Renowned scientists from each field will highlight ongoing progress in state-of-the-art lectures followed by discussion and case presentations.

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1 Dear colleagues, On behalf of the Porto, Clinical Nephrology Update we are pleased to invite you to attend this event jointly organized by the Nephrology Collaborative Group of the Mayo Clinic and Department of Nephrology of the Faculty of Medicine of Porto to be held on October 2019 in Porto, the old city that gave the name to Portugal, world famous for its wine, its gastronomy, its historic center, classified as World Heritage by UNESCO and the University of Porto. The event has a high profile in the clinical nephrology field and will provide information about the latest scientific advances regarding new pathophysiological aspects and diagnosis of the main kidney diseases, including acute kidney injury, review new management strategies for kidney damage associated to systemic diseases, peritoneal dialysis and transplantation and summarize data from current trials on the treatment of primary and secondary kidney diseases, among other relevant topics. Renowned scientists from each field will highlight ongoing progress in state-of-the-art lectures followed by discussion and case presentations. Come to Porto, stay on the cutting edge of clinical nephrology and enjoy the beauty of this amazing city. Sincerely, Karina Soto, Fernando Fervenza, Manuel Pestana Co-chairs Endorsed by:

2 MEETING OVERVIEW Title: Porto Clinical Nephrology Update Date: October, 11th 12th, 2019 Venue: Congress Centre Porto Palácio Hotel, Porto, Portugal ORGANIZATION Mayo Nephrology Collaborative Group Nephrology Dept. of Faculty of Medicine of University of Porto CO-CHAIRS Karina Soto Fernando Fervenza Manuel Pestana SCIENTIFIC COMMITTEE Fernando Fervenza, Karina Soto, Fernando Cosio, Manuel Pestana ORGANIZING COMMITTEE António Cabrita, Ana T Nunes, Inês Ferreira, Isabel Tavares, João C. Fernandes, João M Frazão, Luciano Pereira, Luis Coentrão, Rui Alves, Susana Sampaio TO WHOM IT IS ADRESSED This course is designed for nephrologists, residents, internists, and other clinicians who seek a concise update on pathogenesis and treatment of kidney diseases. This activity will deliver updated and cutting-edge information that can be integrated into clinical practice. The participants can expect a series of lectures, literature reviews and illustrative clinical case presentations covering the main aspects of clinical nephrology.

3 THEMES FACULTY 1 FSGS news in classification: differentiating from secondary 2 Clinical trials in ANCA-associated vasculitis: what do and don t tell us to effectively manage the patient 3 Membranous Nephropathy an updated review and serology-based approach FERNANDO FERVENZA ULRICH SPECKS FERNANDO FERVENZA 4 Clinical utility of biomarkers in ANCA-associated vasculitis ULRICH SPECKS 5 Sepsis-associated AKI: heart-kidney cross talk 6 What is new in IgA Nephropathy 7 Computer clinical decision support for AKI: where do we stand and what can we expect KIANOUSHI KASHANI FERNANDO FERVENZA KIANOUSHI KASHANI 8 New treatment strategies in lupus nephritis LADAN ZAND 9 Update on Nephrotoxicity MARK PERAZELLA 10 Updating the relationship between parathyroid hormone levels and outcomes in CKD LADAN ZAND 11 Amyloidosis: Improving diagnostic tests and exploring new treatment options NELSON LEUNG 12 Update in genetic testing and therapeutic approach of polycystic kidney disease VICENTE TORRES 13 Monoclonal gammopathies of renal significance: new challenges in diagnosis and treatment NELSON LEUNG 14 Mass spectrometry approach in kidney biopsies 15 Proteomic approach in kidney disease MARIAM PRIYA ALEXANDER MARIA ALIICE C WILLRICH 16 Collagen type IV related hereditary nephropathies JOÃO P OLIVEIRA 17 Update in complement testing MARIA ALICE C WILLRICH 18 Update on the BANF classification LYNN CORNELL 19 Lessons learned from protocol biopsies of kidney allografts: what do we need to do to improve survival? FERNANDO COSIO 20 Immune monitoring for controlling the risk of immunosuppression HATEM AMER 21 Recurrent Glomerulonephritis in Kidney Transplant FERNANDO COSIO

4 PROGRAMME Friday, October 11 th, :15 Registration 08:45-09:00 Opening Session 09:00 09:40 FSGS news in classification: differentiating from secondary FERNANDO FERVENZA 09:40 10:20 10:20 10:40 Coffee-break Clinical trials in ANCA-associated vasculitis: what do and don't tell us to effectively manage the patient 10:40 11:20 Membranous Nephropathy an updated review and serology-based approach ULRICH SPECKS FERNANDO FERVENZA 11:20 12:00 12:00 13:00 Clinical utility of biomarkers in ANCA-associated vasculitis Selected Clinical Cases Discussion (primary glomerulonephritis) ULRICH SPECKS FERNANDO FERVENZA (Chair) 13:00 14:30 Lunch Break 14:30 15:05 Sepsis-associated AKI: heart-kidney cross talk KIANOUSHI KASHANI 15:05 15:40 What is new in IgA Nephropathy 15:40 16:15 16:15 16:30 Coffee-break Computer clinical decision support for AKI: where do we stand and what can we expect FERNANDO FERVENZA KIANOUSHI KASHANI 16:30 17:05 New treatment strategies in lupus nephritis LADAN ZAND 17:05 17:40 Update on Nephrotoxicity MARK PERAZELLA 17:40 18:15 Updating the relationship between parathyroid hormone levels and outcomes in CKD LADAN ZAND 18:15 19:15 Selected Clinical Cases Discussion (Nephrotoxicity) MARK PERAZELLA (Chair)

5 PROGRAMME Saturday, October 12 th, :00-09:40 Amyloidosis: Improving diagnostic tests and exploring new treatment options NELSON LEUNG 09:40 10:20 Update in genetic testing and therapeutic approach of polycystic kidney disease VICENTE TORRES 10:20 10:35 Coffee-break 10:35 11:15 Monoclonal gammopathies of renal significance: new challenges in diagnosis and treatment NELSON LEUNG 11:15 11:45 Mass spectrometry approach in kidney biopsies MARIAM PRIYA ALEXANDER 11:45 12:15 Proteomic approach in kidney disease MARIA ALIICE C WILLRICH 12:15-13:15 Selected Clinical Cases Discussion (secondary glomerulonephritis) FERNANDO FERVENZA (Chair) 13:15 14:45 Lunch Break 14:45 15:15 Collagen type IV related hereditary nephropathies JOÃO P OLIVEIRA 15:15 15:45 Update in complement testing MARIA ALICE C WILLRICH 15:45 16:15 Update on the BANF classification LYNN CORNELL 16:15 16:30 Coffee-break 16:30 17:05 Lessons learned from protocol biopsies of kidney allografts: what do we need to do to improve survival? FERNANDO COSIO 17:05 17:40 Immune monitoring for controlling the risk of immunosuppression HATEM AMER 17:40 18:15 Recurrent Glomerulonephritis in Kidney Transplant FERNANDO COSIO 18:15 19:45 Selected Clinical Cases Discussion (kidney transplant) FERNANDO COSIO (Chair)

6 VENUE PORTO PALÁCIO CONGRESS CENTRE, PORTO, PORTUGAL Av. da Boavista, Porto The Porto Clinical Nephrology Update welcomes you in Porto! Porto is a city full of heritage. From the picturesque streets of downtown Porto to the churches and monuments, there are many reasons why the city of Porto was classified as World Heritage by UNESCO. Known for its architecture, historical center, sightseeing, nightlife, and gastronomy, this amazing city had the privilege to be considered European best destination in 2012, 2014 and most recently in The Porto Palácio Congress Centre has a privileged location. Is situated in one of Porto s principal avenues, with great access, near to a lot of areas of interest and 16 km away from Porto airport (Francisco Sá Carneiro-OPO). SECRETARIAT Tel: Tlm: paula.nora@norahsevents.pt

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