23andMe Reports GENETIC HEALTH RISK REPORTS. Increased risk for breast and ovarian cancer. function

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1 1 23andMe Reports GENETIC HEALTH RISK REPORTS BRCA1/BRCA2 Late-Onset Alzheimer's Disease Parkinson's Disease Age-Related Macular Degeneration Alpha-1 Antitrypsin Deficiency Celiac Disease G6PD Deficiency Hereditary Hemochromatosis (HFE Related) Hereditary Thrombophilia Increased risk for breast and ovarian cancer Memory loss and impaired mental function nervous system disorder affecting the motor system Vision loss Lung and liver disease disease of small intestine and gluten intolerance red cell blood disorder that can cause anemia in men Iron overload disorder Increased risk of blood clots Wellness Alcohol Flush Reaction Caffeine Consumption Deep Sleep Genetic Weight Lactose Intolerance Muscle Composition Saturated Fat and Weight Sleep Movement

2 2 Ability to Match Musical Pitch Asparagus Odor Detection Back Hair Bald Spot Bitter Taste Cheek Dimples Cilantro Taste Aversion Cleft Chin Earlobe Type Early Hair Loss Earwax Type Eye Color Fear of Heights Finger Length Ratio TRAITS Freckles Hair Photobleaching Hair Thickness Light or Dark Hair Misophonia Newborn Hair Photic Sneeze Reflex Red Hair Sweet vs. Salty Skin Pigmentation Toe Length Ratio Unibrow Wake-Up Time Widow's Peak

3 3 ARSACS Andermann syndrome Agenesis of the Corpus Callosum with Peripheral Neuropathy Autosomal recessive polycystic kidney disease Beta Thalassemia and Related Hemoglobinopathies Bloom Syndrome Canavan or Bertrand Disease Congenital Disorder of Glycosylation Type 1a (PMM2- CDG) Cystic Fibrosis D-Bifunctional Protein Deficiency Dihydrolipoamide Dehydrogenase Deficiency Familial Dysautonomia or Riley- Day Syndrome Familial Hyperinsulinism (ABCC8-Related) Fanconi Anemia Group C GRACILE Syndrome or Fellman Disease GENE DISORDERS-CARRIER Lack of coordination and balance resulting in frequent falls Weak and wasting muscles, abnormal reflexes, and loss of sensations in limbs Abnormal kidney and liver Kidney cysts Sickle cell anemia Short Stature High cancer risk Damages nerve cells in brain and causes intellectual disability and loss of motor skills Metabolic disorder and malfunction of nervous system, muscles and intestines Difficulty breathing and coughing up mucus Unable to break down fats in diet, causing neuro Metabolic disorder Affects the nervous system Insensitivity to pain/no tears/ Problems with speech and swallowing Hyperinsulinism Insulin dysregulation Malfunction of bone marrow causing pre-leukemia and leukemia and other cancers Growth retardation, amino acids in the urine, iron overload, early Sardinian, Cypriot, Italian/Siilian, Greek Dannish Ashkenzi Jews, Northern Europe Hispanic & Latino Finnish and Saudi Arabian descent Ashkenazi Jew Finnish death Gaucher Disease Type 1 Liver and spleen involvement Swedes from Norrbotten

4 4 Glycogen Storage Disease Type Ia or Andersen Disease Glycogen Storage Disease Type Ib Hereditary Fructose Intolerance Herlitz Junctional Epidermolysis Bullosa (LAMB3-Related) Leigh Syndrome, French Canadian Type Dystrophy Type 2D Results pending Dystrophy Type 2E Dystrophy Type 2I MCAD Deficiency Maple Syrup Urine Disease Type 1B Mucolipidosis Type IV Neuronal Ceroid Lipofuscinosis (CLN5-Related) Batten Disease Neuronal Ceroid Lipofuscinosis (PPT1-Related) Niemann-Pick Disease Type A Nijmegen Breakage Syndrome Berlin Breakage Syndrome Nonsyndromic Hearing Loss and Deafness, DFNB1 (GJB2- Related) Pendred Syndrome and DFNB4 Hearing Loss (SLC26A4- Related) Phenylketonuria and Related Disorders Primary Hyperoxaluria Type 2 Rhizomelic Chondrodysplasia Punctata Type 1 Deficiency of a liver enzyme leading to hypoglycemia intellectual disability Body cannot break down complex sugar Intolerance of fructose, sucrose, and sorbitol Skin disorder- fragile with blistering and skin erosion Affects the central nervous system- lesions in the brain Body cannot break down fats Hypoglycemai Metabolic disorder- Urine smells like maple syrup. Cannot process proteins Intellectual and motor disabilities Severe vision loss Nervous system disorder- vision, movement and thinking. Build up of fats and proteins Nervous system disorder- vision, movement and thinking. Build up of fats and proteins Harmful fatty lipids accumulate in the spleen, liver, lungs, brain and bone marrow Short stature and small head (microcephaly) Intellectual disabilities, higher risk of cancer Hearing loss and deafness Congenital inner ear hearing loss and low thyroid function Mexican, Chinese, and Japanese descent European Descent Amish Northern European Descent West Slavic descent- Poland, European Descent North European

5 5 Salla Disease Sickle Cell Anemia Sjögren-Larsson Syndrome Tay-Sachs Disease Tyrosinemia Type I Usher Syndrome Type 1F Usher Syndrome Type 3A Zellweger Syndrome Spectrum (PEX1-Related) Finnish, Swedish descent African American and African Descent Swedish Ashkenazi Jew, Cajun Descent