Why We Care. Why We Care 2/5/2014. Update on Medication in Lactation. Most moms take something Most meds ok with breastfeeding

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Ernest Farmer
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Update on Medication in Lactation Mary DeNicola, DNP, FNP-BC, CLC Director, Breastfeeding Medicine Caduceus Medical Group Why We Care Most moms take something Most meds ok

1 Update on Medication in Lactation Mary DeNicola, DNP, FNP-BC, CLC Director, Breastfeeding Medicine Caduceus Medical Group Why We Care Most moms take something Most meds ok with breastfeeding Most pharmacies don t teach this Many providers don t know this Many moms quit breastfeeding/pumping unnecessarily Why We Care Some things have changed 1

2 Medication in Mother s Milk T I 1 C M MW, ph, PB, ½ T H P D Meds Moms Should Take If the medication returns the body to a normal state, then it is in the best interest of both Mom and baby, for a nursing Mom to take these meds: Maternal Medication Analysis The Journey Pregnancy Maternal Ingestion Mom's Bloodstream Baby's Bloodstream Breastfeeding Maternal Ingestion Mom's Bloodstream Mom's Milk Baby's Tummy Baby's Bloodstream 2

3 Medication Risk/Benefit Ratio Oftentimes the known benefits of breast milk outweigh the theoretical, minimal risks of medication exposure? Hale Rating L1 Safest Hale Rating L2 Safer Hale Rating L3 Moderately Safe Hale Rating L4 Possibly hazardous Hale Rating L5 Contraindicated Based on ingestion volumes of 150cc/kg/day and maximum maternal Concentrations Approved by the American Academy of Pediatrics for use in breastfeeding mothers Critical Analysis Parameter Definition + Breastfeeding T 1/2 Half Life SHORT PHL Peds Half Life SHORT M/P Milk/Plasma Ratio <1 PK Peak Concentration SHORT PB Protein Binding HIGH Oral Oral Bioavailability LOW Vd Volume of Distrib. DWAI pka Cousin of ph LOW MW Molecular Weight >200 Hale Ratings L1 Medications L 2 Medications L 3 Medications Tylenol Reglan Fenugreek Motrin Labetalol Methadone Mag SO4 Prednisone Vicodin Cefzil Benedryl Percocet Amoxacillin Digixon Glucophage Augmentin Robitussin Sudafed Keflex Macrobid Prozac Heparin Zoloft Wellbutrin Ampicillin Paxil Doxycycline 3

4 Hale Rating L 4 Medications Heroin Herbal Teas Sage Appetite Suppressants Concerta L 5 Medications Gold Lead Stronium-89 Chloride Blue Cohosh Mitoxantrone Contracetpion Estrogen fights with Prolactin so standard BCPs not recommended. Estrogen also significantly reduces the lactose and protein production in the alveolar epithelial cells of the breast. Any hormonal contraceptive can negatively impact milk supply during artificial lactogenesis Depression SSRIs: Zoloft is safest, Paxil and Luvox well studied and safe, Prozac has longest half life, reports of colic, losing position on the safe list as of Smoking Cessation Bupropion (Wellbutrin, Zyban) also good for depression (L3) Nicotine Patch/Gum produce serum nicotine levels 1/3 that of smoking 1 pack cigarettes Fever Tylenol Motrin 4

5 Hypertension Apresoline good choice for eclampsia, gestational, pp HTN Most first line beta blockers are safe for breastfeeding (Metoprolol, Labetalol, Inderal) Diuretics have been well studied and are safe (Lasix) Neonates are particularly sensitive to ACE inhibitors, esp. during the first month. Captopril has AAP approval Mastitis Dicloxacillin 500mg QID x 14 days (L1) Keflex 500mg QID x 14 days (L1) Augmentin (L1) Seizures Dilantin at first glance appears safer than Phenobarb (both L3); half life of Phenobarb is hours, while half life of Dilantin is 6-24 hours Diabetes Insulin has MW>6000 and zero oral bio-availability Type II Drugs Sulfonylureas (Diabinase is L3) oral hypoglycemic works in pancreas Biguanides (Glucophage is L3) oral antihyperglycemic y works in liver Thiazolidinediones (Avandia is L3) oral antidiabetic decreases insulin resistance Nausea REGLAN Headaches Tylenol, Motrin, Naproxyn Codeine (all AAP approved). Avoid Aspirin because of Reyes Syndrome Migraine may need Imitrex (L3)or sq triptan B t bl k t k Beta blockers; most ok Ergotamines (Cafergot L4) should NOT be used because they decrease Prolactin level UTI Septra (L3), Macrobid (L2) Most antibiotics are safe 5

6 OTC Galactagogues atole, avena, barley, basil, beer, brewer s yeast, cardamon, cinnamon, coconut, fennel seed, fenugreek, fish soup, garlic, ginger, goat s rue, marshmallow root, milk thistle, millet, nettle, nuts, oatmeal, olives, olive oil, sesame seeds, thyme, turmeric, whole grains.. OTC Galactgogues Oatmeal - in ANY form Fenugreek - start with 3 tablets tid Brewer s yeast - start with 3 tablets tid So many cultural recipes. Rx Galactagogues Metoclopramide vs Domperidone 6

7 RX Galactogogues Metoclopramide (Reglan) Thought to act by increasing prolactin levels Side effect profile more concerning FDA black box warning Easy to find Inexpensive Sig: 10mg tid RX Galactogogues Domperidone (Motilium) Thought to act by increasing prolactin levels Safer side effect profile FDA withdrew approval Compounding pharmacy Expensive Sig: 10-20mg tid-qid How do you decide if it s safe? 7

Benefits of Human Milk No longer in question Medication References http://toxnet.nlm.nih.

8 Benefits of Human Milk No longer in question Medication References Epocrates Medscape Infant Risk Center (Thomas Hale) 8

Why We Care. Why We Care

Why We Care. Why We Care Update on Medication in Lactation Mary DeNicola, DNP, FNP-BC, CLC Director, Breastfeeding Medicine Caduceus Medical Group Why We Care Most moms take something Most meds ok with breastfeeding Most pharmacies