Evaluation of renal function and oxidative stress after adjuvant epalrestat treatment of early diabetic nephropathy
|
|
- Elaine Nash
- 5 years ago
- Views:
Transcription
1 Journal of Hainan Medical University 2017; 23(4): Journal of Hainan Medical University Evaluation of renal function and oxidative stress after adjuvant epalrestat of early diabetic nephropathy Ge Zhao 1, Min-Xiu Yao 2 1 Endocrinology Department, Qingdao University in Shandong Province, Qingdao City, Shandong Province, Endocrinology Department, Qingdao Central Hospital in Shandong Province, Qingdao City, Shandong Province, ARTICLE INFO Article history: Received 4 Nov 2016 Received in revised form 13 Nov 2016 Accepted 12 Nov 2016 Available online 24 Nov 2016 Keywords: Early diabetic nephropathy Epalrestat Renal function Oxidative stress ABSTRACT Objective: To explore the influence of adjuvant epalrestat of early diabetic nephropathy on renal function and oxidative stress. Methods: A total of 80 patients with early diabetic nephropathy who were treated in our hospital between January 2013 and February 2016 were collected and divided into observation group and control group according to singleblind parallel control. Control group of patients received routine therapy, and observation group of patients received adjuvant epalrestat on this basis. 8 weeks of, automatic biochemical analyzer was used to detect the renal function indexes of two groups of patients; RIA method was used to detect the serum renal fibrosis index levels; enzyme-linked immunosorbent assay (ELISA) was used to detect serum oxidative stress index levels. Results:, differences in serum renal function, renal fibrosis and oxidative stress index levels were not statistically significant between two groups of patients; after 8 weeks of, serum renal function indexes Scr, BUN, CysC and 毬 2-MG levels of observation group were lower than those of control group, renal fibrosis indexes CⅣ, CTGF and TGF- 毬 1 levels were lower than those of control group, oxidation indexes ROS, LHP and AOPPs levels were lower than those of control group, anti-oxidation indexes SOD, VitE, VitC and T-AOC levels were significantly higher than those of control group, and the differences were statistically significant. Conclusion: Adjuvant epalrestat therapy can optimize the renal function and reduce the systemic oxidative stress response in patients with early diabetic nephropathy. 1. Introduction Diabetic nephropathy (DN) is one of the most important complications in diabetic patients with poor control of blood glucose, there is complex metabolic disorder in such patients, and once it progresses to end-stage renal disease, the clinical will be very difficult[1]. Prevention or early of DN is the most reliable way to circumvent the end-stage renal diseases, and therefore, the of early diabetic nephropathy (EDN) has become the clinical research emphasis at present. EDN is the early stage of DN that is without severe renal dysfunction, the disease is reversible, and the reasonability of the choice of will directly decide outcome[2,3]. Epalrestat belongs to aldose reductase inhibitor, it reversibly inhibits the aldose reductase in the polyol metabolism process to reduce the production of sorbitol that affects nerve cell function, and it has been successfully applied in diabetic peripheral neuropathy[4]. At present, some scholars put forward that epalrestat can also optimize renal function and can be used as the adjuvant drug for EDN, but the relevant research reports are fewer. In the following study, the influence of adjuvant epalrestat of early diabetic nephropathy on renal function and oxidative stress was analyzed. Corresponding Author: Min-Xiu Yao, Endocrinology Department, Qingdao Central Hospital in Shandong Province, Qingdao City, Shandong Province, Tel: Fund Project: Medical Science and Technology Development Plan Project of Shandong Province No: 2014WS Information and methods 2.1 General information
2 70 A total of 80 patients with early diabetic nephropathy who were treated in our hospital between January 2013 and February 2016 were included and divided into observation group and control group (n=40) according to single-blind parallel control. Control group included 23 male cases and 17 female cases, they were years old, the body weight was kg and (59.73±7.55) kg in average, and the course of diabetes was 9-21 years and (13±2) years in average; observation group included 22 male cases and 18 female cases, they were years old, the body weight was kg and (57.69±7.81) kg in average, and the course of diabetes was 8-20 years and (12±2) years in average. The included patients signed the informed consent themselves, the research process was approved by the hospital ethics committee, and the differences in the distribution of gender, age and course of disease were not statistically significant (P>0.05). 2.2 Inclusion and exclusion criteria Inclusion criteria: (1) in accordance with the diagnostic criteria for EDN[5]; (2) 80 years old; (3) not receiving major surgery6 months prior to admission. Exclusion criteria: (1) with acute or chronic glomerulonephritis; (2) with severe heart, liver and kidney failure; (3) associated with systemic infectious diseases; (6) allergic to epalrestat; (7) pregnant or breastfeeding women. 2.3 Treatment methods Control group of patients received routine clinical EDN, including diet control, fitting exercise, insulin aspart (Novo Nordisk Pharmaceuticals Co., LTD., approved by S ) for glucose lowering, nifedipine (Shanghai Scond Pharmaceutical Co., LTD., approved by H ) for blood pressure lowering, and aspirin (Sichuan Pacific Pharmaceutical Co., LTD., approved by H ) for platelet lowering therapy. On the basis of conventional, the observation group received adjuvant epalrestat therapy as follows: oral administration of epalrestat tablets (Yangtze River Pharmaceutical Group Nanjing Hailing Pharmaceutical Co., LTD., approved by H ), 2.5 g/time, 3 times /d, for continuous 8 weeks. 2.4 Observation indexes Renal function and renal fibrosis 2 ml of peripheral venous blood was extracted from two groups of patients at the same point in time immediately after admission and after 8 weeks of, the blood was centrifuged, the supernatant was obtained and cryopreserved in -40 refrigerator (Shanghai Siqi Scientific Instrument Co., LTD., the article number MDF-40V50) for testing, and the detection indexes were as follows: (1): renal function: automatic biochemical analyzer (Xuzhou Haoyu Science and Technology Development Co., LTD., model Senlo8008) was used to detect serum creatinine (Scr), blood urea nitrogen (BUN), cystatin C (CysC) and 毬 2 microglobulin ( 毬 2-MG) levels; (2) renal fibrosis: RIA kit (Sigma Company in the United States, the article number RA109) instructions were followed to detect serum renal fibrosis indexes collagen type Ⅳ (CⅣ), connective tissue growth factor (CTGF) and transforming growth factor 毬 1 (TGF- 毬 1) levels Oxidative stress The same method was used to obtain serum from two groups of patients immediately after admission and after8 weeks of, and then determine (1) oxidation indexes: reactive oxygen species (ROS), lipid hydrogen peroxide (LHP) and advanced oxidation protein products (AOPPs); (2) anti-oxidation indexes: superoxide dismutase (SOD), vitamin E (VitE), vitamin C (VitC) and total antioxidant capacity (T-AOC). 2.5 Statistical methods SPSS 15.0 software was used for statistical processing, measurement data was in terms of Mean ± SD, comparison within same group before and after was by paired t test, measurement data comparison between two groups was by t test, and P<0.05 indicated statistical significance in differences. 3. Results 3.1 Renal function Analysis of serum renal function indexes Scr (μmol/l), BUN (mmol/l), CysC (mg/l) and 毬 2-MG (μg/mmol) levels between two groups of patients was as follows: before, differences in Table 1. Comparison of serum renal function index levels. Scr BUN CysC β2-mg Groups n Observation ± ±9.56 ab 15.48± ±0.71 ab 2.18± ±0.19 ab 3.92± ±0.28 ab Control ± ±10.14 a 15.62± ±1.83 a 2.15± ±0.21 a 3.98± ±0.38 a t value P value >0.05 <0.05 >0.05 >0.05 <0.05 <0.05 >0.05 <0.05 Note: compared with same group before, a P<0.05; compared with control group after, b P<0.05.
3 71 serum renal function indexes Scr, BUN, CysC and 毬 2-MG levels were not statistically significant between two groups of patients (P>0.05); after 8 weeks of, serum Scr, BUN, CysC and 毬 2-MG levels of both groups were significantly lower than those before, and the differences were statistically significant (P<0.05). 8 weeks of, serum Scr, BUN, CysC and 毬 2-MG levels of observation group were significantly lower than those of control group, and the differences were statistically significant (P<0.05), shown in Table 1., differences in serum oxidation indexes ROS, LHP and AOPPs levels were not statistically significant between two groups of patients (P>0.05); after 8 weeks of, serum ROS, LHP and AOPPs levels of both groups were significantly lower than those before, and the differences were statistically significant (P<0.05). 8 weeks of, serum ROS, LHP and AOPPs levels of observation group were significantly lower than those of control group, and the differences were statistically significant (P<0.05), shown in Table Renal fibrosis, differences in serum renal fibrosis indexes CⅣ, CTGF and TGF- 毬 1 levels were not statistically significant between two groups of patients (P>0.05); after 8 weeks of, serum CⅣ, CTGF and TGF- 毬 1 levels of both groups were significantly lower than those before, and the differences were statistically significant (P<0.05). 8 weeks of, serum CⅣ, CTGF and TGF- 毬 1 levels of observation group were significantly lower than those of control group, and the differences were statistically significant (P<0.05), shown in Table Oxidation indexes 3.4 Anti-oxidation indexes Comparison of serum anti-oxidation indexes SOD (μg/ml), VitE (μg/ml), VitC (μg/ml) and T-AOC (U/mL) levels between two groups of patients before and after was as follows: before, differences in serum anti-oxidation indexes SOD, VitE, VitC and T-AOC levels were not statistically significant between two groups of patients (P>0.05); after 8 weeks of, serum SOD, VitE, VitC and T-AOC levels of both groups were significantly higher than those before, and the differences were statistically significant (P<0.05). 8 weeks of, serum SOD, VitE, VitC and T-AOC levels of observation group were significantly higher than those of control group, and the differences were statistically significant (P<0.05), shown in Table 4. Table 2. Comparison of serum renal fibrosis index levels (μg/l). Groups n CⅣ CTGF TGF-β1 Observation ± ±5.65 ab 19.72± ±0.94 ab ± ±8.62 ab Control ± ±9.52 a 19.64± ±1.94 a ± ±18.76 a t value P value >0.05 <0.05 >0.05 <0.05 >0.05 <0.05 Note: compared with same group before, a P<0.05; compared with control group after, b P<0.05. Table 3. Comparison of serum oxidation index levels (μmol/l). Groups n ROS LHP AOPPs Observation ± ±42.64 ab ± ±45.75 ab 7.82± ±0.35 ab Control ± ±70.85 a ± ±56.86 a 7.91± ±0.67 a t value P value >0.05 <0.05 >0.05 <0.05 >0.05 <0.05 Note: compared with same group before, a P<0.05; compared with control group after, b P<0.05. Table 4. Comparison of serum anti-oxidation index levels. SOD VitE VitC T-AOC Groups n Observation ± ±9.11 ab 5.09± ±0.89 ab 15.37± ±3.09 ab 19.82± ±3.88 ab Control ± ±7.58 a 5.11± ±0.76 a 15.48± ±2.78 a 19.63± ±3.42 a t value P value >0.05 <0.05 >0.05 >0.05 <0.05 <0.05 >0.05 <0.05 Note: compared with same group before, a P<0.05; compared with control group after, b P<0.05.
4 72 4. Discussion EDN is the early stage of DN, and positive intervention during this period can reverse the renal function damage and largely reduce and even avoid the disease progression to end-stage renal disease[6]. Diet control, glucose lowering, blood pressure control and so on are the common strategies for EDN, their effect on delaying disease progression is limited, and other targeted drugs are also required to expand the curative effect. Polyol metabolism plays an important role in both occurrence and development of DN, and epalrestat, as aldose reductase inhibitor, can block the polyol metabolism pathways and reduce the generation of advanced glycation end-products[7]. There are many studies about epalrestat of diabetic peripheral neuropathy, but there are fewer studies about its role in the EDN patients. In the study, epalrestat was used as auxiliary means and applied in the of patients with EDN in our hospital, and the effect of the drug on patients renal function and oxidative stress was expounded. Trace albuminuria is the main performance of the EDN, and along with the increase of the proteinuria levels, substantial renal damage will gradually appear in patients. glomerular filtration function damage, the metabolites accumulate in the body, Scr and BUN levels in the blood circulation increase, and the specific rising degree is consistent with renal damage[8,9]. It has been confirmed in many studies that CysC and 毬 2-MG are directly correlated with the renal impairment in patients, CysC is the metabolite of sulfur-containing amino acid, its content keeps dynamic balance under physiological state, and the CysC accumulation mostly means kidney damage; 毬 2-MG belongs to the macromolecular protein, and serum 毬 2-MG level may increase in the early glomerular filtration function injury[10,11]. In the study, serum levels of above renal functionrelated indexes were detected at first, and it was found that compared with the control group, observation group were with lower serum Scr, BUN, CysC and 毬 2-MG levels after, indicating that after adjuvant epalrestat therapy, the renal function in patients with END is significantly optimized, and confirming the positive effect of epalrestat on improving the renal function in patients with END. In addition to hypertension and urine proteinuria, renal fibrosis is also an important feature in patients with DN. In the condition of diabetes, the oxygen free radicals produced in kidney tissue can activate p38mapk signaling pathway, prompt the massive transcription and expression of fibrosis factors CⅣ and CTGF through TGF- 毬 1, and eventually make extracellular matrix excessively deposit and form renal fibrosis[12]. the formation of renal fibrosis, the TGF- 毬 1, CⅣ and CTGF in the tissue can be partially released into the circulating blood and be detected, so the high serum expression of TGF- 毬 1, CⅣ and CTGF is a reliable sign of renal fibrosis[13]. It was found in the study that compared with control group, observation group were with lower serum TGF- 毬 1, CⅣ and CTGF levels after, indicating that the adjuvant epalrestat therapy reduces the degree of renal fibrosis in patients with EDN. Under high glucose state, the polyol metabolism increases from 5% of the baseline value to about 30%, active polyols metabolism is a precipitating factor of renal fibrosis, and the above anti-fibrosis effect of epalrestat may be realized by inhibiting polyols. Many studies have confirmed that oxidative stress is an important factor of the occurrence and development of DN, and the mitochondrial respiratory chain induced by high glucose causes excessive ROS, which directly damage the kidney tissue and lead to renal inflammation and fibrosis[14,15]. Oxidation/anti-oxidation imbalance is the core factor that leads to sustained kidney damage progression and end-stage renal disease, ROS, LHP, AOPPs and other oxidation products are massively produced under high glucose condition, and they inhibit the protective effect of antioxidants SOD, VitE, VitC and T-AOC on the body, further attack the kidney tissue cells and cause the aggravation of kidney dysfunction[16]. Detecting oxidation/anti-oxidation index levels in patients with EDN can accurately assess the damage of kidney tissue, and it is also a reliable way to judge the effect of adjuvant epalrestat therapy[17]. It was found in the study that compared with control group, observation group were with lower serum oxidation indexes ROS, LHP and AOPPs levels, and higher anti-oxidation indexes SOD, VitE, VitC and T-AOC levels after, showing that adjuvant epalrestat therapy can effectively reduce the systemic oxidative stress in patients with EDN, and this is also one of the fundamental mechanisms for it to protect renal function. To sum up, it is concluded as follows: adjuvant epalrestat therapy can optimize the renal function and reduce the systemic oxidative stress response in patients with early diabetic nephropathy, and it s worth popularization and application in clinical practice in the future. References [1] XU Yu-mei, JIN Gui-lan, ZHENG Jun. Epalrestat Tablets combined with orka capsule of 60 cases of diabetic nephropathy. Herald Med 2014; 33(11): [2] Halfon M, Rotman S, Egli M, Venetz JP, Pascual M. Continuous subcutaneous insulin pump associated with absence of recurrent kidney allograft diabetic nephropathy. Acta diabetologica 2015; 52(6): [3] SU Xiu-hai, LV Shu-quan, ZHANG Shu-fang, LI Shu-lin, YU Wen-xia, GUO Rui-qing, et al. Clinical observation of Sanhuangyishen capsule combined with epalrestat of early diabetic nephropathy. J Basic Chin Med 2015; 21(9): [4] Hu J, Yang S, Wang Y, Goswami R, Peng C, Gao R, et al. Serum bisphenol A and progression of type 2 diabetic nephropathy: a 6-year prospective study. Acta diabetologica 2015; 52(6):
5 73 [5] Zhao Ling-jun, Liu Yu-feng, Wu Lin-lin, Liu Shu-jun. Clinical application research of the latest international pathological diagnostic criteria for diabetic nephropathy. Chin J Lab Diagn 2014; 18(5): [6] Patel L, Thaker A. The effects of adenosine A2B receptor inhibition on VEGF and nitric oxide axis-mediated renal function in diabetic nephropathy. Renal Failure 2014; 36(6): [7] Zhiqing W, Jing W, Haili X, Shaozhuang L, Chunxiao H, Haifeng H, et al. Renal function is ameliorated in a diabetic nephropathy rat model through a duodenal-jejunal bypass. Diabetes Res Clin Pract 2014; 103(1): [8] Lu Q, Zuo WZ, Ji XJ, Zhou YX, Liu YQ, Yao XQ, et al. Ethanolic Ginkgo biloba leaf extract prevents renal fibrosis through Akt/mTOR signaling in diabetic nephropathy. Phytomedicine 2015; 22(12): [9] Ding Ling, Hu Yi, Yuan Ye. The influence of Atorvastatin on blood lipid, inflammatory factors and renal function in patients with early diabetic nephropathy. China Pharm 2015; 26(15): [10] Peng De-zhi, Kong Li, Li Han-yu. Effects of alprostadil on renal function and serum inflammatory factors of patients with early diabetic nephropathy. J Hainan Med Univ 2015; 21(2): [11] He Fang, Zhang Xiao, Chen He-jun, Li Jie, He Shi-xue. Systemic evaluation on effect of ginkgo biloba extract on microalbuminuria and renal function in patients with diabetic nephropathy. Chin J Exp Tradit Med Formulae 2016; 22(3): [12] He F, Peng F, Xia X, Zhao C, Luo Q, Guan W, et al. MiR-135a promotes renal fibrosis in diabetic nephropathy by regulating TRPC1. Diabetologia 2014; 57(8): [13] Jia Hui-yu, Li Zhong-nan, Chen Guang-liang. Effect of transforming growth factor beta 1/Sma-and Mad-related protein signal pathway in diabetic nephropathy and related drugs:a review. Chin J Pharmacol Toxicol 2016; 30(3): [14] Dabhi B, Mistry KN. Oxidative stress and its association with TNFα-308 G/C and IL-1α-889 C/T gene polymorphisms in patients with diabetes and diabetic nephropathy. Gene 2015; 562(2): [15] Man-hua ZUO, Jun TANG. Evaluation of elderly diabetic nephropathy patients' serum oxidative stress, angiogenesis targets and peripheral blood T cells contents during different stages. China J Modern Med 2015; 25(31): [16] Guo Fu-tuan, Xu Xiong-wei, Pan Jian-feng, Lin Pei-li, Zheng Ni. The anti-oxidative effect of Ramulus mori polysaccharides on diabetic nephropathy mice. Chin Pharmacol Bull 2016; 32(8): [17] Hsu YC, Lee PH, Lei CC, Ho C, Shih YH, Lin CL. Nitric oxide donors rescue diabetic nephropathy through oxidative-stress-and nitrosativestress-mediated Wnt signaling pathways. J Diabetes Invest 2015; 6(1):
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
CORRECTION NOTICE Nat. Genet. 42, 759 763 (2010); published online 22 August 2010; corrected online 27 August 2014 Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects
More informationEMPEROR'S COLLEGE MTOM COURSE SYLLABUS HERB FORMULAE I
COURSE DESCRIPTION The first of three courses in the Herb Formulae series. These courses can be taken in any order. The Herb Formulae series analyzes the functions, ingredients, and properties of approximately
More informationCanqiu Yu 1, Jinwei Chen 2, Li Huang 3*
A STUDY ON THE ANTITUMOUR EFFECT OF TOTAL FLAVONOIDS FROM PTERIS MULTIFIDA POIR IN H22 TUMOUR-BEARING MICE 459 Canqiu Yu 1, Jinwei Chen 2, Li Huang 3* 1 Department of General Surgery, The Second Xiangya
More information24 h. P > h. R doi /j. issn
38 4 2015 4 Vol. 38 No. 4 Apr. 2015 Journal of Beijing University of Traditional Chinese Medicine 271 2 ~ 3 * 1 2 2 2 2 2 1# 1 201203 2 2 ~ 3 55 2 18 37 24 2 0 8 16 24 24 h 2 P > 0. 05 P < 0. 05 P < 0.
More informationEMPEROR'S COLLEGE MTOM COURSE SYLLABUS HERB FORMULAE II
COURSE DESCRIPTION The second of three courses in the Herb Formulae series. Categories covered in Formulae II include the Tonify Qi and Blood, Regulate Qi, Invigorate the Blood, Stop Bleeding, Stabilize
More informationProtective effect of the n-butanol Toona sinensis seed extract on diabetic nephropathy rat kidneys
Protective effect of the n-butanol Toona sinensis seed extract on diabetic nephropathy rat kidneys W.Z. Li 1, X.H. Wang 1, H.X. Zhang 2, S.M. Mao 3 and C.Z. Zhao 3 1 College of Pharmacy, Weifang Medical
More informationLiu Jing and Liu Jing Diagnosis System in Classical TCM Discussions of Six Divisions or Six Confirmations Diagnosis System in Classical TCM Texts
Liu Jing and Liu Jing Diagnosis System in Classical TCM Discussions of Six Divisions or Six Confirmations Diagnosis System in Classical TCM Texts Liu Jing Bian Zheng system had developed about 1800 years
More informationJournal of Chemical and Pharmaceutical Research, 2017, 9(3): Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2017, 9(3):214-218 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Extraction Optimization and Antioxidant Activity
More informationRapid Detection of Milk Protein based on Proteolysis Catalyzed by Trypsinase
Rapid Detection of Milk Protein based on Proteolysis Catalyzed by Trypsinase Yafeng Chen Institute of Food Quality and Safety, University of Shanghai for Science and Technology Shanghai 93, China Email:cyfxy498@6.com
More informationResearches on Fermentation Engineering of Polysaccharide of
13 1 Vol13 No1 1 2009 2 Life Science Research Feb 2009 1a 1b, 2, 1 416000 2 416000 3 410300 : (Cordyceps militaris), :, 6% 1% 25, ; 6% 1% 22, : ; ; ; ; ; : TQ92 : A : 1007-7847(2009)01-0065-06 Researches
More informationRoot & Branch Bulk Formula List
An asterisk * indicates the inclusion of 1 or more granule versions of an herb because of limited availability on the American herbal market. These products are usually animal in nature like E Jiao, Shui
More informationProstate Disease A Pass By TANG QIAN LI ZHU BIAN
Prostate Disease A Pass By TANG QIAN LI ZHU BIAN Oxytocin and the Human Prostate in Health and - and PSA is then able to pass into the proliferation within the normal prostate. 4.4. Oxytocin and prostate
More informationGinkgo biloba extract postconditioning reduces myocardial ischemia reperfusion injury
Ginkgo biloba extract postconditioning reduces myocardial ischemia reperfusion injury K. Ran 1, D.-L. Yang 1, Y.-T. Chang 1, K.-M. Duan 2, Y.-W. Ou 2, H.-P. Wang 3 and Z.-J. Li 1 1 Department of Anesthesiology,
More informationAVINASH CHANDRA, MD. September 16 th, Business Address: Buffalo Neuroimaging Analysis Center
AVINASH CHANDRA, MD September 16 th, 2014 Title: MRI Fellow Business Address: Buffalo Neuroimaging Analysis Center 100 High Street; Buffalo, NY 14203 Work: 716 859 7040 Email: achandra@bnac.net Education
More informationCORRELATION BETWEEN SURVIVIN OVEREXPRESSION AND CLINICO-PATHOLOGICAL FEATURES OF INVASIVE CERVICAL CANCER: A META-ANALYSIS
Acta Medica Mediterranea, 2018, 34: 1091 CORRELATION BETWEEN SURVIVIN OVEREXPRESSION AND CLINICO-PATHOLOGICAL FEATURES OF INVASIVE CERVICAL CANCER: A META-ANALYSIS HUI-RONG LI 1, JI-LI BAI 2*, RUI XU 2,
More informationEffects of beraprost sodium on renal function and inflammatory factors of rats with diabetic nephropathy
Effects of beraprost sodium on renal function and inflammatory factors of rats with diabetic nephropathy J. Guan 1,2, L. Long 1, Y.-Q. Chen 1, Y. Yin 1, L. Li 1, C.-X. Zhang 1, L. Deng 1 and L.-H. Tian
More informationThe association between methylenetetrahydrofolate reductase gene C677T polymorphisms and breast cancer risk in Chinese population
Tumor Biol. (2015) 36:9153 9158 DOI 10.1007/s13277-015-3321-6 EDITORIAL The association between methylenetetrahydrofolate reductase gene C677T polymorphisms and breast cancer risk in Chinese population
More informationDiabetes Care Publish Ahead of Print, published online August 19, 2010
Diabetes Care Publish Ahead of Print, published online August 19, 2010 Neck circumference positively related with central obesity, overweight and metabolic syndrome in Chinese people with type 2 diabetes:
More informationratio in patients treated by sorafenib alone decreased after treatment (P<0.05), while CD 8
Int J Clin Exp Med 2016;9(2):4625-4629 www.ijcem.com /ISSN:1940-5901/IJCEM0015836 Original Article Effect of sorafenib combined with CIK cell treatment on immunity and adverse events in patients with late-stage
More informationSeasonal and geographical dispersal regularity of airborne pollens in China LI Quan-sheng, JIANG Sheng-xue, LI Xin-ze, ZHU Xiao-ming, WEI Qing-yu *
Med J Chin PLA, Vol. 42, No. 11, November 1, 2017 951 [] [ ] [ ] R562.25[ ] A[] 0177-7402(2017)11-0951-05 [DOI] 10.11855/j.issn.0577-7402.2017.11.03 Seasonal and geographical dispersal regularity of airborne
More informationJournal of Chinese Medicine. Vol.20, No.1, Vol.20, No.3,
163 Journal of Chinese Medicine Vol.20, No.1,2 1-96 Vol.20, No.3,4 97-162 ~ - 145 45-135 21 117 79-19 137-135 ~ - 137 65 87-65 - 145-65 - 153-79 - 153-87 47-137 - 65-87 - 47-145 - 145-47 - 19 164 153 HT7
More informationOriginal Article Application of AFP whole blood one-step rapid detection kit in screening for HCC in Qidong
Am J Cancer Res 2017;7(6):1384-1388 www.ajcr.us /ISSN:2156-6976/ajcr0048028 Original Article Application of AFP whole blood one-step rapid detection kit in screening for HCC in Qidong Jie Jin 1*, Xiao-yan
More informationAppropriate Quality regarde as
A systematic review of antibiotic prescription associated with upper respiratory tract infections in China (Jing Li, MS 1 ) Supplemental Digital Content-Table 1. Quality assessment of included studies
More informationFOUNDATIONS, ACUPUNCTURE, CHINESE HERBAL MEDICINE, BIO-MEDICINE. Stage Four Review
ICAOM LEARNING PROFICIENCY EXAMINATION FOUNDATIONS, ACUPUNCTURE, CHINESE HERBAL MEDICINE, BIO-MEDICINE Review and know the following: Stage Four Review 1. Familiar with the disease or symptom of the following
More informationAn excessive increase in glutamate contributes to glucose-toxicity in. β-cells via activation of pancreatic NMDA receptors in rodent diabetes
An excessive increase in glutamate contributes to glucose-toxicity in β-cells via activation of pancreatic NMDA receptors in rodent diabetes Xiao-Ting Huang 1, Chen Li 1,3, Xiang-Ping Peng 1, Jia Guo 1,5,
More informationCorrelations among copeptin, ischemia-modified albumin, and the extent of myocardial injury in patients with acute carbon monoxide poisoning
Correlations among copeptin, ischemia-modified albumin, and the extent of myocardial injury in patients with acute carbon monoxide poisoning J. Li, J.S. Wang, Z.X. Xie, W.Z. Wang, L. Wang, G.Y. Ma, Y.Q.
More informationExploration of pathological prediction of chronic kidney diseases. by a novel theory of bi-directional probability
Exploration of pathological prediction of chronic kidney diseases by a novel theory of bi-directional probability Yuan Yang 1,2, Min Luo 1, Li Xiao 1, Xue-jing Zhu 1, Chang Wang 1, Xiao Fu 1, Shu-guang
More informationPreliminary Agenda. 9:55-10:20 How to overcome TKI resistance? James Chih-Hsin Yang 10:20-10:40 Discussion All 10:40-10:55 Coffee break
Preliminary Agenda November 7, 2018 14:00-17:00 Registration and check in Satellite Symposia with Dinner 17:00-18:30 Jiangsu Hengrui Medicine Co., Ltd 17:00-18:30 Satellite Symposia with Dinner 17:00-18:30
More informationAmniotic fluid stem cells provide considerable advantages in epidermal. regeneration: B7H4 creates a moderate inflammation
Amniotic fluid stem cells provide considerable advantages in epidermal regeneration: B7H4 creates a moderate inflammation microenvironment to promote wound repair Qing Sun 1, +, Fang Li 1, +, Hong Li 2,
More informationROS as targets for therapeutic intervention of diabetic nephropathy
36 th Autumn Congress of Korean Diabetes Association September 16-17, 2010, BEXCO, Busan, Korea ROS as targets for therapeutic intervention of diabetic nephropathy Hunjoo Ha Department of Bioinspired Science
More informationPhase IV clinical trial of Shufeng Jiedu Capsule in the treatment of cases of acute upper espiratory infection of wind-heat syndrome
tp tp Phase IV clinical trial of Shufeng Jiedu Capsule in the treatment of 2 031 cases of acute upper espiratory infection of wind-heat syndrome XU Yan-ling 1, ZHANG Hui-hong 2, XUE Yun-li 2, YANG Jing-sheng
More informationValue of serum galectin-3 and midkine level determination for assessing tumor severity in patients with thyroid cancer
148 Journal of Hainan Medical University 2017; 23(3): 148-152 Journal of Hainan Medical University http://www.hnykdxxb.com Value of serum galectin-3 and midkine level determination for assessing tumor
More informationConstruction of the Vesselcollateral. Guidance for Prevention and Treatment of Vasculopathy. Section 1. China. Clinical Trials.
Section 1 05 Clinical Trials Construction of the Vesselcollateral Theory and its Guidance for Prevention and Treatment of Vasculopathy China Yiling Wu The Integration of Traditional and Western Medical
More informationA 4-year study of Red Yeast Rice extract known as Xuezhikang which lowers cholesterol... Monday, July 27, 2009
A 4-year study of Red Yeast Rice extract known as Xuezhikang which lowers cholesterol... 1 At a dose of 600 mg twice a day... 2 Reduced coronary events by 37%... 3 Reduced death from coronary heart disease
More informationEffect of low-dose aspirin and Danshen injection on hemorheology, vascular endothelial function and oxidative stress in pregnancy-induced hypertension
Journal of Hainan Medical University 2018; 24(6): 63-67 63 Journal of Hainan Medical University http://www.hnykdxxb.com Effect of low-dose aspirin and Danshen injection on hemorheology, vascular endothelial
More informationJournal of Hainan Medical University. Kun-Feng Zhang 1, Hui Chen 2, Jing-Song Ding Introduction
30 Journal of Hainan Medical University 2017; 23(11): 30-34 Journal of Hainan Medical University http://www.hnykdxxb.com Influence of budesonide and salbutamol atomization inhalation on Th17/ Treg balance
More informationinstrument. When 13C-UBT positive value is greater than or equal to / - 0.4, the the subject can be 1. Data and methods details are as follows:
Application of 13 C-urea breath test in screening helicobacter pylori infection during health examination in Chengdu, Sichuan YANG Yan-hua. LIU Yu-ping. CHENG You-fu, SHUAI Ping. LU Qiao. ZHENG Xiao-xia,
More informationCharacteristics of Patients Initializing Peritoneal Dialysis Treatment From 2007 to 2014 Analysis From Henan Peritoneal Dialysis Registry data
DIALYSIS Characteristics of Patients Initializing Peritoneal Dialysis Treatment From 7 to 14 Analysis From Henan Peritoneal Dialysis Registry data Xiaoxue Zhang, 1 Ying Chen, 1,2 Yamei Cai, 1 Xing Tian,
More informationHuman leukocyte antigen-b27 alleles in Xinjiang Uygur patients with ankylosing spondylitis
Human leukocyte antigen-b27 alleles in Xinjiang Uygur patients with ankylosing spondylitis H.-Y. Zou, W.-Z. Yu, Z. Wang, J. He and M. Jiao Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou
More informationOriginal Article Influence of retinal photocoagulation applied to severe diabetic retinopathy on the life quality of patients
Int J Clin Exp Med 2016;9(2):4630-4634 www.ijcem.com /ISSN:1940-5901/IJCEM0016207 Original Article Influence of retinal photocoagulation applied to severe diabetic retinopathy on the life quality of patients
More informationSingle Herbs III / Quiz I
Single Herbs III / Quiz I 1. What herb is good to generate fluids? A. Ren Shen C. Xi Yang Shen B. Tai Zi Shen D. All the Shens 2. What herb is best for Qi collapse? A. Huang Qi C. Dang Shen B. Ren Shen
More informationClinical Investigation II (Other Diseases and Safety) August 20, 2017, 9:30 12:00
Clinical Investigation II (Other Diseases and Safety) August 20, 2017, 9:30 12:00 Panel members Chairman: Ge LIN The Chinese University of Hong Kong Co-Chairman: Wei-Jen CHENG Chang Gung Memorial Hospital,
More informationLecture 19 Summary Gestational Diabetes and Complications of Diabetes. Gestational diabetes;
Lecture 19 Summary Gestational Diabetes and Complications of Diabetes Gestational diabetes; - Type of diabetes that only develops during pregnancy Usually diagnosed in late pregnancy Causes high blood
More informationXi Yang, Ri-Bao Wei, Ping Li, Yue Yang, Ting-Yu Su, Yu-Wei Gao, Qing-Ping Li, Xue-Guang Zhang, Xiang-Mei Chen
Int J Clin Exp Pathol 2016;9(9):9401-9407 www.ijcep.com /ISSN:1936-2625/IJCEP0028098 Original Article Correlation between serum hepatitis B virus DNA replication level and clinicopathology in 235 patients
More informationISSN: X (Print) (Online) Journal homepage:
Renal Failure ISSN: 0886-0X (Print) 155-6049 (Online) Journal homepage: http://www.tandfonline.com/loi/irnf0 Use of Ophiocordyceps sinensis (syn. Cordyceps sinensis) combined with angiotensin-converting
More informationWelcome Message. We look forward to seeing you in Nanjing in Welcome to Nanjing! Sincerely yours,
Welcome Message On behalf of the organising committee, it gives us immense pleasure to invite you to participate in the 6th ISMAAR World Congress on Mild Approaches in Assisted Reproduction, which will
More informationCURRICULUM VITAE. Yuan Lin, M.D., Ph.D.
CURRICULUM VITAE Yuan Lin, M.D., Ph.D. Visiting Assistant Professor, Epidemiology Richard M. Fairbanks School of Public Health, Indiana University Health Sciences Building (RG) 5122 1050 Wishard Blvd.
More informationCase Report Summary of the diagnosis and treatment of diabetic ketoacidosis complicated by multiple organ dysfunction syndrome in 21 patients
Int J Clin Exp Med 2018;11(5):5305-5309 www.ijcem.com /ISSN:1940-5901/IJCEM0071523 Case Report Summary of the diagnosis and treatment of diabetic ketoacidosis complicated by multiple organ dysfunction
More information290 Biomed Environ Sci, 2016; 29(4):
290 Biomed Environ Sci, 2016; 29(4): 290-294 Letter to the Editor Prevalence and Predictors of Hypertension in the Labor Force Population in China: Results from a Cross-sectional Survey in Xinjiang Uygur
More informationThe progressing research of traditional Chinese medicine treatment of. insomnia. Liu Jing1 a
4th International Conference on Education, Management and Computing Technology (ICEMCT 2017) The progressing research of traditional Chinese medicine treatment of insomnia Liu Jing1 a 1 Shandong University
More informationDIAGNOSTIC SIGNIFICANCE OF CHANGES IN SERUM HUMAN EPIDIDYMIS EPITHELIAL SECRETORY PROTEIN 4 AND CARBOHYDRATE ANTIGEN 125 IN ENDOMETRIAL CARCINOMA
Acta Medica Mediterranea, 2018, 34: 785 DIAGNOSTIC SIGNIFICANCE OF CHANGES IN SERUM HUMAN EPIDIDYMIS EPITHELIAL SECRETORY PROTEIN 4 AND CARBOHYDRATE ANTIGEN 125 IN ENDOMETRIAL CARCINOMA PATIENTS JING-LI
More information24 (TUDCA) TUDCA TUDCA. [DOI] /j.issn
968 2017 11 1 42 11 [ ] Wistar 56 6 50 10% 8 24 (TUDCA) (VFW) (FBG) (FINS) (HOMA-IR) (TC) (TG) (SBP) (DBP) N- - -D- (NAG) (m-alb) (BUN) (Scr) VFW FINS HOMA-IR TC TG SBP DBP NAG (P0.05)
More informationCURRICULUM VITAE. Professional Employment and Teaching Experience:
CURRICULUM VITAE Name: Current Address: Hong Chen American Academy of Acupuncture and Oriental Medicine 1925 West County Road B2 Roseville, MN 55113 Tel: (651) 631-0204 Fax: (651) 631-0361 E-mail: hongyu1229@hotmail.com
More informationLiu et al., Afr J Tradit Complement Altern Med. (2013) 10(4):78-82
78 A COMPARATIVE STUDY OF ANTI-GASTRIC CANCER ACTIVITY BETWEEN AQUEOUS EXTRACT AND ETHANOL EXTRACT OF FOLIUM CORDYLINES FRUTICOSAE Shaojun Liu 1, Dongbo Cao 2, Zhiming Xiao 1, Fen Liu 1, Xiaoyan Wang 1,
More informationNormal Reference Value of Hemoglobin of Middleaged Women and Altitude
YALE JOURNAL OF BIOLOGY AND MEDICINE 77 (2004), pp. 117-123. Copyright 2005. All rights reserved. ORIGINAL CONTRIBUTION Normal Reference Value of Hemoglobin of Middleaged Women and Altitude Ge Miao, a,*
More information4-1 Dyspnea (Chuan, 喘 )
4-1 Dyspnea (Chuan, 喘 ) Concept Breathing with difficulty (open wide mouth, raise shoulders) Etiology and pathogenesis Climatic factors Phlegm fluid Emotion Chronic diseases Exertion Over sex Diagnosis
More informationA high-performance liquid chromatography (HPLC) method for determination of chlorogenic acid and emodin in Yinhuang Jiangzhi Tea
Journal of Hainan Medical University 2016; 22(12): 17-21 17 Journal of Hainan Medical University http://www.jhmuweb.net/ A high-performance liquid chromatography (HPLC) method for determination of chlorogenic
More informationDiagnostic Accuracy of Intracellular Mycobacterium. tuberculosis Detection for Tuberculous Meningitis
Diagnostic Accuracy of Intracellular Mycobacterium tuberculosis Detection for Tuberculous Meningitis Running title: Laboratory diagnosis of tuberculous Guo-Dong Feng (MD PhD);Ming Shi(MD PhD); Lei Ma(MD
More informationSummary of Chapter 44 of the Líng Shū
Summary of Chapter 44 of the Líng Shū Shùn Qì Yī Rì Fēn Wéi Sì Shí The Human Healthy Energy in the Day and Night Corresponds with the Energies of the Four Seasons Paragraph 1 The initiation of the various
More informationACTA PHYSIOLOGICA SINICA
Acta Physiologica Sinica, Volume 63, Contents (1 6) 619 ACTA PHYSIOLOGICA SINICA (Continuing The Chinese Journal of Physiology Started in 1927) VOLUME 63 CONTENTS (1 6) No. 1 INVITED REVIEW Neuronal signaling
More informationLetter to the Editor. Association of TCF7L2 and GCG Gene Variants with Insulin Secretion, Insulin Resistance, and Obesity in New-onset Diabetes *
814 Biomed Environ Sci, 2016; 29(11): 814-817 Letter to the Editor Association of TCF7L2 and GCG Gene Variants with Insulin Secretion, Insulin Resistance, and Obesity in New-onset Diabetes * ZHANG Lu 1,^,
More informationHISTORY OF TRADITIONAL CHINESE MEDICINE
HISTORY OF TRADITIONAL CHINESE MEDICINE Shang Dynasty (1523 BC - 1027 BC) *Shamanic and Ancestral Medicine. Zhou Dynasty (1027 BC - 221 BC) Warring States *I Jing *Confucianism arose in the middle Zhou
More informationZhenju Jiangya Tablet-induced Acute Kidney Injury: A Case Report and Literature Review B Li 1, Q Wen 2, Z Gao 1, Z Hu 1, X Yang 1, T Peng 1
Zhenju Jiangya Tablet-induced Acute Kidney Injury: A Case Report and Literature Review B Li 1, Q Wen 2, Z Gao 1, Z Hu 1, X Yang 1, T Peng 1 INTRODUCTION Zhenju Jiangya tablet is used to control hypertension,
More informationClinical efficacy of ultrafiltration in the treatment of acute decompensated heart failure with diuretic resistance.
Biomedical Research 2017; 28 (14): 6155-6159 ISSN 0970-938X www.biomedres.info Clinical efficacy of ultrafiltration in the of acute decompensated heart failure with diuretic resistance. Jian Zhang, Qi
More informationInhibition of cisplatin-resistant tumor cells on activated CD4+ T cells in ovarian cancer and its mechanism
Pharmaceutical Inhibition of cisplatin-resistant tumor cells on activated CD4+ T cells in ovarian cancer and its mechanism Objective: To investigate the inhibition of cisplatin-resistant tumor cells on
More informationZORBAX Eclipse XDB-C 18 (100 mm 4.6 mm 3.5 µm) Lichrospher-C 18 (200 mm 4.6 mm 5 µm) Megres5-C 18 (250 mm 4.6 mm 5 µm)
1 11 Tab. 1 Similarity of 11 batches of Formula Granule of Artemisiae Scopariae Herba /% S1 0904181 0.991 S2 1002065 0.985 S3 1009047 0.998 S4 1101070 0.963 S5 1104052 0.991 S6 1108069 0.975 S7 1110021
More informationEffect of Humic Acid Application on the Yield and Quality of Flue-Cured Tobacco
Journal of Agricultural Science; Vol. 6, No. 11; 2014 ISSN 1916-9752 E-ISSN 1916-9760 Published by Canadian Center of Science and Education Effect of Humic Acid Application on the Yield and Quality of
More informationLEVEL OF FLUORIDE AND ARSENIC IN HOUSEHOLD SHALLOW WELL WATER IN WAMIAO AND XINHUAI VILLAGES IN JIANGSU PROVINCE, CHINA
192 Xiang, Wang, Yang, Zhang, Xu 192 LEVEL OF FLUORIDE AND ARSENIC IN HOUSEHOLD SHALLOW WELL WATER IN WAMIAO AND XINHUAI VILLAGES IN JIANGSU PROVINCE, CHINA Quanyong Xiang, a Yijun Wang, b Mingli Yang,
More informationSeasonal Changes in Leaf Magnesium and Boron Contents and Their Relationships to Leaf Yellowing of Navel Orange Citrus sinensis Osbeck
2010 37 81317 1324 Acta Horticulturae Sinica 1, 1,2,* 1 3 2 400712 400716 3 341000 6 P < 0.01 0.9082 0.9063 P > 0.05 S 666.4 A 0513-353X 2010 08-1317-08 Seasonal Changes in Leaf Magnesium and Boron Contents
More informationAnalysis of regulatory T cell subsets in the peripheral blood of immunoglobulin A nephropathy (IgAN) patients
Analysis of regulatory T cell subsets in the peripheral blood of immunoglobulin A nephropathy (IgAN) patients S. Yang, B. Chen, J. Shi, F. Chen, J. Zhang and Z. Sun Department of Nephrology, Huaihe Hospital
More informationAnalysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China H.L. Wei, J.R. Pei, C.X. Jiang, L.W. Zhou, T. Lan, M. Liu and T. Wang Center for Endemic Disease
More informationSingle Herbs III / Quiz II
Single Herbs III / Quiz II 1. What herb can nourish St Yin and brightens the eyes? A. Mai Dong C. Sha Shen B. Shi Hu D. Tian Dong 2. What herb can be used for an exterior invasion with Yin Xu? A. Sha Shen
More informationOriginal Article Clinical value of serum lipid profile and renal function for the management of hyperuricemia in adults in southern China
Int J Clin Exp Med 2017;10(2):3387-3393 www.ijcem.com /ISSN:1940-5901/IJCEM0030843 Original Article Clinical value of serum lipid profile and renal function for the management of hyperuricemia in adults
More informationAnalysis on nutritional components of the fruits in three population of Sichuan Pyracantha fortunaeana
IOP Conference Series: Earth and Environmental Science PAPER OPEN ACCESS Analysis on nutritional components of the fruits in three population of Sichuan Pyracantha fortunaeana To cite this article: Xi
More informationFundamentals of Traditional Chinese Medicine
Fundamentals of Traditional Chinese Medicine World Century Compendium to TCM Volume 1 Volume 2 Volume 3 Volume 4 Volume 5 Volume 6 Volume 7 Fundamentals of Traditional Chinese Medicine by Hong-zhou Wu,
More informationCancer incidence and patient survival rates among the residents in the Pudong New Area of Shanghai between 2002 and 2006
Chinese Journal of Cancer Original Article Cancer incidence and patient survival rates among the residents in the Pudong New Area of Shanghai between 2002 and 2006 Xiao-Pan Li 1, Guang-Wen Cao 2, Qiao
More information(A) [DOI] /j.issn
Med J Chin PLA, Vol. 41, No. 3, March 1, 2016 175 [ ] 30 SD 5 (A) (B) (C) (D) (E) 0.206 0.514 1.028mg/(kg d) ELISA HE Masson (TGF- ) 9(MMP-9) C D E A B (P
More information211 Coronary Heart Disease How To Do By WU NING HAN DING ZHU BIAN READ ONLINE
211 Coronary Heart Disease How To Do By WU NING HAN DING ZHU BIAN READ ONLINE Jian-Hua Li Di Xie Wen-Yan Lai Jia-Yi Wu Ping with non-st elevation acute coronary syndrome referred for Yang Hui Fan Hong-Li
More informationEffects of Yam Polysaccharides on P-Selectin Expression and Macrophage Infiltration in Diabetic Nephropathy Model Rats
Clinical and Experimental Medical Sciences, Vol. 3, 2015, no. 1, 11-21 HIKARI Ltd, www.m-hikari.com http://dx.doi.org/10.12988/cems.2015.521 Effects of Yam Polysaccharides on P-Selectin Expression and
More informationAnalysis of Related Factors of Overweight and Obesity among Secondary School Students in Chongqing, China
Available online at www.sciencedirect.com Physics Procedia 33 (2012 ) 104 110 2012 International Conference on Medical Physics and Biomedical Engineering Analysis of Related Factors of Overweight and Obesity
More informationCadmium and Chromium Accumulation in the Tissues of the Chinese Rice Grasshopper, Oxya chinensis
2011,30(12):2440-2445 Journal of Agro-Environment Science Oxya chinensis 1 1 2 1 1 3 1 1* 1. 030006 2. 030006 3. 030031 Oxya chinensis > > > > > > > > > > 6.798 4 mg kg -1 3.347 7 mg kg -1 P >
More informationInhaled Formaldehyde Induces Bone Marrow Toxicity via Oxidative Stress in Exposed Mice
DOI:http://dx.doi.org/1.731/APJCP.1.1.13.3 RESEARCH ARTICLE Inhaled Formaldehyde Induces Bone Marrow Toxicity via Oxidative Stress in Exposed Mice Guang-Yan Yu 1, Xiang-Fu Song 1, Ying Liu 1, Zhi-Wei Sun
More informationOutline of the Report on Cardiovascular Disease in China, 2010
Biomed Environ Sci, 2012; 25(3): 251 256 251 Report Outline of the Report on Cardiovascular Disease in China, 2010 National Center for Cardiovascular Disease, China HU Sheng Shou 1, KONG Ling Zhi 2, GAO
More informationIntegrative network analysis: Bridging the gap between Western medicine and traditional Chinese medicine
Hong Kong Baptist University HKBU Institutional Repository HKBU Staff Publication 2015 Integrative network analysis: Bridging the gap between Western medicine and traditional Chinese medicine Bing He Hong
More informationC 22. Calming LV, tranquilizing internal wind (13) LV yang. Shi Jue Ming ** Properties: Salty, mild cold LV. Actions: Suppress LV yang, clear eye heat
C 22. Calming LV, tranquilizing internal wind (13) LV yang Shi Jue Ming ** Zhen Zhu Mu * (Long Gu -)*** Mu Li *** Dai Zhe Shi ** Bai Ji Li/Ci Ji Li Wind/spasm Gou Teng ** Tian Ma *** Di Long ** Quan Xie
More informationBiomed Environ Sci, 2018; 31(2):
Biomed Environ Sci, 2018; 31(2): 159-162 159 Letter to the Editor Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure * MAO Gen Xiang 1,, CAO Yong Bao 1,, YANG
More informationStress and Displacement Analysis of Dental Implant Threads Using Three-Dimensional Finite Element Analysis
1 Research Article Stress and Displacement Analysis of Dental Implant Threads Using Three-Dimensional Finite Element Analysis Aswin Yodrux* Department of Materials Handling and Logistics for Engineering,
More informationCorrelation between serum P450arom and sex hormones in males with late-onset hypogonadism: a pilot study
European Review for Medical and Pharmacological Sciences 2019; 23: 70-74 Correlation between serum P450arom and sex hormones in males with late-onset hypogonadism: a pilot study J.-Q. WANG 1, D.-W. WANG
More informationChinese Pharmacological Bulletin 2012 Sep ~ 6. http / /www. cnki. net /kcms /detail / R html
1262 1262 ~ 6 2012-8 - 14 17 19 http / /www. cnki. net /kcms /detail /34. 1086. R. 20120814. 1719. 018. html MG - 63 1 1 2 2 1. 453003 2. 361005 doi 10. 3969 /j. issn. 1001-1978. 2012. 09. 018 A 1001-1978
More informationRole of IL-8 rs4073 and rs polymorphisms in the development of primary gouty arthritis in a Chinese population
Role of IL-8 rs4073 and rs2227306 polymorphisms in the development of primary gouty arthritis in a Chinese population Y.X. Cui, H. Zhao and H.Q. Guo Department of Rheumatism, Yan an University Affiliated
More informationAnalysis on the Effect of Modified Taijiquan on Stroke Patients in Rehabilitation of Movement Function
ORIGINAL ARTICLE Analysis on the Effect of Modified Taijiquan on Stroke Patients in Rehabilitation of Movement Function ZHANG Gao-feng College of Physical Education, Yangtze University, Jingzhou 434000,
More informationChina. Keywords: Synergistic Effects, Antioxidant, Ginkgo Leaves Flavonoid, Loquat Leaves Flavonoid, Response Surface Method(RSM).
2016 International Conference on Energy Development and Environmental Protection (EDEP 2016) ISBN: 978-1-60595-360-1 Antioxidant Synergistic Effect and Formulation Optimization of Ginkgo Leaves Flavonoid
More informationXiao-Ling Chi, Mei-Jie Shi, Huan-Ming Xiao, Yu-Bao Xie, and Gao-Shu Cai. Correspondence should be addressed to Xiao-Ling Chi;
Evidence-Based Complementary and Alternative Medicine Volume 2016, Article ID 3743427, 6 pages http://dx.doi.org/10.1155/2016/3743427 Research Article The Score Model Containing Chinese Medicine Syndrome
More informationThe changes of serum BDNF, blood lipid and PCI in the elderly patients with coronary heart disease complicated with diabetes mellitus
184 Journal of Hainan Medical University 2016; 22(16): 184-188 Journal of Hainan Medical University http://www.hnykdxxb.com/ The changes of serum BDNF, blood lipid and PCI in the elderly patients with
More informationGUOPEI LUO, PhD, MD. Shanghai Cancer Center, Shanghai, China. Joint-trained Ph.D. student, from 2008 to 2009, University of California, Irvine
GUOPEI LUO, PhD, MD EDUCATION Shanghai Cancer Center, Shanghai, China Joint-trained Ph.D. student, from 2008 to 2009, University of California, Irvine Ph.D. student specialized in pancreatic cancer, from
More informationAssociation between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis
Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis J.M. Xu 1,2, X. Song 3, F. Gao 4 and R. Wang 5 1 Medical College of Shandong University, Jinan, Shandong Province,
More informationScreening of Monacolin K-high-yielding Monascus strain by combinative mutation treatment
264507~5162007 Mycosystema 1 550002 2 100039 3 550002 4 550000 Monascus purpureus 45s 1.0 Monacolin K Monascus purpureus ZT32 5 Monacolin K 219.9µg/mL 2 Monacolin K 8.33mg/g 3.3 Q939.5 A 1672-6472200704-0507-0516
More informationEffect of Ginkgo biloba leaf extract on electroencephalography of rat with cerebral ischemia and reperfusion
157 2003, Acta Pharmacologica Sinica Chinese Pharmacological Society Shanghai Institute of Materia Medica Chinese Academy of Sciences http://www.chinaphar.com Effect of Ginkgo biloba leaf extract on electroencephalography
More informationResearch on Digital Testing System of Evaluating Characteristics for Ultrasonic Transducer
Sensors & Transducers 2014 by IFSA Publishing, S. L. http://www.sensorsportal.com Research on Digital Testing System of Evaluating Characteristics for Ultrasonic Transducer Qin Yin, * Liang Heng, Peng-Fei
More information