SEEG and the Hippocampus

Transcription

1 THE SIXTH CLEVELAND CLINIC BRAIN MAPPING WORKSHOP September 6-9, 2017 HiMSS Technology Showcase at the Cleveland Convention Center One St. Clair Ave NE Cleveland, OH Limited to just 40 participants

2 THE SIXTH CLEVELAND CLINIC BRAIN MAPPING WORKSHOP About the Workshop Epilepsy surgery classical indications are lesional epilepsies. MRI has accordingly oriented epileptologists towards the anatomical location of visible abnormalities and gradually given second place to the clinical and electrophysiological data relevant for surgical decision. One of the best examples is hippocampal atrophy. Despite of a huge number of papers and reports in literature, the rationale of temporal epilepsy surgery remains opaque or even contradictory, inviting to perform standard temporal lobectomy in presence of MRI hippocampal hypersignal and/or FDG-PET hypometabolism. Possibly the limited progress in TLE surgery outcome holds, at least in part, to such confusion between the localization of a visible lesion and the contour of its related epilepsy. Surgical outcome after temporal lobectomy is better than after amygdalo-hippocampectomy. Failures of temporal lobectomy are most of the time due to the extent of Epileptogenic Zone outside the temporal lobe. Therefore, hippocampus as the leading structure in temporal lobe epilepsy is likely a too simplistic view. Several aspects of TLE pathophysiology remain elusive and even the role of hippocampal sclerosis once epilepsy installed is ambiguous. The aim of this workshop is to demonstrate and exemplify, through a practical and comprehensive approach, the utility of the stereo-electroencephalography methodology in mapping functional networks and their relations to lesions, therefore figure out which structures are essential in the epileptogenic network at seizure onset and in spreading patterns. Learning Objectives Discuss the analyses methods for ictal video-recordings. Explore the correlations between ictal signs, semiology and EEG patterns. Discuss the correlations between emergence of semiology, early ictal discharges and cortical functional anatomy in SEEG. Explore the role of semiology in presurgical investigations, especially in tailoring the SEEG electrode implantation. Apply the network concept of seizure organization in practice from planning the implantation to the final resection strategy. Target Audience Neurosurgeons and Neurologists Workshop Directors Andreas Alexopoulos, MD, MPH Juan Bulacio, MD Guest Faculty Philippe Derambure Lille 2 University Lille, France Louis Maillard, MD, PhD Lorraine University Nancy, France Guy McKhann, MD Columbia University New York, NY Anca Nica, MD Rennes I University Rennes, France Cleveland Clinic Faculty Jocelyn Bautista, MD William Bingaman, MD Robyn Busch, MD Ajay Gupta, MD Balu Krishnan, MD Patrick Chauvel, MD and Aix-Marseille University Jorge Gonzalez-Martinez, MD, PhD Alison Pack, MD Columbia University New York, NY Ivan Soltesz, PhD Stanford University Stanford, CA Clarissa Lin Yasuda, MD, PhD University of Campinas UNICAMP, Brazil Dileep Nair, MD Imad Najm, MD Irene Wang, PhD Gabrielle Yeaney, MD Zhong Ying, MD, PhD

3 Agenda The Sixth Cleveland Clinic Brain Mapping Workshop Wednesday, September 6 3:30-4:00pm 4:00-4:15pm 4:15-5:15pm 5:15-6:15pm 6:15-7:00pm 7:00pm Registration Welcome & Introductions Talk 1: Hippocampus in Epilepsy: Much Ado About Nothing? Patrick Chauvel Talk 2: Neural Circuits of the Hippocampus Ivan Soltesz Welcome Reception Thursday, September 7 8:00-9:00am 9:00-10:00am 10:00-10:30am 12:30-2:00pm Talk 3: Temporal Lobe and Neural Networks Dileep Nair Talk 4: Anatomo-electroclinical Correlation in Mesial Temporal Lobe Epilepsy Louis Maillard Small Workshops Tutors: Andreas Alexopoulos, Jocelyn Bautista, William Bingaman, Juan Bulacio, Patrick Chauvel, Philippe Derambure, Jorge Gonzalez-Martinez, Ajay Gupta, Louis Maillard, Guy McKhann, Dileep Nair, Imad Najm, Anca Nica, Alison Pack, Zhong Ying Hands-on Moderators: Balu Krishnan, Irene Wang Lunch 2:00-4:45pm Grand Workshop, Surgical Cases, Plenary Discussion Phase 1 Moderators: Andreas Alexopoulos and Imad Najm 4:45-5:00pm 5:00-6:00pm 6:00-7:00pm 7:00-7:30pm 7:30pm Talk 5: Neuroimaging Perspective. Is Hippocampal Sclerosis a Focal Lesion? Clarissa Lin Yasuda Talk 6: SEEG Implantation Techniques Jorge Gonzalez-Martinez Adjourn Open Evening

4 Agenda (continued) Friday, September 8 8:00-9:00am 9:00-10:00am 10:00-10:30am 12:30-2:00pm Talk 7: Defining the Epileptic Hippocampus by SEEG. When it has to be resected. Imad Najm Talk 8: Surgery Guided by SEEG in Mesial Temporal and Temporo-Perisylvian Epilepsies Jorge Gonzalez-Martinez Small Workshops Tutors: Andreas Alexopoulos, Jocelyn Bautista, William Bingaman, Juan Bulacio, Patrick Chauvel, Philippe Derambure, Jorge Gonzalez-Martinez, Ajay Gupta, Louis Maillard, Guy McKhann, Dileep Nair, Imad Najm, Anca Nica, Alison Pack, Zhong Ying Hands-on Moderators: Balu Krishnan, Irene Wang Lunch 2:00-4:45pm Grand Workshop, Surgical Cases, Plenary Discussion Phase 1 Moderators: Patrick Chauvel and Jorge Gonzalez-Martinez 4:45-5:00pm 5:00-6:00pm 6:00-7:00pm 7:00-7:30pm 7:30pm Talk 9: Pathological Classification in Mesial Temporal Sclerosis Gabrielle Yeaney Talk 10: Can We Predict Neurocognitive Outcomes of Temporal Lobe Epilepsy Surgery? Robyn Busch Reception Saturday, September 9 8:30-10:00am Case Discussion: Andreas Alexopoulos, Philippe Derambure, Anca Nica, Alison Pack Lesional hippocampus + temporal lesion Lesional hippocampus + extratemporal lesion Non lesional hippocampus + temporal lesion Non lesional hippocampus + extratemporal lesion 10:00-10:30pm Non-CME Case Discussion: Presented by workshop participants 12:30 pm Adjourn

5 General Information Location HiMSS Technology Showcase at the Cleveland Convention Center One St. Clair Ave NE Cleveland, OH Hotel Reservations Hotel reservations are separate from the course registration and are the responsibility of the participant. Rooms have been blocked for attendees at the ClevelandMarriott Hotel at Key Center. To obtain the workshop rate of $134 (plus 16.5% tax), please contact the hotel s group reservations at by Friday, August 18, 2017 to receive this rate. Accreditation is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. designates this live activity for a maximum of 23.0 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association Council on Continuing Medical Education for Category 2 credit. Faculty Disclosure Statement has implemented a policy to comply with the current Accreditation Council for Continuing Medical Education Standards for Commercial Support requiring resolution of all faculty conflicts of interest. Faculty declaring a relevant commercial interest will be identified in the activity syllabus. Americans with Disabilities Act fully intends to comply with the legal requirements of the Americans with Disabilities Act. If you need assistance, please notify Martha Tobin at or tobinm@ccf.org at least two weeks prior to the activity. Information For further information about this activity, contact Martha Tobin at Local: Toll Free: x tobinm@ccf.org Registration and Cancellation Information Course#: Fee Neurologists and Neurosurgeons $1500 Residents/Fellows/PhDs $725 Preregistrations are accepted until 2:00 pm ET, August 28, 2017 or until workshop attendance has reach capacity. In case of cancellation, notification is required to process your refund. A full refund will be issued if canceled by August 9, After August 9, 2017, a $300 cancellation fee will be deducted from your refund. No refunds will be issued after August 28, For questions about registration or cancellation, us at cmeregistration@ccf.org or call Cleveland Clinic Center for Continuing Education reserves the right to cancel or postpone an activity at our sole discretion. In the unlikely event that this occurs, any registration fee(s) paid will be refunded. Be advised that Cleveland Clinic is not responsible for related costs including airline tickets, hotel costs, or any similar fee penalties incurred as a result of any activity cancellations or changes. To Register Go To: CCF employees should check fees and register online at the web address listed above.