCA cycle and Amphibolic role of the cycle, and Glyoxalic acid cycle, HMP shunt in
More informationChap 3 Metabolism and Growth
Chap 3 Metabolism and Growth I. Metabolism Definitions: Metabolism includes two parts: anabolism and catabolism Catabolism: Anabolism: Aerobic metabolism: catabolism anabolis m catabolis anabolis m Anaerobic
More informationIntroduction to Carbohydrate metabolism
Introduction to Carbohydrate metabolism Some metabolic pathways of carbohydrates 1- Glycolysis 2- Krebs cycle 3- Glycogenesis 4- Glycogenolysis 5- Glyconeogenesis - Pentose Phosphate Pathway (PPP) - Curi
More informationIII. 6. Test. Respiració cel lular
III. 6. Test. Respiració cel lular Chapter Questions 1) What is the term for metabolic pathways that release stored energy by breaking down complex molecules? A) anabolic pathways B) catabolic pathways
More informationCELLULAR RESPIRATION SUMMARY EQUATION. C 6 H 12 O 6 + O 2 6CO2 + 6H 2 O + energy (ATP) STEPWISE REDOX REACTION
CELLULAR RESPIRATION SUMMARY EQUATION C 6 H 12 O 6 + O 2 6CO2 + 6H 2 O + energy (ATP) STEPWISE REDOX REACTION Oxidation: partial or complete loss of electrons Reduction: partial or complete gain of electrons
More informationCellular Respiration: Harvesting Chemical Energy
Chapter 9 Cellular Respiration: Harvesting Chemical Energy You should be able to: 1. Explain how redox reactions are involved in energy exchanges. Name and describe the three stages of cellular respiration;
More informationSyllabus for BASIC METABOLIC PRINCIPLES
Syllabus for BASIC METABOLIC PRINCIPLES The video lecture covers basic principles you will need to know for the lectures covering enzymes and metabolism in Principles of Metabolism and elsewhere in the
More information