interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug int

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1 MedicineNet does not provide medical advice, diagnosis or treatment. See additional information. Nausea, bloating, breast tenderness, headache, change in vaginal discharge, mood swings, blurred vision, dizziness, drowsiness, or weight gain /loss may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.tell your doctor immediately if any of these serious side effects occur: unusual vaginal bleeding (e.g., spotting, breakthrough bleeding), mental/mood changes (e.g., depression, memory loss ), swelling of the hands/ feet, frequent/burning/painful urination, breast lumps, dark patches on the skin or face ( melasma ), yellowing eyes/skin, unusual tiredness.this medication may rarely cause very serious (possibly fatal) problems from blood clots (e.g., heart attack, stroke, blood clots in the lungs or legs, blindness ). Seek immediate medical attention if you experience any of the following: chest/jaw/left arm pain, weakness on one side of the body, slurred speech, sudden vision changes (e.g., blurred/ double vision, loss of vision, bulging eyes), confusion, sudden severe headache, severe dizziness, fainting, trouble breathing, coughing up blood, pain /redness/swelling/weakness of the arms/legs, calf pain /swelling that is warm to the touch.a very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching /swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.this is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.in the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at FDA In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada. Drug interactions may change how your

2 interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.some products that may interact with this drug include: aminoglutethimide, drugs affecting liver enzymes that remove medroxyprogesterone from your body (such as rifampin, St. John's wort, azole antifungals including itraconazole, certain anti- seizure medicines including carbamazepine /phenobarbital/ phenytoin ).This medication can affect the results of certain lab tests. Make sure laboratory personnel and all your doctors know you use this medication. Medroxyprogesterone is sometimes used with another medication (a type of estrogen ) as combination hormone replacement therapy ( HRT ) in women after menopause. Combination HRT can rarely cause very serious side effects such as heart disease (e.g., heart attacks), stroke, serious blood clots (e.g., in the lungs and legs), dementia, and breast cancer. Some of these risks appear to depend on the length of treatment and other factors. Therefore, combination HRT should be used for the shortest possible length of time at the lowest effective dose so you can obtain the benefits and minimize the chance of serious side effects from long-term treatment. Combination HRT should not be used to prevent heart disease or dementia. Discuss the risks and benefits of treatment and your personal health history with your doctor. If you take combination HRT, check with your doctor regularly (e.g., every 3-6 months) to see if you still need to take it. Rheumatoid Arthritis (RA) What's the difference between RA and arthritis?. PRECAUTIONS: Before taking medroxyprogesterone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Some Canadian brands of this product may contain inactive ingredients (such as soybean), which can cause allergic reactions or other problems.

3 cause allergic reactions or other problems. Some people who are allergic to peanuts may also be allergic to soy. Talk to your pharmacist for more details.this medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of blood clots, history of bleeding in the brain, liver disease, cancer of the breast or other female organs, vaginal bleeding of unknown cause, a loss of pregnancy with some tissue remaining in the uterus ("missed abortion"), recent stroke or heart attack (within 1 year).before using this medication, tell your doctor or pharmacist your medical history, especially of: family medical history (especially breast lumps and cancer ), TEENney disease, obesity, heart disease (e.g., past heart attacks, coronary artery disease, congestive heart failure ), high blood pressure, seizures, migraine. STORAGE: Store at room temperature between degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from TEENren and pets.do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Report Problems to the Food and Drug Administration. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. There are many causes of pelvic pain in women. Pelvic pain has symptoms that can be uncomfortable, but luckily there are treatments for pelvic pain if you can identify the cause. Deep Vein Thrombosis How to know if you have a blood clot in your leg. headaches, asthma, high blood levels of

4 leg. headaches, asthma, high blood levels of cholesterol / fats, depression, diabetes, strokes.this drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.notify your doctor beforehand if you will be having surgery or will be confined to a chair/bed for a long time (e.g., a long plane flight). You may need to stop the medication for a time or take special precautions because of the increased risk for blood clots. Ask your doctor for more details.do not smoke. Smoking combined with this medication further increases your risk for strokes, blood clots, high blood pressure, and heart attacks.this medication may cause blotchy, dark areas on your skin ( melasma ). Sunlight may worsen this effect. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen, and wear protective clothing when outdoors.this medication must not be used during pregnancy because it may harm an unborn baby, especially during the first 4 months of pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately.this drug passes into breast milk. Consult your doctor before breastfeeding. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call FDA If you use this medication for an extended period, you should have a complete physical exam at regular intervals (e.g., once a year) or as directed by your doctor. See Notes section. How Is Your MS Care Routine? Assess Yourself. USES: Medroxyprogesterone is a type of female hormone (progestin). This medication is similar to the progesterone that your body naturally makes and is given to replace the hormone when your body is not making enough of it. This medication has several uses. In women who are not pregnant and not going through menopause, this medication is used to treat abnormal bleeding from the uterus and to restore normal menstrual periods in women who have stopped having them for several months ( amenorrhea

5 months ( amenorrhea ).Medroxyprogesterone is also used as part of combination hormone replacement therapy with estrogens to reduce menopause symptoms (e.g., hot flashes ). Medroxyprogesterone is added to estrogen replacement therapy to reduce the risk of cancer of the uterus.this medication must not be used to test for pregnancy. NOTES: Do not share this medication with others.keep all appointments with your doctor and the laboratory. You should have a complete physical examination that includes blood pressure measurements and breast/pelvic examinations at regular intervals (e.g., once a year) or as directed by your doctor. Follow your doctor's instructions on how to examine your own breasts and report any lumps immediately. You should also be regularly screened for cervical cancer (e.g., Pap test ) and have periodic mammograms as determined by your doctor. Consult your doctor for more details. MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. MedicineNet does not provide medical advice, diagnosis or treatment. See additional information. OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at Canada residents can call a provincial poison control center. Symptoms of overdose may include severe nausea and vomiting. Read more: Pelvic Pain: What's Causing Your Pelvic Pain?. HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using this drug and each time you get a refill. If you have any questions, consult your doctor or pharmacist.take this medication by mouth as directed by your doctor. Follow the dosing schedule carefully. Ask your doctor if you have any questions. The dosage is based on your medical condition and response to therapy.for use in combination hormone replacement therapy with estrogens, take this medication usually once daily for the prescribed number of days

6 once daily for the prescribed number of days each month as directed.for the treatment of stopped menstrual periods (amenorrhea) and abnormal bleeding from the uterus, take this drug usually once daily for 5-10 days during the second half of the planned menstrual cycle or as directed by your doctor. Withdrawal bleeding usually occurs within 3-7 days after you stop taking the medication.inform your doctor if your condition does not improve or if it worsens. Liver Function Discontinue Depo-Provera CI use if jaundice or acute or chronic disturbances of liver function develop. Do not resume use until markers of liver function return to normal and Depo-Provera CI causation has been excluded. medroxyprogesterone (oral) (me DROX ee proe JES ter one) Brand Name:. It is unknown if use of Depo-Provera Contraceptive Injection during adolescence or early adulthood, a critical period of bone accretion, will reduce peak bone mass and increase the risk for osteoporotic fracture in later life. Drugs to stop menstrual bleeding include hormonal birth control, progesterone and GnRH agonists. Both the 1 ml vial and the 1 ml prefilled syringe of Depo-Provera CI should be vigorously shaken just before use to ensure that the dose being administered represents a uniform suspension Sexually Transmitted Diseases Patients should be counseled that Depo-Provera CI does not protect against HIV infection (AIDS) and other sexually transmitted diseases. Store at room temperature away from moisture and heat. a hormone-related cancer such as breast or uterine cancer;. heart disease, congestive heart failure, recent stroke or heart attack. heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;. premenstrual type symptoms ( bloating, fluid retention, mood changes);. Symptoms When You Do Not Ovulate From Perimenopause. Thromboembolic Disorders There have been reports of serious thrombotic events in women using Depo-Provera CI (150 mg). However, Depo-Provera CI has not been causally associated with the induction of thrombotic or thromboembolic disorders.

7 thrombotic or thromboembolic disorders. Any patient who develops thrombosis while undergoing therapy with Depo-Provera CI should discontinue treatment unless she has no other acceptable options for birth control. Do not re-administer Depo-Provera CI pending examination if there is a sudden partial or complete loss of vision or if there is a sudden onset of proptosis, diplopia, or migraine. Do not re-administer if examination reveals papilledema or retinal vascular lesions. Depo-Provera Contraceptive Injection should not be used as a long-term birth control method (i.e., longer than 2 years) unless other birth control methods are considered inadequate [ see Warnings and Precautions (5.1) ]. Follow all directions on your prescription label. Do not take Provera in larger or smaller amounts or for longer than recommended. Ectopic Pregnancy Be alert to the possibility of an ectopic pregnancy among women using Depo-Provera CI who become pregnant or complain of severe abdominal pain Weight Gain Women tend to gain weight while on therapy with Depo-Provera CI. From an initial average body weight of 136 lb, women who completed 1 year of therapy with Depo- Provera CI gained an average of 5.4 lb. Women who completed 2 years of therapy gained an average of 8.1 lb. Women who completed 4 years gained an average of 13.8 lb. Women who completed 6 years gained an average of 16.5 lb. Two percent of women withdrew from a large-scale clinical trial because of excessive weight gain. Subscribe to receive notifications whenever new articles are published. Call your doctor at once if you have:. Dosage and Administration, Prevention of Pregnancy ( 2.1 ) 11/ Relationship of fracture incidence to use of DMPA 150 mg IM or non-use by women of reproductive age. symptoms of depression (sleep problems, dizziness, mood changes, headache );. Shapiro et al. (2000): age, ethnic group, socioeconomic status, and any combined estrogen/progestogen oral contraceptive use.

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