The ADDITION Study: A study about screening for diabetes. Screening Case Report Form

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1 ADDITION Study, Leicester Participant Identification Label: Date: / / The ADDITION Study: A study about screening for diabetes Screening Case Report Form You will need to have the following things done during the morning Fasting blood samples Health questionnaire Hip/waist measurements Blood Pressure Weight and Body Fat Heart Tracing (ECG) 2 hour blood samples Height Last blood samples due at

2 Personal Details Name: Home Address: Sex: Male Female Date of Birth: / / Contact Telephone Number GP Name: Practice Number: Occupation: NHS Number Patients must not have any of the following: Housebound Terminal Illness Pregnant or lactating Be taking part in any other clinical trials Active Psychotic illness which means patient cannot give informed consent No No No No No

3 Consent Consent taken: Consent for stored sample No (Do not take orange sample or 9ml brown sample if patient has not consented for samples to be stored) Consent for Genetic Sample: No Blood Tests (venous whole blood) (fasting): Orange 9ml (for freezer): (Do not take if not consented for stored samples) Brown 1 x 5ml, Brown 1 x 9ml (9ml for freezer) (Do not take if not consented for stored samples) Yellow 2.7ml: Red 2.5ml EDTA OGTT 394 mls lucozade: Time started: Urine Dipstick Result: Negative Other (please specify) MSU sent No MSU Result Urine sample sent to lab

4 Sample Spinning Blood samples spun Orange Stored in rack: Numbers: Brown: Stored in rack: Numbers: INSTRUCTIONS FOR FREEZER SAMPLES: Orange sample should be spun and pipetted into 4 x 1ml vials within 30 minutes and then transferred to 30 freezer. Yellow lids Brown sample should be left to clot for 30 minutes and then spun and pipetted into 4 x 1ml vials and then transferred to 30 freezer. Brown lids All samples should be taken down to -70 freezer at end of screening session. If patient has not consented for genetics but has consented for stored samples please use a white label on top of coloured lid

5 Blood Pressure Arm used for Blood Pressure Left Right Arm circumference cms BP Cuff size used Blood pressure 1: / mmhg Systolic Diastolic Blood pressure 2: / mmhg Systolic Diastolic Blood pressure 3: / mmhg Systolic Diastolic Average of last two = / mmhg Systolic Diastolic

6 Smoking Status Non-smoker Ex-smoker Date stopped smoking / / How Many Used to smoke Per Day? Current smoker How Many Per Day? Medical History: Does the patient have a history of: MI No Heart Valve Disease No Heart Failure No Atrial Fibrillation No Angina No Stroke No Angioplasty/CABG No Leg Angioplasty/bypass No Peripheral Vascular Disease No High Blood Pressure No High Cholesterol No IGT/IFG No Gestational Diabetes No Polycystic Ovary Syndrome No Please list any other medical conditions such as recent surgery, asthma, epilepsy etc:

7 Does the patient currently take any new medications? Medication Type ACE-Inhibitor Alpha-Blocker ARB Beta-Blockers Calcium Channel Blockers Diuretics/Thiazides Aspirin Lipid Lowering Statin Lipid Lowering Fibrate Steroids No If yes, please enter details below: Name of Reason for Use Medication Glyceryl Trinitrate (GTN) (for angina) Please state whether steroids are oral, inhaled or injected Oral Injected Inhaled Thyroid/Anti-Thyroid Other drugs:

8 Drug Category ACE-Inhibitors Alpha-Blockers ARB s Angiotensin-II receptor antagonists) B-Blockers Calcium Channel Blockers Diuretis/Thiazides Lipid Lowering: Statins Lipid Lowering: Fibrates Trade Name Cilazipril; Enalapril; Fosinopril; Imidapril; Perindopril; Quinapril; Ramipril; Trandolapril Doxazosin; Induramin; Phaechromocytosin; Prazosin; Terazosin; Candesartan; Eprosartan; Irbersartan; Losartan; Telmisartan; Valsartan Acubatolol; Atenolol; Bisoprolol; Carvedilol; Celiprolol; Labetolol; Metoprolol; Nadolol; Nebivolol; Oxprenonol; Pindolol; Propanolol; Sotalol; Timolol Amlodipine; Diltiazem; Felodopine; Lacidipine; Lercanidipine; Nicardipine; Nifedipine; Nimodipine; Verapamil Bendrofluazide; Benzthiazide; Cyclopenthiazide Hydrochlorothiazide; Indapamide; Metolazone; Xipamide Atorvastatin; Fluvastatin; Pravastatin; Simvastatin Bezafibrate; Ciprofibrate; Fenofibrate; Gemfibrozil; Steroids/Corticosteroids Thyroid/Anti-Thyroid Drugs Budesonide; Diclometasone Dipropionate; Fluticasone Propionate; Carbimazole; Iodine; Propranolol; Propylthiouracil; Thyroxine;

9 Family History Which family member and at what age? Diabetes (ask which type) Number of 1 st degree relatives with diabetes (mother, father, brother or sister): Parent or sibling with diabetes: Parent and sibling with diabetes Stroke Which family member and at what age? Peripheral Vascular Disease Does the patient have a family history of Heart Disease? No If yes, please enter details below: Problem Age Which Family member

10 Blood Tests (120 mins) Time taken: Yellow 1 x 2.7 mls: Red 10 ml EDTA (genetic) (Do not take if patient has not consented for genetic analysis) 12 Lead ECG? Normal Abnormal (to be completed by Doctor) Comments: Has patient had ABPI? No (If yes, please complete separate CRF ABPI) Other Measurements Height:. m Weight:. kg Waist Measurement: cm Hip Measurement: cm Body Fat:. % BMI: Final Diagnosis Project Manager Use Only Comments: Normal IFG IGT Both Diabetes

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