ALKA VITA DIABETES TEST

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1 ALKA VITA DIABETES TEST By PCO PreCleanOmics Indianapolis, Indiana

2 Study Number: Aug - 21 Sep Date of Study: 24 Animals Used in Study: ZDF-obese males Date of Birth: 17-Jun-4 Group 1 - RO H2O Group 2 -.5% Group 3-1.% Group % Alka Vita Group 5-2. % Glucose (mg/dl) ANIM AL 12-Aug Aug Aug Aug Aug Aug 7-Sep Sep Sep ID HOUR HOUR HOUR HOUR HOURDAY 5 DAY 7 DAY DAY DAY DAY DAY TIME S S S S S MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM

3 Study Number: Date of Study: 11 Aug - 21 Sep 24 Animals Used in Study: ZDF-obese males Date of Birth: 17-Jun-4 ANIMAL ID Triglicerides (mg/dl) 12-Aug 16-Aug 18-Aug 23-Aug 3-Aug 7-Sep 13-Sep 2-Sep TIME 8 HOUR DAY 5 DAY 7 DAY 12 DAY 19 DAY 28 DAY 34 DAY 41 Group 1 - RO H2O Group 2 -.5% Group 3-1.% Group % Group 5-2. % MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM

4 Study Number: Aug - 21 Sep Date of Study: 24 Animals Used in Study: ZDF-obese males 17-Jun- Date of Birth: 4 Group 1 - RO H2O Group 2 -.5% Group 3-1.% Group % Group 5-2. % Cholesterol (mg/dl) 12-Aug 23- Aug 3-Aug 7-Sep 13-Sep 2-Sep ANIMAL ID DAY TIME 8 HOUR 12 DAY 19 DAY 28 DAY 34 DAY MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM

5 Study Number: Date of Study: 11 Aug - 21 Sep 24 Animals Used in Study: ZDF-obese males Date of Birth: 17-Jun-4 ANIMAL ID Body Weight (g) 11-Aug 12-Aug 18-Aug 25-Aug 1-Sep 8-Sep 15-Sep 2-Sep DAY DAY 1 DAY 7 DAY 14 DAY 21 DAY 28 DAY 35 DAY 4 Group 1 - RO H2O Group 2 -.5% Group 3-1.% Group % Group 5-2. % MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM MEAN ST DEV SEM

6

7 PCO-52: Effect of on Cataract 1 % of rats showing cataract PreClinOmics, Inc 1% AV

8 PCO-52: Effect of on Cataract 1% AV Cateract Cateract Left eye Right eye Left eye Right eye A A A Terminated A A C B B B B A Dead B C B B B C B C C A B Grading from A-D, A the lowest, D the highest Observation on week 2, 8 weeks after metformin treatment

9 PCO-61: Effect of on Glucose Start Oral gavaging at week % 1 % 3 Glucose (mg/dl)

10 PCO-61: Effect of on Glucose 4 Metformin(5 mg/kg)/h2o Metformin(5 mg/kg)/.5% AV 3 Glucose (mg/dl) 2 1 Start Metformin dosing

11 PCO 52: Effect of on Fed Glucose (ZDF obese male rat starting at 11 weeks old; starting n=15) 6 * Glucose (mg/dl) % * P=.93 1 Metformin (5 mg/kg, p.o.)

12 PCO-61: Effect of on Triglyceride 15.5 % 1 % 1 TG (mg/dl)

13 PCO-61: Effect of on Triglyceride 15 Metformin(5 mg/kg)/h2o Metformin(5 mg/kg)/.5% AV 1 TG (mg/dl) 5 Start Metformin dosing

14 PCO-61: Effect of on Cholesterol Start Oral gavaging at week % 1% 2 CHOL (mg/dl)

15 PCO-61: Effect of on Cholesterol 23 2 Metformin(5 mg/kg)/h2o Metformin(5 mg/kg)/.5% AV CHOL (mg/dl) Start Metformin dosing

16 PCO-61: Effect of on Body Weight (B6.V-Lep<OB>/J male mouse, starting at 11 weeks old) Start Oral gavaging at week % 1 % Body Weight (gram)

17 PCO-61: Effect of on Body Weight (B6.V-Lep<OB>/J male mouse, starting at 11 weeks old) 75 7 Metformin(5 mg/kg)/h2o Metformin(5 mg/kg)/.5% AV Body Weight (gram) Start Metformin dosing

18 PCO-61: Effect of on Body % HbA1C % 1 % 4 % HbA1C

19 PCO-61: Effect of on Body % HbA1C 6 5 Metformin(5 mg/kg)/h2o Metformin(5 mg/kg)/.5% AV 4 % HbA1C Start Metformin dosing

20 PCO-61: Effect of on HDL Start Oral gavaging at week % 1 % HDL (mg/dl)

21 PCO-61: Effect of on HDL 25 2 Metformin(5 mg/kg)/h2o Metformin(5 mg/kg)/.5% AV HDL (mg/dl) Start Metformin dosing

22 PCO-61: Effect of on AST Start Oral gavaging at week % 1% AST(IU/L)

23 PCO-61: Effect of on AST 7 6 Metformin(5 mg/kg)/h2o Metformin(5 mg/kg)/.5% AV 5 AST(IU/L) Start Metformin dosing

24 PCO-61: Effect of on ALT Start Oral gavaging at week % 1 % ALT (IU/L)

25 PCO-61: Effect of on ALT 1 Metformin(5 mg/kg)/h2o Metformin(5 mg/kg)/.5% AV 8 ALT (IU/L) Start Metformin dosing

26 PCO-61: Effect of 1% of on mesenteric fat % Fat (g) % of body weight. Absolute fat weight % change

27 PCO-61: Effect of 1% of on epididimal fat 1. 1% 4 Fat (g) % of body weight. Absolute fat weight % change

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