Curriculum Vitae, Joseph J. Savon, M.D.

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1 CONTACT INFORMATION: Joseph J. Savon, M.D. Hassman Research Institute, LLC. 175 Cross Keys Road Centennial Center, Bldg. 300 B Berlin, NJ Site Selection and Information: Bobbie Theodore, Alliance Director Tel. (916) Fax (208) clinicaltrials@alliancesites.com Site Contact: Kimberley Myers, EMBA, Director of Operations Tel. (856) x 337 Fax (856) kmyers@hritrials.com AFFILIATIONS: Berlin Medical Associates 175 Cross Keys Rd, Suite 300A Berlin, NJ Comprehensive Clinical Research 175 Cross Keys Road Berlin, NJ EDUCATION: Doctor of Medicine UMDNJ - Robert Wood Johnson Medical School, Piscataway, NJ Undergraduate B.S. Biology St. Joseph's University, Philadelphia, PA INTERNSHIP AND RESIDENCY: Residency Thomas Jefferson University, Philadelphia, PA Internship Thomas Jefferson University, Philadelphia, PA FELLOWSHIP: Gastroenterology Fellowship Presbyterian Medical Center of Philadelphia, Philadelphia, PA Updated 6/1/17 1

2 LICENSURE: State of New Jersey 25MA CERTIFICATION: Board Certified in Addiction Medicine American Board of Internal Medicine Recertified American Board of Internal Medicine Gastroenterology PROFESSIONAL EXPERIENCE: Investigator, Present Hassman Research Institute, LLC., Berlin, NJ Investigator, present Comprehensive Clinical Research, Berlin, NJ Owner/Physician Present South Jersey Gastroenterology, Marlton, NJ Owner/Physician present The Endo Center, Voorhees, NJ Owner/Physician BZ Gastrointestinal, PA, Marlton, NJ Owner/Physician Gastrointestinal Associates, PA, Marlton, NJ Consultant Wyeth Ayerst Pharmaceuticals, Collegeville PA INVESTIGATOR EXPERIENCE: Addiction Bipolar Disorder Chronic Pain Crohn's Disease Depression Dermatology Diabetes GERD Hepatic Impairment Migraine Opioid-Induced Constipation Opioid Use Disorder Osteoarthritis Pain Phase I PTSD Renal Impairment Ulcerative Colitis Sleep Disorder Updated 6/1/17 2

3 CLINICAL TRIAL EXPERIENCE: Phase I A Phase Ib, Randomized, Blinded, Placebo-controlled, Multiple Ascending-dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous XXX in patients with Type 2 diabetes mellitus and Nonalcoholic fatty liver disease A Phase I, Open label, Multicenter, Single Dose Study to Evaluate the Pharmacokinetics of XXX in Healthy Subjects with Normal Renal Function and Subjects with Impaired Renal Function A Phase I, Open Label, Multicenter, Single Dose Study to Evaluate the Pharmacokinetics of XXX in Healthy Subjects with Normal Hepatic Function and Subjects with Impaired Hepatic Function A Phase I Study Comparing the Pharmacokinetics of Intranasal XXX in Subjects With Severe Renal Impairment and Subjects With Normal Renal Function Addiction A Phase II, Multi-Center Trial of XXX in the treatment of Cocaine Use Disorder An Open-Label, Long-Term Safety and Tolerability Study of Depot XXXX in Treatment- Seeking Subjects With Opioid Use Disorder A Phase III, Randomized, Double-Blind, Active-Controlled, Parallel-Group, Multi-center Trial Assessing the Efficacy and Safety of a Once-Weekly and Once-Monthly, Long-Acting Subcutaneous Injectable Depot of XXXXX in Treatment of Adult Outpatients with Opioid Use Disorder An Open-Label Multicenter Study Assessing the Long-Term Safety of a Once-Weekly and Once-Monthly, Long-Acting Subcutaneous Injection Depot of Buprenorphine XXXXX in Adult Outpatients with Opioid Use Disorder Bipolar Disorder A Phase III, Multicenter, Randomized, Double-blind, Double dummy, Placebo-controlled Study of the Efficacy and Safety of XXX in Subjects with Bipolar I Disorder Experiencing an Acute Manic Episode Crohn's Disease A Phase IIa, Randomized, Open-label, Parallel, Study to Determine the Tolerability, Pharmacokinetics, and Efficacy of XXX in Subjects with Crohn s disease experiencing Abdominal Pain Updated 6/1/17 3

4 CLINICAL TRIAL EXPERIENCE (continued): A Phase I Randomized, Double-Blind, Placebo-Controlled, Ascending Multiple-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of XXX in Healthy Subjects and Subjects With Mild to Severe Crohn's Disease A Phase III Multi-national, Multi-centre, Open Label, Safety Study to Assess the Safety of Reexposure After a Variable Interval and Subsequent Chronic Therapy With the Humanised Anti- TNF PEG Conjugate XXX 400 mg sc, (Dosed at Weeks 0, 2 and 4 Then Every 4 Weeks), in the Treatment of Patients With Active Crohn's Disease Who Have Previously Been Withdrawn From Studies XXX or XXX Due to an Exacerbation of Crohn's Disease A Phase III Multi-national, Multi-centre, Open Label, Safety Study to Assess the Safety of Chronic Therapy With the Humanised Anti-TNF PEG Conjugate XXX 400 mg sc, (Dosed 4- weekly), in the Treatment of Patients With Active Crohn's Disease Who Have Previously Completed Studies XXX or XXX A Phase III Multi-national, Multi-centre, Double-blind Placebo-controlled Parallel Group, 26 Week Study to Assess the Maintenance of Clinical Response to Humanised Anti-TNF PEG Conjugate, XXX 400 mg sc, (Dosed 4-weekly From Weeks 8 to 24), in the Treatment of Patients With Active Crohn's Disease Who Have Responded to Open Induction Therapy (Dosed at Weeks 0, 2 and 4) With XXX A Phase II, Pilot, Double-Blind, Placebo-Controlled, Parallel Group Study of the Safety Clinical Activity of XXX in Patients With Moderate to Severe Crohn s Disease A Phase II Open-label Trial of XXX, A Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), in Active Crohn's Disease Depression A Phase IIIb, Efficacy and Safety Study of Adjunctive XXX in Treatment Refractory Major Depressive Disorder A Phase II, Two-Part (Open-Label Followed by Double-Blind) Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of XXX in the Treatment of Adult Subjects With Moderate to Severe Major Depressive Disorder A Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled Study of the Safety and Efficacy of XXX as an Adjunctive Treatment for Patients with Major Depressive Disorder with an Inadequate Response to Current Antidepressant Treatment A Randomized, Double-Blind, Placebo-Controlled, Phase IV, Relapse Prevention Study Evaluating the Efficacy and Safety of XXX (5, 10 and 20 mg) in Adults With Major Depressive Disorder Updated 6/1/17 4

5 CLINICAL TRIAL EXPERIENCE (continued): A Phase II, Multicenter, Randomized, Double-blind, Placebo controlled, Study to Evaluate the Efficacy and Safety of Adjunctive XXX in Major Depressive Disorder Dermatology A Phase IIa, Double-Blind, Randomized, Placebo-controlled, Exploratory Study to Evaluate the Safety, Biological Activity and Pharmacokinetics of XXX in Adult Patients With Moderate-to- Severe Atopic Dermatitis Fibromyalgia A Phase IIa, Randomized, Double-Blind Placebo-controlled, Parallel-group Study to Assess the Analgesic Efficacy and Safety of XXX in Patients with Fibromyalgia GERD A Phase II Study to Assess the Efficacy, Safety and Tolerability of XXX Alone and in Combination With XXX Given Orally in Patients With Symptoms of Symptomatic Gastroesophageal Reflux Disease (sgerd) Insomnia A One-Month, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Active Comparator, Parallel-Group Study of the Efficacy and Safety of XXX in Subjects 55 Years and Older with Insomnia Disorder Pain A Phase IIa, Multicenter, Randomized, Double-blind, Placebo-controlled and Active-controlled, Parallel-group Study Evaluating the Analgesic Efficacy and Safety of XXX in Subjects with Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee A Phase III, Parallel Group, Double-Blind, Randomized, Placebo Controlled, Phase 3 Trial to Evaluate the Efficacy, and Safety, of XXX Administered Intravenously in Patients with Chronic Migraine A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy, Tolerability and Safety Study of XXX in Episodic Migraine With or Without Aura A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Study to Evaluate the Efficacy and Safety of XXX for the Treatment of Opioid-Induced Constipation in Adults Taking Opioid Therapy for Chronic Non-Cancer Pain Updated 6/1/17 5

6 CLINICAL TRIAL EXPERIENCE (continued): A Randomized, Double-blind, Placebo-controlled, Parallel-group Study of XXX in the Treatment of Opioid-induced Constipation in Subjects With Non-malignant Chronic Pain Receiving Opioid Therapy Post Traumatic Stress Disorder A Phase III, 12-Week Open-Label Extension Study to Evaluate XXX Taken Daily at Bedtime in Patients with PTSD A Phase II, Multicenter, Randomized, Double-blind, Placebo- and Active-controlled Trial of XXX (1-3 mg/day) as Monotherapy or as Combination Therapy in the Treatment of Adults with Post-traumatic Stress Disorder (PTSD) A Phase III, Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of XXX Taken Daily at Bedtime in Patients with Military-Related Posttraumatic Stress Disorder (PTSD) A Phase III, Multicenter, Randomized, Double-Blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Intramuscular Injections of XXX in Patients with Acute Exacerbation of A Phase III, 52-Week, Open-Label, Extension Study of XXX for the Adjunctive Treatment of A Phase III Study to Evaluate Weight Gain of XXX Compared to XXX in Adults with An Multi-center, Prospective, Randomized, Double-blind, Placebo-controlled Study of the Safety and Efficacy of XXX as an Add-on Treatment for in Adults Ulcerative Colitis A Phase III, Multi-Center, Randomized, Double-Blind, Parallel-Arm, 52-Week Dose Comparison Study of the Efficacy and Safety of 25 mg QD and 50 mg QD of XXX Oral Tablets and 800 mg BID of XXX in the Maintenance of Ulcerative Colitis Remission PUBLICATIONS: Savon, J.J. et al. "Gastrointestinal Bleeding with Low Dose Aspirin Ingestion". American Journal of Gastroenterology, April, Updated 6/1/17 6

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