Obesity mediated hypertension and renal dysfunction
|
|
|
- Thomasina Gordon
- 5 years ago
- Views:
Transcription
1 Obesity mediated hypertension and renal dysfunction Gergely Bodor Marion Hervouet Nicky Honnef Mariarosaria Malgadi Julie Robert Tutor: Pr Alina Parvu
2 Objectives 1. Introduction 2. Renal structural and functional changes in obesity 3. Role of adipocytes mediators in obesity 4. Renin angiotensin aldosterone system in obesity 5. Sympathetic nervous system in obesity 6. Obesity paradox 7. Conclusion
3 1.Introduction
4 Overweight and obesity «abnormal or excessive fat accumulation that may impair health» WHO BMI = weight / height² Limits of BMI: OBESITY = HETEROGENOUS CONDITION Others markers of obesity: waist circumference MRI,, cumputed tomography imaging, impedence Tchernof A, Després JP 2014
5 Abdominal obesity waist circumference > 102 cm (men) > 88 cm (women) Expansion of dysfunctional subcutaneous adipose tissue Ectopic triglyceride storage = Risk factors Tchernof A, Després JP 2014
6 Visceral obesity Excess intra-abdominal adipose tissue accumulation = main driving force for most of the disorders associated with obesity Tchernof A, Després JP 2014
7 CKD = Chronic Kidney Disease «The presence of reduced kidney function, or kidney damage, for a period of 3 months or greater» - Chronicity - Constant progression - Systemic consequences Table 2: Stage Description egfr(ml/min/1.73 m2) 1 CKD with normal or increased GFR >90 2 Mild GFR loss Moderate GFR loss Severe GFR loss Kidney failure <15 or dialysis Garland, J. S. (2014).
8 MS: metabolic syndrome; HBP: high blood pressure; DM: diabetes mellitus; CVD: cardiovascular disease; CKD: chronic kidney disease.
9
10 Mechanisms of CKD in obesity Indirect Hypertension Direct Hemodynamic effects Hormonal effects Diabetes Na reabsorption Fatty kidney Compression Compensatory mechanism Increased filtration Vasodilatation Proteinuria ESRD CKD Glomerulosclerosis
11 The role of adipocytes mediators in obesity
12 Cells, and adipokines of WAT Preadipocytes Adipocytes Fibroblasts Macrophages Leukocytes Endothel cells Leptin Adiponectin Visfatin Resistin
13 Resistin Antagonizes insulin Increases Endothelin-1 production Effects of ET-1: Vasoconstrictor tone Nitric oxide bioavailability In CKD Endothelial dysfunction GFR Briffa JF; 2013
14 Visfatin TNF-α, IL-6, IL-1B ROS Renin and Angiotensinogen mrna Inflammation Oxydative stress renal pathology GFR Sommer G; 2008
15 Adiponectin Effects: Cardioprotective: Insulin sensitivity ROS production Acivates AMP activated protein kinase In podocytes: downregulation of NADPH oxidase Adiponectin levels are correlated: Negatively: Body fat %, Type-2 diabetes, Insulin resistance, Hypertension Positively: Albuminuria, CKD, Type-2 diabetes Sweiss N; 2014
16 Leptin SNS activation Hall JE; 2005
17 Hall JE; 2005 Leptin-receptor metiated pathways
18 Leptin in the kidneys ROS, ET-1 HT,Endothelial dysfunction glomerulosclerosis TGF-β1 EC matrix expansion Alix PM; 2014
19 nflamation of WAT in obesity Overstretched adipocytes TNF-α, IL-6, MCP-1 Systemic subclinical inflammatory response
20 OBESITY INFLAMMATION OXIDATIVE STRESS CKD
21 Renin angiotensin aldosterone system in obesity
22 Blood pressure Juxtaglomerular cells PHYSIOLOGICALLY Angiotensinogen Cardio-pulmonar baroreceptor (SNS) Macula densa renin ACE Angiotensin I Angiotensin II Aldosterone Arteriolar Vasoconstriction Vascular tone ENaC and Na/K pump Na reabsorption Fluid volume Blood pressure
23 Adipose tissue VISCERAL OBESITY Production of bioactives molecules RAAS receptors and components RAAS activation SNS angiotensinogen Adipose tissue differenciation and proliferation Aldosterone Activation of mineralocorticoides and glucocorticoides receptors Blood Pressure 1 Garland (2014) 2 Kurukulasurya (2011)
24 Obesity CKD Hypertension
25 OBESITY PARADOX????!
26 Therapeutic perspectives
27 Obesity First line therapy Body weight reduction obesity - Calorie intake - Physical exercise Not effective in producing long term weight loss Second line therapy pharmacological treatment bariatric surgery (Bidani, 2013; Lambers Heerspink, 2012; XU, 2014)
28 Pharmacological treatments Retrieved from:
29 Thank you for your attention
Adipose Tissue as an Endocrine Organ. Abdel Moniem Ibrahim, MD Professor of Physiology Cairo University
Adipose Tissue as an Endocrine Organ Abdel Moniem Ibrahim, MD Professor of Physiology Cairo University Functions of Adipose Tissue Adipose tissue expresses and secretes a variety of bioactive peptides,
In The Name Of God. In The Name Of. EMRI Modeling Group
In The Name Of God In The Name Of God EMRI Modeling Group Cells work together in functionally related groups called tissues Types of tissues: Epithelial lining and covering Connective support Muscle movement
HSN301 Diet and Disease Entire Note Summary
Topic 1: Metabolic Syndrome Learning Objectives: 1. Define obesity 2. Factors causing obesity 3. Obesity as a risk factor for metabolic syndrome 4. The pathogenesis of metabolic syndrome 5. Treatment of
Obesity and Chronic Kidney. The Catholic University of Korea Cheol Whee Park, M.D.
Obesity and Chronic Kidney Disease The Catholic University of Korea Cheol Whee Park, M.D. Epidemic Obesity and type 2 Diabetes in Asia Yoon KH, et al. Lancet 368:1681-1688, 2006 [1 단계 ] 지방세포가커진다 [2 단계
Roadmap. Diabetes and the Metabolic Syndrome in the Asian Population. Asian. subgroups 8.9. in U.S. (% of total
Diabetes and the Metabolic Syndrome in the Asian Population Alka Kanaya, MD Associate Professor of Medicine, UCSF Feb 26, 2010 Roadmap 1. Diabetes in Asian Americans Prevalence in the U.S. Risk factors
HSN301 REVISION NOTES TOPIC 1 METABOLIC SYNDROME
HSN301 REVISION NOTES TOPIC 1 METABOLIC SYNDROME What does the term Metabolic Syndrome describe? Metabolic syndrome describes a cluster of cardio-metabolic conditions that increase one's risk of developing
Metabolic Syndrome in Asians
Metabolic Syndrome in Asians Alka Kanaya, MD Asst. Professor of Medicine, UCSF Asian CV Symposium, November 17, 2007 The Metabolic Syndrome Also known as: Syndrome X Insulin Resistance Syndrome The Deadly
ΦΛΕΓΜΟΝΗ ΚΑΙ ΔΙΑΒΗΤΗΣ
ΦΛΕΓΜΟΝΗ ΚΑΙ ΔΙΑΒΗΤΗΣ ΘΩΜΑΣ ΠΑΠΑΔΟΠΟΥΛΟΣ, MD, PHD ΕΠΕΜΒΑΤΙΚΟΣ ΚΑΡΔΙΟΛΟΓΟΣ ΙΑΤΡΙΚΟ ΔΙΑΒΑΛΚΑΝΙΚΟ ΚΕΝΤΡΟ Inflammation as a cause of disease has entered the popular imagination. Diet ( macronutrients )
Obesity, Metabolic Syndrome, and Diabetes: Making the Connections
Obesity, Metabolic Syndrome, and Diabetes: Making the Connections Alka M. Kanaya, M.D. Associate Professor of Medicine & Epi/Biostats University of California, San Francisco February 26, 21 Roadmap 1.
JOSHUA K. KAYIMA INTERLINKING CARDIOVASCULAR DISEASE, CHRONIC KIDNEY DISEASE, AND OBESITY
INTERLINKING CARDIOVASCULAR DISEASE, CHRONIC KIDNEY DISEASE, AND OBESITY JOSHUA K. KAYIMA ASSOCIATE PROFESSOR DEPT. OF CLINICAL MEDICINE AND THERAPEUTICS UNIVERSITY OF NAIROBI Introduction According to
Cardiovascular Complications Of Chronic Kidney Disease. Dr Atir Khan Consultant Physician Diabetes & Endocrinology West Wales Hospital, Carmarthen
Cardiovascular Complications Of Chronic Kidney Disease Dr Atir Khan Consultant Physician Diabetes & Endocrinology West Wales Hospital, Carmarthen Markers of kidney dysfunction Raised Albumin / Creatinine
Blood Pressure Regulation 2. Faisal I. Mohammed, MD,PhD
Blood Pressure Regulation 2 Faisal I. Mohammed, MD,PhD 1 Objectives Outline the intermediate term and long term regulators of ABP. Describe the role of Epinephrine, Antidiuretic hormone (ADH), Renin-Angiotensin-Aldosterone
Blood Pressure Regulation 2. Faisal I. Mohammed, MD,PhD
Blood Pressure Regulation 2 Faisal I. Mohammed, MD,PhD 1 Objectives Outline the intermediate term and long term regulators of ABP. Describe the role of Epinephrine, Antidiuretic hormone (ADH), Renin-Angiotensin-Aldosterone
3/20/2011. Body Mass Index (kg/[m 2 ]) Age at Issue (*BMI > 30, or ~ 30 lbs overweight for 5 4 woman) Mokdad A.H.
![3/20/2011. Body Mass Index (kg/[m 2 ]) Age at Issue (*BMI > 30, or ~ 30 lbs overweight for 5 4 woman) Mokdad A.H.](/thumbs/82/84935173.jpg "3/20/2011. Body Mass Index (kg/[m 2 ]) Age at Issue (*BMI > 30, or ~ 30 lbs overweight for 5 4 woman) Mokdad A.H.")
U.S. Adults: 1988 Nineteen states with 10-14% 14% Prevalence of Obesity (*BMI > 30, or ~ 30 lbs overweight for 5 4 woman) Metabolic John P. Cello, MD Professor of Medicine and Surgery, University of California,
Psoriasis and the metabolic syndrome
Psoriasis and the metabolic syndrome MD, PhD James G. Krueger 1 Inflammation as a foundation of metabolic dysregulation and cardiovascular disease risk Diseases of systemic immune activation and inflammation,
Metabolic Syndrome and Chronic Kidney Disease
Metabolic Syndrome and Chronic Kidney Disease Definition of Metabolic Syndrome National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III Abdominal obesity, defined as a waist circumference
Metabolic Syndrome: An overview. Kevin Niswender MD, PhD Vanderbilt University School of Medicine
Metabolic Syndrome: An overview. Kevin Niswender MD, PhD Vanderbilt University School of Medicine Setting the scene GB, 43 yo AA man followed for hypothyroidism returns on LT4 125 mcg/d and has a TSH=1.1
An update on the obesity epidemics in CKD and in ESRD. Does it really matter?
EURECA-m 2011 An update on cutting-edge Cardiovascular and Renal Medicine themes. An update on the obesity epidemics in CKD and in ESRD. Does it really matter? Francesca Mallamaci BMI>30 25 Ireland 20
014 Chapter 14 Created: 9:25:14 PM CST
014 Chapter 14 Created: 9:25:14 PM CST Student: 1. Functions of the kidneys include A. the regulation of body salt and water balance. B. hydrogen ion homeostasis. C. the regulation of blood glucose concentration.
Adrenal gland And Pancreas
Adrenal gland And Pancreas Structure Cortex Glucocorticoids Effects Control of secretion Mineralocorticoids Effects Control of secretion Sex steroids Medulla Catecholamines Adrenal cortex 80% of an adrenal
Cardiovascular Protection and the RAS
Cardiovascular Protection and the RAS Katalin Kauser, MD, PhD, DSc Senior Associate Director, Boehringer Ingelheim Pharmaceutical Inc. Micardis Product Pipeline Scientific Support Ridgefield, CT, USA Cardiovascular
Dysglycaemia and Hypertension. Dr E M Manuthu Physician Kitale
Dysglycaemia and Hypertension Dr E M Manuthu Physician Kitale None Disclosures DM is MI equivalent MR FIT Objective was to assess predictors of CVD mortality among men with and without diabetes and
Metabolic syndrome, obesity, diabetes, and theier implications
Metabolic syndrome, obesity, diabetes, and theier implications jan.krtil@lf1.cuni.cz Institute of Medical Biochemistry and Laboratory Diagnostics &1 st Department of Medicine Diabetes mellitus type 2 (T2DM)
Doppler ultrasound, see Ultrasonography. Magnetic resonance imaging (MRI), kidney oxygenation assessment 75
Subject Index Acidemia, cardiorenal syndrome type 3 146 Acute Dialysis Quality Initiative (ADQI) acute kidney injury biomarkers, see Acute kidney injury; specific biomarkers cardiorenal syndrome, see specific
Obesity related nephropathy in children the need for greater awareness
EDITORIAL Port J Nephrol Hypert 2016; 30(2): 89-93 Advance Access publication 7 May 2016 Obesity related nephropathy in children the need for greater awareness Liane Correia-Costa 1,2,3, Ana Azevedo 1,4,
Diabetes and Concomitant Cardiovascular Disease: Guideline Recommendations and Future Directions
Diabetes and Concomitant Cardiovascular Disease: Guideline Recommendations and Future Directions Diabetes is one of the largest global health emergencies of 21 st century, with the number of people with
The Metabolic Syndrome Update The Metabolic Syndrome: Overview. Global Cardiometabolic Risk
Update 2013 Marc Cornier, M.D. Associate Professor of Medicine Division of Endocrinology, Metabolism & Diabetes Anschutz Health and Wellness Center University of Colorado School of Medicine Denver Health
Obesity in the pathogenesis of chronic disease
Portoroz October 16th 2013 Obesity in the pathogenesis of chronic disease Rocco Barazzoni University of Trieste Department of Medical, Surgical and Health Sciences Obesity Trends* Among U.S. Adults BRFSS,
Metabolic Syndrome: Bad for the Heart and Bad for the Brain? Kristine Yaffe, MD Univ. of California, San Francisco
Metabolic Syndrome: Bad for the Heart and Bad for the Brain? Kristine Yaffe, MD Univ. of California, San Francisco Why would diabetes and obesity be bad for the brain? Insulin receptors in brain Insulin
Role of the fat tissue in the pathogenesis of arterial hypertension and chronic kidney disease
The 17th Budapest Nephrology School (Nephrology, Hypertension, Dialysis, Transplantation) Under the auspices of ISN, ERA-EDTA and ISP 26-31 August, 2010 Role of the fat tissue in the pathogenesis of arterial
BIOL212 Biochemistry of Disease. Metabolic Disorders - Obesity
BIOL212 Biochemistry of Disease Metabolic Disorders - Obesity Obesity Approx. 23% of adults are obese in the U.K. The number of obese children has tripled in 20 years. 10% of six year olds are obese, rising
Blood pressure control Contin. Reflex Mechanisms. Dr. Hiwa Shafiq
Blood pressure control Contin. Reflex Mechanisms Dr. Hiwa Shafiq 17-12-2018 A. Baroreceptor reflexes Baroreceptors (stretch receptors) located in the walls of several large systemic arteries( specially
renoprotection therapy goals 208, 209
Subject Index Aldosterone, plasminogen activator inhibitor-1 induction 163, 164, 168 Aminopeptidases angiotensin II processing 64 66, 214 diabetic expression 214, 215 Angiotensin I intrarenal compartmentalization
Dietary practices in patients with chronic kidney disease not yet on maintenance dialysis: What are the relevant components?
Dietary practices in patients with chronic kidney disease not yet on maintenance dialysis: What are the relevant components? 3 rd International Conference of European Renal Nutrition Working Group of ERA-EDTA
FAT. It s Not All That! A Closer Look at the Two Main Types of Fat in Our Bodies: Visceral and Subcutaneous Fat
Mary-Kate Perrone Capstone Seminar July 14, 2007 Draft #2 Fat Stats FAT. It s Not All That! A Closer Look at the Two Main Types of Fat in Our Bodies: Visceral and Subcutaneous Fat According to the 2003-2004
Managing patients with renal disease
Managing patients with renal disease Hiddo Lambers Heerspink, MD University Medical Centre Groningen, The Netherlands Asian Cardio Diabetes Forum April 23 24, 216 Kuala Lumpur, Malaysia Prevalent cases,
Hypertension and obesity. Dr Wilson Sugut Moi teaching and referral hospital
Hypertension and obesity Dr Wilson Sugut Moi teaching and referral hospital No conflict of interests to declare Obesity Definition: excessive weight that may impair health BMI Categories Underweight BMI
Prof. Andrzej Wiecek Department of Nephrology, Endocrinology and Metabolic Diseases Medical University of Silesia Katowice, Poland.
What could be the role of renal denervation in chronic kidney disease? Andrzej Wiecek, Katowice, Poland Chairs: Peter J. Blankestijn, Utrecht, The Netherlands Jonathan Moss, Glasgow, UK Prof. Andrzej Wiecek
Adipose Tissue Dysfunction and Diabetic Cardiovascular Disease
Adipose Tissue Dysfunction and Diabetic Cardiovascular Disease Xin-Liang Ma, MD, PhD Thomas Jefferson University Philadelphia, PA USA CVD As The #1 Causes of Death In USA Male Female Heart Disease and
RENAL PHYSIOLOGY. Physiology Unit 4
RENAL PHYSIOLOGY Physiology Unit 4 Renal Functions Primary Function is to regulate the chemistry of plasma through urine formation Additional Functions Regulate concentration of waste products Regulate
Effects of the angiotensin II type-1 receptor antagonist telmisartan on endothelial activation induced by advanced glycation endproducts
Effects of the angiotensin II type-1 receptor antagonist telmisartan on endothelial activation induced by advanced glycation endproducts Serena Del Turco, Teresa Navarra, Giuseppina Basta, Raffaele De
DOWNLOAD PDF ADIPOSE TISSUE AND ADIPOKINES IN HEALTH AND DISEASE (NUTRITION AND HEALTH)
Chapter 1 : Adiposity, Adipokines, and Adiposopathy - Sick Fat Explained Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue
Questions? Homework due in lab 6. PreLab #6 HW 15 & 16 (follow directions, 6 points!)
Questions? Homework due in lab 6 PreLab #6 HW 15 & 16 (follow directions, 6 points!) Part 3 Variations in Urine Formation Composition varies Fluid volume Solute concentration Variations in Urine Formation
Effects of Exercise and Physical Activity on Diabetes Mellitus and Obesity
1 EXERCISE IS MEDICINE: The Science Behind the Movement Effects of Exercise and Physical Activity on Diabetes Mellitus and Obesity Rosa Allyn G. Sy, MD, FPCP, FPSEDM Endocrinology, Diabetes, Metabolism
SGLT2 inhibition in diabetes: extending from glycaemic control to renal and cardiovascular protection
SGLT2 inhibition in diabetes: extending from glycaemic control to renal and cardiovascular protection Hiddo Lambers Heerspink Department of Clinical Pharmacy and Pharmacology University Medical Center
RENAL PHYSIOLOGY WESTMEAD PRIMARY EXAM
RENAL PHYSIOLOGY WESTMEAD PRIMARY EXAM RENAL PHYSIOLOGY - ANATOMY Glomerulus + renal tubule Each kidney has 1.3 million nephrons Cortical nephrons (85%) have shorter Loop of Henle than Juxtamedullary nephrons
BIOH122 Human Biological Science 2
BIOH122 Human Biological Science 2 Session 17 Urinary System 2 Glomerular Filtration Bioscience Department Endeavour College of Natural Health endeavour.edu.au Session Plan o Overview of Renal Physiology
Veins. VENOUS RETURN = PRELOAD = End Diastolic Volume= Blood returning to heart per cardiac cycle (EDV) or per minute (Venous Return)
Veins Venous system transports blood back to heart (VENOUS RETURN) Capillaries drain into venules Venules converge to form small veins that exit organs Smaller veins merge to form larger vessels Veins
Effects of growth hormone secretagogue receptor agonist and antagonist in nonobese type 2 diabetic MKR mice
Effects of growth hormone secretagogue receptor agonist and antagonist in nonobese type 2 diabetic MKR mice Rasha Mosa (MBCHC, M.D, PhD candidate) School of Biomedical Sciences University of Queensland
Analysis of AVP functions via V1a and V1b receptors with knockout mice. Akito Tanoue
Analysis of AVP functions via V1a and V1b receptors with knockout mice Akito Tanoue Department of Pharmacology, National Research Institute for Child Health and Development Arginine-Vasopressin (AVP) is
Fluid and electrolyte balance, imbalance
Fluid and electrolyte balance, imbalance Body fluid The fluids are distributed throughout the body in various compartments. Body fluid is composed primarily of water Water is the solvent in which all solutes
FAPESP Week /21/2017
Texas Tech University Dr Naima Moustaid-Moussa Texas Tech University FAPESP Week 2017 09/21/2017 University of Sao Paulo Dr Sonia Jancar ICB-USP Theresa Ramalho MS PhD candidate, Immunology ICB-USP Dr
Na + /K + interaction in the kidney, blood vessels, brain, and beyond
Na + /K + interaction in the kidney, blood vessels, brain, and beyond Horacio J. Adrogué, M.D. Professor of Medicine, Baylor College of Medicine Chief, Clinical Nephrology and Hypertension. Houston Methodist
Cardiovascular System B L O O D V E S S E L S 2
Cardiovascular System B L O O D V E S S E L S 2 Blood Pressure Main factors influencing blood pressure: Cardiac output (CO) Peripheral resistance (PR) Blood volume Peripheral resistance is a major factor
New therapeutic targets for T2DM
New therapeutic targets for T2DM Targeting inflammation: NF- B, salsalate Gwanpyo Koh Department of Internal Medicine Jeju National University School of Medicine Introduction Obesity is occurring at epidemic
β adrenergic blockade, a renal perspective Prof S O McLigeyo
β adrenergic blockade, a renal perspective Prof S O McLigeyo Carvedilol Third generation β blocker (both β 1 and β 2 ) Possesses α 1 adrenergic blocking properties. β: α blocking ratio 7:1 to 3:1 Antioxidant
Launch Meeting 3 rd April 2014, Lucas House, Birmingham
Angiotensin Converting Enzyme inhibitor (ACEi) / Angiotensin Receptor Blocker (ARB) To STOP OR Not in Advanced Renal Disease Launch Meeting 3 rd April 2014, Lucas House, Birmingham Prof Sunil Bhandari
Blood Pressure Regulation Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.
Blood Pressure Regulation Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction There are two basic mechanisms for regulating
Obesity and the kidney
22. NATIONAL CONGRESS OF RENAL DISEASES, DIALYSIS & TRANSOPLANATATION NURSING 29. NATIONAL CONGRESS OF NEPHROLOGY, HYPEERTENSION DIALYSIS & TRANSPLANTATION 14-18 November 2012 Obesity and the kidney Prof.
ALLHAT RENAL DISEASE OUTCOMES IN HYPERTENSIVE PATIENTS STRATIFIED INTO 4 GROUPS BY BASELINE GLOMERULAR FILTRATION RATE (GFR)
1 RENAL DISEASE OUTCOMES IN HYPERTENSIVE PATIENTS STRATIFIED INTO 4 GROUPS BY BASELINE GLOMERULAR FILTRATION RATE (GFR) 6 / 5 / 1006-1 2 Introduction Hypertension is the second most common cause of end-stage
The Study of Endothelial Function in CKD and ESRD
The Study of Endothelial Function in CKD and ESRD Endothelial Diversity in the Human Body Aird WC. Circ Res 2007 Endothelial Diversity in the Human Body The endothelium should be viewed for what it is:
Subject Index. postprandial glycemia and suppression in serum 51 recommendations 119, 120 supplementation pros and cons 118, 119
Acarbose, diabetes prevention trials 32, 33, 40 42 Accelerator hypothesis accelerators beta cell autoimmunity 140, 141, 147, 150, 151 insulin resistance 140, 142 144, 150 obesity 145 148 diabetes risk
SLOWING PROGRESSION OF KIDNEY DISEASE. Mark Rosenberg MD University of Minnesota
SLOWING PROGRESSION OF KIDNEY DISEASE Mark Rosenberg MD University of Minnesota OUTLINE 1. Epidemiology of progression 2. Therapy to slow progression a. Blood Pressure control b. Renin-angiotensin-aldosterone
Tomasz J Guzik. Diabetes, perivascular adipose tissue and inflammation.
Tomasz J Guzik Diabetes, perivascular adipose tissue and inflammation. Translational Research Laboratory Department of Internal and Agricutural Medicine Jagiellonian University School of Medicine Cracow,
Pharmacology - Problem Drill 11: Vasoactive Agents
Pharmacology - Problem Drill 11: Vasoactive Agents Question No. 1 of 10 1. Vascular smooth muscle contraction is triggered by a rise in. Question #01 (A) Luminal calcium (B) Extracellular calcium (C) Intracellular
RENAL PHYSIOLOGY DR.CHARUSHILA RUKADIKAR ASSISTANT PROFESSOR PHYSIOLOGY
RENAL PHYSIOLOGY DR.CHARUSHILA RUKADIKAR ASSISTANT PROFESSOR PHYSIOLOGY GROSS ANATOMY Location *Bean-shaped *Retroperitoneal *At level of T12 L1 vertebrae. *The right kidney lies slightly inferior to left
Metabolic Consequences of Anti Hypertensives: Is It Clinically Important?
Metabolic Consequences of Anti Hypertensives: Is It Clinically Important?,FACA,FICA,MASH,FVBWG,MISCP CONSULTANT OF CARDIOLOGY DIRECTOR OF PORT-FOUAD HOSPITAL CCU Consideration of antihypertensive agents
METABOLIC SYNDROME IN REPRODUCTIVE FEMALES
METABOLIC SYNDROME IN REPRODUCTIVE FEMALES John J. Orris, D.O., M.B.A Division Head, Reproductive Endocrinology & Infertility, Main Line Health System Associate Professor, Drexel University College of
Hypertension is a persistent elevation of B.P. above the normal level. Approximately 1 billion people have hypertension
ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com STUDY OF LEVEL IN ESSENTIAL HYPERTENSION Krithika Mohanraj 1 *, Dr.R.Rajeswari 2 Bharath University, Chennai.
Renal Regulation of Sodium and Volume. Dr. Dave Johnson Associate Professor Dept. Physiology UNECOM
Renal Regulation of Sodium and Volume Dr. Dave Johnson Associate Professor Dept. Physiology UNECOM Maintaining Volume Plasma water and sodium (Na + ) are regulated independently - you are already familiar
METABOLISM of ADIPOSE TISSUE
METABOLISM of ADIPOSE TISSUE 2. LF UK Prof. Rudolf Poledne, PhD. TYPES OF ADIPOSE TISSUE brown adipose tissue subcutaneous adipose tissue visceral adipose tissue ADIPOSE TISSUE FUNCTIONS: thermal isolation
Energy balance. Factors affecting energy input. Energy input vs. Energy output Balance Negative: weight loss Positive: weight gain
1 Energy balance Energy input vs. Energy output Balance Negative: weight loss Positive: weight gain Special implications Infancy, Illness, Pregnancy & Lactation, Sports Factors affecting energy input neuro-endocrine
Objectives. Objectives. Alejandro J. de la Torre, MD Cook Children s Hospital May 30, 2015
Alejandro J. de la Torre, MD Cook Children s Hospital May 30, 2015 Presentation downloaded from http://ce.unthsc.edu Objectives Understand that the obesity epidemic is also affecting children and adolescents
Changes in Cardiotrophin-1 and Fibroblast Growth Factor-21 with Weight Loss. Robert Lawrence Bowers
Changes in Cardiotrophin-1 and Fibroblast Growth Factor-21 with Weight Loss by Robert Lawrence Bowers A dissertation submitted to the Graduate Faculty of Auburn University in partial fulfillment of the
Index. Note: Page numbers of article titles are in boldface type.
Heart Failure Clin 2 (2006) 101 105 Index Note: Page numbers of article titles are in boldface type. A ACE inhibitors, in diabetic hypertension, 30 31 Adipokines, cardiovascular events related to, 6 Advanced
ARGININE VASOPRESSIN (AVP)
ARGININE VASOPRESSIN (AVP) AFFECTS BLOOD PRESSURE AND RENAL WATER REABSORPTION WHAT ELSE DOES IT DO? Michael F. Michelis, M.D., F.A.C.P., F.A.S.N. Director, Division of Nephrology Lenox Hill Hospital,
Regulation of Arterial Blood Pressure 2 George D. Ford, Ph.D.
Regulation of Arterial Blood Pressure 2 George D. Ford, Ph.D. OBJECTIVES: 1. Describe the Central Nervous System Ischemic Response. 2. Describe chemical sensitivities of arterial and cardiopulmonary chemoreceptors,
http://noodlemaz.wordpress.com/category/science/cancer/ Outline Introduction Serious nature of Cardiovascular Disease (CVD) How to prevent CVD? The disease process Damage and plaque development Current
Diabetic Nephropathy 2009
Diabetic Nephropathy 2009 Michael T McDermott MD Director, Endocrinology and Diabetes Practice University of Colorado Hospital Michael.mcdermott@ucdenver.edu Diabetic Nephropathy Clinical Stages Hyperfunction
Getting Ahead of the Curve in the Trouble with Fat
Getting Ahead of the Curve in the Trouble with Fat Zhaoping Li, M.D., Ph.D. Professor of Medicine David Geffen School of Medicine, UCLA VA Greater Los Angeles Health Care System Obesity Pandemic Predicted
Changes and clinical significance of serum vaspin levels in patients with type 2 diabetes
Changes and clinical significance of serum vaspin levels in patients with type 2 diabetes L. Yang*, S.J. Chen*, G.Y. Yuan, D. Wang and J.J. Chen Department of Endocrinology, Affiliated Hospital of Jiangsu
Establishment of Efficacy of Intervention in those with Metabolic Syndrome. Dr Wendy Russell - ILSI Europe Expert Group
Establishment of Efficacy of Intervention in those with Metabolic Syndrome Dr Wendy Russell - ILSI Europe Expert Group Conflict of interest regarding this presentation: I have no conflict of interest to
Chapter 15 Fluid and Acid-Base Balance
Chapter 15 Fluid and Acid-Base Balance by Dr. Jay M. Templin Brooks/Cole - Thomson Learning Fluid Balance Water constitutes ~60% of body weight. All cells and tissues are surrounded by an aqueous environment.
BIPN100 F15 Human Physiology (Kristan) Lecture 18: Endocrine control of renal function. p. 1
BIPN100 F15 Human Physiology (Kristan) Lecture 18: Endocrine control of renal function. p. 1 Terms you should understand by the end of this section: diuresis, antidiuresis, osmoreceptors, atrial stretch
About OMICS Group Conferences
About OMICS Group OMICS Group International is an amalgamation of Open Access publications and worldwide international science conferences and events. Established in the year 2007 with the sole aim of
Cardiovascular Disease in CKD. Parham Eftekhari, D.O., M.Sc. Assistant Clinical Professor Medicine NSUCOM / Broward General Medical Center
Cardiovascular Disease in CKD Parham Eftekhari, D.O., M.Sc. Assistant Clinical Professor Medicine NSUCOM / Broward General Medical Center Objectives Describe prevalence for cardiovascular disease in CKD
Targeting Adipose Tissue in Rheumatoid Arthritis TARA study HOFFA L SCAPTIPL 0.1013606 0.270906 0.3759505 0.3373511 0.4050987 0.404667 11.6 DISCUSSIONS The study targeted the serum levels of adipokines
Males- Western Diet WT KO Age (wks) Females- Western Diet WT KO Age (wks)
Relative Arv1 mrna Adrenal 33.48 +/- 6.2 Skeletal Muscle 22.4 +/- 4.93 Liver 6.41 +/- 1.48 Heart 5.1 +/- 2.3 Brain 4.98 +/- 2.11 Ovary 4.68 +/- 2.21 Kidney 3.98 +/-.39 Lung 2.15 +/-.6 Inguinal Subcutaneous
THE ROLE OF URIC ACID IN THE PROGRESSION OF CKD Mehmet Kanbay, Istanbul, Turkey
THE ROLE OF URIC ACID IN THE PROGRESSION OF CKD Mehmet Kanbay, Istanbul, Turkey Chairs: Gerjan Navis, Groningen, The Netherlands Kamil Serdengecti, Istanbul, Turkey Dr. M. Kanbay Division of Nephrology
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,900 116,000 120M Open access books available International authors and editors Downloads Our
Faculty. Disclosures. Learning Objectives. Definitions. Definitions (cont) The Role of the Kidney in Cardiometabolic Disease
Faculty The Role of the Kidney in Cardiometabolic Disease Christian W. Mende, MD, FACP, FACN, FASN, FASH Clinical Professor of Medicine University of California at San Diego San Diego, California Disclosures
Glomerular Capillary Blood Pressure
Glomerular Capillary Blood Pressure Fluid pressure exerted by blood within glomerular capillaries Depends on Contraction of the heart Resistance to blood flow offered by afferent and efferent arterioles
Physio 12 -Summer 02 - Renal Physiology - Page 1
Physiology 12 Kidney and Fluid regulation Guyton Ch 20, 21,22,23 Roles of the Kidney Regulation of body fluid osmolarity and electrolytes Regulation of acid-base balance (ph) Excretion of natural wastes
Special Lecture 11/08/2013. Hypertension Dr. HN Mayrovitz
Special Lecture 11/08/2013 Hypertension Dr. HN Mayrovitz Arterial Blood Pressure (ABP) Major Factors Summarized Sympathetic Hormones Arteriole MAP ~ Q x TPR + f (V / C) SV x HR Renal SBP Hypertension =
Cardiovascular Mortality: General Population vs ESRD Dialysis Patients
Cardiovascular Mortality: General Population vs ESRD Dialysis Patients Annual CVD Mortality (%) 100 10 1 0.1 0.01 0.001 25-34 35-44 45-54 55-64 66-74 75-84 >85 Age (years) GP Male GP Female GP Black GP
The principal functions of the kidneys
Renal physiology The principal functions of the kidneys Formation and excretion of urine Excretion of waste products, drugs, and toxins Regulation of body water and mineral content of the body Maintenance
Cardiorenal Syndrome
SOCIEDAD ARGENTINA DE CARDIOLOGIA Cardiorenal Syndrome Joint session ESC-SAC ESC Congress 2012, Munich César A. Belziti Hospital Italiano de Buenos Aires I have no conflicts of interest to declare Cardiorenal
Proceedings of the 34th World Small Animal Veterinary Congress WSAVA 2009
www.ivis.org Proceedings of the 34th World Small Animal Veterinary Congress WSAVA 2009 São Paulo, Brazil - 2009 Next WSAVA Congress : Reprinted in IVIS with the permission of the Congress Organizers PROTEINURIA
THE ENDOCANNABINOID SYSTEM IN ADIPOSE TISSUE. Key Points
December 2008 (Vol. 1, Issue 3, pages 31-35) THE ENDOCANNABINOID SYSTEM IN ADIPOSE TISSUE By Uberto Pagotto, MD, PhD Endocrinology Unit and Center of Applied Biomedical Research (C.R.B.A.), Department
Prognosis in CKD Can we do anything about it? Rodney D Gilbert
Prognosis in CKD Can we do anything about it? Rodney D Gilbert A diagnosis of end stage renal failure implies what degree of loss of life expectancy? A. 10% B. 20% C. 30% D. 40% E. 50% F. 60% 38% 22% 16%