The 12 th Japan-Korea Diabetic Nephropathy Seminar

Transcription

1 FINAL REPORT For Japan-Korea Joint Seminar AREA 1. Humanities and Social Sciences 2. Science/Engineering(Excluding Biology and Medicine) 3. Biology/Medicine 4. Interdisciplinary Study 1. Title of Seminar: The 12 th Japan-Korea Diabetic Nephropathy Seminar 2. Period of Seminar: From 11 th /October/2013 To 13 th /October/2013 ( date ) ( date ) 3. Place of Seminar: Gyeongju, Korea ( city ) ( country) 4. Total Budget 3 days a. Financial Support by JSPS: Total amount: thousand yen b. Other Financial Support : Total amount: 0 thousand yen 5. Co-Organizers a. Japanese Organizer Name Institution / Department Daisuke Koya Kanazawa Medical University/Endocrinology & Metabolism Position b. Korean Organizer Name Institution / Department Hunjoo Ha College of Pharmacy/ Vascular Cell Biology Position 1

2 6. Participants a. List of Japanese-side Participants (Except for Organizer) Name Institution/Department Position Ryuichi Kikkawa Toshiyasu Sasaoka Shin-ichi Araki Munehiro Kitada Otoda Toshiki Yuki Tanaka Kosuke Yamahara Mako Yasuda Norikazu Ueki Toyama University Kanazawa Medical University Kanazawa Medical University Juntendo University Emeritus Assistant Assistant Assistant Attendant Post Graduate Post Graduate Post Graduate b. List of Korean-side Participants (Except for Organizer) Name Institution/Department Position Chang Joo Oh Post-doctoral fellow Eun Hee Koh Hi Bahl Lee Inah Hwang Keumji Kim Gayoung Lee In-Kyu Lee Jaechan Leem Jung Eun Jang Keun-kyu Park Ki-Up Lee Kwi-Hyun Bae Chae-Myeong Ha Mi-Kyung Kim Jung Eun Jang Hyug Moo Kwon Ling Juan Piao Ye-Seul Park Jae-Han Jeon Mijin Kwon Soo-Yeon Choi Asan Medical Center, Soon Chun Hyang University College of Medicine Keimyung University School of Medicine Ulsan National Institute of Science and Technology Assistant Distinguished 1 Post-doctoral fellow Post-doctoral fellow Post-doctoral fellow c. List of Other Countries Participants Name Institution/Department Position 2

3 Number of Participants: Japanese: 10 Korean: 22 Others: 7. Objective of Seminar Diabetes is increasing in epidemic proportion: The latest WHO estimate for diabetes is 171 million in 2000 ( This will increase to at least 366 million by 2030 without urgent action. The rate of increase is especially high in Asia. Diabetes in Japan and Korea is expected to be 8.9 and 3.4 million, respectively, at The number of end stage of renal disease attributed to diabetes is increasing year by year: Diabetes causes about 5% of all deaths globally each year. Diabetic nephropathy, one of diabetic microvascular complications, is the leading cause of end stage of renal disease requiring renal replacement therapy. Furthermore, diabetic patients under dialysis therapy have higher risk for cardiovascular events as well as mortality, as compared to those without diabetes. In order to reduce mortality and morbidity and to improve the quality of life of patients with diabetes, we must continue basic as well as clinical research and provide forum for international exchanges of information.: The Japan-Korea Basic Scientific Cooperation Program FY 2012 is will be a forum to exchange our understanding of the molecular mechanism of diabetic nephropathy and to search for new therapeutic targets of diabetic nephropathy as the previous 8 seminars were. 8. Schedule and Topics of Seminar The 12 th Japan-Korea Diabetic Nephropathy Seminar Date: October 11-13, 2013 Venue: The-K Gyeongju Hotel, Gyeongju, Korea October 11 (Fri), :00-15:40 Lunch Registration Welcome Remark Hi Bahl Lee 3

4 Session 1 Chaired by Ki-Up Lee, Daisuke Koya 15:40-17:00 Mi-Kyung Kim, Keimyung University Clusterin/apolipoprotein J Attenuates Angiotensin II-induced Renal Fibrosis Gayoung Lee, 8-OhdG protects kidney injury in high-fat fed mice Mako Yasuda, Shiga University Saturated and unsaturated fatty acids have opposite effects on podocyte apoptosis by regulating the pro-apoptotic function of mtorc1 Hyug Moo Kwon, UNIST TonEBP/NFAT5 transcription factor promotes diabetic nephropathyvia local inflammation 17:00-17:20 Coffee Break Session 2 Chaired by Keun-Kyu Park, Shin-ichi Araki 17:20-18:40 Daisuke Koya, Kanazawa Medical University Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to- mesenchymal transition in a therapeutic regimen Chang Joo Oh, Kyungpook University Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-b/smad signaling Keumji Kim, Renoprotective mechasnism of fenofibrate : AMPK activation Yuki Tanaka, Shiga University A new strategy for the treatment of diabetic nephropathy: regulation of AMPK/ACC pathway in podocytes. 4

5 18:40 Discussion & Dinner October 12 (Sat), :30-9:00 Morning Lecture Hi Bahl Lee Metabolic disturbances in chronic kidney disease Session 3 Chaired by In-Kyu Lee, Toshiyasu Sasaoka 9:00-10:20 Jaechan Leem, Sphingomyelin synthase 1 is a novel mediator of hepatocyte injury and nonalcoholic steatohepatitis development in mice Toshiki Otoda, Kanazawa Medical University Proteasome dysfunction links obesity and endoplasmic reticulum stress leading to insulin resistance in the liver Kwi-Hyun Bae, Kyungpook University Fasting and alpha lipoic acid induce hepatic fibroblast growth factor21 expression via up-regulation of Nur77 and CREBH Toshiyasu Sasaoka, University of Toyama Impact of hypothalamic orexin on hepatic insulin resistance induced by chronic social defeat stress in mice 10:20-10:40 Coffee Break Session 4 Chaired by Hunjoo Ha, Eun Hee Koh 10:40-12:00 Inah Hwang, 5

6 Catalase deficiency accelerates nonalcoholic fatty liver disease Jung Eun Jang, Fluvastatin prevents steatohepatitis in mice fed methionine and choline deficient diet by increasing peroxisomal fatty acid oxidation and plasmalogen synthesis in the liver Chae-Myeong Ha, Kyungpook University Dimethylfumarate protects vascular smooth muscle cell calcification mediated by increased Nrf2 activity Kosuke Yamahara, Shiga University Podocyte-specific autophagy deficiency exacerbates high-fat diet-induced glomerular injury 12:00-12:10 Closing Remark Ryuichi Kikkawa 12:10-13:10 Lunch 13:10- Gyeongju Tour 6