Types of target values, acceptable ranges

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1 Types of target values, acceptable ranges As the differential of rounding, maximum 1 percent point deviation is allowed from the maximum acceptable range Clinical chemistry (wet) 1. Calcium RMV Chloride RMV 8 3. Potassium RMV 8 4. Sodium RMV 5 5. Iron AV TIBC (total iron-binding capacity) AV Transferrin AV Copper AV 24 (1) 9. Lithium RMV Magnesium RMV Inorganic phosphate AV/RMV Total protein RMV Albumin AV Albumin (elpho) AV Gamma globulins (elpho) AV Bilirubin (total) AV Bilirubin (direct) AV Glucose RMV Uric acid RMV Urea RMV Creatinine RMV Triglycerides RMV Cholesterol RMV Alkaline phosphatase AV α-amylase AV Cholinesterase (Che) AV CK RMV γ-gt RMV/AV GLDH AV GOT/ASAT RMV/AV GPT/ALAT RMV/AV α-hbdh AV LDH RMV LAP AV Lipase AV Acid phosphatase (total) AV Prostatic acid phosphatase AV IgA RMV/AV IgG AV IgM RMV/AV Osmolality AV Lactate AV Pancreas amylase AV 30 (1) 24% from 2013, 18% in previous years 1

2 110. Neonatal bilirubin 1. Bilirubin (total) consensus Dry chemistry - Reflotron 3. Bilirubin (total) AV Cholesterol RMV HDL- Colesterol AV Glucose RMV Uric acid RMV Urea RMV Creatinine RMV Triglycerides RMV α-amilase AV Alkaline phosphatase AV CK RMV γ-gt RMV GOT/ASAT AV/RMV GPT/ALAT AV/RMV Potassium RMV Pancreas amilase AV Dry chemistry - Vitros 1. Albumin AV Bilirubin (total) AV Bilirubin (conjugate) AV 26 (1) 5. Bilirubin (unconjugate) AV 26 (1) 7. Cholesterol RMV HDL-cholesterol AV Total protein AV Glucose AV Uric acid AV Urea AV Creatinine RMV Lactate AV Triglycerides RMV α-amilase AV 30 (2) 17. Alkaline phosphatase AV Cholinesterase (Che) AV CK RMV CK-MB AV γ-gt RMV/AV GOT/ASAT RMV/AV GPT/ALAT RMV/AV LDH RMV Lipase AV Calcium RMV Chloride RMV Iron AV 14 2

3 30. Potassium RMV Lithium RMV 14 (3) 32. Magnesium RMV Sodium RMV Inorganic phosphate RMV/AV 16 (1) In case of <14 µmol/l it can be even 100% (2) Under 40 U/l it can be even 100% (3) Under 0.5 mmol/l it can be even 100% Glycated proteins I.-II. 1. Haemoglobin A 1 (%) AV Haemoglobin A 1C (%) RMV * 3. Haemoglobin A 1C mmol/mol RMV Fructosamine µmol/mol consensus 24 *Lower and upper limits of the acceptance ranges are calculated from the lower and upper limits of Haemoglobin A 1C (mmol/mol) using the following equation: Haemoglobin A 1C (%) = Haemoglobin A 1C (mmol/mol) Glycated proteins - POCT 1. Haemoglobin A 1C (mmol/mol) AV Lipids/lipoproteins 1. Cholesterol RMV/consensus Triglycerides RMV/consensus HDL-cholesterol AV/consensus Apolipoprotein A1 AV/consensus Apolipoprotein B AV/consensus Phospholipids AV/consensus LDL-cholesterol AV/consensus Total protein consensus Urine chemistry, quantitative 1. Protein in urine consensus 24 (1) 2. Glucose consensus 22 (2) 3. Uric acid consensus Urea consensus Creatinine consensus Microalbuminuria consensus 40 (3) 7. Calcium consensus Chloride consensus Iron consensus 30 (4) 10. Potassium consensus Copper consensus 60 (5) 12. Magnesium consensus 20 (6) 3

4 13. Sodium consensus Inorganic phosphate consensus α-amilase consensus 45 (7) 16. Osmolality consensus 12 (1) Under 100 mg/l of target value or in case of group comprising of various methods, reagents, it can be even 100% (2) negative = under 2 mmol/l of sample it can be even 100% (3) In case of mg/l of microalbumin obtained by using test trip or in case of 0-20 mg/l of microalbumin obtained by using other methods it can be even 100% (4) Under 5 µmol/l it can be even 100% (5) Under 2 µmol/l it can be even 100% (6) mmol/l: 54%; under 0.8 mmol/l it can be even 100% (7) Under 30 U/l it can be even 100% 196. Therapeutic drugs, hormones 1. Amikacin AV Desipramine AV Digoxin AV Phenytoin AV Phenobarbital AV Gentamicin AV Imipramine AV Carbamazepine AV Chloramphenicol AV Lithium AV Nortriptyline AV Primidone AV Teophylline AV Tobramycin AV Valproic acid AV Vancomycin AV Ferritin AV Vitamin B12 AV ACTH AV Aldosterone AV deoxycortisol AV α-hydroxyprogesterone AV C-peptide AV DHEA AV DHEA-S AV FSH AV Gastrin AV HCG (total) AV HCG (total+ß) AV ß-HCG AV HGH AV IgE AV Insulin AV Calcitonin AV Vitamin D (25-OH-cholecalciferol) AV Cortisol AV LH AV Estradiol AV Estriol AV 54 4

5 43. Progesterone AV Prolactin AV PTH Intact AV Testosterone (total) AV Testosterone (free) AV PTH (C-terminal) AV Acetaminophen AV Salicylate AV Hormones 1. ACTH AV Aldosterone AV deoxycortisol AV α-hydroxyprogesterone AV C-peptide AV DHEA AV DHEA-S AV FSH AV Gastrin AV HCG (total) AV HCG (total+ß) AV ß-HCG AV HGH AV IgE AV Insulin AV Calcitonin AV Vitamin D(25-OH-cholecalciferol) AV Cortisol AV LH AV Estradiol AV Estriol AV Progesterone AV Prolactine AV Testosterone (total) AV Testosterone (free) AV PTH Intact AV PTH (C-terminal) AV PTH MM AV Estriol (free) AV Blood cell count 1. Haemoglobin consensus 5 2. Erythrocytes consensus MCV consensus 8 4. Haematocrit (centrifugated) consensus Haematocrit (electronic) consensus Leucocyte consensus Platelet count consensus 20 5

6 221. Haemostasis I. 1. Prothrombin time (sec) AV/consensus INR AV/consensus APTT rate AV/consensus Haemostasis II. 2. Fibrinogen AV/consensus TI rate AV/consensus Haemostasis III. 2. Factor II (Prothrombin) (%) AV/consensus Factor VII (Proconvertin) (%) AV/consensus Factor X (Stuart-Prower) (%) AV/consensus Factor V (Proaccelerin) (%) AV/consensus Haemostasis IV. 6. Factor IX (Antihemophilic B globulin) (%) AV/consensus Factor XI (Rosenthal) (%) AV/consensus Factor XII (Hagemann) (%) AV/consensus Factor XIII (Laki-Lorand, fibrin stabilizing) (%) AV/consensus Haemostasis V. 1. Antithrombin III AV/consensus Protein C AV/consensus Protein S AV/consensus C1- inhibitor AV/consensus Haemostasis VI. 1. D-Dimer AV/consensus (1) (1) Physiologically normal sample: Haemostasis VII. 1. Factor VIII (Antihemophilic A globulin) (%) AV/consensus Willebrand-factor Ag (%) AV/consensus Willebrand-factor RiCof (%) AV/consensus 45 6

7 244. High sensitive CRP 1. High sensitive CRP AV Hemostaseology (INR) - POCT 1. INR AV/consensus Tumour markers 1. Alpha-1-foetoprotein (AFP) AV CEA AV β2-microglobulin AV TPA AV CA 15-3 AV CA 19-9 AV CA 125 AV Prostate acid phosphatase (PAP) AV HCG (total) AV HCG (total+ß) AV PSA (total) AV SCC AV 30 (1) 13. CA 72-4 AV CYFRA 21-1 AV PSA (free) AV ß-HCG AV NSE AV TPS AV PSA (complex) AV Thyreoglobulin AV Calcitonin AV 60 (1) Under 1.2 ng/ml it can be even 50% 294. Thyroid hormones 1. Total T3 (nmol/l = ng/ml) AV Free T3 (pmol/l = pg/ml) AV Total T4 (nmol/l = µg/dl) AV/ RMV Free T4 (pmol/l = ng/dl) AV TSH 2.IRP (1983) - 80/558 AV TBG AV T-Uptake (qualitative) qualitative CRP / 326. CRP - POCT 1. C-reactive protein AV/consensus 20 (1) (1) In case of < 5 mg/l it can be even 100% 7

8 620. Arteriosclerosis 1. Homocystein AV Vitamin B6 AV Vitamin B12 AV Folic acid AV Ethanol Type of target value 1. Ethanol AV Maximum acceptable range (± %) g/l: g/l: Glucose 1. Glucose AV/RMV/consensus 15 8

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