Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)

Size: px
Start display at page:

Download "Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)"

Transcription

1 Design and development of Metformin hydrochloride Tried sustained release tablets Venkateswara Rao T 1 *, Bhadramma N 1, Raghukiran CVS 2 and Madubabu K 3 Bapatla College of Pharmacy, Bapatla, Guntur Tigala Krishna Reddy College of Pharmacy, Hyderabad. Hetro Drugs Ltd, Hyderabad Corresponding author: ABSTRACT Diabetes is one of the major causes of death and disability in the world. Diabetes results from decreased secretion of insulin, decreased insulin action or both. The main aims of the investigation was to design and development of tri floating tablets of metformin hydrochloride and also study the influence of concentrations of HPMCK 100 on various properties of tablet and tri- tablets were formulated by wet granulation method. Drug - excipient compatibility studies were conducted by FTIR spectroscopy. The prepared granules, tablets were evaluated. In-vitro release data revealed that F5 formulation sustained the release for 12 hours and the release data was fitted into zero order, first order, Higuchi and Peppas equations. The drug release from the formulation followed zero kinetics and exhibits Peppas mechanism. Release exponents n was found less than 0.85 indicating the release governed by non-fickian anomalous transport mechanism. Key words: Tri i floating tablets, Hydroxy propyl methyl cellulose (HPMCK100) INTRODUCTION Diabetes is one of the major causes of death and disability in the world. Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia (fasting plasma glucose 7.0 mmol / 1 or 2 hours post 75 g oral glucose load plasma glucose 11.1 mmol / on two or more occasions). Diabetes results from deficient insulin secretion, decreased insulin action, or both. The oral route of drug administration was most convenient method for controlled delivery of drug. It provides the continuous oral delivery of a drug also the system that target the delivery of a drug to a specific region within the GI tract for either local / systemic action. One of the most feasible approaches for affecting a prolonged and predictable drug delivery in the GI tract is to control the GRT. Metformin hydrochloride is an antihyperglycemic agent, which improves the glucose tolerance in type 2 diabetes. People with type 2 diabetes are not able to make enough insulin or respond normally to the insulin their bodies make. This leads to serious medical problems including kidney damage, amputations and blindness. The absolute bioavailability of Metformin hydrochloride is 50-60%, biological half life is hours and the main site of absorption of metformin hydrochloride is proximal end of small intestine. The HBS system was planned for Metformin hydrochloride as such a system when administered it remain buoyant on the gastric fluids for a prolonged period of time and the drug it remain buoyant on the gastric fluids for a prolonged period of time and the drug would be available in the dissolved format. This would leads to improvement in the bioavailability of the drug, to increase its bioavailability gastro retentive drug delivery systems were choosen for development in the form of tablet. In this way it stands as an advantage over conventional dosage form, which needs to be administered twice or thrice a day. MATERIALS AND METHODS Metformin hydrochloride was received from Alkem laboratories ltd, Mumbai as gift sample, HPMC, sodium bicarbonate, talc was procured from S.D fine chem.all other chemicals and solvents used in this study were LR grade Preparation of tri-i Metformin Hydrochloride floating tablets: The preparation of tri tablet involves three steps and the granules were prepared by wet granulation method using water as binding solution, lactose as diluent. Formulation of the upper and bottom : The granules for upper and bottom were prepared as per the formulae shown in table no 1.1.The cohesive mass were prepared passed through sieve no 12. The granules were dried in an oven at 55 0 for 2 hrs. the dried granules were passed through sieve no 16, lubricated with talc and magnesium stearate for compression into tablet. Formulation of the middle : The granules were prepared by wet granulation method as per the formulae shown in table no 1.1.The dough mass was prepared by the addition of water as binding a solution into the mixture of drug, polymer and diluent. The obtained dough mass was passed through sieve no 12, granules were dried in an oven at 55 0 for 2hrs. The dried granules were passed through sieve no 16. The IJRPB 1(6) November December 2013 Page 893

2 upper bottom upper bottom upper bottom upper bottom upper bottom dried granules were mixed with talc and magnesium stearate, then subjected to compression. Compression of tri tablet: The compression of the tablet involves three steps. The granules for bottom were compressed slightly, then the granules for middle were poured over the above compact, again compressed with minimum force to form a second and then top granules were added over the above, then compressed into a tablet by Cadmach Rotary tablet machine ie tried tablet by using a16 mm flat - faced punches. Table.1.Composition of metformin hydrochloride tri floating tablets with HPMC K100M Ingredients ( mg/ tablet) F1 F2 F3 F4 F5 Metformin hydrochloride HPMC K 100 M Sodium bicarbonate Lactose Talc Magnesium stearate Total weight Characterization of granules: The prepared granules were evaluated for the following parameters[10,11]. Bulk density: The bulk density was determined by measuring the volume occupied by the pre weighed granules,it was calculated by the following equation. Bulk density = Mass of Granules /Volume of packing Tapped bulk density: The granules whose weight was determined earlier was transferred in to 100ml of graduated cylinder and subjected to 100 taps. Then the volume occupied by the granules (Tapped volume) were determined. Tapped density was calculated by the following formula Tapped density = Mass of granules/tapped volume Carr'sindex: The percentage of compressibility of granules was determined by Carr's/Compressibility index. Carr's index (%) = Tapped density- Bulk density /tapped density 100 Hausner s ratio: Hausner ratio of granules determined by comparing the tapped density to the bulk density by using the formulae Hausner,s ratio = Tapped density/bulk density Angle of repose: The prepared granules were assessed for its flow property by determining the angle of repose by open tube method. The angle of repose was determined by the following formula h = height of heap r = radius of the base. Loss on drying: Granules (Igm) were kept in an oven at 105 c and dried up to constant weight. Loss on drying was calculated using the following formulae. Loss on drying = (Initial weight - Final weight)/initial weight 100 Moisture content: Granules (1gm) were kept in an oven at 105 c and dried up to constant weight. Moisture content was calculated using the following formulae. Moisture content = (Initial weight - Final weight)/final weight 100 Evaluation of tablets: The formulated tablets were evaluated for the following parameters. Thickness: The thickness and diameter of the formulated tablets were measured by using Vernier calipers. IJRPB 1(6) November December 2013 Page 894

3 Weight variation: The formulated tablets were tested for weight uniformity. 20 tablets were collectively and individually. From the collective weight, average weight was calculated. Each tablet weight was then compared with average weight to ascertain whether it is within permissible limits or not. % Weight Variation = (Average weight-individual weight)/ average weight 100 Hardness: The tablet crushing strength, which is the force required to break the tablet by compression in the diametric direction was measured in triplicate by using Pfizer tablet hardness tester. Friability: The Roche friability test apparatus was used to determine the friability of the tablets. 20 pre weighed tablets were placed in the apparatus, which was subjected to 100 revolutions. Then the tablets were reweighed. The percentage friability calculated was using the formula. % Friability = Initial weight- Final weight / initial weight 100 characteristics: characteristics were determined by using USP dissolution XI apparatus at 100 rpm using 900 ml of 0.1 N HCl and temperature was maintained at 37 c. lag time: The tablet was placed in dissolution apparatus and the time taken to float on the dissolution medium was noted. time: The total duration of the time that the tablets float on dissolution medium was noted. Swelling index: Tablet was weighed (W 0 ) and placed in dissolution medium containing 0.1N HClmaintained at 37 c. At predetermined time intervals the tablet was and blotted to remove excess water and weighed (Wt). The percentage of swelling index calculated. Swelling index = (W t - W o )/W t x 100 W t = final weight of the tablet W o = initial weight of the table Drug content: Twenty tablets were weighed and powdered. The quantity of powder equivalent to 100 mg of Metformin hydrochloride was dissolved in 0.1 N HC1 diluted to 100ml with 0.1N HC1 then the solution was filtered and suitably diluted. The drug content was estimated spectrometrically at 233 nm. In-vitro dissolution studies: In-Vitro dissolution studies were conducted by using USP type II paddle dissolution apparatus with 900ml of 0.1N Hydrochloric acid as dissolution medium, maintained the temperature of medium at 37±0.5 and stirrer speed at 100 rpm. 5 ml of aliquots of dissolution medium was withdrawn at regular time intervals and the same volume of pre-warmed (37±0.5 ) fresh dissolution medium was replaced. The samples were filtered and drug content of Metformin hydrochloride in each sample was analyzed after suitable dilutions, filtered and filtrates are analyzed by Shimadzu UVspectrophotometer at 233 nm. RESULTS AND DISCUSSION Drug- excipient compatibility studies were conducted by FTIR spectroscopy, results revealed that no chemical interactions were observed from the FTIR as shown in fig 2, 3 and 4. The prepared granules for floating and sustained release were evaluated found to have free flow properties, results given in table 2 and also the tablets were subjected to thickness, weight variation, hardness, floating time, floating log time, swelling index, drug content and in-vitro dissolution studies.the thickness of the tablets was found in the range of mm to mm. The weight variation ranged between to , the hardness of the floating tablets were ranged between 6.0 kg/cm 2 to 7..3kgcm 2. The percent friability of prepared tablets was well as within the acceptable limit. The range between the formulations had desired floating log time to mg and total floating time found between 6.5-9hrs regardless of concentrations of polymers incorporated, results given in the table 3. The swelling index result was observed in a range between ± 0.02 to ± 0.03, that increase in percent swelling was increasing with increasing concentration of polymers. The drug content in all formulations was within the range of 499.2mg ± 0.01 to 499.5mg ± 0.03, ensuring the uniformity of the drug content in the formulation. The percentage of drug release for F1, F2, F3, F4, F5 were found to be ± 0.23, ± 0.53, ± 0.04, ± 0.85 and ± at the end of 6.5, 7.5, 8.5, 9 and 11hours respectively, in vitro release profiles as shown in fig 1. In vitro release data fitted into the zero order, first order, matrix and peppas equations. The formulations followed zero order kinetics and exhibited peppas transport mechanism, release exponent found less than 1, indicates non fickian diffusion mechanism. Results revealed that as concentration of polymer increases, the floating time was found to be increased and prolonged the release of the drug due to the swelling of HPMC and high uptake of medium, floating time influenced by the gas generating agent and also it influences the drug release. Among all prepared formulation F5 sustained the release for prolonged time; hence it was suitable for the sustained release for the patient in the treatment of diabetes and enhances the bioavilabilty of the drug in the form of floating delivery system. In tri tablet, the drug was sustained for prolonged period of time due to the gelling property of polymer and drug sand witched between the two s formulated with the HPMCK100M so drug release was prolonged for more time. IJRPB 1(6) November December 2013 Page 895

4 % Drug Released Table.2.Characterization of Metformin hydrochloride trilateral floating granules formulated with HPMC K100M Formulations Bulk density(g/ml) Tapped density(g/ml) Carr s index (%) Hausner s ratio Angle of repose ( 0 ) Loss on drying (%) Moisture content (%) F ± ± ± ± ± ± ±0.01 F ± ± ± ± ± ± ±0.03 F ± ± ± ± ± ± ±0.02 F ± ± ± ± ± ± ±0.04 F ± ± ± ± ± ± ±0.01 Table.3.Characterization of Metformin hydrochloride tri floating tablets formulated with HPMC K 100 M Formulations Thickness(mm) Weight variation(%) Hard ness(kg/cm 2 ) Friability( %) lag time(min) Floting time (hr) Swelling index)(%) Drug content(mg) F1 3.1± ± ± ±0.01 4± ± ±0.01 F2 3.5± ± ± ±0.02 4± ± ±0.03 F3 3.5± ± ± ±0.03 4± ± ±0.01 F4 3.8± ± ± ±0.02 3± ± ±0.05 F5 3.8± ± ± ±0.04 3± ± ±0.03 Figure.1. Dissolution profiles of Metformin hydrochloride bi floating tablets formulated with HPMC k100m F1 F2 F3 F4 F Time(hrs) Figure.2.IR spectrum of Metformin hydrochloride Figure.3. IR Spectrum of HPMC K 100 M IJRPB 1(6) November December 2013 Page 896

5 Figure.4. IR spectrum of best formulation CONCLUSION The objective of present study was design and development of tri-ed floating tablet of Metformin hydrochloride for sustained the release. The HPMCK 100M as a polymer more reliable and sustained the drug for a prolonged period of time by increasing the concentration of it. More over the high swelling property of the polymer helped in maintaining the buoyancy with the minimal utilization of gas evolving excipients such as sodium bicarbonate which increased a marked impact on the gastro intestinal fluids by its alkaline nature. The formulations followed zero order kinetics and exhibits the peppas transport mechanism and hence finally concluded that tri formulations were found to be suitable for the floating drug delivery systems. REFERENCES Atyabi F, Sharma HL, Mohammed HAH, Fell JT, In vivo evaluation of a novel gastro retentive formulation based on ion exchange resins, J. Control Release, 42, 1996, Dave B.S, Amin A.F & Patel M.M, G astro retentive drug delivery system of ranidine hydrochloride formulation and in vitro evaluation, AAPS Pharm. Sci. Tech, 5(2), 2004, 1-6. Hwang J, H. Park, K. Park, Gastric retentive drug delivery systems, Drug carrier Syst, 15, 1998, Indian pharmacopoeia, The controller of publications, New Delhi, 4 th edition, vol II, 1996, 469. Vantrappen GR., Peeters TL, Janssen SJ, The secretary component of interdigestive migratory motor complex in man: scan d J. Gastro enterol, 19, 1979, Yeole P.G, Khan S., Patel V.F, drug delivery systems: Need and development, Indian. J. pharma.sci, 67(3), 2005, IJRPB 1(6) November December 2013 Page 897

Design and In-vitro Evaluation of Silymarin Bilayer Tablets

Design and In-vitro Evaluation of Silymarin Bilayer Tablets CODEN (USA)-IJPRUR, e-issn: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Original Article Design and In-vitro Evaluation of Silymarin

More information

Available Online through Research Article

Available Online through Research Article ISSN: 0975-766X Available Online through Research Article www.ijptonline.com DESIGN AND EVALUATION OF GASTRORETENTIVE TABLETS FOR CONTROLLED DELIVERY OF NORFLOXOCIN Ganesh Kumar Gudas*, Subal Debnath,

More information

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011 ISSN: 223-7346 Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp -394-43, Oct -Dec 211 FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE

More information

DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF METFORMIN HYDROCHLORIDE

DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF METFORMIN HYDROCHLORIDE ISSN: 0975-8232 IJPSR (2010), Vol. 1, Issue 8 (Research article) Received 11 April, 2010; received in revised form 17 June, 2010; accepted 13 July, 2010 DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED

More information

Maisammaguda, Dulapally, Secundrabad.

Maisammaguda, Dulapally, Secundrabad. 121 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(6): November-December 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY

More information

DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG

DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG M Seth *, DS Goswami,

More information

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Volume: 2: Issue-3: July-Sept -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Ajaykumar Patil*, Ashish Pohane, Ramya Darbar, Sharanya Koutika, Alekhya

More information

Formulation and Development of Sustained Release Tablets of Valsartan Sodium

Formulation and Development of Sustained Release Tablets of Valsartan Sodium INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article Formulation and Development of Sustained Release Tablets of Valsartan Sodium G. Sandeep * and A. Navya Department of

More information

A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac

A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac Asian Journal of Chemistry Vol. 22, No. 6 (2010), 4239-4244 A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac K.P.R. CHOWDARY*

More information

OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105

OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105 Digest Journal of Nanomaterials and Biostructures Vol. 9, No. 3, July September 2014, p. 1077-1084 OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105

More information

International Journal of Medicine and Pharmaceutical Research

International Journal of Medicine and Pharmaceutical Research International Journal of Medicine and Pharmaceutical Research Journal Home Page: www.pharmaresearchlibrary.com/ijmpr Research Article Open Access Formulation and Evaluation of Gastroretentive Floating

More information

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS Int. J. Chem. Sci.: 7(4), 2009, 2555-2560 FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS HINDUSTAN ABDUL AHAD *, B. PRADEEP KUMAR, C.

More information

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 975-1491 Vol 4, Suppl 5, 212 FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE

More information

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD Int. J. Chem. Sci.: 6(3), 2008, 1270-1275 FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD K. P. R. CHOWDARY, P. TRIPURA SUNDARI and K. SURYA

More information

FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN

FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN Ms. Jyoti Rathore 1*, Mr. Hitesh Kumar Parmar 1 Ujjain Institute of Pharmaceutical Sciences, Ujjain. Email- hkparmar7@rediffmail.com ABSTRACT

More information

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS Int. J. Chem. Sci.: 10(4), 2012, 1934-1942 ISSN 0972-768X www.sadgurupublications.com STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS K. VENUGOPAL * and K. P. R. CHOWDARY a Nirmala College

More information

FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE

FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE ISSN: 2395 1338 FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE B. Venkateswara Reddy *, K. Navaneetha Department of Pharmaceutics, St.Paul s College

More information

FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS

FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS G. Subba Rao

More information

Asian Journal of Biochemical and Pharmaceutical Research

Asian Journal of Biochemical and Pharmaceutical Research ISSN: 2231-2560 Research Article Asian Journal of Biochemical and Pharmaceutical Research Design and Evaluation of Gastroretentive Floating Tablets of Dipyridamole: Influence of Formulation Variables A.

More information

Asian Journal of Research in Biological and Pharmaceutical Sciences

Asian Journal of Research in Biological and Pharmaceutical Sciences Research Article ISSN: 2349 4492 Asian Journal of Research in Biological and Pharmaceutical Sciences Journal home page: www.ajrbps.com APPLICATION OF FACTORIAL DESIGN AND OPTIMIZATION OF GLIMEPIRIDE SUSTAINED

More information

Journal of Chemical and Pharmaceutical Research

Journal of Chemical and Pharmaceutical Research Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(3):159-164 Studies on formulation and in vitro evaluation

More information

FORMULATION AND EVALUATIONOF AMOXYCILLIN: THREE-LAYER GUAR GUM MATRIX TABLET

FORMULATION AND EVALUATIONOF AMOXYCILLIN: THREE-LAYER GUAR GUM MATRIX TABLET Gupta and Singh, IJPSR, 2013; Vol. 4(7): 2683-2690. ISSN: 0975-8232 IJPSR (2013), Vol. 4, Issue 7 (Research Article) Received on 05 March, 2013; received in revised form, 29 April, 2013; accepted, 29 June,

More information

FORMULATION AND IN VITRO EVALUATION OF FAMOTIDINE FLOATING TABLETS BY LIPID SOLID DISPERSION SPRAY DRYING TECHNIQUE

FORMULATION AND IN VITRO EVALUATION OF FAMOTIDINE FLOATING TABLETS BY LIPID SOLID DISPERSION SPRAY DRYING TECHNIQUE INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND IN VITRO EVALUATION OF FAMOTIDINE FLOATING TABLETS BY LIPID SOLID DISPERSION

More information

MODULATION OF GASTROINTESTINAL TRANSIT TIME OF SALBUTAMOL SULPHATE BY FLOATING APPROCHES

MODULATION OF GASTROINTESTINAL TRANSIT TIME OF SALBUTAMOL SULPHATE BY FLOATING APPROCHES Pooja et al Journal of Drug Delivery & Therapeutics; 213, 3(3), 37-41 37 Available online at http://jddtonline.info RESEARCH ARTICLE MODULATION OF GASTROINTESTINAL TRANSIT TIME OF SALBUTAMOL SULPHATE BY

More information

Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol

Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol K.Viveksarathi, K.Kannan*, S.Selvamuthu Kumar, R.Manavalan Department of Pharmacy, Faculty of Engineering

More information

Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting

Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting Biresh Kumar Sarkar* 1, Devananda Jain 1, Mamta Parwal 2 1. Bhagwant University, Dept.of Pharmaceutical Tech and Sciences,

More information

Sivakasi , Tamil Nadu, India. ABSTRACT KEYWORDS:

Sivakasi , Tamil Nadu, India. ABSTRACT KEYWORDS: 276 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 4(1): January-February 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND

More information

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN

More information

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Research Journal of Pharmaceutical, Biological and Chemical Sciences Research Journal of Pharmaceutical, Biological and Chemical Sciences Formulation And Invitro Evaluation Of Sustained Release Matrix Tablets Of Ibuprofen S Shanmugam, T Vetrichelvan and P Niranjan* Adhiparasakthi

More information

EVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data

EVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data EVALUATION OF EFFERVESCENT FLOATING TABLETS 6.1 Technological characteristics of floating tablets 6.2 Fourier transform infrared spectroscopy (FT-IR) 6.3 Differential scanning calorimetry (DSC) 6.4 In

More information

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES Int. J. Chem. Sci.: 10(1), 2012, 297-305 ISSN 0972-768X www.sadgurupublications.com FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES K. P.

More information

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN Research Article

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY  ISSN Research Article INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 8407 Research Article FORMULATION AND EVALUATION OF BILAYERED FLOATING TABLETS OF METFORMIN HYDROCHLORIDE R.Margret Chandira*, P.Palanisamy,

More information

Formulation and evaluation of gastro retentive floating drug delivery system of Atenolol

Formulation and evaluation of gastro retentive floating drug delivery system of Atenolol 2014; 3(5): 11-18 ISSN: 2277-7695 TPI 2014; 3(5): 11-18 2013 TPI www.thepharmajournal.com Received: 05-06-2014 Accepted: 12-06-2014 Kameswara Rao Sankula Assistant Professor, Department of Pharmaceutics,

More information

Design and Evaluation of Atenolol Floating Drug Delivery System

Design and Evaluation of Atenolol Floating Drug Delivery System Available online on www.ijcpr.com International Journal of Current Pharmaceutical Review and Research, 4(1), 1-26 Research Article ISSN: 976-822X Design and Evaluation of Atenolol Floating Drug Delivery

More information

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012 STUDIES ON EFFECT OF SUPERDISINTEGRANTS ON ETORICOXIB TABLET FORMULATIONS Chowdary K. P. R 1, Venugopal. K *2 1 College of Pharmaceutical Sciences, Andhra University, Vishakapattanam. 2 * Nirmala college

More information

DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN

DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN Int. J. Chem. Sci.: 10(4), 2012, 2199-2208 ISSN 0972-768X www.sadgurupublications.com DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN K. V. R. N. S. RAMESH *, B. HEMA KIRNAMAYI

More information

FORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETED DOSAGE FORM OF IBUPROFEN

FORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETED DOSAGE FORM OF IBUPROFEN FORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETED DOSAGE FORM OF IBUPROFEN Pranjal Kumar Singh*, Sanjoo Kumar, T.S.Easwari, V.K.Shukla, Guru Sharan Department of Pharmaceutics, IIMT College of Medical

More information

Int. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN:

Int. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN: International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2014; 4(1):47-51 Research Article FORMULATION AND EVALUATION

More information

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums 1368 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue 1 April-June 211 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue

More information

Development And Evaluation Of Gastroretentive Floating Tablet Of Rosuvastatin

Development And Evaluation Of Gastroretentive Floating Tablet Of Rosuvastatin Development And Evaluation Of Gastroretentive Floating Tablet Of Rosuvastatin Amiya kumar Prusty, Archana P. Chand Institute of Pharmacy and Technology, salipur, Biju Patnaik University of technology,

More information

Formulation and evaluation of immediate release salbutamol sulphate

Formulation and evaluation of immediate release salbutamol sulphate 5 Formulation, optimization and evaluation of immediate release layer of salbutamol sulphate Salbutamol is moderately selective beta (2)-receptor agonist similar in structure to terbutaline and widely

More information

Journal of Global Trends in Pharmaceutical Sciences. Journal home page:

Journal of Global Trends in Pharmaceutical Sciences. Journal home page: ISSN: 2230-7346 G Sridhar Babu et al. / JGTPS/ 5(4)-(2014) 2085-2092 (Research Article) Journal of Global Trends in Pharmaceutical Sciences Journal home page: www.jgtps.com FORMULATION AND IN-VITRO CHARACTERIZATION

More information

Formulation and Evaluation

Formulation and Evaluation Chapter-5 Formulation and Evaluation 5.1 OBJECTIVE After successful taste masking and solubility enhancement of drugs in preliminary studies, by using Mannitol Solid Dispersion, next step includes the

More information

Development and evaluation of controlled release mucoadhesive tablets of Tramadol Hydrochloride

Development and evaluation of controlled release mucoadhesive tablets of Tramadol Hydrochloride Development and evaluation of controlled release mucoadhesive tablets of Tramadol Hydrochloride R. Margret Chandira*, C.M. Sahu and B. Jayakar Department of Pharmaceutics Vinayaka Mission s College of

More information

Formulation and Evaluation of Sustain Release Bilayer Tablets of Metformin and Gliclazide

Formulation and Evaluation of Sustain Release Bilayer Tablets of Metformin and Gliclazide Research Article Formulation and Evaluation of Sustain Release Bilayer Tablets of Metformin and Gliclazide Priyamvada AR Barthwal*, Ganarajan and Preeti Kothiyal Shri guru ram rai institute of technology

More information

Fabrication and evaluation of Nimesulide Azadirachta indica fruit mucilage based sustained release matrix tablets

Fabrication and evaluation of Nimesulide Azadirachta indica fruit mucilage based sustained release matrix tablets International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.2, No.2, pp 937-941, April-June 2010 Fabrication and evaluation of Nimesulide Azadirachta indica fruit mucilage based

More information

Formulation and evaluation of gastro retentive floating tablets of Terbutaline sulphate

Formulation and evaluation of gastro retentive floating tablets of Terbutaline sulphate Formulation and evaluation of gastro retentive floating tablets of Terbutaline sulphate Lokesh Kumar*, Virendra Singh, Rakesh Kumar Meel Department of Pharmaceutics, Goenka College of Pharmacy, NH-11,

More information

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium Available online on www.ijddt.com International Journal of Drug Delivery Technology 214; (3); 98-13 Research Article ISSN: 97 441 Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast

More information

Feasibility of using natural gums for development of sustained release matrix tablet of itopride

Feasibility of using natural gums for development of sustained release matrix tablet of itopride Available online at wwwscholarsresearchlibrarycom Scholars Research Library Der Pharmacia Lettre, 215, 7 (3):114-123 (http://scholarsresearchlibrarycom/archivehtml) ISSN 975-571 USA CODEN: DPLEB4 Feasibility

More information

Formulation and Evaluation of Metronidazole Enteric Coated Tablets for Colon Targeting

Formulation and Evaluation of Metronidazole Enteric Coated Tablets for Colon Targeting Human Journals Research Article May 2015 Vol.:3, Issue:2 All rights are reserved by Srilakshmi N et al. Formulation and Evaluation of Metronidazole Enteric Coated Tablets for Colon Targeting Keywords:

More information

Int. J. Pharm. Sci. Rev. Res., 28(1), September October 2014; Article No. 21, Pages:

Int. J. Pharm. Sci. Rev. Res., 28(1), September October 2014; Article No. 21, Pages: Research Article V.T. Iswariya 1 *, A Hariom Prakash Rao 1, V Lokeswara Babu 1, Mohd Abdul Hadi 1, A Srinivasa Rao 2 1 Dept. of Pharmaceutics, Bhaskar Pharmacy College, Bhaskar Nagar, Yenkapally (V), Moinabad

More information

Preparation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium

Preparation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium Preparation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium Florida Sharmin 1, Md. Abdullah Al Masum 1, S. M. Ashraful Islam 1 and Md. Selim Reza 2 1 Department of Pharmacy,

More information

Effect of Polymer Concentration and Viscosity Grade on Atenolol Release from Gastric Floating Drug Delivery Systems

Effect of Polymer Concentration and Viscosity Grade on Atenolol Release from Gastric Floating Drug Delivery Systems Effect of Polymer Concentration and Viscosity Grade on Atenolol Release from Gastric Floating Drug Delivery Systems 1 1 1 2 U.V. Bhosale*, V. Kusum Devi, Nimisha Jain and P.V. Swamy 1 Al-Ameen College

More information

CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR

CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR Efavirenz and ritonavir, two widely prescribed anti retroviral

More information

Pelagia Research Library

Pelagia Research Library Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2013, 4(4):141-150 ISSN: 0976-8688 CODEN (USA): PSHIBD Development and in-vitro evaluation of intra gastric cefadroxil monohydrate

More information

Formulation and evaluation of sustained release atenolol

Formulation and evaluation of sustained release atenolol 9 Formulation, optimization and evaluation of sustained release layer of atenolol Atenolol is a cardioselective β-blocker widely prescribed for asymptomatic condition such as hypertension. It is poorly

More information

FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING AGENTS

FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING AGENTS Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Suppl 1, 2012 Research Article FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING

More information

International Journal of Chemistry and Pharmaceutical Sciences

International Journal of Chemistry and Pharmaceutical Sciences Ramesh Naik M et al IJCPS, 2014, Vol.2(11): 1259-1264 Research Article ISSN: 2321-3132 International Journal of Chemistry and Pharmaceutical Sciences Fabrication and Evaluation of Montelukastsodium Sustained

More information

Scholars Research Library. Formulation Development of Pioglitazone Tablets Employing β Cyclodextrin- Poloxamer 407- PVP K30: A Factorial Study

Scholars Research Library. Formulation Development of Pioglitazone Tablets Employing β Cyclodextrin- Poloxamer 407- PVP K30: A Factorial Study Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3 (6):24-30 (http:scholarsresearchlibrary.comarchive.html) ISSN 0974-248X USA CODEN: DPLEB4 Formulation

More information

Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch

Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch Abstract K.P.R. Chowdary et al. / International Journal of Pharma Sciences and Research (IJPSR) Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch K.P.R. Chowdary*,

More information

Journal of Chemical and Pharmaceutical Research, 2015, 7(5): Research Article

Journal of Chemical and Pharmaceutical Research, 2015, 7(5): Research Article Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2015, 7(5):1225-1231 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Formulation and evaluation of raft forming sustained

More information

Formulation Development and Evaluation of Sitagliptin Floating Tablets Containing Natural Polymer

Formulation Development and Evaluation of Sitagliptin Floating Tablets Containing Natural Polymer Human Journals Research Article May 2015 Vol.:3, Issue:2 All rights are reserved by Tanvi P Gunjal et al. Formulation Development and Evaluation of Sitagliptin Floating Tablets Containing Natural Polymer

More information

Research Article Formulation and Evaluation of Dual Component Tablets of Metoprolol tartrate

Research Article Formulation and Evaluation of Dual Component Tablets of Metoprolol tartrate Research Article Formulation and Evaluation of Dual Component Tablets of Metoprolol tartrate Rashmin N. Patel 1 * and Praful D. Bharadia 2 Department of Pharmaceutics, B. S. Patel Pharmacy College, Saffrony

More information

Formulation and Evaluation of Gastroretentive Dosage form of Ciprofloxacin Hydrochloride.

Formulation and Evaluation of Gastroretentive Dosage form of Ciprofloxacin Hydrochloride. Available online on www.ijcpr.com International Journal of Current Pharmaceutical Review and Research, 3(4), 105-109 Research Article ISSN: 0976-822X Formulation and Evaluation of Gastroretentive Dosage

More information

Optimization of Valsartan SR Floating Tablet Formulation by 2 2 Factorial Design and Multiple Regression Technique

Optimization of Valsartan SR Floating Tablet Formulation by 2 2 Factorial Design and Multiple Regression Technique Optimization of Valsartan SR Floating Tablet by 2 2 Factorial Design and Multiple Regression Technique K. Srinivasa Reddy 1, Surya Kanta Swain 2, K. P. R. Chowdary *3, S. V. U. M. Prasad 4 1 School of

More information

Pavan K et al IJARPB: 2013, 3(2), ISSN: Available online on Research Article

Pavan K et al IJARPB: 2013, 3(2), ISSN: Available online on  Research Article Available online on www.ijarpb.com Research Article Received on 15/01/2013; Revised on 23/01/2013; Accepted on 27/01/2013; Fast Dissolving Tablets Of Pioglitazone Hydrochloride By Use Of Various Superdisintegrants

More information

Formulation and evaluation of sublingual tablets of lisinopril

Formulation and evaluation of sublingual tablets of lisinopril Journal of GROVER Scientific & Industrial AGARWAL: Research FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF LISINOPRIL Vol. 71, June 2012, pp. 413-417 413 Formulation and evaluation of sublingual tablets

More information

Formulation Development and Evaluation of Modified Release Tablet using a Fixed Dose Combination of Antidiabetic Agents

Formulation Development and Evaluation of Modified Release Tablet using a Fixed Dose Combination of Antidiabetic Agents Research Article Formulation Development and Evaluation of Modified Release Tablet using a Fixed Dose Combination of Antidiabetic Agents Nishit Gohel 1*, D M Patel 2, Komal Patel 3, Jignasa Modi 4 1 School

More information

Formulation and evaluation of oral dispersible tablets of aripiprazole

Formulation and evaluation of oral dispersible tablets of aripiprazole IJPAR Vol.6 Issue 2 April - June -17 Journal Home page: ISSN:23-2831 Research article Open Access Formulation and evaluation of oral dispersible tablets of aripiprazole A.Madhusudhan Reddy*, P.Srinivasababu,

More information

Design and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets

Design and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets Research Reviews: Pharmacy & Pharmaceutical Sciences e-issn: 2320-1215 www.rroij.com Design and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets Sowjanya Battu*, Madhavi K, Bhikshapathi

More information

Formulation and Evaluation of Glicazide Mouth Dissolving Tablets

Formulation and Evaluation of Glicazide Mouth Dissolving Tablets Research Article Vishakha S. Hastak*, Yogyata S. Pathare, Kiran C. Mahajan Department of Pharmaceutics, Shree Chanakya Education Society's Indira college of Pharmacy, Tathawade, Pune, Maharashtra, India.

More information

Formulation development of Glipizide matrix tablet using different proportion of natural and semi synthetic polymers

Formulation development of Glipizide matrix tablet using different proportion of natural and semi synthetic polymers Pharm Methods, 2017; 8(1): 45-53 A multifaceted peer reviewed journal in the field of Pharm Analysis and Pharmaceutics www.phmethods.net www.journalonweb.com/phm Research Article Formulation development

More information

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND GLIMEPIRIDE

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND GLIMEPIRIDE Research Article Ghanshyam Patel,, 2012; Volume 1(6): 75-87 ISSN: 2277-8713 FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND GLIMEPIRIDE -QR CODE GHANSHYAM PATEL 1, Dr. RAGIN

More information

The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation

The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation METHOCEL Premium Cellulose Ethers Application Data The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation INTRODUCTION Hydrophilic matrices

More information

Journal of Chemical and Pharmaceutical Research, 2012, 4(6): Research Article. Studies on Carica Papaya Starch as a Pharmaceutical Excipient

Journal of Chemical and Pharmaceutical Research, 2012, 4(6): Research Article. Studies on Carica Papaya Starch as a Pharmaceutical Excipient Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2012, 4(6):3134-3138 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Studies on Carica Papaya Starch as a Pharmaceutical

More information

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.1, No.4, pp 1381-1385, Oct-Dec 2009 FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS

More information

Design and Characterization of Gastroretentive Bilayer Tablet of Amoxicillin Trihydrate and Ranitidine Hydrochloride for H.

Design and Characterization of Gastroretentive Bilayer Tablet of Amoxicillin Trihydrate and Ranitidine Hydrochloride for H. Pharmaceutical Research Design and Characterization of Gastroretentive Bilayer Tablet of Amoxicillin Trihydrate and Ranitidine Hydrochloride for H. pylori Infection Shikha Jain, Vikas Jain, S.C. Mahajan

More information

Volume: I: Issue-3: Nov-Dec ISSN

Volume: I: Issue-3: Nov-Dec ISSN Volume: I: Issue-3: Nov-Dec -2010 ISSN 0976-4550 DESIGN AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE BASED ON COMBINATION OF NATURAL AND SYNTHETIC POLYMERS Hindustan Abdul Ahad 1,

More information

CHAPTER 8 HYDROGEL PLUG FORMULATION AND EVAUATION

CHAPTER 8 HYDROGEL PLUG FORMULATION AND EVAUATION CHAPTER 8 HYDROGEL PLUG FORMULATION AND EVAUATION 8.1 Preparation of erodible tablet plug (Hydrogel Plug) Direct compression method was used to prepare the erodible tablet plug. The compositions of different

More information

PREPARATION AND INVITRO EVALUATION OF RABEPRAZOLE SODIUM DELAYED RELEASE ENTERIC COATED TABLETS

PREPARATION AND INVITRO EVALUATION OF RABEPRAZOLE SODIUM DELAYED RELEASE ENTERIC COATED TABLETS Page1000 Indo American Journal of Pharmaceutical Research, 2014 ISSN NO: 2231-6876 Journal home page: http:///index.php/en/ INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH PREPARATION AND INVITRO EVALUATION

More information

Formulation and In vitro Release Characterization of Metoprolol Succinate Extended Release Tablets

Formulation and In vitro Release Characterization of Metoprolol Succinate Extended Release Tablets Sakthikumar et al: Formulation and In vitro Release Characterization of Metoprolol Succinate Extended Release Tablets 1537 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue

More information

Available online Research Article

Available online   Research Article Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 26, 8(2):7-7 Research Article ISSN : 975-7384 CODEN(USA) : JCPRC5 Optimization of directly compressible mixtures of microcrystalline

More information

372 J App Pharm Vol. 6; Issue 4: ; October, 2014 Moazzem et al, 2014

372 J App Pharm Vol. 6; Issue 4: ; October, 2014 Moazzem et al, 2014 372 J App Pharm Vol. 6; Issue 4: 372-379; October, 2014 Moazzem et al, 2014 Original Research Article EFFECT OF SUPERDISINTEGRATING AGENT ON THE RELEASE OF METFORMIN HCl FROM IMMEDIATE RELEASE TABLETS

More information

Formulation, In-vitro evaluation and stability studies of bilayer floating tablets of Trandolapril and nifedipine combinations

Formulation, In-vitro evaluation and stability studies of bilayer floating tablets of Trandolapril and nifedipine combinations 2018; 7(9): 306-313 ISSN (E): 2277-7695 ISSN (P): 2349-8242 NAAS Rating: 5.03 TPI 2018; 7(9): 306-313 2018 TPI www.thepharmajournal.com Received: 01-07-2018 Accepted: 03-08-2018 Kareem Unnisa Department

More information

SBT JOURNALS. Design, development and evaluation of osmotic drug delivery system using Tramadol HCl RESEARCH ARTICLE

SBT JOURNALS. Design, development and evaluation of osmotic drug delivery system using Tramadol HCl RESEARCH ARTICLE INTERNATIONAL JOURNAL OF DRUG DELIVERY AND NANOTECHNOLOGY VOL. 1 ISSUE 1, 2015; 53 60; SBT JOURNALS RESEARCH ARTICLE Design, development and evaluation of osmotic drug delivery system using Tramadol HCl

More information

May Vol: 06 Issue: 01 (1-12)

May Vol: 06 Issue: 01 (1-12) May 16 Vol: 6 Issue: 1 (1-1) RESEARCH PAPER Formulation and Evaluation of Extended Release Tablets of Metformin HCl Anamika Chouhan*1, Deepak Marothia1, Khushboo Ranka1, Kamal Singh Rathore 1Department

More information

Formulation and evaluation of oro-dispersible tablets of lafutidine

Formulation and evaluation of oro-dispersible tablets of lafutidine Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):226-235 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

Journal of Chemical and Pharmaceutical Research, 2013, 5(1): Research Article

Journal of Chemical and Pharmaceutical Research, 2013, 5(1): Research Article Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2013, 5(1):320-328 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Development of modified release tablet dosage forms

More information

Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets

Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets Pharmaceutics Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets Remya KS, Beena P, Bijesh PV, Sheeba A Nazareth College

More information

DEVELOPMENT AND EVALUATION OF FLOATING TABLETS FOR GASTRIC RETENTION USING SILYMARIN AS A MODEL DRUG

DEVELOPMENT AND EVALUATION OF FLOATING TABLETS FOR GASTRIC RETENTION USING SILYMARIN AS A MODEL DRUG wjpmr, 2018,4(12), 242-253 SJIF Impact Factor: 4.639 Ramya Srilekhaet et al. al. Research Article WORLD JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH ISSN 2455-3301 www.wjpmr.com WJPMR DEVELOPMENT AND

More information

FORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER PVPK30 INCLUSION COMPLEXES

FORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER PVPK30 INCLUSION COMPLEXES Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER 407 - PVPK30 INCLUSION COMPLEXES K.P.R. Chowdary*, K. Surya Prakasa

More information

Formulation and Evaluation of Bilayer Tablets of Glimepiride and Metformin HCL

Formulation and Evaluation of Bilayer Tablets of Glimepiride and Metformin HCL IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-issn: 2278-38, p-issn:2319-7676. Volume 9, Issue 1 Ver. IV (Jan. 214), PP 38-45 Formulation and Evaluation of Bilayer Tablets of Glimepiride

More information

INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CHEMICAL SCIENCES

INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CHEMICAL SCIENCES Research Article Formulation, Development and Evaluation of Fast Dissolving Tablet of Salbutamol Sulphate by Using Superdisintegrants of Various Concentrations Santosh K 1 *, Meenakshi B 2 and Jyoti M

More information

Int J Pharm Bio Sci. Harshal P. Gahiwade *et al Available Online through IJPBS Volume 2 Issue 1 JAN-MARCH

Int J Pharm Bio Sci. Harshal P. Gahiwade *et al  Available Online through  IJPBS Volume 2 Issue 1 JAN-MARCH Page166 IJPBS Volume 2 Issue 1 JAN-MARCH 2012 166-172 FORMULATION AND IN-VITRO EVALUATION OF TRIFLUOPERAZINE HYDROCHLORIDE BILAYER FLOATING TABLET Harshal P. Gahiwade *, Manohar V. Patil, Bharat W. Tekade,

More information

FORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS

FORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS International Journal of PharmTech Research CODEN( USA): IJPRIF ISSN : 0974-4304 Vol.1, No.3, pp 634-638, July-Sept 2009 FORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS K. Reeta Vijaya

More information

Available online through ISSN

Available online through  ISSN Research Article Available online through www.ijrap.net ISSN 2229-3566 FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS OF METOPROLOL TARTRATE BY DIRECT COMPRESSION USING SUPER DISINTEGRANTS A. Senthil*

More information

Formulation and Evaluation of Saxagliptin Immediate Release and METFORMIN Hydrochloride Sustained Release Tablet

Formulation and Evaluation of Saxagliptin Immediate Release and METFORMIN Hydrochloride Sustained Release Tablet 36 International Journal of Health Sciences, Vol. 1 No. 1, December 2013 Formulation and Evaluation of Saxagliptin Immediate Release and METFORMIN Hydrochloride Sustained Release Tablet R. Margret Chandira

More information

Formulation Development and Evaluation of Sustained Release Matrix Tablets of Guaiphenesin

Formulation Development and Evaluation of Sustained Release Matrix Tablets of Guaiphenesin 3312 Int J Pharm Sci Nanotech Vol 9; Issue 3 May June 2016 International Journal of Pharmaceutical Sciences and Nanotechnology Research Paper Volume 9 Issue 3 May June 2016 MS ID: IJPSN-4-6-16-BASARKAR

More information

Journal of Pharmaceutical and Scientific Innovation Research Article

Journal of Pharmaceutical and Scientific Innovation   Research Article Journal of Pharmaceutical and Scientific Innovation www.jpsionline.com Research Article FORMULATION AND IN VITRO EVALUATION OF GLIPIZIDE AS FLOATING DRUG DELIVERY SYSTEM WITH NATURAL POLYMER (GUAR-GUM)

More information

Scholars Research Library

Scholars Research Library Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3(1): 38-44 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information