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1 - ( ). 2 2 * Downloaded from ijdld.tums.ac.ir at 5:5 IRDT on Friday March 22nd : : 8. Stratified. 500 HbAC 2. : HbAC HbAC :. 2 : : emrc@tums.ac.ir : : : 88//28: 88/0/26 : 88/8/20 :

2 ... : 70 Downloaded from ijdld.tums.ac.ir at 5:5 IRDT on Friday March 22nd 209 [ ]... [6 7 ] [5]. [8] [9] [20 2] [22]..[2].[2] mrna.[25] ).(87 86.[] 2 [2] [] 2....[]. [5] [6 7] [8]..[9]..[0 ]. [ 2].[2].[2] 2. - C-terminal cross-linked telopeptide of type I collagen

3 7 ( ). Downloaded from ijdld.tums.ac.ir at 5:5 IRDT on Friday March 22nd ( ) GOD/PAP HPLC (HbAC) (High Pressure Liquid Chromatography) DS5 Ingland. Bioscience (Nortic Bioscience Diagnostic A/S (CV),Denmark) 2.. % /7 %2/6 Bioscience (Nortic Bioscience Diagnostic A/S,Denmark) % 5/. % 6/6 ELISA 0pg/ml % 7/5 % / 5 Human visfatin ELISA kit,adipogen ).(Pharmaceuticals, Belmont, Seoul Korea ELISA 00pg/ml %/82 %5/5 Human Adiponectin ELISA kit, AdipoGen ).(Pharmaceuticals, Belmont Seoul, Korea (Camellia sinensis). 86 F.P Coefficient of variation - Inter-assay - Intra-assay 5- Intra-assay.[26] (WHO ) 0 kg/m 2 25 (BMI). 2 - ) (.. Stratified. 8. ). ) (0/ kg. (0/ cm C GPO-PAP GOD/PAP Endpoint. (HDL) Randox.(Hitachi 902) (OGTT). [27] - World Health Organization

4 ... : 72 Downloaded from ijdld.tums.ac.ir at 5:5 IRDT on Friday March 22nd /) 0-0/0.( % 22/2 %/.(P=0/09). ] HbAC (P =0/02) 89/5±6/7 2/5±57/ [(P=0/0) 7/7±/5 5/9± 0/5 2/±2/9 8/± 8/6). (P=0/0). %7 HbAC %7) HbAc %75 ( HbAc > %/.(P= 0/05) ) 500. ( ± 5 SPSS Paired t-test. t-test... Chi-square 0 / (%9.5) 6 ±. (%80.5) 0/9±0/06 kg/m 2 29/90±/9 5± (P=0/07) 2 (P= 0/00). HbAC 2 - Microcrystalline cellulose

5 7 ( ). - 5 ± ( ) 68±5 ( ) 29/9±/ (kg/m2) 70±62 (mg/dl) Downloaded from ijdld.tums.ac.ir at 5:5 IRDT on Friday March 22nd ±8 (mg/dl) 2 7 /6±/8 (%)Hb AC /7±6 (µlu/ml) 6/9±/9 (µg/ml) 7/2±/8 (ng/ml) 7/±0/5 (ng/ml) ±0/ (ng/ml) HbAc; glycosylated hemoglobin AC. ± * -2 26= 29/8±/6 0±/ 5 (kg/m2) 0/90±0/07 0/9±0/ 06 69±70 62± 65 (mg/dl) 220±77 27± 85 (mg/dl) 2 7/2±/8 7 /2±/ 6 (%)HbAC 6/7±8/9 5/9±7/ *(µlu/ml) 8/±2/6 6/8±/ (µg/ml) 7/8±/ 7/±8/ 5 (ng/ml) ±0/5 /±0/ (ng/ml) 5/±9/ 2/6± 0 (ng/ml) -0/±0/7 0/0±0/ /±0/2 0/8±0/ 5 * HbAc; glycosylated hemoglobin Ac.(P< 0/05) P *. ±

6 ... : 7 Downloaded from ijdld.tums.ac.ir at 5:5 IRDT on Friday March 22nd 209-6= 29/8± 29/7± (kg/m2) 0/9±0/07 0/8±0/ 05 85±72 75± 62 (mg/dl) 206±6 2± 8 (mg/dl) 2 8/±2 7 /6± 2 (%)Hb AC 5/5±7 /±/ (µlu/ml) 7/±5/ 7/±/ (µg/ml) 6/±/9 8/6±5/ 6 (ng/ml) 0/9±0/ 0/9±0/ (ng/ml) 5/±0/2 5±0/ (ng/ml) -0/±0/ -0/±0/ 6 /±0/ /±0/ HbAc; glycosylated hemoglobin AC.(P> 0/05) P *. ± [2] Fukino 2 HbAC Ryu. []. HbAC.[0]... mrna.[] 2.[28] 2..[29] 2...[0 ] HbAC.

7 75 ( ). Downloaded from ijdld.tums.ac.ir at 5:5 IRDT on Friday March 22nd 209.[7 9] [0] Okazaki Rosato. []. HbAC....[2]. [] Shen In vivo 6 In. mrna vitro.[5].[6]. [7] Kanazawa. HbAC BMI BMI Kanazawa [8 6 22].. HbAC - Deoxypyridinoline - Fenton reaction 2- Caspase

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