Positive correlation of serum leptin with estradiol levels in patients with polycystic ovary syndrome
|
|
- Mark Carroll
- 6 years ago
- Views:
Transcription
1 Brazilian Journal of Medical and Biological Research (2004) 37: Leptin and polycystic ovary syndrome ISSN X 729 Positive correlation of serum leptin with estradiol levels in patients with polycystic ovary syndrome H.C. Mendonça 1, R.M. Montenegro 2, M.C. Foss 2, M.F. Silva de Sá 1 and R.A. Ferriani 1 1 Departamento de Ginecologia e Obstetrícia, and 2 Divisão de Endocrinologia e Metabologia, Departamento de Clínica Médica, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil Correspondence R.A. Ferriani Departamento de Ginecologia e Obstetrícia, HC, FMRP, USP 1º Andar Ribeirão Preto, SP Brasil Fax: raferria@fmrp.usp.br Research supported by FAPESP and CNPq. Received February 27, 2003 Accepted January 5, 2004 Abstract Patients with polycystic ovary syndrome (PCOS) usually are obese, insulin resistant and hyperinsulinemic. The known association between leptin, obesity and insulin action suggests that leptin may have a role in PCOS but this has only been addressed peripherally. This study was designed to assess the relationship between serum leptin and the anthropometric, metabolic and endocrine variables of obese (body mass index, BMI 30 kg/m 2 ) and non-obese (BMI <30 kg/m 2 ) PCOS patients. Twenty-eight PCOS patients and 24 control women subdivided into obese and non-obese groups were evaluated. Leptin, androgens, lipids, gonadotrophins and insulin-glucose response to the oral glucose tolerance test were measured by radioimmunoassay in all participants. The assays were done all in one time. The areas under the insulin curve (AUC-I) and the glycemia curve were calculated to identify patients with insulin resistance. Mean leptin levels were not significantly higher in patients with PCOS compared to the control group (21.2 ± 10.2 vs 27.3 ± 12.4 ng/ml). Leptin levels were found to be significantly higher in the obese subgroups both in patients with PCOS (26.9 ± 9.3 vs 14.1 ± 7.0 ng/ml) and in the control group (37.3 ± 15.5 vs 12.9 ± 5.8 ng/ml). The leptin of the PCOS group was correlated with BMI (r = 0.74; P < ) and estradiol (r = 0.48; P < 0.008) and tended to be correlated with the AUC-I (r = 0.36; P = 0.05). Of the parameters which showed a correlation with leptin in PCOS, only estradiol and probably insulinemia (AUC-I) did not show a significant correlation with BMI, suggesting that the other parameters were correlated with leptin due to their correlation with BMI. Estradiol correlated with leptin in PCOS patients regardless of their weight. Key words Leptin Polycystic ovary syndrome Insulin Insulin sensitivity Estrogen Introduction The polycystic ovary syndrome (PCOS) affects approximately 5-10% of women of reproductive age and is characterized by menstrual disorders, chronic anovulation and hyperandrogenism (1). About 50-60% of PCOS patients are obese, hyperinsulinemic and insulin resistant (2). A relationship between body weight and reproductive function has been observed. Women with low body fat stores such as dancers, Olympic
2 730 H.C. Mendonça et al. runners and those with nervous anorexia frequently show infertility. At the other end of the spectrum, obese women present an elevated incidence of oligomenorrhea or amenorrhea and infertility (3). The discovery of leptin (4) opened new perspectives about the relation between body fat and menstrual disorders. Leptin is secreted by adipocytes in proportion to the amount of body fat and exerts a potent inhibitory action on food intake. In humans, serum leptin concentrations correlate positively with percent body fat. Weight loss and fat reduction are associated with lower levels of serum leptin (5,6). This suggests that obesity, rather than being caused by deficient leptin production in the adipose tissue, may be caused by resistance to leptin due to an alteration in its receptor, which would hinder the action of central mechanisms responsible for the reduction of appetite (5). The very close association between hyperinsulinemia and hyperleptinemia suggests that expression of the ob gene, which codes for leptin, may be mediated by insulin both in humans and in rats (7). In addition, it has been suggested that insulin indirectly regulates leptin secretion due to its trophic effect on the adipocytes (8). Thus, insulin, leptin, body weight, ovarian steroidogenesis and ovulation show complex interrelations. According to Poretsky et al. (9), it appears that insulin stimulates leptin secretion, increases the pituitary gonadotrophin response to gonadotrophin-releasing hormone (GnRH) and promotes steroidogenesis. Leptin stimulates all levels of the reproductive axis, i.e., hypothalamus, pituitary and ovary. In view of these effects, the possibility was raised that high levels of leptin may contribute to the physiopathology of PCOS (10), although others report that the significance of the increase is lost when leptin concentrations are adjusted for body mass index (BMI) (11-13). Since obesity exerts complex effects on glucose tolerance and insulin sensitivity, it is necessary to control these effects by separately studying groups of obese and non-obese PCOS patients and comparing them to control groups of obese and non-obese ovulatory women. The aim of the present study was to determine the relationship between serum leptin and estradiol and investigate the potential association with BMI, waist:hip ratio (WHR) and insulin resistance calculated by area under the insulin curve (AUC-I) in PCOS patients and weight-matched ovulatory women. Material and Methods Patients In this prospective clinical study, 52 women of reproductive age (16-43 years) were allocated to four groups: 13 obese women with PCOS (BMI 30 kg/m 2 ), 13 obese controls, 15 non-obese women with PCOS (BMI <30 kg/m 2 ), and 11 non-obese controls. The PCOS patients were selected at the Endocrine Gynecology Outpatient Clinic of a public institution. The controls were volunteers who freely agreed to participate in the study. All women gave informed written consent before participating in the study, which was approved by the Ethics Committee of the Hospital. Inclusion and exclusion criteria PCOS group. Twenty-eight women with amenorrhea or oligomenorrhea (six or less menses/year) associated with signs of clinical and/or laboratory hyperandrogenemia according to NIH criteria (1990). Clinical hyperandrogenemia involves hirsutism (Ferriman index 8) and elevated serum testosterone or androstenedione levels. Congenital adrenal hyperplasia was excluded after serum measurement of dehydroepiandrosterone (DHEAS, cut-off 350 µg/dl) and 17-hydroxyprogesterone (17-OH, cutoff 180 ng/dl). Control group. Twenty-four ovulatory
3 Leptin and polycystic ovary syndrome 731 women with regular menstrual cycles (serum progesterone >5 ng/ml on the 22nd day of the cycle) and no clinical signs of hyperandrogenemia. Women submitted to hormonal or oral contraceptive treatment during the 3 months preceding the study or with hyperglycemia, thyroid or prolactin alterations were excluded from the study. Anthropometric assessment Weight was assessed on the basis of BMI (14) calculated by dividing weight (in kilograms) by the height squared. Patients and controls were subgrouped as obese (BMI 30 kg/m 2 ) and non-obese (BMI <30 kg/ m 2 ). To indirectly assess body fat distribution we adopted the WHR. Oral glucose tolerance test After a h fast, 75 g dextrose was administered orally to all participants and blood was collected every 30 min over a period of 2 h for the measurement of glucose and insulin. Insulin resistance was determined indirectly by calculating the AUC-I and the area under the glycemia curve (AUC- G) and the ratio of the two curves was taken to be AUC-I/AUC-G. Hormonal and biochemical tests The analyses were carried out during the follicular phase in women who had menstrual periods and in any phase of the cycle in the amenorrheic PCOS patients. The subjects were instructed to ingest an amount of calories adequate for their daily energy needs, with at least 200 g carbohydrates, for a minimum period of 3 days before the test. Blood samples were collected for the analysis of leptin, testosterone, androstenedione, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E 2 ), total cholesterol, HDL, LDL, and triglycerides. All samples were centrifuged and stored at -20ºC until the assay. All determinations for each experiment were made in a single assay. Leptin was assayed by radioimmunoassay (RIA; LINCO Research Inc., St. Charles, MO, USA) with a 5.7% intra-assay error and a mean value of 20.4 ± 7.8 ng/ml for control population. Insulin was assayed in duplicate by solid phase RIA (double antibody) and the results are reported as µu/ml. The minimum amount of insulin detected was 1.0 µu/ml. Intra- and interassay coefficients of variation were 5.5 and 16.5%, respectively. Androstenedione, testosterone, DHEAS, and 17-OH were also assayed by RIA. LH, FSH, prolactin, E 2, progesterone (P 4 ), thyroid-stimulating hormone and free thyroxine (T 4 ) were assayed by chemiluminescence (DPC, Los Angeles, CA, USA). Plasma glucose was measured by the glucose oxidase method. Total cholesterol and triglycerides were determined by enzymatic methods using Dimension kits (Dade Behring, Newark, DE, USA) and HDL cholesterol was determined by phosphotungstate-magnesium chloride precipitation. On the 22nd day of the cycle, P 4 was measured in normal volunteers in order to confirm the ovulatory condition. All subjects were submitted to pelvic ultrasound always in the first phase of the menstrual cycle, transvaginally whenever possible, using an ATL-HDI 2000 instrument (ATL, Bothell, WA, USA) and a MHz transducer, in order to assess ovarian morphology, with emphasis on the presence of multiple cysts 8 mm in diameter. Statistical analysis Data are reported as medians, means and standard deviation. The normality criteria used to interpret the glucose curves were those of the American Diabetes Association (15). AUC-G and AUC-I were calculated using the trapezoid rule. Data were analyzed statistically by the nonparametric Kruskal-
4 732 H.C. Mendonça et al. Wallis test for comparison of the medians and by analysis of variance (ANOVA) for comparison of the means. When necessary, logarithmic or mean square root transformation of the data was carried out. The Student- Newman-Keuls test was used for inter-mean discrimination. Simple Spearman linear correlation and regression were used to determine the correlation between variables for the four groups. The level of significance was set at P < 0.05 for all analyses. Results PCOS group versus the control group The clinical and metabolic characteristics of all subgroups (obese and non-obese women with PCOS and obese and non-obese controls) are listed in Table 1. When analyzed as a group, PCOS patients (obese and non-obese) had similar BMI to that of control women (obese and non-obese), but PCOS women were younger, had significantly higher concentrations of LH, LH/FSH, testosterone, and androstenedione, and a higher degree of insulin resistance. Approximately 68% of the PCOS patients presented hirsutism and 75% presented insulin resistance (78.6% of obese patients and 71.4% of nonobese patients). There was no difference between groups in lipid profile or total cholesterol/hdl index in spite of body weight. Mean serum leptin levels were similar in patients with PCOS and controls (21.2 ± 10.2 vs 27.3 ± 12.4 ng/ml, respectively). When mean serum leptin levels were compared between obese and non-obese women in both groups, they were significantly higher in the obese women (32.2 ± 9.3 ng/ml vs 13.5 ± 6.8 ng/ml; Figure 1). Correlation analyses were performed between leptin levels and all other parameters. There was a significant positive correlation between serum leptin levels and BMI both in the PCOS group and in the control group (r = 0.74; P < and r = 0.82; P < , respectively). Nevertheless, when obese and non-obese subjects were compared this correlation was demonstrable only for the obese groups (PCOS patients: r = 0.74; P < 0.05, and controls: r = 0.54; P < 0.05) but not in the non-obese groups (PCOS patients: r = 0.28; P > 0.05, and control group: r = 0.10; P > Table 1. Clinical and metabolic characteristics of the groups studied. Variable Obese Non-obese PCOS (N = 13) Control (N = 13) PCOS (N = 15) Control (N = 11) Age (years) 23.5 ± 4.5 a 32.1 ± 5.6 b 20.0 ± 5.2 a 30.0 ± 6.3 b BMI (kg/m 2 ) 35.6 ± 6.2 a 39.8 ± 7.6 a 23.2 ± 2.3 b 22.3 ± 2.2 b Waist (cm) 99.0 ± 12.4 a ± 9.7 a 74.3 ± 7.3 b 74.7 ± 6.2 b Waist:hip ratio 0.85 ± 0.06 a 0.83 ± 0.07 a 0.77 ± 0.03 b 0.76 ± 0.04 b FSH (miu/ml) 4.3 ± 1.0 a 6.4 ± 2.5 b 4.4 ± 1.0 a 4.7 ± 1.7 a LH (miu/ml) 7.4 ± 2.9 a 3.0 ± 1.7 b 8.4 ± 5.2 a 3.8 ± 3.0 b LH/FSH 1.7 ± 0.8 a 0.5 ± 0.4 b 1.9 ± 0.8 a 0.8 ± 0.5 b E 2 (pg/ml) 35.3 ± 12.9 a 29.2 ± 7.3 a 30.5 ± 10.5 a 35.0 ± 21.6 a Testosterone (ng/dl) ± 42.8 a 46.0 ± 20.2 b 92.0 ± 31.9 a 51.4 ± 18.8 b Androstenedione (ng/dl) ± 69.8 a ± 59.6 b ± 70.8 a ± 65.2 b Fasting plasma glucose (mg/dl) 78.0 ± 10.4 a 87.3 ± 8.8 b 76.8 ± 7.2 a 81.9 ± 7.9 b Fasting serum insulin (µu/ml) 23.8 ± 13.6 a 17.1 ± 7.2 a 14.9 ± 7.9 a 7.9 ± 3.6 b AUC-I/AUC-G 1.47 ± 0.6 a 0.75 ± 0.2 b 1.40 ± 0.8 a 0.53 ± 0.2 c Data are reported as means ± SD. AUC-G = area under the curve for glucose; AUC-I = area under the curve for insulin; BMI = body mass index; NS = not significant; PCOS = polycystic ovary syndrome. See text for other abbreviations. Means followed by different letters differed significantly (P < 0.05, Kruskal-Wallis test and ANOVA).
5 Leptin and polycystic ovary syndrome ). There was a positive and significant correlation between leptin levels and waist measurement, E 2 and AUC-G in PCOS patients (Table 2), but no correlation between leptin and AUC-I, WHR, LH, FSH, testosterone, androstenedione, total cholesterol, HDL-cholesterol, LDL-cholesterol and AUC-I/AUC- G. There was a trend of correlation between leptin and AUC-I. Of the parameters which showed a correlation with leptin in PCOS, only estradiol did not show a significant correlation with BMI, suggesting that the other parameters correlated with leptin only because of their correlation with BMI. In the control group, leptin levels correlated positively with waist measurement (r = 0.82; P < 0.05) and AUC-I (r = 0.54; P < 0.01) but not with AUC-G (P = 0.05). However, all of these parameters correlated significantly with BMI, suggesting that these correlations were due only to BMI. LH and the LH/FSH ratio correlated negatively with leptin in the obese group as a whole (r = -0.56; r = -0.49) and in the obese PCOS patients (r = -0.69; r = -0.76). Discussion Leptin, an ob gene product, is produced by the human fat body stores and appears to be involved in the regulation of the reproductive axis. In the present study we attempted to correlate leptin with PCOS taking into consideration body weight and several metabolic parameters. Our results confirm a positive correlation of leptin with body weight and waist measurement in humans (11-13). Brzechffa et al. (10) studied the effects of leptin on PCOS pathogenesis and observed higher concentrations of leptin in some women in spite of their BMI and sensitivity to insulin, suggesting that leptin signaling anomalies in the reproductive axis could be involved in the physiopathology of PCOS. Later studies (11-13) provided strong evidence against the report that leptin levels were elevated in PCOS women when compared to control groups (10) and affirmed that high leptin was the result of the high body weight of PCOS patients. Our findings that leptin levels were not higher in patients with PCOS compared to the control group and it was correlated with the amount of fat tissue not only in patients with PCOS but also in healthy women confirm these reports. However, our most interesting result was the correlation between leptin and E 2. We found a positive and statistically sig- Leptin (ng/ml) a Obese PCOS (N = 13) 37.3 a Obese control (N = 13) 14.1 b Non-obese PCOS (N = 15) 12.9 b Non-obese control (N = 11) Figure 1. Serum leptin levels for the polycystic ovary syndrome (PCOS) and control groups according to body mass index. Data are reported as means ± SD. Means followed by different letters differed significantly (P < 0.05, Student-Newman-Keuls test). Table 2. Anthropometric and metabolic measurements in 28 PCOS patients and their correlations with leptin and body mass index (BMI). PCOS patients Mean ± SD Correlation Correlation with leptin with BMI r P r P BMI (kg/m 2 ) 29.9 ± < Waist (cm) 87.1 ± < < Waist:hip ratio 0.81 ± NS 0.77 < E 2 (pg/ml) 34.8 ± < NS Triglycerides (mg/dl) ± NS AUC-I 18,232.5 ± 11, NS 0.27 NS AUC-G 12,718.3 ± 2, < <0.04 Leptin (ng/ml) 21.2 ± < Data are reported as means ± SD. NS = not significant (P > 0.05). For abbreviations, see legend to Table 1. The Spearman correlation and regression tests were used.
6 734 H.C. Mendonça et al. nificant correlation between E 2 and leptin, in agreement with Shimizu et al. (16) and Messinis et al. (17), suggesting that E 2 can be an important regulator of leptin production in women. Nevertheless, our findings first showed a correlation of leptin with E 2 in PCOS patients; also, this correlation was independent of BMI. We may speculate if the abnormal ovarian hormone milieu (elevated E 2 levels) may have any influence on gonadotrophin secretion in PCOS patients via leptin action. In rats, elevated E 2 levels enhanced leptin levels and neuropeptide Y expression and resulted in lower GnRH and gonadotropin secretion (18). In addition, altered fat distribution is a consequence of steroid metabolism, but the mechanisms responsible are unknown. Increased adiposity in ovariectomized rats can be reversed with 17beta-estradiol treatment (19), but this animal model suggests that obesity is not associated with hypoleptinemia or decreased ob gene expression, but is associated with insensitivity to central leptin administration caused by estrogen deficiency. Women both in pre- and post-menopause have higher serum leptin levels than men (20,21). Licinio et al. (22) have shown that women needed twice as leptin as men to maintain their normal weight. Estradiol may stimulate the production of leptin from the adipocytes (23). Leptin could act in the pituitary ovarian axis during fasting to improve reproductive function by partly stimulating estrogen secretion (23). Thus, the role of leptin in PCOS may occur by ways other than the simple concentration of the hormone in the circulation, and estrogen metabolism may be involved in this role. On the other hand, in vitro studies do not corroborate these animal findings. A possible direct intra-ovarian effect of leptin was noted in a study on rats in which the action of insulin-like growth factor (IGF-1) and FSH on estradiol production by granulosa cells in culture was attenuated by the addition of leptin (24). It was shown that leptin inhibits LH-stimulated E 2 production by human granulosa cells in culture (25). Studies in which 24-h LH pulses were observed in PCOS patients (26,27) identified an inverse relationship between LH and BMI and between leptin and 24-h mean LH, suggesting that leptin could act at the hypothalamic or hypophyseal levels as a mediator for the negative feedback on LH secretion. Although we found a negative and significant correlation between leptin and LH levels in obese subjects as a whole and in obese PCOS patients, we did not find a significant correlation between LH and BMI in any of the groups. Many obese women are hyperinsulinemic and insulin resistant (28,29). Our data do not support this, since the obese group as a whole responded to insulin similarly to the non-obese women. Nevertheless, the PCOS patients presented higher insulin resistance than the control group. These results suggest that insulin resistance does not only depend on obesity but also on the presence of PCOS, as previously described (2). The results about the relation between leptin and insulin levels and insulin resistance are contradictory. Some investigators did not find any association (5,30), indicating that other factors besides insulin are involved in the regulation of leptin concentration, whereas other studies have shown a positive association (31,32). In the present study, we found a correlation between leptin and insulinemia probably explained by the correlation also found between insulinemia and BMI. On average, control women were older than PCOS women, but the women in both groups were in the same phase of reproductive life, i.e., menacme, with no important difference between groups from an endocrine-gynecological point of view. In the present study, there was no correlation between serum leptin levels and age (r = 0.14; P = 0.32), in agreement with other studies (10,33). The lipid profile of the subjects studied
7 Leptin and polycystic ovary syndrome 735 here was normal. We observed only elevated triglycerides that were related to high BMI, independent of the presence of PCOS. Escobar-Morreale et al. (34), studying patients with hirsutism without PCOS, suggested that leptin may participate in the development of hyperandrogenemia. Brzechffa et al. (10) and Rouru et al. (35) found a correlation between leptin and free testosterone in PCOS patients. However, we did not observe a correlation between the androgens assayed in this study and leptin, in agreement with Spritzer et al. (36). The fact that leptin levels are normal in a large proportion of women with PCOS does not exclude the possibility that leptin is involved in the pathophysiology of this syndrome. Although leptin values do not differ significantly between PCOS patients and controls, it is not known if body composition can affect leptin concentrations. On the other hand, leptin is secreted in a pulsatile way, and it is not known if the normal pattern of pulsatile secretion of leptin is altered in PCOS (37). Further studies are required to clarify the effects of leptin on the ovary and its possible pathophysiological role in PCOS. The idea that circulating leptin concentrations in PCOS patients could differ from those of subjects with regular cycles was not confirmed in the present investigation. However, it may be possible to approach the question of the role of leptin in PCOS by ways other than the simple measurement of circulating leptin levels. It appears that leptin does not play a role in LH, FSH, androgen or lipid secretion in PCOS patients or in control subjects. However, a possible link between leptin and estradiol may exist. They were positively correlated in PCOS patients regardless of their weight. References 1. Dunaif A (1992). Insulin resistance and ovarian hyperandrogenism. Endocrinologist, 2: Dunaif A (1994). Molecular mechanisms of insulin resistance in the polycystic ovary syndrome. Seminars in Reproduction and Endocrinology, 12: Green BB, Weiss NS & Daling JR (1988). Risk of ovulatory infertility in relation to body weight. Fertility and Sterility, 50: Zhang Y, Proença R, Maffei M, Barone M, Leopold L & Friedman JM (1994). Positional cloning of the mouse obese gene and its human homologue. Nature, 372: Considine RV, Sinha MK, Heiman ML, Kriaugiunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ & Bauer TL (1996). Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine, 334: Halaas JL & Friedman JM (1997). Leptin and its receptor. Journal of Endocrinology, 155: Cusin I, Dryden S, Wang Q, Rohner-Jeanrenaud F, Jeanrenaud B & Williams G (1995). Effect of sustained physiological hyperinsulinaemia on hypothalamic neuropeptide Y and NPY mrna levels in the rat. Journal of Neuroendocrinology, 7: Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J & Caro JF (1996). Acute and chronic effects of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes, 45: Poretsky L, Cataldo NA, Rosenwaks Z & Giudice LC (1999). The insulin-related ovarian regulatory system in health and disease. Endocrine Reviews, 20: Brzechffa PR, Jakimiuk AJ, Agarwal SK, Weitsman SR, Buyalos RP & Magoffin DA (1996). Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 81: Mantzoros CS, Dunaif A & Flier JS (1997). Leptin concentrations in the polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 82: Pirwany IR, Fleming R, Sattar N, Greer IA & Wallace AM (2001). Circulating leptin concentrations and ovarian function in polycystic ovary syndrome. European Journal of Endocrinology, 145: Telli MH, Yildirim M & Noyan V (2002). Serum leptin levels in patients with polycystic ovary syndrome. Fertility and Sterility, 77: Keys A, Fidanza F, Karvonen MJ, Kimura N & Taylor HL (1972). Indices of relative weight and obesity. Journal of Chronic Diseases, 25: American Diabetes Association Clinical Practice Recommendations (2000). Gestational diabetes mellitus. Diabetes Care, 23: Shimizu H, Shimomura Y, Nakanishi Y, Futawatari T, Ohtani K, Sato N & Mori M (1997). Estrogen increases in vivo leptin production in rats and human subjects. Journal of Endocrinology, 154: Messinis IE, Milingos S, Zikopoulos K, Kollios G, Seferiadis K & Lolis D (1998). Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone. Human Reproduction, 13: Sun F & Yu J (2000). The effect of a special herbal tea on obesity and anovulation in androgen-sterilized rats. Proceedings of the Society for Experimental Biology and Medicine, 223: Ainslie DA, Morris MJ, Wittert G, Turnbull H, Projetto J & Thorbum
8 736 H.C. Mendonça et al. AW (2001). Estrogen deficiency causes central leptin-insensitivity and increased hypothalamic neuropeptide Y. International Journal of Obesity and Related Metabolic Disorders, 25: Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F & Leibel RL (1996). Effects of gender, body composition, and menopause on plasma concentrations of leptin. Journal of Clinical Endocrinology and Metabolism, 81: Castracane VD, Kraemer RR, Franken MA, Kraemer GR & Gimpel T (1998). Serum leptin concentration in women: effect of age, obesity, and estrogen administration. Fertility and Sterility, 70: Licinio J, Negrao AB, Mantzoros C et al. (1998). Sex differences in circulating human leptin pulse amplitude: Clinical implications. Journal of Clinical Endocrinology and Metabolism, 83: Tanaka M, Nakava S, Kurnai T, Watanabe M, Taeish T, Shimizu H & Kobayashi S (2001). Effects of estrogen on serum leptin levels and leptin mrna expression in adipose tissue in rats. Hormone Research, 56: Zachow RJ & Magoffin DA (1997). Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-i on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells. Endocrinology, 138: Karlsson C, Lindell K, Svensson E, Bergh C, Lind P, Billig H, Carlsson LM & Carlsson B (1997). Expression of functional leptin receptors in the human ovary. Journal of Clinical Endocrinology and Metabolism, 82: Taylor AE, McCourt B, Martin KA, Anderson EJ, Adams JM, Schoenfeld D & Hall JE (1997). Determinants of abnormal gonadotrophin secretion in clinically defined women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 82: Laughlin GA, Morales AJ & Yen SS (1997). Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia. Journal of Clinical Endocrinology and Metabolism, 82: Kopelman PG (1994). Hormones and obesity. Baillieres Clinical Endocrinology and Metabolism, 8: Maggio CA & Pi-Sunyer FX (1997). The prevention and treatment of obesity. Diabetes Care, 20: Micic D, Macut D, Popovic V, Sumarac-Dumanovic M, Kendereski A, Colic M, Dieguez C & Casanueva FF (1997). Leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome. Gynecology and Endocrinology, 11: Saad MF, Khan A, Sharma A, Michael R, Riad-Gabriel MG, Boyadjian R, Jinagouda SD, Steil GM & Kamdar V (1998). Physiological insulinemia acutely modulates plasma leptin. Diabetes, 47: Fernandez-Real JM, Casamitjana R & Ricart-Engel W (1998). Leptin is involved in gender-related differences in insulin sensitivity. Clinical Endocrinology, 49: Gennarelli G, Holte J, Wide L, Berne C & Lithell H (1998). Is there a role for leptin in the endocrine and metabolic aberrations of polycystic ovary syndrome? Human Reproduction, 13: Escobar-Morreale HF, Serrano-Gotarredona J, Varela C, Garcia-Robles R & Sancho JM (1997). Circulating leptin concentrations in women with hirsutism. Fertility and Sterility, 68: Rouru J, Anttila L, Koskinen P, Penttila TA, Irjala K, Huupponen R & Koulu M (1997). Serum leptin concentrations in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 82: Spritzer PM, Poy M, Wiltgen D, Mylius LS & Capp E (2001). Leptin concentrations in hirsute women with polycystic ovary syndrome or idiopathic hirsutism: influence on LH and relationship with hormonal, metabolic, and anthropometric measurements. Human Reproduction, 16: Messinis IE & Millings SD (1999). Leptin in human reproduction. Human Reproduction Update, 5: (Review).
Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone
Human Reproduction vol.13 no.5 pp.1152 1156, 1998 Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone I.E.Messinis 1,4, S.Milingos
More informationROLE OF HORMONAL ASSAY IN DIAGNOSING PCOD DR GAANA SREENIVAS (JSS,MYSURU)
ROLE OF HORMONAL ASSAY IN DIAGNOSING PCOD DR GAANA SREENIVAS (JSS,MYSURU) In 1935, Stein and Leventhal described 7 women with bilateral enlarged PCO, amenorrhea or irregular menses, infertility and masculinizing
More informationCirculating leptin levels during ovulation induction: relation to adiposity and ovarian morphology
FERTILITY AND STERILITY VOL. 73, NO. 3, MARCH 2000 Copyright 2000 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Circulating leptin levels
More informationPolycystic Ovary Syndrome HEATHER BURKS, MD OU PHYSICIANS REPRODUCTIVE MEDICINE SEPTEMBER 21, 2018
Polycystic Ovary Syndrome HEATHER BURKS, MD OU PHYSICIANS REPRODUCTIVE MEDICINE SEPTEMBER 21, 2018 Learning Objectives At the conclusion of this lecture, learners should: 1) Know the various diagnostic
More informationSerum leptin concentrations during the menstrual cycle in normal-weight women: effects of an oral triphasic estrogen progestin medication
European Journal of Endocrinology (2000) 142 174 178 ISSN 0804-4643 CLINICAL STUDY Serum leptin concentrations during the menstrual cycle in normal-weight women: effects of an oral triphasic estrogen progestin
More informationIJBCP International Journal of Basic & Clinical Pharmacology. Leptin in non PCOS and PCOS women: a comparative study
Print ISSN: 2319-2003 Online ISSN: 2279-0780 IJBCP International Journal of Basic & Clinical Pharmacology doi: 10.5455/2319-2003.ijbcp20140224 Research Article Leptin in non and women: a comparative study
More informationCase Questions. Polycystic Ovarian Syndrome: Treatment Goals and Options. Differential Diagnosis of Hyperandrogenic Anovulation
Polycystic Ovarian Syndrome: Treatment Goals and Options Marc Cornier, MD Division of Endocrinology, Metabolism and Diabetes Colorado Center for Health and Wellness University of Colorado School of Medicine
More informationPolycystic Ovarian Syndrome (PCOS) LOGO
Polycystic Ovarian Syndrome (PCOS) Ma qianhong Ob/Gyn Department LOGO Contents Epidemiology and Definition Pathophysiology, Endocrinological Features Diagnostic Criteria Treatment Prognosis Introduction
More informationINSULIN RESISTANCE, POLYCYSTIC OVARIAN SYNDROME An Overview
INSULIN RESISTANCE, POLYCYSTIC OVARIAN SYNDROME An Overview University of PNG School of Medicine & Health Sciences Division of Basic Medical Sciences PBL MBBS III VJ Temple 1 Insulin Resistance: What is
More informationEffect of troglitazone on endocrine and ovulatory performance in women with insulin resistance related polycystic ovary syndrome
FERTILITY AND STERILITY VOL. 71, NO. 2, FEBRUARY 1999 Copyright 1999 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Effect of troglitazone
More informationInsulin, leptin, IGF-I and insulin-dependent protein concentrations after insulin-sensitizing therapy in obese women with polycystic ovary syndrome
European Journal of Endocrinology (2001) 144 509±515 ISSN 0804-4643 CLINICAL STUDY Insulin, leptin, IGF-I and insulin-dependent protein concentrations after insulin-sensitizing therapy in obese women with
More informationDiagnostic Performance of Serum Total Testosterone for Japanese Patients with Polycystic Ovary Syndrome
Endocrine Journal 2007, 54 (2), 233 238 Diagnostic Performance of Serum Total Testosterone for Japanese Patients with Polycystic Ovary Syndrome TAKESHI IWASA, TOSHIYA MATSUZAKI, MASAHIRO MINAKUCHI, NAOKO
More informationPolycystic Ovary Syndrome
Polycystic Ovary Syndrome Definition: the diagnostic criteria Evidence of hyperandrogenism, biochemical &/or clinical (hirsutism, acne & male pattern baldness). Ovulatory dysfunction; amenorrhoea; oligomenorrhoea
More informationCorrelation between circulating leptin and luteinizing hormone during the menstrual cycle in normal-weight women
European Journal of Endocrinology (1998) 139 190 194 ISSN 0804-4643 Correlation between circulating leptin and luteinizing hormone during the menstrual cycle in normal-weight women Tomi Teirmaa, Virve
More informationInvestigation of adrenal functions in patients with idiopathic hyperandrogenemia
European Journal of Endocrinology (26) 155 37 311 ISSN 84-4643 CLINICAL STUDY Investigation of adrenal functions in patients with idiopathic hyperandrogenemia Hulusi Atmaca, Fatih Tanriverdi 1, Kursad
More informationAchieving Pregnancy: Obesity and Infertility. Jordan Vaughan, MSN, APN, WHNP-BC Women s Health Nurse Practitioner Nashville Fertility Center
Achieving Pregnancy: Obesity and Infertility Jordan Vaughan, MSN, APN, WHNP-BC Women s Health Nurse Practitioner Nashville Fertility Center Disclosures Speakers Bureau EMD Serono Board of Directors Nurse
More informationLeptin levels and menstrual function in HIV-infected women in rural India
Leptin levels and menstrual function in HIV-infected women in rural India Annie Phoebe. K¹, Mini Jacob.S¹, Hemalatha.R², Sivakumar M.R¹ ¹Department of Experimental Medicine, The Tamil Nadu Dr. MGR Medical
More informationSerum Leptin Level in Women with Polycystic Ovary Syndrome: Correlation with Adiposity, Insulin, and Circulating Testosterone
Original Article Serum Leptin Level in Women with Polycystic Ovary Syndrome: Correlation with Adiposity, Insulin, and Circulating Testosterone Chakrabarti J Department of Biotechnology, Presidency University
More informationOverview of Reproductive Endocrinology
Overview of Reproductive Endocrinology I have no conflicts of interest to report. Maria Yialamas, MD Female Hypothalamic--Gonadal Axis 15 4 Hormone Secretion in the Normal Menstrual Cycle LH FSH E2, Progesterone,
More informationReproductive FSH. Analyte Information
Reproductive FSH Analyte Information 1 Follicle-stimulating hormone Introduction Follicle-stimulating hormone (FSH, also known as follitropin) is a glycoprotein hormone secreted by the anterior pituitary
More informationJessicah S. Collins, Jennifer P. Beller, Christine Burt Solorzano, James T. Patrie, R. Jeffrey Chang, John C. Marshall, Christopher R.
Supplemental Materials for manuscript entitled Blunted Day-Night Changes in Luteinizing Hormone Pulse Frequency in Girls with Obesity: the Potential Role of Hyperandrogenemia Jessicah S. Collins, Jennifer
More informationclinical outcome and hormone profiles before and after laparoscopic electroincision of the ovaries in women with polycystic ovary syndrome
& clinical outcome and hormone profiles before and after laparoscopic electroincision of the ovaries in women with polycystic ovary syndrome Zulfo Godinjak¹*, Ranka Javorić² 1 Gynecology and Obstetrics
More informationPCOS and Obesity DUB is better treated by OCPs
PCOS and Obesity DUB is better treated by OCPs Dr. Ritu Joshi Senior consultant Fortis escorts Hospital, Jaipur Chairperson Family welfare com. FOGSI (20092012) Vice President FOGSI 2014 Introduction One
More informationNitasha Garg 1 Harkiran Kaur Khaira. About the Author
https://doi.org/10.1007/s13224-017-1082-4 ORIGINAL ARTICLE A Comparative Study on Quantitative Assessment of Blood Flow and Vascularization in Polycystic Ovary Syndrome Patients and Normal Women Using
More informationPolycystic Ovarian Syndrome: Diagnosis, Preconceptional Management and Health Risks
Polycystic Ovarian Syndrome: Diagnosis, Preconceptional Management and Health Risks Kate D. Schoyer, M.D. May 6, 2016 Objectives To review how to make the diagnosis of Polycystic Ovarian Syndrome (PCOS)
More informationCorrelation of leptin and sex hormones with endocrine changes in healthy Saudi women of different body weights
Original Article Correlation of leptin and sex hormones with endocrine changes in healthy Saudi women of different body weights Rowyda N. Al-Harithy, Huda Al-Doghaither, Khalid Abualnaja Background: A
More informationSelection criteria of normal controls to predict reliable cut-off values of various endocrine parameters in infertility
J Obstet Gynecol India Vol. 55, No. 1 : January/February 2005 Pg 72-76 ORIGINAL ARTICLE The Journal of Obstetrics and Gynecology of India Selection criteria of normal controls to predict reliable cut-off
More informationJournal of Clinical and Biomedical Sciences. Assessment of Leptin and Testosterone in women with Polycystic ovarian syndrome.
316 Journal of Clinical and Biomedical Sciences Journal homepage: www.jcbsonline.ac.in Original Article Assessment of Leptin and Testosterone in women with Polycystic ovarian syndrome. B V Ravi* 1, Sadaria
More informationRelation of luteinizing hormone levels to body mass index in premenopausal women
FERTILITY AND STERILITY VOL. 69, NO. 3, MARCH 1998 Copyright 1998 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Relation of luteinizing
More informationPolycystic Ovary Syndrome
What is the polycystic ovary syndrome? Polycystic Ovary Syndrome The polycystic ovary syndrome (PCOS) is a clinical diagnosis characterized by the presence of two or more of the following features: irregular
More informationWEIGHT GAIN DURING MENOPAUSE EMERGING RESEARCH
MENOPAUSE WHEN DOES IT OCCUR? The cessation of the menstrual cycle for one year. WEIGHT GAIN DURING MENOPAUSE EMERGING RESEARCH Jan Schroeder, Ph.D. Chair of The Department of Kinesiology California State
More informationFeedback inhibition of insulin secretion and insulin resistance in polycystic ovarian syndrome with and without obesity
European Review for Medical and Pharmacological Sciences 1997; 1: 17-171 Feedback inhibition of insulin secretion and insulin resistance in polycystic ovarian syndrome with and without obesity d. sinagra,
More informationAssociation between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome
Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome S.B. Lecke 1,2, D.M. Morsch 1,2 and P.M. Spritzer 1,2 1 Unidade de Endocrinologia
More informationPolycystic Ovarian Syndrome: Diagnosis, Preconceptional Management and Health Risks. Kate D. Schoyer, M.D. May 6, 2016
Polycystic Ovarian Syndrome: Diagnosis, Preconceptional Management and Health Risks Kate D. Schoyer, M.D. May 6, 2016 Objectives To review how to make the diagnosis of Polycystic Ovarian Syndrome (PCOS)
More informationTHE PREVALENCE AND ETIOLOGY OF POLYCYSTIC OVARIAN SYNDROME (PCOS) AS A CAUSE OF FEMALE INFERTILITY IN CENTRAL TRAVANCORE
NSave Nature to Survive 9(1): 01-06, 2014 www.thebioscan.in THE PREVALENCE AND ETIOLOGY OF POLYCYSTIC OVARIAN SYNDROME (PCOS) AS A CAUSE OF FEMALE INFERTILITY IN CENTRAL TRAVANCORE K. ROY GEORGE AND N.
More informationHormone Balance - Female Report SAMPLE. result graph based on Luteal Phase. result graph based on Luteal Phase
Patient Name: Patient DOB: Gender: Physician: Test Hormone Balance - Female Report SAMPLE Grote, Mary Jane Batch Number: B6437 2/16/1954 Accession Number: N52281 F Date Received: 2/3/2015 Any Lab Test
More informationClinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes
POLYCYSTIC OVARY SYNDROME Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes Ettore Guastella, M.D., a Rosa Alba Longo, M.D., b and Enrico Carmina, M.D. b a Department
More informationDaily blood hormone levels related to the luteinizing hormone surge in anovulatory cycles
FRTILITY AND STRILITY Copyright 1983 The American Fertility Society Printed in U.8A. Daily blood hormone levels related to the luteinizing hormone surge in anovulatory cycles Chung H. Wu, M.D. * F. Susan
More informationPolycystic Ovarian Syndrome. Heidi Hallonquist, MD Concord Hospital Concord Obstetrics and Gynecology
Polycystic Ovarian Syndrome Heidi Hallonquist, MD Concord Hospital Concord Obstetrics and Gynecology Outline Definition Symptoms Causal factors Diagnosis Complications Treatment Why are we talking about
More informationRelationships between free leptin and insulin resistance in women with polycystic ovary syndrome
Iranian Journal of Reproductive Medicine Vol.7. No.2. pp: 53-58, Spring 2009 Relationships between free leptin and insulin resistance in women with polycystic ovary syndrome Javad Mohiti-Ardekani 1 Ph.D.,
More informationEndocrine control of female reproductive function
Medicine School of Women s & Children s Health Discipline of Obstetrics & Gynaecology Endocrine control of female reproductive function Kirsty Walters, PhD Fertility Research Centre, School of Women s
More informationMetformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome
IJMS Vol 36, No 2, June 2011 Original Article Metformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome Marzieh Farimani Sanoee 1, Nosrat Neghab 1, Soghra
More informationCan Sex hormone Binding Globulin Considered as a Predictor of Response to Pharmacological Treatment in Women with Polycystic Ovary Syndrome?
www.ijpm.in www.ijpm.ir Can Sex hormone Binding Globulin Considered as a Predictor of Response to Pharmacological Treatment in Women with Polycystic Ovary Syndrome? Ferdous Mehrabian, Maryam Afghahi Department
More informationPolycystic Ovary Syndrome
Polycystic Ovary Syndrome Kathleen Colleran, MD Professor of Medicine University of New Mexico HSC Presented for COMM-TC May 4, 2012 Objectives Understand the pathophysiology of PCOS Understand how to
More informationHyperleptinaemia is associated with impaired gonadotrophin response to GnRH during late puberty in obese girls, not boys
European Journal of Endocrinology (1998) 138 653 658 ISSN 0804-4643 Hyperleptinaemia is associated with impaired gonadotrophin response to GnRH during late puberty in obese girls, not boys Claire Bouvattier
More informationDr Stella Milsom. Endocrinologist Fertility Associates Auckland. 12:30-12:40 When Puberty is PCO
Dr Stella Milsom Endocrinologist Fertility Associates Auckland 12:30-12:40 When Puberty is PCO Puberty or Polycystic Ovary Syndrome? Stella Milsom Endocrinologist Auckland DHB, University of Auckland,
More informationThe contributions of oestrogen and growth factors to increased adrenal androgen secretion in polycystic ovary syndrome
Human Reproduction vol.14 no.2 pp.307 311, 1999 The contributions of oestrogen and growth factors to increased adrenal androgen secretion in polycystic ovary syndrome E.Carmina 1, F.Gonzalez 2, A.Vidali
More informationTest Briefing on Hormonal Disorders and Infertility
Test Briefing on Hormonal Disorders and Infertility Test Briefing on Hormonal Disorders Common Tests FSH LH Progesterone Estradiol Prolactin Testosterone AFP AMH PCOS Panel FSH (Follicle Stimulating Hormone)
More informationCASE 41. What is the pathophysiologic cause of her amenorrhea? Which cells in the ovary secrete estrogen?
CASE 41 A 19-year-old woman presents to her gynecologist with complaints of not having had a period for 6 months. She reports having normal periods since menarche at age 12. She denies sexual activity,
More informationDoppler flow velocities of uterine and ovarian arteries & hormonal patterns in patients with Polycystic Ovary Syndrome (PCOS)
Original article: Doppler flow velocities of uterine and ovarian arteries & hormonal patterns in patients with Polycystic Ovary Syndrome (PCOS) Dr. Deepali Dhingra*#, Dr. Shashi Prateek*, Dr. Renuka Sinha*,
More informationRegulation of serum leptin levels by gonadal function in rats
European Journal of Endocrinology (1999) 140 468 473 ISSN 0804-4643 Regulation of serum leptin levels by gonadal function in rats L Pinilla 1, L M Seoane 2, L Gonzalez 1, E Carro 2, E Aguilar 1, F F Casanueva
More informationAntim ullerian hormone and polycystic ovary syndrome
Antim ullerian hormone and polycystic ovary syndrome Yi-Hui Lin, M.D., a Wan-Chun Chiu, Ph.D., c Chien-Hua Wu, Ph.D., b,e Chii-Ruey Tzeng, M.D., d Chun-Sen Hsu, M.D., a and Ming-I Hsu, M.D. a a Department
More informationReproductive outcome in women with body weight disturbances
Reproductive outcome in women with body weight disturbances Zeev Shoham M.D. Dep. Of OB/GYN Kaplan Hospital, Rehovot, Israel Weight Status BMI (kg/m 2 ) Underweight
More informationDOES INSULIN RESISTANCE CAUSE HYPERANDROGENEMIA OR HYPERANDROGENEMIA CAUSES INSULIN RESISTANCE IN PCOS
DOES INSULIN RESISTANCE CAUSE HYPERANDROGENEMIA OR HYPERANDROGENEMIA CAUSES INSULIN RESISTANCE IN PCOS D R. G A N A P A T H I. B D E P T. O F E N D O C R I N O L O G Y S T. J O H N S M E D I C A L C O
More informationClinical Study Hyperandrogenism Does Not Influence Metabolic Parameters in Adolescent Girls with PCOS
International Endocrinology Volume 2012, Article ID 434830, 5 pages doi:10.1155/2012/434830 Clinical Study Hyperandrogenism Does Not Influence Metabolic Parameters in Adolescent Girls with PCOS Kim Forrester-Dumont,
More information12/13/2017. Important references for PCOS. Polycystic Ovarian Syndrome (PCOS) for the Family Physician. 35 year old obese woman
Polycystic Ovarian Syndrome (PCOS) for the Family Physician Barbara S. Apgar MD, MS Professor or Family Medicine University of Michigan Ann Arbor, Michigan Important references for PCOS Endocrine Society
More informationPolycystic Ovary Syndrome (PCOS):
Polycystic Ovary Syndrome (PCOS): Current diagnosis and treatment Anatte E. Karmon, MD Disclosures- Anatte Karmon, MD No financial relationships to disclose 2 Objectives At the end of this presentation,
More informationCorrelation Between Insulin, Leptin and Polycystic Ovary Syndrome
Original Article Correlation Between Insulin, Leptin and Polycystic Ovary Syndrome Mohamed Nabih El Gharib, Thoraya Elsayed Badawy 1 Departments of Obstetrics and Gynecology, 1 Clinical Pathology, Faculty
More informationAbstract. Introduction. RBMOnline - Vol 10. No Reproductive BioMedicine Online; on web 15 November 2004
RBMOnline - Vol 10. No 1. 2005 100-104 Reproductive BioMedicine Online; www.rbmonline.com/article/1484 on web 15 November 2004 Article Metformin monotherapy in lean women with polycystic ovary syndrome
More informationEffects of estradiol and FSH on leptin levels in women with suppressed pituitary
Geber et al. Reproductive Biology and Endocrinology 2012, 10:45 RESEARCH Open Access Effects of estradiol and FSH on leptin levels in women with suppressed pituitary Selmo Geber 1,2*, Augusto HF Brandão
More informationS. AMH in PCOS Research Insights beyond a Diagnostic Marker
S. AMH in PCOS Research Insights beyond a Diagnostic Marker Dr. Anushree D. Patil, MD. DGO Scientist - D National Institute for Research in Reproductive Health (Indian Council of Medical Research) (Dr.
More informationProf.Dr. Nabil Lymon Head of Internal Medicine Department
By Prof.Dr. Nabil Lymon Head of Internal Medicine Department Definitions: Hirsutism: Is the presence of terminal hair in androgendependent sites where hair does not normally grow in women. This hair growth
More informationMETABOLIC RISK MARKERS IN WOMEN WITH POLYCYSTIC OVARIAN MORPHOLOGY
Vuk Vrhovac University Clinic Dugi dol 4a, HR-10000 Zagreb, Croatia Original Research Article Received: February 18, 2010 Accepted: March 3, 2010 METABOLIC RISK MARKERS IN WOMEN WITH POLYCYSTIC OVARIAN
More informationIMPACT OF NUTRITION ON GYNECOLOGICAL HEALTH OF FEMALE ADOLESCENTS
IMPACT OF NUTRITION ON GYNECOLOGICAL HEALTH OF FEMALE ADOLESCENTS Kedikova S. MD, PhD Medical University Sofia, Bulgaria University Hospital Maichin dom Sofia NUTRITION WHO - Nutrition is the intake of
More informationAFTER THE FIRST publications reporting the treatment
0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(8):4593 4598 Printed in U.S.A. Copyright 2005 by The Endocrine Society doi: 10.1210/jc.2004-2283 Metformin and Weight Loss in
More informationlactotrophs 120 min- FSH 60 min- LH Hypothalamus GnRH pituitary Estradiol +/- Progesterone _ FSH L H Ovary Uterus Ovulation Antral follicle >2mm
lactotrophs Hypothalamus GnRH 120 min- 60 min- LH Progesterone _ pituitary L H + Ovary + Estradiol +/- Uterus Antral follicle >2mm Ovulation Preovulatory follicles atresia Follicular phase Luteal phase
More informationEffect of Resistin on Granulosa and Theca Cell Function in Cattle
1 Effect of Resistin on Granulosa and Theca Cell Function in Cattle D.V. Lagaly, P.Y. Aad, L.B. Hulsey, J.A. Grado-Ahuir and L.J. Spicer Story in Brief Resistin is an adipokine that has not been extensively
More informationReproductive Health and Pituitary Disease
Reproductive Health and Pituitary Disease Janet F. McLaren, MD Assistant Professor Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology jmclaren@uabmc.edu Objectives
More informationCase. 24 year old female presented to your office complaining of excess hair growth on her face and abdomen. Questions?
Hirsutism Case 24 year old female presented to your office complaining of excess hair growth on her face and abdomen Questions? Started around puberty with gradual progression Irregular menstrual cycle
More informationWEIGHT CHANGE AND ANDROGEN LEVELS DURING CONTRACEPTIVE TREATMENT OF WOMEN AFFECTED BY POLYCYSTIC OVARY
ENDOCRINE REGULATIONS, VOL. 40, 119-123, 2006 119 WEIGHT CHANGE AND ANDROGEN LEVELS DURING CONTRACEPTIVE TREATMENT OF WOMEN AFFECTED BY POLYCYSTIC OVARY J. VRBIKOVA, K. DVORAKOVA, M. HILL, L. STARKA Institute
More informationKaren E. Remsberg, Ph.D., Evelyn O. Talbott, Dr.P.H., Jeanne V. Zborowski, Ph.D., Rhobert W. Evans, Ph.D., and Kathleen McHugh-Pemu, M.P.H.
FERTILITY AND STERILITY VOL. 78, NO. 3, SEPTEMBER 2002 Copyright 2002 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Evidence for competing
More informationThe Effect of Vitamin D Replacement Therapy on Serum Leptin and Follicular Growth Pattern in Women with Clomiphene Citrate Resistant Polycystic Ovary
Med. J. Cairo Univ., Vol. 84, No. 2, June: 85-89, 2016 www.medicaljournalofcairouniversity.net The Effect of Vitamin D Replacement Therapy on Serum Leptin and Follicular Growth Pattern in Women with Clomiphene
More informationPCOS Awareness Symposium Atlanta September 24 th, Preventing Diabetes & Cardiovascular Disease in PCOS
PCOS Awareness Symposium Atlanta September 24 th, 2016 Preventing Diabetes & Cardiovascular Disease in PCOS Katherine Sherif, MD Professor & Vice Chair, Department of Medicine Director, Jefferson Women
More informationInternational Journal of Health Sciences and Research ISSN:
International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article A Study on Assessment of Testosterone, Insulin Resistance and HbA1c in Women with Polycystic
More informationRELATIONSHIP BETWEEN BMI, TOTAL TESTOSTERONE, SEX HORMONE-BINDING-GLOBULIN, LEPTIN, INSULIN AND INSULIN RESISTANCE IN OBESE MEN
Archives of Andrology, 52:355 361, 2006 Copyright # Informa Healthcare ISSN: 0148-5016 print/1521-0375 online DOI: 10.1080/01485010600692017 RELATIONSHIP BETWEEN BMI, TOTAL TESTOSTERONE, SEX HORMONE-BINDING-GLOBULIN,
More informationPrevalence of Anovulation in Subfertile Women in Kerbala 2012, A descriptive Cross-Sectional Study
Prevalence of Anovulation in Subfertile Women in Kerbala 2012, A descriptive Cross-Sectional Study Mousa Mohsen Ali* Wasan Ghazi* HayderAamerAbboud^ *Kerbala University, College of Medicine, Gynecology
More informationNature and Science 2017;15(8)
Prognostic Value of Day 3 Luteinising Hormone (LH) in the prediction of Ovarian Response in Patients with Polycystic Ovary syndrome Mohammed Samir Fouad 1 ; Mohammed Said El-Shorbagy 2, Mohammed Mohammed
More informationEFFECT OF WEIGHT LOSS ON OVARIAN AND ADRENAL ANDROGEN SENSITIVITY. Department OB/GYN. EVMA Norfolk, Va Telephone: (804)
This study predates but predicts the use of glucophage, exercise and diet for the treatment of PCO. EFFECT OF WEIGHT LOSS ON OVARIAN AND ADRENAL ANDROGEN SENSITIVITY Principal Investigator: Hofheimer Hall
More informationAdolescent polycystic ovary syndrome: pathophysiology and implications of the disease
Invited review Adolescent polycystic ovary syndrome: pathophysiology and implications of the disease Sajal Gupta, Dinah Chen, Katherine O Flynn O Brien, Anjali Chandra, Lauren Metterle, Shubhangi Kesavan,
More informationPolycystic Ovary Syndrome Therapy Dr. Pilar Vigil MD, PhD, FACOG
Polycystic Ovary Syndrome Therapy Dr. Pilar Vigil MD, PhD, FACOG What is an ovulatory dysfunction? Mrs. Susana Godoy, Nurse-Midwife San José, Costa Rica Abril 2018 PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
More informationClinical correlation with biochemical status in polycystic ovarian syndrome
J Obstet Gynecol India Vol. 55, No. 1 : January/February 2005 Pg 67-71 ORIGINAL ARTICLE The Journal of Obstetrics and Gynecology of India Clinical correlation with biochemical status in polycystic ovarian
More informationMetformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome
FERTILITY AND STERILITY VOL. 69, NO. 4, APRIL 1998 Copyright 1998 American Society for Reproductive Medicine Published by Elsevier Science Inc. Printed on acid-free paper in U.S.A. Metformin therapy improves
More informationMetfornim and Pioglitazone in polycystic ovarian syndrome: A comparative study
Original Research Article Metfornim and Pioglitazone in polycystic ovarian syndrome: A comparative study Allanki Suneetha Devi 1, Jalem Anuradha 2* 1 Associate Professor, Department of Obstetrics and Gynecology,
More informationPolycystic ovary syndrome
Polycystic ovary syndrome Overview Polycystic ovary syndrome (PCOS) is a condition most often characterized by irregular menstrual periods, excess hair growth and obesity, but it can affect women in a
More information16 YEAR-OLD OBESE FEMALE WITH OLIGOMENORRHEA
16 YEAR-OLD OBESE FEMALE WITH OLIGOMENORRHEA Katie O Sullivan, MD Adult/Pediatric Endocrinology Fellow University of Chicago ENDORAMA Thursday, September 4th, 2014 Disclosures No financial interests. Will
More informationApproach to ovulation induction and superovulation in women with a history of infertility. Anatte E. Karmon, MD
Approach to ovulation induction and superovulation in women with a history of infertility Anatte E. Karmon, MD Disclosures- Anatte Karmon, MD No financial relationships to disclose 2 Objectives At the
More informationFemale androgen profiles by MS for PCOS patients. CS Ho APCCMS 2010, Hong Kong 14 January 2010
Female androgen profiles by MS for PCOS patients CS Ho APCCMS 2010, Hong Kong 14 January 2010 873 women with increased serum androgens Androgen-secreting neoplasms 0.2% Classical CAH 0.6% Non-classical
More informationComparative study of metabolic profile of women presenting with polycystic ovary syndrome in relation to body mass index
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Akshaya S et al. Int J Reprod Contracept Obstet Gynecol. 2016 Aug;5(8):2561-2565 www.ijrcog.org pissn 2320-1770 eissn 2320-1789
More informationLeptin Concentrations in Women in the San Antonio Heart Study: Effect of Menopausal Status and Postmenopausal Hormone Replacement Therapy
American Journal of EpWemtokagy Copyright O 1997 by The Johns Hopkins University School of Hygiene and Public Health All rights reserved Vol. 146, No. 7 Printed In USA. A BRIEF ORIGINAL CONTRIBUTION Leptin
More informationRelationship between Energy Expenditure Related Factors and Oxidative Stress in Follicular Fluid
Original Article Relationship between Energy Expenditure Related Factors and Oxidative Stress in Follicular Fluid Abstract This study evaluated the impact of body mass index (BMI), total calorie intake
More informationSCREENING OF POLYCYSTIC OVARIAN SYNDROME AMONG ADOLESCENT GIRLS AT CAIRO UNIVERSITY
SCREENING OF POLYCYSTIC OVARIAN SYNDROME AMONG ADOLESCENT GIRLS AT CAIRO UNIVERSITY Sahar Mansour Ibrahim, Yossria Ahmed Elsayed, Reda Esmail Reyad 4 and Hanan Fahmy Azzam 1* 2 3 1 Assistant Lecturer,
More informationMetabolic changes in menopausal transition
Metabolic changes in menopausal transition Terhi T. Piltonen M.D., Associate Professor Consultant, Clinical Researcher for the Finnish Medical Foundation Department of Obstetrics and Gynecology PEDEGO
More informationGonadotrophin treatment in patients with Polycystic Ovary Syndrome
Int. J. Adv. Res. Biol. Sci. (218). 5(4): 95-99 International Journal of Advanced Research in Biological Sciences ISSN: 2348-869 www.ijarbs.com DOI: 1.22192/ijarbs Coden: IJARQG(USA) Volume 5, Issue 4-218
More informationX/06/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 91(1):2 6 Copyright 2006 by The Endocrine Society doi: /jc.
0021-972X/06/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 91(1):2 6 Printed in U.S.A. Copyright 2006 by The Endocrine Society doi: 10.1210/jc.2005-1457 EXTENSIVE CLINICAL EXPERIENCE Relative
More informationObjectives 1. Be able to describe the classic presentation and diagnostic criteria 2. Be able to explain long-term health concerns associated with the diagnosis 3. Understand what basic treatment options
More informationReproductive physiology
Reproductive physiology Sex hormones: Androgens Estrogens Gestagens Learning objectives 86 (also 90) Sex Genetic sex Gonadal sex Phenotypic sex XY - XX chromosomes testes - ovaries external features Tha
More informationPOLYCYSTIC OVARIAN SYNDROME Laura Tatpati, MD Reproductive Endocrinology and Infertility. Based on: ACOG No. 108 Oct 2009; reaffirmed 2015
POLYCYSTIC OVARIAN SYNDROME Laura Tatpati, MD Reproductive Endocrinology and Infertility Based on: ACOG No. 108 Oct 2009; reaffirmed 2015 NO DISCLOSURES PATIENT 26 years old presents with complaint of
More informationJMSCR Vol 05 Issue 05 Page May 2017
www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i5.14 Hyperinsulinemia in Polycystic Ovary Syndrome
More informationPolycystic Ovary Disease: A Common Endocrine Disorder in Women
Polycystic Ovary Disease: A Common Endocrine Disorder in Women Paul Kaplan, M.D. Clinical Professor of Reproductive Endocrinology - OHSU Courtesy Senior Research Associate, Human Physiology University
More informationNew PCOS guidelines: What s relevant to general practice
New PCOS guidelines: What s relevant to general practice Dr Michael Costello Fertility Specialist IVF Australia UNSW Royal Hospital for Women Sydney How do we know if something is new? Louvre Museum, Paris
More information