Innovation and Promise in Epilepsy Research 3 rd International UCI EpiCenter Symposium

Transcription

1 Innovation and Promise in Epilepsy Research 3 rd International UCI EpiCenter Symposium Thursday, February 20 th 4:00 5:00 pm Registration Terrace Promenade 5:00 5:05 pm Welcome Tallie Z. Baram and Ivan Soltesz, University of California, Irvine 5:05 7:05 pm Session I Terrace Room State of the Art and Emerging Hot Topics in Epilepsy Conveners: Tallie Z. Baram and Ivan Soltesz, University of California, Irvine 5:05 6:00 pm Keynote Presentation: Dr. Henrik Klitgaard, UCB Pharma Epilepsy Therapy: Anticonvulsants, Lessons Learned and Unmet Needs 6:15 6:30 pm Oral presentations to be selected from Abstracts 6:30 6:45 pm Oral presentations to be selected from Abstracts 6:45 7:00 pm Session Discussion 7:15 8:15 pm Welcome Reception Terrace Promenade

2 Friday, February 21 st 7:30 8:30 am Continental Breakfast Bay Pool 8:30 10:30 am Session II Terrace Room Novel Approaches to the Study of Ion Channels in Epilepsy Convener: Alan Goldin, University of California, Irvine 8:30 8:50 am Heather Mefford, University of Washington, Gene Discovery in the Epileptic Encephalopathies 8:55 9:15 am Diane O Dowd, University of California, Irvine, Modeling SCN1A-Related Seizure Disorders with Drosophila Knock-in Mutants 9:20 9:40 am Jack Parent, University of Michigan, Modeling Severe Genetic Epilepsies of Childhood with Induced Pluripotent Stem Cells 9:45 10:05 am Janice Naegele, Wesleyan University, Stem cell -derived GABAergic interneuron Transplantation for Neural Circuit Repair and Seizure Suppression in Temporal Lobe Epilepsy" 10:10 10:30 am Session Discussion 10:35 10:50 am Coffee Break Terrace Promenade 10:50 12:50 pm Session III Terrace Room Brain Networks in Epilepsy Convener: Jack Lin, University of California, Irvine 10:50 11:10 am Douglas Coulter, University of Pennsylvania, Hippocampal Circuit Disruption in Epilepsy: Causes, Consequences, and Treatment 11:15 11:35 am Graeme Jackson, Epilepsy Research Centre, The Near Future of Imaging in Epilepsy 11:40 12:00 pm Robert Knight, University of California, Berkeley, Insights Into Cognition from Electrocorticography 12:05 12:25 pm William D. Gaillard, Children s National Medical Center, Capacity and Constraints of Language Network Plasticity in Human Focal Epilepsy

3 Friday, February 21 st 12:30 12:50 pm Session Discussion 12:50 1:50 pm Lunch Bay Pool 2:00 4:00 pm Session IV Terrace Room Gene Networks in Epilepsy Convener: Tallie Z. Baram, University of California, Irvine 2:00 2:20 pm Annamaria Vezzani, Mario Negri Institute for Pharmacological Research, Danger Signal Proteins at the Crossroads Between Innate Immunity and Seizures 2:25 2:45 pm David Henshall, Royal College of Surgeons in Ireland, MicroRNA and Epilepsy; Profiling, Functions and Potential Clinical Applications 2:50 3:10 pm Tallie Z. Baram, University of California, Irvine, Transforming Normal Neurons into Epileptic Ones Via Coordinate Transcriptional Regulation 3:15 3:35 pm Eric Nestler, Icahn School of Medicine at Mount Sinai, Transcriptional and Epigenetic Mechanisms of Depression 3:40 4:00 pm Session Discussion 4:05 4:25 pm Coffee Break Terrace Promenade 4:30 6:30 pm Session V Terrace Room Optogenetics in Epilepsy Convener: Ivan Soltesz, University of California, Irvine 4:30-4:50 pm Ofer Yizhar, Weizmann Institute of Sciences, "Optogenetic Tools and Approaches for Studying Cortical Circuits" 4:55 5:15 pm Attila, Losonczy, Columbia University, Functional Imaging Hippocampal Circuits in Fitness and Disease"

4 Friday, February 21 st 5:20 5:40 pm Meno P. Witter, Norwegian University for Science and Technology, Architecture of Entorhinal Layers Differences and Similarities 5:45 6:05 pm Ester Krook-Magnuson, On-Demand Optogenetics: A Light-Guide in Temporal Lobe Epilepsy 6:10 6:30 pm Session Discussion 6:35 8:35 pm Poster Session Terrace Room Informal reception and refreshments

5 Saturday, February 22 nd 8:00 9:00 am Breakfast Bay Pool 9:00 11:00 am Session VI Terrace Room Epigenetics in Epilepsy Convener: Marcelo Wood, University of California, Irvine 9:00 9:20 am Marcelo Wood, University of California, Irvine. "Nucleosome-remodeling: A missing link in our understanding of epigenetic mechanisms underlying intellectual disability disorders." 9:25 9:45 am Schahram Akbarian, University of Massachusetts Medical School, Epigenetic Regulation in Developing and Diseased Human 9:50 10:10 am Lisa Monteggia, University Texas Southwestern, Analysis of the Unique Roles of Individual hdacs in Behavior and Synaptic Plasticity 10:15 10:35 am Jenny Hsieh, University of Texas Southwestern, Catching Fire: New Roles for Neurogenesis in the Generation of Epilepsy 10:40 11:00 am Session Discussion 11:00 11:20 am Coffee Break Terrace Promenade 11:20 12:35 pm Session VII Terrace Room Novel Approaches to Neuronal Compartmentalization Convener: Oswald Steward, University of California, Irvine 11:20 11:40 am Oswald Steward, University of California, Irvine, Regulating Protein Synthesis at the Synapse 11:45 12:05 pm Matthias Kneussel, University of Hamburg Medical School, Transport and Trafficking of Synaptic Proteins underlying Plasticity at GABAergic Synapses" 12:10 12:30 pm Kelsey Martin, University of California, Los Angeles, Spatial Regulation of Gene Expression in Neurons

6 Saturday, February 22 nd 12:35 1:35 pm Lunch Bay Pool 1:40 3:40 pm Session VIII Lipid Signaling in Epilepsy Convener: Daniele Piomelli, University of California, Irvine 1:45 2:05 pm Daniele Piomelli, University of California, Irvine, Postsynaptic and Presynaptic Control of Retrograde Endocannabinoid Signals 2:10 2:30 pm Nicholas Bazan, Louisiana State University Health Science Center, Hippocampal synaptic network modulation by the bioactive mediator Neuroprotectin D1 derived from excitable membrane lipids 2:35 2:55 pm Jerold Chun, The Scripps Research Institute, Lysophospholipid Receptors as Modulators of Neural Activity" 3:00 3:20 pm Shuh Narumiya, Kyoto University, TBA 3:25 3:50 pm Session Discussion 3:50 4:10 pm Coffee Break Terrace Promenade 4:10 6:20 pm Session IX Spine Plasticity in Learning and Epilepsy Convener: Christine Gall, University of Caifornia, Irvine 4:10 4:30 pm Peter Penzes, Northwestern University, "Molecular Substrates of Synaptic Structural Plasticity and Pathology" 4:35 4:55 pm Christine Gall, University of Caifornia, Irvine, Spine Actin Remodeling and the Control of Synaptic Strength 5:00 5:20 pm Gavin Rumbaugh, Scripps Florida, Impact of an ID/Epilepsy/ASD Gene on Life-Long Cortical Excitability and Cognition 5:25 5:45 pm Courtney Miller, Scripps Florida, Selective, Retrieval-Independent Disruption of Drug-Associated Memory by Actin Depolymerization 5:50 6:10 pm Session Discussion

7 6:15 6:20 pm Concluding Remarks: Tallie Z. Baram, University of California, Irvine