殧 KCNJ11 11 KCNJ11 8 KCNJ11 P < KCNJ11 HDL-C. TT CT t = P =
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1 JOURNAL OF HYGIENE RESEARCH Vol. 47 No. 2 Mar 檾檾檾檾 DANONE INSTITUTE CHINA Young Scientists' Forum 檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾 KCNJ KCNJ KCNJ h P < KCNJ11 rs5219 CC TG TC HDL-C TT CT t = P = rs GG AA AG t = P = KCNJ11 rs5219 CC rs GG KCNJ11 R R455 Q591 A Effects of exercise intervention on the relationship between KCNJ11 gene polymorphism and glucose and lipid metabolism in pre-diabetes mellitus Hou Peiwei Yu Fangqing Physical Education College of Liaocheng University Liaocheng China caxasf@ 163. com 1 Abstract Objective To investigate the effect of exercise intervention on the relationship between KCNJ11 gene polymorphism and glycolipid metabolism in pre-diabetic population. Methods From January 2017 to March communities were selected by stratified cluster random sampling method in Liaocheng City Shandong Province and 46 cases of pre-diabetes data were collected through public welfare physical examination activities. The exercise intervention was performed for 8 weeks with their consent and cooperation. The polymorphism of KCNJ11 gene and the index of glucose and lipid metabolism were detected before and after exercise intervention and the correlation between them was also discussed. Results After 8 weeks of exercise intervention 2 h postprandial blood glucose fasting glucose glycosylated hemoglobin and four indicators of blood lipids were significantly improved in pre-diabetes populations P < KCNJ11 gene polymorphism analysis showed
2 that the TG TC and HDL-C lipid metabolism indexes of CC genotype in rs5219 locus were more significant than those of TT and CT genotypes t = and P = and after exercise intervention the changes of FPG and HbAlc glucose metabolism indexes in GG genotype population of rs locus were more significant than those in AA and AG genotypes t = and P = and Conclusion The CC genotype of the KCNJ11 gene rs5219 site and the GG genotype of rs site can be used as the dominant gene to evaluate the change of glucose lipid metabolism in the early stage of diabetes intervention. Key words pre-diabetes exercise intervention KCNJ11 gene polymorphism glucose and lipid metabolism 1 KCNJ11 KCNQ body mass index BMI ~ ~ min 1999 WHO 3 ~ 4 60 min 5 ~ 8 80 min 6. 1 ~ 7. 0 mmol /L 2 h 7. 8 ~ mmol /L min 2 20 min min 3 40 kg 90 kg 40 min 20 min
3 2. KCNJ glycosylated hemoglobin HbAlc Go Fit triglyceride TG total cholesterol TC low density lipoprotein-cholesterol LDL-C high density lipoprotein-cholesterol HDL-C 1 2 h h PPG 30 s KCNJ ml - DNAKCNJ11 rs5219 rs s 4 Premier PCR KCNJ SPSS x 珋 ± s 8 t P < / POLAR ~ ± ~ cm ± cm BMI ~ ± / fasting plasma glucose FPG P < FPG / 1 n = 46 x 珔 ± s ± ± ± ± ± ± ± ± ± ± ± ± ± ± t P FPG 2 h PPG 2 HbAlc TG TC LDL-C HDL-C 2. 3 rs5219 TG TC HDL-C P < TT CT 2 2 CC TG TC HDL-C
4 rs5219 CC TG TC HDL-C 2 n FPG / rs5219 TT ± ± ± ± ± ± ± ± ± ± ± ± ± ± CT ± ± ± ± ± ± ± ± ± ± ± ± ± ± CC ± ± ± ± ± ± ± ± ± ± ± ± ± ± P < FPG 2 h PPG 2 HbAlc TG TC LDL-C HDL-C 2. 4 rs P < 0. 05AA AG FPG HbAlc 3 GG rs GG FPG HbAlc FPG HbAlc 3 n FPG / rs AA ± ± ± ± ± ± ± ± ± ± ± ± ± ± AG ± ± ± ± ± ± ± ± ± ± ± ± ± ± GG ± ± ± ± ± ± ± ± ± ± ± ± ± ± P < FPG 2 h PPG 2 HbAlc TG TC LDL-C HDL-C IGT IFG 46 KCNJ11 KCNJ11 rs5219 rs KCNJ11 46 rs CC rs GG 8 KCNJ11 2 h TG TC LDL-C HDL-C P < 0. 05
5 2. KCNJ J J KCNJ11 rs5219 CC 6. HbAlc J. rs GG KCNJ11 7. rs rs J FABP2 J J KCNJ J. 2. KCNJ11 E23K Meta J. 10. Meta J VDR HOMA J M ALBALA C EBBELING C B CIFUENTES M et al. Effects of replacing the habitual consumption of sugarsweetened beverages with milk in Chilean children J. Am J Clin Nutr CADOGAN J EASTELL R JONES N et al. Milk intake and bone mineral acquisition in adolescent girls randomized controlled intervention trial J. BMJ Clin Res J MIXED J J GRILLENBERGER M NEUMANN C G MURPHY S P et al. Food supplements have a positive impact on weight gain and the addition of animal source foods increases lean body mass of Kenyan school children J. J Nutr GRILLENBERGER M NEUMANN C G MURPHY S P et al. Intake of micronutrients high in animalsource foods is associated with better growth in rural Kenyan school children J. Br J Nutr J J
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