KEEP 2.0 Annual Data Report Chapter Five

Size: px

Start display at page:

Download "KEEP 2.0 Annual Data Report Chapter Five"

Fay West
6 years ago
Views:

1 KEEP 2. Annual Data Report Chapter Five

2 Figure 5.1 percent distribution of KEEP participants with elevated serum creatinine levels, overall & by age 16 Percent of participants All <6 yrs 6 yrs KEEP: n=1,725; excludes participants with missing serum creatinine values; elevated levels: >1.5 mg/dl in men, >1.3 mg/dl in women

3 Figure 5.2 percent distribution of KEEP participants with elevated serum creatinine levels, by race 8 Percent of participants White Black Nat Am Asian Pac Isl Other KEEP: n=1,413; excludes participants with missing serum creatinine values or unknown or missing race; elevated levels: >1.5 mg/dl in men, >1.3 mg/dl in women

4 Figure 5.3 % distribution of KEEP participants with egfr using MDRD & Cockroft-Gault methods, overall & by age & gender 7 Percent of participants MDRD egfr (<6 ml/min/1.73 m 2 ) Cockroft-Gault Creatinine Clearance (<6 ml/min/1.73 m 2 ) All Male Female KEEP: MDRD egfr, n=1,725; CG, n=1,614; excludes participants with missing values

5 Figure 5.4 percent distribution of KEEP Percent of participants participants with egfr using MDRD & Cockroft-Gault methods, by race MDRD egfr (<6 ml/min/1.73 m 2 ) Cockroft-Gault Creatinine Clearance (<6 ml/min/1.73 m 2 ) White Black Nat Am Asian Pac Isl Other KEEP: MDRD egfr, n=1,413; CG, n=1,38; excludes participants with missing values

6 Figure 5.5 % distribution of KEEP participants with egfr using MDRD & Cockroft-Gault methods, by Hispanic ethnicity Percent of participants MDRD egfr (<6 ml/min/1.73 m 2 ) Cockroft-Gault Creatinine Clearance (<6 ml/min/1.73 m 2 ) Non-Hispanic Mexican Puerto Rican Cuban Other Hispanic KEEP: MDRD egfr, n=7,195; CG, n=7,142; excludes participants with missing ethnicity

7 Figure 5.6 percent distribution of KEEP participants with egfr using MDRD & Cockroft-Gault methods, by U.S. region Percent of participants MDRD egfr (<6 ml/min/1.73 m 2 ) Cockroft Gault (CG) Creatinine Clearance (<6 ml/min/1.73 m 2 ) Northeast Midwest South West KEEP: MDRD egfr, n=1,725; CG, n=1,614; excludes participants with missing values

8 Figure 5.7 percent distribution of KEEP participants with CKD, by CKD status 5 Percent of participants All Stage 1 Stage 2 Stage 3 Stage 4-5 CKD stages Stage 1: CCR 9, microalbuminuria =+ Stage 2: CCR 6 89, microalbuminuria = + Stage 3: CCR 3 59 Stage 4: CCR Stage 5: CCR <15 or patient on dialysis KEEP: n=1,651; excludes participants with missing egfr; CKD defined by egfr <6 ml/min/1.73 m 2 (MDRD formula) or presence of microalbuminuria if egfr 6 ml/min/1.73 m 2

9 Figure 5.8 percent distribution of KEEP participants with CKD, by age & gender 7 Percent of participants with CKD Male Female KEEP: n=1,651; excludes participants with missing egfr; CKD defined by egfr <6 ml/min/1.73 m 2 (MDRD formula) or presence of microalbuminuria if egfr 6 ml/min/1.73 m 2

10 Figure 5.9 percent distribution of KEEP participants with CKD, by race & Hispanic ethnicity 5 Percent of participants with CKD White Black Other Hispanic Non-Hispanic KEEP: n=1,343; excludes participants with missing egfr or race; CKD defined by egfr <6 ml/min/1.73 m 2 (MDRD formula) or presence of microalbuminuria if egfr 6 ml/min/1.73 m 2. Race & Hispanic ethnicity are not mutually exclusive.

11 Figure 5.1 percent distribution of KEEP participants with CKD, by BMI 6 Percent of participants with CKD BMI index BMI <18.5: UW: Underweight BMI : N: Normal BMI : OW: Overweight BMI : OB: Obese BMI 4: EO: Extremely Obese UW N OW OB EO KEEP: n=11,122; excludes participants with missing egfr or BMI values; CKD defined by egfr <6 ml/min/1.73 m 2 (MDRD formula) or presence of microalbuminuria if egfr 6 ml/min/1.73 m 2

12 Figure 5.11 percent distribution of KEEP participants with a family history of kidney disease, overall & by gender % participants w/family history of kidney disease All Male Female KEEP: n=1,96 total, 2,77 with a reported family history of kidney disease; excludes participants with missing family history

13 Figure 5.12 percent distribution of KEEP participants with a family history of kidney disease, by race % participants w/family history of kidney disease White Black Nat Am Asian Pac Isl Other KEEP: n=1,637, 2,68 with a reported family history of kidney disease; excludes participants with missing family history or race

14 Figure 5.13 percent distribution of KEEP participants with a family history of kidney disease, by Hispanic ethnicity % participants w/family history of kidney disease Non-Hispanic Mexican Puerto Rican Cuban Other Hispanic KEEP: n=7,356, 1,845 with a reported family history of kidney disease; excludes participants with missing family history or ethnicity

15 Table 5.1 concordance of egfr, BSA-CG creatinine clearance, & gender-specific cut-points for categorizing abnormal kidney function Serum MDRD egfr BSA-CG creatinine clearance creatinine <6 6 All <6 6 All Elevated Not elevated 1,77 9,111 1,188 1,25 9,61 1,86 All 1,61 9,124 1,725 1,342 9,272 1,614 Elevated: men >1.5, women >1.3 mg/dl Not elevated: men 1.5, women 1.3 mg/dl egfr <6 ml/min/1.73 m 2 = moderate reduction in kidney function

16 Table 5.2 blood pressure levels, by stage of CKD, MDRD egfr, & BSA-CG creatinine clearance Systolic (mmhg) Diastolic (mmhg) Interquar. Interquar. Mean Median SD range Mean Median SD range MDRD Stage I Stage II Stage III Stages IV V Missing Cockcroft-Gault Stage I Stage II Stage III Stages IV V Missing CKD stages Stage 1: CCR 9, microalbuminuria =+ Stage 4: CCR Stage 2: CCR 6 89, microalbuminuria = + Stage 5: CCR <15 or patient on dialysis Stage 3: CCR 3 59

17 Figure 5.14 percent distribution of KEEP participants with elevated blood pressure, by CKD stage 1 14/9 mmhg Percent of participants /85 mmhg CKD stages Stage 1: CCR 9, microalbuminuria =+ Stage 2: CCR 6 89, microalbuminuria = + Stage 3: CCR 3 59 Stage 4: CCR Stage 5: CCR <15 or patient on dialysis Stage 1 Stage 2 Stage 3 Stage 4-5 KEEP: n=1,584; excludes participants with missing CKD stage or blood pressure value

18 Percent of participants Figure 5.15 percent distribution of KEEP participants with elevated blood pressure, by CKD stage, anemia, & egfr 14/9 mmhg 13/85 mmhg A NA A NA A NA A NA Stage 1 Stage 2 Stage 3 Stage 4-5 CKD stages Stage 1: CCR 9, microalbuminuria =+ Stage 2: CCR 6 89, microalbuminuria = + Stage 3: CCR 3 59 Stage 4: CCR Stage 5: CCR <15 or patient on dialysis KEEP: n=1,319; excludes participants with missing CKD stage, anemia status, or blood pressure value; anemia defined by NKF-K/DOQI: males: Hgb <12 g/dl; females age >5: Hgb <12 g/dl; females age 5: Hgb <11 A= anemia, NA= no anemia

19 Figure 5.16 percent distribution of KEEP participants with elevated blood pressure, by CKD & smoking status 1 Percent of participants Smoking Used to smoke Never smoked CKD stages Stage 1: CCR 9, microalbuminuria =+ Stage 2: CCR 6 89, microalbuminuria = + Stage 3: CCR 3 59 Stage 4: CCR Stage 5: CCR <15 or patient on dialysis JNC VI hypertension Stage I: systolic or diastolic 9 99 Stage II: systolic or diastolic 1 19 Stage 1 Stage 2 Stage 3 Stage 4-5 Stage III: systolic ³18 or diastolic ³11 KEEP: n=9,94; excludes participants with missing CKD status, blood pressure status, or smoking status. Hypertension based on JNC definition.

H e alth his to r y. Chapter 3 Health history. s29

H e alth his to r y. Chapter 3 Health history. s29 3 H e alth his to r y My mama died from undetected kidney disease in Oct. 22. It was only after 2 years of being treated for high blood pressure, a blood test [was done] to check on her kidneys. She went