SPIRE PATHOLOGY SERVICES PATHOLOGY TEST REPERTOIRE. SPS-QM-0500 National Pathology Compliance Manager. Issued By: Date: March 2016

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1 SPIRE PATHOLOGY SERVICES PATHOLOGY TEST REPERTOIRE Ref: Issued By: Approved By: SPS-QM-0500 National Pathology Compliance Manager Pathology Director Date: March 2016 Applies to sites: Applies to staff groups: All Pathology Departments All Pathology Staff PATHOLOGY TEST REPERTOIRE THIS IS A CONTROLLED DOCUMENT. Ensure it is the current version as managed in Q-Pulse

2 Key to Vacutainers Vacutainer Anticoagulant Capacity Sample Types Lavender EDTA 4ml Gold SST/Gel 3.5ml, 5ml Blue Citrate 4.5ml Red None 6ml Black Sodium Citrate 5 ml Green Lithium heparin 6ml Pink EDTA 6ml Grey Fluoride oxalate 2ml De scription Code S a mple N otes / T A T erence Range U nits In-House A Albumin ALB g/l Alkaline Phosphatase ALP IU/L Allergy Screen (See Total and Specific IgE) Alpha 1 Anti-trypsin (Faeces) Alpha 1 Anti-trypsin Genotype (S and Z variant) Alpha 1 Anti-trypsin Phenotype 33 FAIA Solid Stool 1, 2, 3 14 See report mg/gww A1AG 4 45 See Report A1AP 4 12 See Report Alpha 1 Anti-trypsin AIA g/l (serum) Alpha Feto Protein AFP KU/L Alanine Aminotransferase ALT 4 Adult Female : 1-31 Adult Male : 1-41 Amylase AMY IU/L Amylase (Fluid) AMYF Fluid 5 2 See Report IU/L Amylase (Urine) UAMY Random Urine 5 2 < 1100 U/L Angiotensin Converting Enzyme ANCE U/L Anti DNA ADNA 2 Negative <10 Equivocal Positive >15 Anti Extractable Nuclear AENA 3 Screen negative : Antibodies (Anti ENA) Negative Screen (includes Anti-Jo- 1,La,RNP,Ro,Scl-70 and positive or equivocal : Sm Antibodies) individual antigens will be tested separately Anti Mullerian Hormone AMH 3 See report pmol/l IU/L IU/mL Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 2 of 15

3 T A T erence Range U nits In-House Anti Neutrophil Cytoplasmic Antibodies (ANCA) ANCA 2 M P O Negative <3.5 Equivocal Positive >5.0 P R3 Negative <2.0 Equivocal Positive >3.0 IU/mL Antinuclear Antibodies(ANA) ANA 3 Positive/Negative/ Cytoplasmic staining seen. If positive, titre is reflexed - reported as titre and pattern Anti Streptolysin O Titre ASOT 2 < 200 IU/mL APTT APT 1, 7, 8 4 Range is however reference ranges are defined locally due to differences in technology in the network Aspartate Transaminase (AST) Autoimmune Antibody Screen (includes : ANA screen, mitochondrial abs, smooth muscle abs, gastric parietal abs, reticulin abs,liver kidney microsomal abs and ribosomal abs) B Borrelia Burgdorferi Antibodies (Lyme disease) AST 4 Female: 1-32 Male: 1-38 AABA 3 Positive/Negative If Positive for smooth muscle or mitochondrial antibodies - reflex test. These reflex tests are reported as a titre. ANBO 9, 10, 37 5 (Confirmato ry test 21 ) Bence Jones Protein BJP Fresh Early Morning Urine See Report 5 7 Reported as negative or class of paraprotein Beta HCG BHCG IU/L Bicarbonate BHCO mmol/l Bilirubin (Total) BILI 4 < 21 µmol/l Blood Culture RMCS/BCU See Note Up to 7 Blood Group (ABO/Rh) GP Blood Group and GRS antibody screen Bone profile BONE 4 See Report Bordetella Pertussis Antibodies Bronchial Washing for Culture Bronchial Washing for Culture and TB Bronchial Washing for TB Culture BORD 9, 10, RMCS/BRW AAFC/BRW AAFB/ BWT Bronchial Washing Bronchial Washing Bronchial Washing Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 3 of 15 secs IU/L (routine culture) 5 Microscopy 48 hours Final 6 Weeks

4 T A T erence Range U nits In-House C C Reactive Protein (CRP) CRP mg/l C1 Esterase Inhibitor C1EF g/l CA 125 C ku/l CA 15-3 C ku/l CA 19-9 C ku/l Caeruloplasmin CAER g/l Calcium (Adjusted) CA Avoid venestasis mmol/l Calcium ( 24 hr Urine ) CA24 24 hr Urine (Acidified) 13, mmol/24 Carcino Embryonic CEA µg/l Antigen Cardiac Enzymes CE 4 See Report Cardiolipin Antibodies (IgG) Cardiolipin Antibodies (IgM) ANCR 2 Negative: < 10 Weak Positive: Positive: > 40 CARM 2 Negative: < 10 Weak Positive: Positive: > 40 Cervical Cytology LBC LBC container 5-7 See Report Chlamydia, Eye Swab CHLE Blue ProbeTec 3 Negative or swab Positive by SDA Chlamydia Genital Swab CHLC ProbeTec Swab 14 2 Negative or Positive by SDA Chlamydia, Urine CHLC Random Urine 5 2 Negative or Positive by SDA Chloride CL mmol/l Cholesterol CHOL mmol/l Chromium (MOM Hip Investigation) U/mL MBCR See report nmol/l Chromium (Nutrtionblood) CHRO < 9.6 nmol/l Citrulline Antibodies ACIT 2 Negative: U/mL (Anti-CCP) Equivocal: Positive: >10.0 CKMB CKMB IU/L Clostridium Difficile Toxin (C. Diff) FCD/FCD Faeces 16, Positive or Negative CMV (Cytomegalovirus) IgG Antibodies CMV (Cytomegalovirus) IgM Antibodies CMVA 5 or Not CMVI 5 or Not Coagulation Screen COAG 1, 7, 8 4 See Report (PT/APTT) Cobalt (Metal on Metal) MBCO See Report nmol/l Cobalt (Nutrition)) COBA nmol/l Coeliac Screen ( request TTG and Endomysial Antibodies) Complement C3 COM g/l Complement C4 COM g/l MPL Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 4 of 15

5 T A T erence Range U nits In-House Copper (Serum) CU µmol/l Copper (24 hr urine) UCU 24 hr Urine 13, 18, 19 7 Less than 0.95 umol/24hr Cortisol CORT 2 Basal: Evening: µmol/24 nmol/l Cortisol (Random Urine) UCOR Random Urine 5 3 See report nmol/l - 24 hour recommended Cortisol (24 hr Urine) 24CO 24 hr Urine 13, nmol/24 hr CPE Screening (Carbapenemase Producing Enterobacteriaceae) RMCS/REC Rectal Swab 1-4 Creatine phosphokinase CK 4 Female: Male: Creatinine CRE 4 Female: Male: IU/L µmol/l Creatinine Clearance CCT +24 hr 13, 19, ml/min Test Urine Creatinine (Random UCRE Random Urine 2 See report mmol/l Urine) Creatinine ( 24 hr Urine ) CR24 24 hr Urine 13 2 Female: 6-13 Male: 9-19 mmol/24 Crossmatch request GRS/ XM 12, plus no. of units Crystals in Fluid FLC/FLC Fluid Crystals in Fluid and Culture RMCS/FLU Fluid 5 Interim 2-3 Final up to 7 RMCS/CSF CSF CSF Culture and Cell Count CSF Glucose CGLU CSF mmol/l CSF Oligoclonal bands OLIG +CSF 5, See Report CSF Protein CPRO CSF g/l Cytology, Fine Needle Aspirate FNA Aspirate 1, Cytology, Fluid FLUID LBC container or universal Cytology, Smear LBC LBC container 5-7 Cytology, Urine URINE Urine 1, D D-Dimer DDIM Contact Laboratory 7, 8, 45 Contact lab ug/ml / Digoxin DIG 23 3 See Report See report E Endocervical swab GENC Charcoal swab 50 2 Growth detected / Not detected Endomysial Antibodies (IgA) Erythrocyte Sedimentation Rate (ESR) AEND 2 Positive/Negative/ Equivocal ESR 4 Female: Male: 6-14 mm/hr Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 5 of 15

6 T A T erence Range U nits In-House F Faecal Calprotectin FECP Stool 16 5 Normal : < 50 µg/g faeces Median : 25 >50 regarded as positive Faeces Culture RMCS/FAE Stool Faecal Elastase FAEE Stool 16 5 Normal: >200 Moderate Pancreatic Insufficiency: Severe Pancreatic Insufficiency: <100 Ferritin FER 2 Female: Male: Fibrinogen FIB 1, 7, 8 24 Generally between See individual reports for specific reference Fluid Or Aspirate For Culture Fluid Or Aspirate For Culture with TB Culture Fluid Or Aspirate For TB Culture RMCS /choose site AAFC /choose site AAFB /choose site State Site 5 Interim 2-3 Final up to 7 State Site 5 Interim 2-3 Final up to 7 (routine culture) State Site 5 Microscopy 48 hours Final 6 Weeks range µg/g faeces Folate ( Serum ) FOL 1, µg/l Follicle Stimulating Hormone FSH 2 Follicular: Ovulation: Luteal: Post Menopause: Free T3 FT pmol/l Free T4 FT pmol/l Full Blood Count (FBC including Differential ) FBC 4 Male Female x10^9/l WBC RBC X10^12/L Hb HCT MCV fl MCH MCHC Platelets Neutrophils absolute Lymphocytes absolute Monocytes absolute Eosinophils absolute Basophils absolute µg/l g/l U/L g/l ratio pg g/l X10^9/L X10^9/L X10^9/L X10^9/L X10^9/L X10^9/L Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 6 of 15

7 T A T erence Range U nits In-House G Gamma Glutamyl Transaminase GGT 4 Female: 1-40 Male: 1-60 Gentamicin GENT 24 1 day See report mg/l Gliadin Antibodies See NICE (replaced by TTG and guidelines Endomysial Antibodies) Glucose (Blood) GLU mmol/l Glucose Tolerance Test GTT By 4 See Report mmol/l arrangement with OPD Glycated Haemoglobin / GLHB 2 See Report % Haemoglobin A1c Gonorrhoea culture GENC Charcoal swab 50 2 Growth detected / not detected Gonorrhoea, PCR GOUM Swab 14 3 Negative or Positive by SDA Gonorrhoea, PCR, (Urine) H Haemoglobin Electrophoresis Harmony (Non Invasive Paternity Test) UGON Urine 5 3 Negative or Positive by SDA HPLC 38, See Report NIPT Contact Lab 9,25 14 See Report HDL Cholesterol HDL 4 Desirable Ranges Female: > 1.2 Male: > 1.0 Helicobacter Pylori Antibody Blood Test Helicobacter Pylori Culture Helicobacter Pylori Faecal Antigen Hepatitis A Antibodies (IgM) Hepatitis B Core Antibodies (IgM/IgG) AHEL 5 or Not Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 7 of 15 IU/L mmol/l RMCS/TIS Gastric Biopsy Days FHA/FHA Stool 16 2 or Not HPA 3 or Not HBCA 2 or Not Hepatitis B Core Antigen HBAN 7-10 or Not Hepatitis B (e) Antibody HBEB 7-10 or Not Hepatitis B (e) Status HPBE 10 or Not Hepatitis B Surface AHBS 2 See Report IU/L Antibodies Hepatitis B Surface HEPB 2 or Not Antigen(HbsAg) Hepatitis C Antibodies HEPC 2 or Not Histology See Note Tissue type See Report dependant HIV 1, 2 Antibodies and p24 Antigen HIV 2 or Not High Vaginal Swab RMCS/HVS See Note I IGF1 (Somatomedin)( also known as Insulin IGF Age and gender related See nmol/l

8 T A T erence Range U nits In-House like GF1 report Immunoglobulins (IgG, IgM, IgA) Immunohistochemistry Infectious Mononucleosis (Mono) IGS 2 See report Fixed tissue on slide 49 Tissue type dependant MONO Up to 2 or Not / INR INR 1, 7, 8 4 Normal ratio Anticoagulation therapy below Target INR 2.5 ( ) Target INR 3.5 ( ) For conditions See note 46 For conditions See note 47 Iron FE µmol/l Iron and TIBC FEUI 2 See Report J JAK2 Mutation JAK2 14 K Karyotyping (X/Y) KARY 1, 4, 30, L Lactate Dehydrogenase LDH 4 Female: Male: LDL Cholesterol (Low LDL mmol/l Density Lipoprotein) Lipid Profile LIP 4 See Report Lithium LITH 4, 31 2 See report See report / Liver Function Tests LFT 4 See Report Lupus Anticoagulant Screen SPLU 1, 3, 6, 7, 8, 25, 34 7 Contact lab for Interpretation of results. Luteinising Hormone LH 2 Follicular : U/L 12.6 Ovulation : Luteal : Post Menopause : M Magnesium (Blood) MG mmol/l Magnesium (Red Cell) MGRC mmol/l Magnesium (Urine) MGUR Random Urine 5 2 Ref Range only mmol/l quoted for 24hr Magnesium ( 24 hr Urine ) MG24 24 hr Urine (Acidified) mmol/24 Malarial Parasites MALP 48 4 hours or Not / Measles Antibodies MEAS 5 or Not (IgG) Measles Antibodies VISC 5 or Not Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 8 of 15 IU/L

9 T A T erence Range U nits In-House (IgM) Metadrenalines (Urine) MADR 24 hr Urine (Acidified) MRSA swab Site Transwab (Blue dependant ) MSSA swab Site dependant Transwab (Blue ) 13, See Report Negative 1-2 Positive 2-3 Negative 1-2 Positive 2-3 Not Isolated or See Report Not Isolated or See Report Mumps IgG Antibodies MUMP 5 or Not Mumps IgM Antibodies VISC 5 or Not Mycology MYCC Skin scrapings, hair or nails ONLY N Norovirus Screening NORO Faeces 16, or Not O Occult Blood FOB Stool x Positive/Negative Oestradiol OEST 2 Follicular : Ovulation : Luteal : Post Menopause : < MALES : pmol/l Ova, cysts and parasites (Faeces) OCP Stool 9, 10, 16 3 P Parathyroid Hormone PTH pg/ml (Intact) PCA3 (Prostate Ag) PCA3 First Catch Urine 25 7 See Report Score Pemphigoid Antibodies APBM 2 Positive/ Negative Pemphigus Antibodies ANPE 2 Positive/ Negative Phosphate PHOS mmol/l Phosphate (Random Urine) Phosphate (24 hr Urine ) PH24 24 hr Urine UPHO Random Urine 5 2 Ref Range only quoted for 24hr mmol/l 13, 18, mmol/24 (Acidified) Plasma Viscosity PV Up to CP Potassium K mmol/l Potassium (Random Urine) UK Random Urine 5 2 Ref Range only quoted for 24hr mmol/l Potassium (24 hr Urine) K24 24 hr Urine mmol/24 Pregnancy Test (Urine) PREG Random Urine 5 4 Negative/Positive probnp pbnp pg/ml Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 9 of 15

10 T A T erence Range U nits In-House Progesterone PROG 2 Follicular: Ovulation: Luteal: Post Menopause: nmol/l Prolactin PROL 2 Woman (not pregnant): Prostate Specific Antigen PSA 2 Age specific See Report Protein (Fluid) PROP Fluid 5 2 See Report g/l Protein (Random Urine) UPRO Random Urine 5 2 Ref Range only g/l quoted for 24hr Protein ( 24 hour Urine) TP24 24 hr Urine g/24 Protein Electrophoresis PE 5 See Report Prothrombin Time PT 1, 7, 8 4 The reference range for prothrombin time depends on the analytical method used, but is usually around seconds (results should always be interpreted using the reference range from the laboratory that performed the test) Q Quantiferon TB Gold TBQ Contact Lab 25 5 Negative, Intermediate or Positive R RAST See Total IgE or Specific IgE IGE (Allergen code added at Spire Edinburgh mu/l ng/ml 33 Red Cell Folate RCF ug/l Rheumatoid Factor RHF 2 Negative: < 3.5 Equivocal: Positive: > 5.0 sec IU/mL Rubella (IgG) RUBG 3 See Report IU/mL Rubella (IgM) VISC 3 See Report U/L S Serum Free Light Chains SFLC 7 Kappa: Lambda : Ratio : Sex Hormone Binding Globulin SHBG Up to 10 Female: Male: mg/l nmol/l Sickle Cell Screen SICK 2 See Report Sodium NA mmol/l Sodium (Fluid) NAF Fluid 5 2 mmol/l Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 10 of 15

11 T A T erence Range U nits In-House Sodium (Random Urine ) UNA Urine 5 2 Ref Range only quoted for 24hr mmol/l Sodium ( 24 hour Urine) NA24 24 hr Urine mmol/24 Specific IgE (Individual Allergens or components) IGE (Allergen code added at Spire Edinburgh ( stock dependant) See report KUA/L Sputum For Culture RMCS/SPU Sputum Sputum For Culture including TB Culture AAFC/SPU Sputum (routine culture) Sputum For TB Culture AAFB/SPU Sputum 5 Microscopy 48 hours Final 6 Weeks Stone (Calculi) Analysis CALC Stone 5 10 Syphilis ATRE 3 or Not (RPR,WDRL,TPHA) Synacthen Test SYNT Up to 3 See Report T TB Culture (Fluid, Aspirate or Tissue) TB Culture (Early morning urine) AAFB/choos e type AAFB/EMU Fluid / Tissue/ ASP Early morning urine 5 Microscopy 48 hours Final 6 Weeks 44 Microscopy 48 hours Final 6 Weeks Testosterone TEST 2 Sex and age nmol/l related See Report Thrombin Time TT 1, 7, sec Thrombophilia screen SPCT 1, 6, 7, 8, 34 7 Contact Lab for Interpretation Thyroglobulin Antibodies Thyroid Peroxidase Antibodies TGAB 3 Normal: < 280 Equivocal: Positive: > 344 TPO 2 Negative: < 60 Equivocal: Positive: > 100 IU/mL IU/mL Thyroid Receptor Antibodies TSHR Laboratory see note 3 12 Positive : > 0.4 U/L Thyroid Stimulating Hormone (TSH) TSH mu/l Tissue for Culture RMCS/TIS State Site 5 Interim 2-3 Final up to 7 Tissue For Culture with TB Culture AAFC/TIS State Site 5 See individual tests See Report See Report Tissue Transglutaminase (TTG) TTG 2 Negative: < 7 Equivocal: 7-10 U/Ml Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 11 of 15

12 T A T erence Range U nits In-House Antibodies IgA Positive: > 10 Total IgE IGE KU/L Total Protein PROT g/l Total Protein ( 24 hr Urine) TP24 24 hr Urine 5, g/24 Triglycerides TRIG mmol/l Troponin T TROT 1, 42 Up to 1 day See report See report / U Urea URE mmol/l Urea (Random Urine) UURE Random Urine 5 2 Ref Range only mmol/l quoted for 24hr Urea (24 hr Urine) UR24 24 hr Urine mmol/24 Urea and Electrolytes UE 4 See Report (U&E) Urea and electrolytes (24 hr Urine) UUE 24 hr Urine 13, 19 2 See Report Urethral swab GENC Charcoal swab 50 2 Growth detected / Not detected Uric Acid (Serum) URTE 4 Female: Male: µmol/l Uric Acid (Fluid) URIF Fluid 5 2 Uric Acid (Random Urine) UUA Random Urine 5 2 Ref Range only quoted for 24hr mmol/l Uric Acid (24 hr Urine) UAUR 24 hr Urine 13, mmol/24 Urine Culture UMCS / choose type Random Urine V Varicella Zoster IgG VARI 5 or Not Varicella Zoster IgM VISC 5 or Not Viral Screening VISC 9 Up to 7 or Not Vitamin B12 B12 3, 36 Avoid ng/l Haemolysis Vitamin D (1,25 125H 1, 35, pmol/l Dihydroxy) Vitamin D (25 Hydroxy) VITD 1, 35 2 Severe deficiency: < 25 Borderline Range: Optimal: Possible toxicity if sustained: >250 nmol/l W X Y Y Microdeletion YMIC 26,30 24 See Report Z Zinc (Serum) ZN µmol/l Zinc (Urine) ZNUR Random Urine 5 7 See report Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 12 of 15

13 Key to Notes 1 Send to lab immediately. 2 Labile - must reach lab on same day as sample collected. Bean sized volume of faeces required in sputum/faeces pot. 3 Send frozen 4 Store between 2-8 C 5 30ml sterile White top Universal container. 6 Sample should be separated and frozen within 2 hours of being taken. If a delay is expected with transportation to the testing laboratory samples must be transported frozen. 7 If collecting using Butterfly system discard initial blue bottle. 8 If possible it is preferable to collect blood WITHOUT using tourniquet. Citrate (Blue bottles) MUST always be taken before other coloured bottles and filled to the line. 9 Clinical history and any medication information must be provided. 10 Provide details of patient travel history. 11 Collect 8-10ml blood aseptically into both the aerobic and anaerobic blood culture bottles. 12 Large PINK bottle. Sample must be labelled clearly by HAND with first name, surname, date of birth and either patient number or postal code. The sample MUST be signed by the person taking the blood. 13 Provide volume/date/time for all 24 hour samples. 14 Use Pink ProbeTec swab for female cervical and Blue ProbeTec swab for male urethral. 15 To avoid external contamination, take two EDTA samples and discard the first. Min 2mls blood. 16 Faeces in sterile blue top stool pot. 17 Formed faeces will not be tested hour Urine container must be acid washed or contain acid, contact lab ml aliquot. Give 24 hour volume in ml. Store aliquot at 2-8 C. Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 13 of 15

14 20 Blood sample must be collected during 24 hour Urine time. 21 State whether CSU, MSU or specific type on sample bottle and request form. White top 30 ml universal container if going immediately to lab. If delay to lab use Red top (Boric Acid) urine bottle. DO NOT use sputum pots. 22 Min 1 ml CSF and min 2ml serum. Paired CSF and serum required (max 5 apart). Store at 4 C. 23 Sample 6-10 post dose. State dose/time 24 State if pre or post dose sample, state dose and other medication. 25 Contact the laboratory for special sample tubes/containers/kit and/or instructions. 26 Collect Monday to Thursday ONLY. MUST arrive at laboratory before NOON. 27 Sample codes are applied at the discretion of the Histopathology staff. All patient demographics and sample description MUST be on both the sample container and the request form. Relevant clinical history should be provided. Samples MUST be completely immersed in formaldehyde. 28 Black swab preferred will accept blue swab. State region swabbed on both sample and request form. 29 Minimum 0.2ml. Freeze until dispatch if >24 hours 30 Special Genetics form must be sent with sample. 31 Collect blood a minimum of 12 hours post last dose of Lithium. 32 GOLD top sample only when processed on the same day (this is only applied when the sample will arrive at Spire Laboratory Centennial Park on the same day). If the sample is transported overnight need EDTA sample spun, separated and frozen. 33 Include copy of allergy referral form with sample 34 Citrated tubes should be double centrifuged 35 Sample should be separated and frozen within 4 hours. 36 Protect from light, wrap completely in foil and transport to lab immediately mls required 38 Full blood count must be performed prior to carrying out the analysis 39 Sample should not be more than 7 old Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 14 of 15

15 40 Send Mg serum result and haematocrit from FBC 41 Stable for 2-4 hours at C, for 24 hours at 2-8 C and at -20 C for one month. Sample should be frozen if a delay is expected with transportation to the testing laboratory, samples must be transported frozen. 42 Do NOT spin. 43 Samples from patients who have not had a transfusion or been pregnant in the last 3 months are able to be cross matched from this sample up to 7 before transfusion; otherwise sample must be taken within 72 hours of the transfusion. Please ensure the laboratory is aware if this is an urgent request. A second sample may be required if there is no historic group available for the patient consecutive early morning whole bladder urine specimens to be collected in large 250ml containers. 45 The units and reference ranges are applicable to Spire laboratories who perform D-Dimer on site (Spire Gatwick Park, Spire Alexandra, Spire Centennial Park(Bushey), Spire Dunedin, Spire Hartswood, Spire Leicester, Spire St Johns and Elizabeths). For all other laboratories please refer to the printed report 46 Treatment of DVT, PE, AF, recurrent DVT off warfarin, symptomatic inherited thrombophilia, cardiomyopathy, mural thrombus, cardioversion. 47 Recurrent DVT while on warfarin, mechanical prosthetic heart valves, antiphospholipid syndrome (some cases) 48 Negative smears will be confirmed by an alternative method 49 ER, PR and Her-2 are referred externally to University College London. Most other C is processed in-house at Spire Manchester, Spire Parkway and Spire Alexandra. 50 Swab must reach the laboratory within 24 hours of being taken otherwise detection of Gonorrhoeae may be compromised. Issued by: National Pathology Compliance Manager Next Review: Managed In Q-Pulse Page 15 of 15

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