Bariatric Surgery: How complex is this? Pradeep Pallati, MD, FACS, FASMBS

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1 Bariatric Surgery: How complex is this? Pradeep Pallati, MD, FACS, FASMBS

2 Nothing to Disclose

3 Types of Bariatric Surgery Restrictive Malabsorptive Combination Restrictive and Malabsorptive Newer Endoluminal Procedures

4 Types of Bariatric Surgery Restrictive Vertical Banded Gastroplasty Adjustable Gastric Banding Sleeve Gastrectomy

5 Restrictive Procedures Vertical Banded Gastroplasty A small gastric pouch is created using both staples and band staples are used to partition the vertical portion of the stomach and a band is used in the lower portion to create a narrow opening and give the restriction. The band is not adjustable

6 Restrictive Procedures Vertical Banded Gastroplasty Staple line disruption 27-48% stomal stenosis 20-33% band erosion 1-7% GERD, weight regain and longterm inadequate weight loss

7 Restrictive Procedures Adjustable Gastric Banding The adjustable gastric band is a silicone belt with an inflatable balloon in the lining that is buckled into a closed ring around the upper stomach. A reservoir port is placed under the skin for adjustments to the stoma size.

8 Restrictive Procedures Sleeve Gastrectomy It involves resection of the major part of the fundus and body of the stomach starting around 6cm proximally from the pylorus

9 Malabsorptive Procedure Jejunoileal Bypass The proximal jejunum is divided 14 inches from Ligament of Treitz and anastomosed to terminal ileum 4 inches proximal to ileocecal valve Severe electrolyte, nutrient and vitamin deficiencies Protein-Energy Malnutrition with alopecia and liver failure Renal oxalate urolithiasis Polyarthropathy

10 Types of Bariatric Surgery Combination Restrictive and Malabsorptive Roux-en-Y Gastric Bypass Mini Gastric Bypass Bilio-Pancreatic Diversion with Duodenal Switch (BPD-DS)

11 Combination Procedures Roux-en-Y Gastric Bypass A small proximal pouch is created out of the larger stomach Gastric pouch is bypassed into a Roux limb Jejuno-jejunostomy distally provides for diversion of food from digestive juices for around 1/3 bowel

12 Combination Procedures Mini-Gastric Bypass Much larger stomach pouch is created similar to sleeve gastrectomy Instead of Roux-en-y configuration, loop gastro-jejunostomy is created around cm length.

13 Combination Procedures BPD-DS standard sleeve Duodenum is divided distal to the pylorus & anastomosed to ileum 250cm proximal to ileocecal valve The bilio-pancreatic limb is anastomosed to ileum 100cm from the ileocecal valve The common channel is only 100cm resulting in significant malabsorption

14 Endo-luminal Procedures Intragastric Balloon (Orbera, Apollo surgery; ReShape Duo, ReShape Medical Inc. & Obalon Balloon system, Obalon Therapeutics, Inc. ) FDA approved for Obese patients with BMI Kg/m2 Typically filled with mL of fluid Even unto 900mL in the dual balloons Should be removed 6 months later 20-40% Excess weight loss (6.6% - 10% of body weight compared to 3.3% with placebo)

15 Bariatric Surgery in % 42% 8% 2%

16 Bariatric Surgery: Short and Long term Complications Pradeep Pallati, MD, FACS, FASMBS

17 Short-term Complications Serious complications leak Stricture Hemorrhage portal venous thrombosis

18 Short-term Complications Leak Mostly at the angle of His after sleeve gastrectomy Usually there is an associated stricture distally Managed conservatively with adequate drainage, endoscopic stents and nutrition

19 Short-term Complications Stricture Near the incisor in sleeve gastrectomy At the gastrojejunal anastomosis in bypass Managed conservatively with endoscopic dilation and in difficult cases, with stenting

20 Short-term Complications Hemorrhage Along the staple lines in both sleeve and gastric bypass Decreased with staple line reinforcement and intraoperative fibrin sealant Managed with transfusion and rarely surgical evacuation

21 Short-term Complications Venous thromboembolism DVT (0.22%), PE (0.2%) & Portal vein thrombosis (0.04%) PVT usually presents as abdominal pain 1-4 weeks after sleeve gastrectomy Can potentially result in intestinal gangrene Only known risk factor is h/o prior DVT From Michigan Bariatric Surgery Collaborative

22 Short-term Complications Medical complications UTI 0.67% Pneumonia or intubation >48 hrs 0.55% Cardiac events 0.05% Renal failure 0.08% C diff infection 0.16%

23 Sleeve Gastrectomy Complications Outcome % of patients (95% CI) Any complication 5.4 ( ) Potentially life-threatening 1.5 ( ) Staple line Leak 0.46 ( ) Stricture 0.28 ( ) Small bowel obstruction 0.06 ( ) Ulcer 0.05 ( ) Hemorrhage (requiring transfusion) 1.6 ( ) Abdominal abscess 0.36 ( ) Medical complications Urinary tract infection 0.67 ( ) Respiratory (pneumonia or intubation >48 hours) 0.55 ( ) Venous thromboembolism 0.28 ( ) Cardiac event 0.05 ( ) Renal failure 0.08 ( ) Clostridium difficile infection 0.16 ( ) Pradarelli, Jason C. et al. Hospital Variation in Perioperative Complications for Laparoscopic Sleeve Gastrectomy in Michigan. Surgery (2016): PMC. Web. 2 Sept

24

25 Composite Complication Rate (%) of 8 procedures in patients with Diabetes Mellitus Aminian, A., Brethauer, S. A., Kirwan, J. P., Kashyap, S. R., Burguera, B. and Schauer, P. R. (2015), How safe is metabolic/diabetes surgery?. Diabetes Obes Metab, 17: doi: /dom.12405

26 Comparative Mortality Trends 0.58% 0.38% 0.27% 0.20% 0.15% 0.06% 0.01% Nguyen et al, SOARD 2012

27 Mortality Trends Nguyen et al, SOARD 2012

28 Long term Complications Ventral hernia Intestinal obstruction Adhesions Internal hernia % Anastomotic stricture 5-27% Marginal Ulcer 1-16% Gallstones 2-20%

29 Long term Complications Nutrient deficiencies Alcohol Use Disorder 7.6% 9.6% Dumping syndrome Early (hypovolemic) - sweating, palpitations, drowsiness, and the need to lie down ~ 19% Late (hypoglycemia) - sweating, drowsiness, trembling, or even coma ~ 12% Nephrolithiasis Increased risk with gastric bypass - RR of1.73 (95% CI, ) Decreased risk with sleeve and Banding - RR of 0.37 (95% CI, ) Depression - increased risk in patients with underlying depression prior bariatric surgery

30 Bariatric Surgery: When is the best time for the surgery Pradeep Pallati, MD, FACS, FASMBS

31 Impact of Gastric Bypass Operation on Survival: A Population-Based Analysis Flum DR and Dellinger EP Journal of the Am College of Surgeons 2004;199: year Mortality No Surgery Surgery All ages 16.3% 11.8% Under % 3%

32 45 year-old female with diabetes and a BMI of 45 kg/m2, and no h/o HTN, CAD or CHF, would gain 6.7 additional years of life expectancy with bariatric surgery (38.4 yrs vs yrs) 45 year-old female with a BMI of 45 kg/m2 and HTN, CAD or CHF would be expected to have much shorter life expectancy but would still gain 6.7 additional years of life expectancy (22.3 yrs vs yrs) A 45 year-old male with diabetes and a BMI of 45 kg/m2, and no h/o HTN, CAD or CHF, also gained an additional 6.5 years of life expectancy with bariatric surgery (33.7 yrs vs yrs) A 45 year-old male with a BMI of 45 kg/m2 and HTN, CAD or CHF would gain 5.4 years of life expectancy (17.0 yrs vs yrs)

33 Prediabetes Well documented, highly significant reduction of new cases of type 2 diabetes Recently onset type 2 diabetes Well documented high potential for diabetes remission; documented reduction in the incidence of macro- and micro- vascular complications Type 2 diabetes with initial macro- and micro-vascular complications Possible regression of macro- and micro-vascular complication suggested in some study Type 2 diabetes with established end-stage macro- or micro-vascular complications No regression and in some cases progression of micro- vascular complications (diabetic nephropathy and retinopathy); no gain in survival

34 Questions?

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