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9 ( )...[ ] : C C C-. C C- C C C.[] - C C.[] - mg/dl. C-.() (P</) AUC. AUC AUC.. C Gwin up. 1. Fix JA. Oral controlled release technology for peptides: status and future prospects. Pharm. Res 1996; 13: Fasno A. Innovative strategies for the oral delivery of drugs and peptides. Trends Biotechnol 1998; 16:
10 ... : 3. Feskens EJ, Kromhout D. Hyperinsulinemia, risk factors and coronary heart disease. The zutphen elderly study. Arterioscler. Thromb 1994 ; 14 : Davis SS. Overcoming barriers to the oral administration of peptide drugs. Trends Pharmacological Sci 1990 ; 11 : Schilling RJ, Mitra AK. Degradation of insulin by trypsin and alpha-chemotrypsin. Pharm Res 1991 ; 8 : Heinmann L, Pfuzner A., Heise T. Alternative routes of administration as an approach to improve insulin thrapy : update on dermal, oral, nasal and pulmonary insulin delivery. Curr Pharm Des 2001; 7: Crane CW, Path MC, Luntz GR. Absorption of insulin from the human small intestine. Diabetes 1968 ; 17 : William T Cefalu. Concept, strategies and feasibility of noninvasive insulin dlivery. Diabetes Care 2004 ; 27: Dorkoosh FA, Verhoef jc, Borchard G, et. al. Intestinal absorption of human Insulin in pigs using delivery system based on superporoushydrogely polymers. Int. J. Pharma 2002; 247: Dorkoosh FA, Setyaningsih D, Borchard G, et.al. Effects of superporous hydrogely on paracellular drug permeability and cytotoxicity studies in caco-2 cell monolayers. Int J Pharma 2002 ; 247: Dorkoosh FA, verhoef J, Bochard G, et.al. Development and charactriziation of anovel peroral peptide drug delivery system. J control Rel 2001; 71: Dorkoosh FA., Borchard G, Rafiee-Tehrani M. Evaluation of superporoushydrogely (SPH) and SPH composites; in porcine intestin ex-vivo: assessment of drug transport morphology effect, and mechanical fixation to intestinal wall. Eur J Pharma 2002; 53: Still JG. Development of oral insulin : progress and current states. Diabetes Metab Res Rev 2002 ; 18 : Larsen PR, Kronenberg HM, Melmed S, Polonsky KS. Williams text book of endocrinology, Suanders; 2003: 1443, 1447, Gwinup G, Elias AN, Domurat ES, Insulin and C-peptide levels following oral administration of insulinin intestinal-enzyme protected capsules. Gen Pharmacol 1991; 22: Chetty D J, Ywo C. Novel methods of Insulin Delivery: an update. Crit. Rev. Ther. Drug Carrier Sys 1998; 15:
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