Nuklearno medicinske preiskave možganov
|
|
- Agatha Park
- 6 years ago
- Views:
Transcription
1 Nuklearno medicinske preiskovalne metode Nuklearno medicinske preiskave možganov Marko Grmek
2 Nuklearno medicinske preiskave možganov PET/CT možganov z 18 F-FDG Perfuzijska scintigrafija možganov (SPECT možganov) z 99m Tc-ECD ali 99m Tc- HMPAO Scintigrafija dopaminskega prenašalca ( 123 I-ioflupane)
3 PET/CT možganov z 18 F-FDG (PET-CT brain imaging using 18 F-FDG) In the brain, glucose metabolism provides approximately 95% of the ATP required for brain function. Under physiological conditions, as well as in several diseases affecting the brain, glucose metabolism is tightly connected to neuronal activity. Therefore, changes in neuronal activity induced by disease are reflected in an alteration in glucose metabolism.
4 PET/CT možganov z 18 F-FDG PET/CT naprava
5 PET-CT možganov z 18 F-FDG EANM procedure guidelines for PET brain imaging using 18 F-FDG. Radiofarmak: 18 F-FDG Odrasli aktivnost 250 MBq Otroci EANM dosage card npr: otrok 20 Kg = 4,86 x 14 = 68 MBq Akvizicija - 30 min. po iniciranju radiofarmaka Low dose CT (čas nekaj sekund) Zaradi lokalizacije sprememb in korekcije atenuacije PET slikanje (10 minut) Ena posteljna lega (bed position)
6 PET-CT možganov z 18 F-FDG Rekonstrukcija: Iterativna iterations 6 subsets 21 Debelina rezine = 3 mm Postrekonstrukcijski programi: True D Scenium Efektivna doza: 7mSv
7 PET-CT možganov z 18 F-FDG Indikacije: Odkrivanje in opredelitev vrste demence (zgodnje odkrivanje in razlikovanje med različnimi vrstami demenc) Določitev mesta epileptogenega žarišča (interictal study) Opredelitev bolezni, ki se izražajo z motnjami gibanja (razlikovanje med Parkinsonovo boleznijo in atipičnimi parkinsonizmi) Nevro-onkološke bolezni (opredeljevanje narave možganskih tumorjev)
8 PET/CT možganov z 18 F-FDG 14 letno dekle Napotna diagnoza: Temporalna epilepsija
9 PET/CT možganov z 18 F-FDG 14 letno dekle Napotna diagnoza: Temporalna epilepsija
10 PET/CT možganov z 18 F-FDG 14 letno dekle Napotna diagnoza: Temporalna epilepsija
11 PET/CT možganov z 18 F-FDG Mesto epileptogenega žarišča
12 PET/CT možganov z 18 F-FDG Scenium Analysis Mesto epileptogenega žarišča
13 PET/CT možganov z 18 F-FDG PET/CT možganov pri bolnikih s Parkinsonovo boleznijo in različnimi atipičnimi parkinsonizmi
14 Perfuzijska scintigrafija možganov (SPECT) z 99m Tc-ECD ali 99m Tc-HMPAO Perfuzijska scintigrafija možganov prikaže regionalno prekrvitev možganov. SPECT/CT naprava
15 Brain perfusion SPECT using 99m Tc-labelled radiopharmaceuticals Physiological properties that radiopharmaceuticals must have to be useful for the measurement of brain perfusion by SPECT are: They must cross the blood brain barrier, Their extraction must be proportional to regional cerebral blood flow (rcbf), They must be retained within the brain in their initial distribution long enough for diagnostic tomographic images to be obtained.
16 Perfuzijska scintigrafija možganov Radiofarmak: 99mTc-HMPAO ali 99mTc-ECD aktivnost 600 MBq (ustrezno manj pri otrocih) Dvoglava gama kamera Z akvizicijo pričnemo min. po aplikaciji radiofarmaka Čas slikanja (skeniranja) ~30 min. (60 x 25 sec.)
17 Perfuzijska scintigrafija možganov Slikanje na gama kameri Dvoglava gama kamera. Visoko ločljivi nizko energijski kolimator (LEHR). Fotovrh pri 141 kev. 15 % okno. 2 x 60 posnetkov (180 stopinj) po 25 sekund. Matrika 128 x 128. Povečava 1,23. Oddaljenost detektorjev od centra rotacije 13,5 cm.
18 Perfuzijska scintigrafija možganov Indikacije: Iste kot za PET/CT možganov z 18 F-FDG (vendar ima SPECT možganov nižjo senzitivnost) Epilepsija - perfuzijska scintigrafija možganov v času epileptičnega napada (iktična) Možganska smrt
19 Perfuzijska scintigrafija možganov Standardne ravnine pri perfuzijski scintigrafiji možganov
20 Perfuzijska scintigrafija možganov Standardne ravnine pri perfuzijski scintigrafiji možganov
21 Perfuzijska scintigrafija možganov ictal interictal ictal interictal
22 Perfuzijska scintigrafija možganov možganska smrt Obvezna kontrola kvalitete radiofarmaka nad 90 % vezava
23 Perfuzijska scintigrafija možganov možganska smrt Aktivnosti v možganih ni možgani niso prekrvljeni
24 Perfuzijska scintigrafija možganov - možganska smrt Prva preiskava Ponovitev preiskave čez 3 dni Vidna je aktivnost v malih možganih Aktivnosti v možganih ni več videti
25 Scintigrafija dopaminskega prenašalca ( 123 I-ioflupane) - DaTSCAN Brain neurotransmission SPECT using 123 I-labelled dopamine transporter ligands
26 Dopaminski prenašalec (DAT) Presinaptični dopaminski nevron kaudatus putamen Postsinaptični dopaminski nevron Enofotonska emisijska tomografija (SPECT) z 123 I-ioflupanom ( 123 I FP-CIT) se uporablja za prikaz nigrostriatalne nevronske integritete. Drugi možni radiofarmaki: 123 I β-cit, 99m Tc TRODAT-1, 18 F DOPA.
27 Scintigrafija dopaminskega prenašalca ( 123 I-ioflupane) - DaTSCAN Bolniku razložimo potek preiskave, povprašamo ga katera zdravila jemlje (amfetamini, kokain, antidepresivi) in o morebitnih alergijah. Eno uro pred preiskavo zaužije bolnik 3 ml 3% KI (blokiramo ščitnico). Počasi intravensko apliciramo MBq 123 I ioflupana ( 123 I FP-CIT, komercialno DaTSCAN). S slikanjem pričnemo 3-4 ure po aplikaciji 123 I ioflupana (Bolnika namestimo v udoben položaj in mu fiksiramo glavo).
28 Scintigrafija dopaminskega prenašalca ( 123 I-ioflupane) - DaTSCAN Slikanje na gama kameri Dvoglava gama kamera. Visoko ločljivi nizko energijski kolimator (LEHR). Fotovrh pri 159 kev. 15 % okno. 2 x 60 posnetkov (180 stopinj) po 25 sekund. Matrika 128 x 128. Povečava 1,23. Oddaljenost detektorjev od centra rotacije 13,5 cm.
29 Scintigrafija dopaminskega prenašalca ( 123 I-ioflupane) - DaTSCAN Rekonstrukcija in ocenjevanje scintigramov Metoda vzvratne projekcije (FBP) ali iterativna metoda. Buterworth filter frekvence 0,45, order 7. Vizualno ocenjujemo niz scintigramov, reorientiranih v AC-PC ravnino, ki prikazujejo aktivnost v rezini možganov. Semikvantitativna ocena: primerjamo aktivnost, ki se je nakopičila v bazalnih ganglijih z nespecifično aktivnostjo v okcipitalnem delu možganov.
30 Scintigrafija dopaminskega prenašalca ( 123 I-ioflupane) - DaTSCAN Parkinsonova bolezen Patološki izvid scintigrafije Parkinsonizmi plus Demenca z Lewyjevimi telesci Klinično neznačilen parkinsonizem ali demenca Normalen izvid scintigrafije Esencialni tremor Vaskularni parkinsonizem Jatrogeni parkinsonizem Alzheimerjeva bolezen Scherfler C. et all. Role of DAT-SPECT in the diagnostic work up of parkinsonism. Mov Disord 2007;22:
31 Scintigrafija dopaminskega prenašalca ( 123 I-ioflupane) - DaTSCAN normalna aktivnost
32 Scintigrafija dopaminskega prenašalca ( 123 I-ioflupane) - DaTSCAN Normalna aktivnost Znižana odsotna aktivnost v bazalnih ganglijih možganov
33 Scintigrafija dopaminskega prenašalca ( 123 I-ioflupane) - DaTSCAN Aktivnost v bazalnih ganglijih možganov je praktično odsotna.
Principi PET-CT preiskave. Marko Grmek
Principi PET-CT preiskave Marko Grmek PET-CT PET pozitronska emisijska tomografija CT računalniška tomografija Fuzijska slika Detektor sevanja - PET skener - CT naprava PET-CT preiskava Radiofarmak - 18
More informationNuclear neurology. Zámbó Katalin Department of Nuclear Medicine
Nuclear neurology Zámbó Katalin Department of Nuclear Medicine To refresh your memory Brain has a high rate of oxidative metabolism. It has no reserves either of oxygen or of glucose and has a very limited
More informationFundamentals of Nuclear Medicine Brain Imaging
Fundamentals of Nuclear Medicine Brain Imaging Nick Gulliver Chief Clinical Technologist, Department of Nuclear Medicine & PET-CT, King s College Hospital NHS Foundation Trust, London, UK EANM Technologist
More informationRecent initiatives of the FANC. Michel Biernaux Health Protection Service Health and Environment Department
Recent initiatives of the FANC Michel Biernaux Michel.biernaux@fanc.fgov.be Health Protection Service Health and Environment Department Reminder objectives of the national survey : 1.Review the average
More informationImpact of CT based attenuation correction on quantitative assessment of DaTSCAN ( 123 I-Ioflupane) imaging in diagnosis of extrapyramidal diseases
Nuclear Medicine Review 2008 Vol. 11, No. 2, pp. 53 58 Copyright 2008 Via Medica ISSN 1506 9680 Impact of CT based attenuation correction on quantitative assessment of DaTSCAN ( 123 I-Ioflupane) imaging
More informationImaging biomarkers for Parkinson s disease
3 rd Congress of the European Academy of Neurology Amsterdam, The Netherlands, June 24 27, 2017 Teaching Course 6 MDS-ES/EAN: Neuroimaging in movement disorders - Level 2 Imaging biomarkers for Parkinson
More informationI-123 SPECT: task groups
I-123 SPECT: task groups Literature Review: Seibyl Claim Formulation Clinical Image Acquisition & Processing: Dewaraja Phantoms/ DRO: Dickson & Zimmerman Quantitative & Image Analysis: Seibyl & Miyaoka
More informationSPECT and PET Imaging: DaT Scan, Cerebral Blood Flow and Epilepsy
SPECT and PET Imaging: DaT Scan, Cerebral Blood Flow and Epilepsy Dana Mathews Ph.D. M.D. Division of Nuclear Medicine Department of Radiology The University of Texas Southwestern Medical Center Financial
More informationSPECT Dopamin Transporter lmaging Agent
SPECT Dopamin Transporter lmaging Agent Product Summary Product Name DATrace-123 Injection Active Ingredient Action Mechanism DATrace-123 is used as a radiopharmaceutical for the SPECT imaging of Dopamine
More informationDopamine transporter imaging 123 I-FP-CIT (DaTSCAN) SPET in differential diagnosis of dopa-responsive dystonia and young-onset Parkinson s disease
Dopamine transporter imaging I-FP-CIT (DaTSCAN) SPET in differential diagnosis of dopa-responsive dystonia and young-onset Parkinson s disease Leposava D. Brajkovic 1 MD Marina V. Svetel 2, MD, PhD Vladimir
More informationCorporate Medical Policy
Corporate Medical Policy Dopamine Transporter Imaging with Single Photon Emission File Name: Origination: Last CAP Review: Next CAP Review: Last Review: dopamine_transporter_imaging_with_single_photon_emission_computed_tomography
More informationIl ruolo di nuove tecniche di imaging per la diagnosi precoce di demenza
Parma, 23 maggio 2017 Il ruolo di nuove tecniche di imaging per la diagnosi precoce di demenza Livia Ruffini SC Medicina Nucleare Azienda Ospedaliero-Universitaria di Parma PET AND SPECT STUDIES OF THE
More informationBrain Perfusion SPECT
APPROVED BY: Director of Radiology Page 1 of 5 Brain Perfusion SPECT Primary Indications: Brain perfusion SPECT is most commonly performed (1) to aid in identification of the epileptogenic focus in patients
More informationUpdate on functional brain imaging in Movement Disorders
Update on functional brain imaging in Movement Disorders Mario Masellis, MSc, MD, FRCPC, PhD Assistant Professor & Clinician-Scientist Sunnybrook Health Sciences Centre University of Toronto 53 rd CNSF
More informationDopamine Transporter Imaging with Single Photon Emission Computed Tomography
Last Review Status/Date: September 2014 Page: 1 of 14 Photon Emission Computed Tomography Description Dopamine transporter imaging with single photon emission computed tomography (DAT-SPECT) is being evaluated
More informationBrain imaging for the diagnosis of people with suspected dementia
Why do we undertake brain imaging in dementia? Brain imaging for the diagnosis of people with suspected dementia Not just because guidelines tell us to! Exclude other causes for dementia Help confirm diagnosis
More informationPOLICY PRODUCT VARIATIONS DESCRIPTION/BACKGROUND RATIONALE DEFINITIONS BENEFIT VARIATIONS DISCLAIMER CODING INFORMATION REFERENCES POLICY HISTORY
Original Issue Date (Created): July 30, 2013 Most Recent Review Date (Revised): May 20, 2014 Effective Date: August 1, 2014 POLICY PRODUCT VARIATIONS DESCRIPTION/BACKGROUND RATIONALE DEFINITIONS BENEFIT
More informationIntroduction, use of imaging and current guidelines. John O Brien Professor of Old Age Psychiatry University of Cambridge
Introduction, use of imaging and current guidelines John O Brien Professor of Old Age Psychiatry University of Cambridge Why do we undertake brain imaging in AD and other dementias? Exclude other causes
More informationNuclear Medicine in the Diabetic Foot
26.11.2015, Uniklinik Balgrist Nuclear Medicine in the Diabetic Foot Martin Hüllner Nuklearmedizin und Neuroradiologie, USZ / UZH Outline A. Imaging modalities brief technical overview B. Nuclear medicine
More informationImaging in epilepsy: Ictal perfusion SPECT and SISCOM
Imaging in epilepsy: Ictal perfusion SPECT and SISCOM Patrick Dupont Laboratory for Cognitive Neurology Laboratory for Epilepsy Research Medical Imaging Research Center KU Leuven, Belgium E-mail: Patrick.Dupont@med.kuleuven.be
More informationAustin Radiological Association BRAIN AMYLOID STUDY (F-18-Florbetapir)
Austin Radiological Association BRAIN AMYLOID STUDY (F-18-Florbetapir) Overview The Brain Amyloid Study with F-18-florbetapir depicts the extracellular deposition of B- amyloid (Aβ) peptides (or plaques
More informationFDG-18 PET/CT - radiation dose and dose-reduction strategy
FDG-18 PET/CT - radiation dose and dose-reduction strategy Poster No.: C-1856 Congress: ECR 2014 Type: Authors: Keywords: DOI: Scientific Exhibit P. Nicholson, S. McSweeney, K. O'Regan; Cork/IE Radiation
More informationAustin Radiological Association Nuclear Medicine Procedure PET SODIUM FLUORIDE BONE SCAN (F-18 NaF)
Austin Radiological Association Nuclear Medicine Procedure PET SODIUM FLUORIDE BONE SCAN (F-18 NaF) Overview Indication Sodium Fluoride F18 injection is a radioactive diagnostic agent for positron emission
More informationCreation and validation of an I-123 FP-CIT template for statistical image analysis using high-resolution SPECT for parkinsonian patients
Ann Nucl Med (2016) 30:477 483 DOI 10.1007/s12149-016-1085-8 ORIGINAL ARTICLE Creation and validation of an I- FP-CIT template for statistical image analysis using high-resolution SPECT for parkinsonian
More informationC-MP4 in amci, AD and LBD
WP.2: Identification of novel neuroimaging targets in neurodegenerative disease P 36 UniHSR ilano Responsible: D. Perani WP.2: Identification of novel neuroimaging targets in neurodegenerative disease
More informationOutline. Lifetime Attributable Risk 10 mgy in 100,000 exposed persons (BEIR VII 2006) SPECT/CT and PET/CT Dosimetry
SPECT/CT and PET/CT Dosimetry Lifetime Attributable Risk 10 mgy in 100,000 exposed persons (BEIR VII 2006) All Solid Tumors Leukemia Frederic H. Fahey DSc Male Female Male Female Children s Hospital Boston
More informationRADIOPHARMACEUTICALS FOR NEUROIMAGING. Prof. Cristina Maria Moriguchi Jeckel Brain Institute of Rio Grande do Sul, PUCRS
RADIOPHARMACEUTICALS FOR NEUROIMAGING Prof. Cristina Maria Moriguchi Jeckel Brain Institute of Rio Grande do Sul, PUCRS Workshop on Quantitative SPECT and PET Brain Studies BRA6024 PUCRS, Porto Alegre,
More informationDepartment of Nuclear Medicine with Positron Emission Tomography
(PET) Unit [1] Contact information: Registration: +48 41 367 4850 Main office: +48 41 367 4860 Fax: +48 41 367 4887 e-mail: zmnsco@onkol.kielce.pl [2] Head of the Department: Professor Janusz Braziewicz
More informationSCINTIGRAPHY OF THE CENTRAL NERVOUS SYSTEM Part 1: Introduction and BBB studies
SCINTIGRAPHY OF THE CENTRAL NERVOUS SYSTEM Part 1: Introduction and BBB studies George N. Sfakianakis MD Professor of Radiology and Pediatrics Director, Division of Nuclear Medicine October 2009 FIRST
More informationPreclinical imaging and therapy. Marion de Jong
Preclinical imaging and therapy Marion de Jong Content Introduction Preclinical Imaging Preclinical Therapy to raise awareness about problems related to translation of animal studies Radiopharmaceuticals
More informationAustin Radiological Association Ga-68 NETSPOT (Ga-68 dotatate)
Austin Radiological Association Ga-68 NETSPOT (Ga-68 dotatate) Overview Ga-68 dotatate binds to somatostatin receptors, with highest affinity for subtype 2 receptors (sstr2). It binds to cells that express
More informationMethods of nuclear medicine
Methods of nuclear medicine Per Wollmer Dept. of Translational Medicine Lund University Gamma camera Positron camera Both frequently combined with CT Ventilation/perfusion scanning Perfusion: Albumin macroaggregates
More informationClinical evaluation of [ 123 I]FP-CIT SPECT scans on the novel brain-dedicated InSPira HD SPECT system: a head-to-head comparison
Adriaanse et al. EJNMMI Research (2018) 8:85 https://doi.org/10.1186/s13550-018-0436-y SHORT COMMUNICATION Clinical evaluation of [ 123 I]FP-CIT SPECT scans on the novel brain-dedicated InSPira HD SPECT
More informationVolume Quantification of 123I-DaTSCAN Imaging by MatLab for the Differentiation and Grading of Parkinsonism and Essential Tremor
Volume Quantification of 123I-DaTSCAN Imaging by MatLab for the Differentiation and Grading of Parkinsonism and Essential Tremor Maria Lyra, John Striligas, Maria Gavrilleli, Nefeli Lagopati Radiation
More informationNuclear medicine studies of the digestiv system. Zámbó Katalin Department of Nuclear Medicine
Nuclear medicine studies of the digestiv system Zámbó Katalin Department of Nuclear Medicine Anatomy of the liver Liver scintigraphy The labelled colloid (200 MBq 99mTc-Fyton) is phagocyted by the Kuppfer-cells
More informationPrecision of pre-sirt predictive dosimetry
International Course on THERANOSTICS AND MOLECULAR RADIOTHERAPY Precision of pre-sirt predictive dosimetry Hugo Levillain Department of Nuclear Medicine Medical Physics Jules Bordet Institute, Université
More informationDopamine Transporter Imaging With Single-Photon Emission Computed. Tomography
Dopamine Transporter Imaging With Single-Photon Emission Computed Tomography Policy Number: 6.01.54 Last Review: 9/2017 Origination: 9/2015 Next Review: 9/2018 Policy Blue Cross and Blue Shield of Kansas
More informationRound table: Moderator; Fereshteh Sedaghat, MD, PhD Brain Mapping in Dementias and Non-invasive Neurostimulation
Round table: Moderator; Fereshteh Sedaghat, MD, PhD Brain Mapping in Dementias and Non-invasive Neurostimulation 1. Reflection of Mild Cognitive Impairment (MCI) and Dementias by Molecular Imaging, PET
More informationFirst Clinical Experience with
First Clinical Experience with Discovery MI Digital PET/CT Martin Huellner Department of Nuclear Medicine University Hospital Zurich / University of Zurich Switzerland Agenda BelNuc GE Symposium 1. Digital
More informationFEP Medical Policy Manual
FEP Medical Policy Manual Effective Date: January 15, 2018 Related Policies: 6.01.06 Miscellaneous (Noncardiac, Nononcologic) Applications of Positron Emission Tomography 6.01.55 β-amyloid Imaging With
More informationHIV/AIDS UPDATE Janez Tomažič Klinika za infekcijske bolezni in vročinska stanja Katedra za infekcijske bolezni in epidemiologijo
HIV/AIDS UPDATE 2017 Janez Tomažič Klinika za infekcijske bolezni in vročinska stanja Katedra za infekcijske bolezni in epidemiologijo Patogeneza okužbe s HIV 1. Sesutje imunskega sistema KLINIČNE OPREDELITVE
More informationDouglas J. Simpkin, Ph.D. Aurora St. Luke s Medical Center Milwaukee, Wisconsin. www.
PET/CT Shielding Design Examples Douglas J. Simpkin, Ph.D. Aurora St. Luke s Medical Center Milwaukee, Wisconsin dsimpkin@wi.rr.com www. http://geocities.com/djsimpkin 1 Sources of Exposure: F-18 in Patients
More informationItroduction to the Nuclear Medicine: biophysics and basic principles. Zámbó Katalin Department of Nuclear Medicine
Itroduction to the Nuclear Medicine: biophysics and basic principles Zámbó Katalin Department of Nuclear Medicine NUCLEAR MEDICINE Application of the radioactive isotopes in the diagnostics and in the
More informationCardiac PET. John Buscombe
Cardiac PET John Buscombe Why PET? Improved resolution-not really required in cardiology Improved sensitivity this may be important-financially as reduced acquisition time Improved attenuation correction-good
More informationMichael Lassmann, PhD, and S. Ted Treves, MD, for the EANM/SNMMI pediatric dosage harmonization working group*
Pediatric Radiopharmaceutical Administration: Harmonization of the 2007 EANM Paediatric Dosage Card (Version 1.5.2008) and the 2010 North America Consensus guideline Michael Lassmann, PhD, and S. Ted Treves,
More informationThe Role of Nuclear Imaging in Heart Failure
The Role of Nuclear Imaging in Heart Failure Mouaz H. Al-Mallah, MD MSc FESC Associate Professor of Medicine Consultant Cardiologist and Division Head, Cardiac Imaging King Abdulaziz Cardiac Centre, National
More informationAdded Value of SPECT/CT Fusion in Assessing Suspected Bone Metastasis
Added Value of SPECT/CT Fusion in Assessing Suspected Bone Metastasis Poster No.: C-1595 Congress: ECR 2015 Type: Scientific Exhibit Authors: M. Mereuta, G. Cobzac, G. Andries ; Cluj-Napoca/RO, Cluj Napoca/RO
More informationDose reduction has been a work in progress in pediatric
Pediatric Radiopharmaceutical Administered Doses: 2010 North American Consensus Guidelines Michael J. Gelfand 1, Marguerite T. Parisi 2, and S. Ted Treves 3 1 Section of Nuclear Medicine, Department of
More informationInterpreting 123 I ioflupane dopamine transporter scans using hybrid scores
Nichols et al. European Journal of Hybrid Imaging (2018) 2:10 https://doi.org/10.1186/s41824-018-0028-0 European Journal of Hybrid Imaging ORIGINAL ARTICLE Open Access Interpreting 123 I ioflupane dopamine
More informationAustin Radiological Association Nuclear Medicine Procedure WHITE BLOOD CELL MIGRATION STUDY (In-111-WBCs, Tc-99m-HMPAO-WBCs)
Austin Radiological Association Nuclear Medicine Procedure WHITE BLOOD CELL MIGRATION STUDY (In-111-WBCs, Tc-99m-HMPAO-WBCs) Overview Indications The White Blood Cell Migration Study demonstrates the distribution
More informationZdravljenje pridobljene hemofilije. Irena Preložnik Zupan
Zdravljenje pridobljene hemofilije Irena Preložnik Zupan CILJI 1. Definicija, klinična slika, diagnoza 2. Zdravljenje zdravljenje akutnih krvavitev odstranjevanje inhibitorjev Pridobljeni inhibitorji koagulacije
More informationFacility IBA 18/9 Cyclotron Accelerates p and d. Facility GMP Grade Clean Room Automated Dispenser Synthera Rig FDG 07/11/2014
Dr Chris Marshall Director Introduction to PET Positron Emission Tomography Positron is anti matter equivalent of the electron Isotopes that are proton rich can decay by emission of a positron Positron
More informationDopamine Transporter Imaging With Single-Photon Emission Computed. Tomography
Dopamine Transporter Imaging With Single-Photon Emission Computed Tomography Policy Number: 6.01.54 Last Review: 9/2018 Origination: 9/2015 Next Review: 9/2019 Policy Blue Cross and Blue Shield of Kansas
More informationAnthem Blue Cross and Blue Shield Virginia Advanced Imaging Procedures Requiring Precertification Revised 02/13/2013
Anthem Blue Cross and Blue Shield Virginia Advanced Imaging Procedures Requiring Precertification Revised 02/13/2013 Modality and CT Head CTA Head: Cerebrovascular MRI Head MRA Head: Cerebrovascular Functional
More informationGE Healthcare. Protocol Manual. Abnormal Scan. Normal Scan. Period-Shaped. Comma-Shaped
GE Healthcare Protocol Manual Normal Scan Comma-Shaped Abnormal Scan Period-Shaped 1 Contents Section 1: Introduction... 4 1.1 Scope 1.2 What is DaTscan? Section 2: Image Acquisition, Interpretation, and
More informationCase 1: 79 yr-old woman with a lump in upper outer quadrant of left breast.
Case 1: 79 yr-old woman with a lump in upper outer quadrant of left breast. Giuliano Mariani Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa (Italy) Relevant history 79-yr
More informationHEMATURIJA PRI OTROCIH HAEMATURIA IN CHILDREN
HEMATURIJA PRI OTROCIH HAEMATURIA IN CHILDREN - ABSTRACT - - UVOD IN OPREDELITEV POJMOV Hematurija je prisotnost krvi v urinu. - - - mesecev. Lahko je - - Hematurija je sicer lahko pomemben znak bolezni
More informationModified Fractal Analysis of Brain PET and SPECT to Assess Grey and White Matter Function
Modified Fractal Analysis of Brain PET and SPECT to Assess Grey and White Matter Function Harold T. Pretorius, M.D., Ph.D., ^Jerome J. Kelly, M.D.,^ Gwen Hubbell M.D.,^ Claire Hubbell M.D., M.B.A.,^ Ellen
More informationTheranostics in Nuclear Medicine
Theranostics in Nuclear Medicine Patrick FLAMEN, MD, PhD Head Nuclear Medicine Institut Jules Bordet Université Libre de Bruxelles (U.L.B.) n Theranostics in Nuclear Medicine n A form of (nuclear) diagnostic
More informationDOWNLOAD PDF DOPAMINERGIC IMAGING IN PARKINSONS DISEASE : SPECT CHRISTOPH SCHERFLER AND WERNER POEWE
Chapter 1 : Imaging Approaches to Parkinson Disease The diagnosis of idiopathic Parkinson's disease (PD) can often be made on clinical grounds with a high degree of accuracy particularly in cases with
More informationWorld Molecular Imaging Society (WMIS) Comment on Proposed Decision Memorandum for Positron Emission Tomography (CAG-00065R2)
January 11, 2013 Director, Coverage and Analysis Group Centers for Medicare & Medicaid Services 7500 Security Blvd Baltimore, MD 21244 By Online Submission RE: World Molecular Imaging Society (WMIS) Comment
More informationLearnings from Parkinson s disease: Critical role of Biomarkers in successful drug development
Learnings from Parkinson s disease: Critical role of Biomarkers in successful drug development Ken Marek Coalition Against Major Diseases and FDA 2014 Annual Scientific Workshop Oct 2014 Disclosure Co-founder
More informationAntikoagulantno zdravljenje
Antikoagulantno zdravljenje (novosti s kongresa ASH 2010) Irena Umek Bricman Oddelek za interno medicino SB Slovenj Gradec Podčetrtek, 15.04.2010 Trajanje antikoagulantne terapije Priporočila: 8th ACCP
More informationGE Healthcare. Protocol Manual. Abnormal Scan. Normal Scan. Period-Shaped. Comma-Shaped
GE Healthcare Protocol Manual Normal Scan Comma-Shaped Abnormal Scan Period-Shaped Contents Section 1: Introduction... 4 1.1 Scope 1.2 What is DaTscan? Section 2: Image Acquisition, Interpretation, and
More informationBone PET/MRI : Diagnostic yield in bone metastases and malignant primitive bone tumors
Bone PET/MRI : Diagnostic yield in bone metastases and malignant primitive bone tumors Lars Stegger, Benjamin Noto Department of Nuclear Medicine University Hospital Münster, Germany Content From PET to
More informationViews and Reviews. [ 123 I]FP-CIT (DaTscan) SPECT Brain Imaging in Patients with Suspected Parkinsonian Syndromes ABSTRACT
Views and Reviews [ 123 I]FP-CIT (DaTscan) SPECT Brain Imaging in Patients with Suspected Parkinsonian Syndromes Robert A. Hauser, MD, Donald G. Grosset, MD From the Departments of Neurology, Molecular
More informationDopamine Transporter Imaging With Single-Photon Emission Computed Tomography
Dopamine Transporter Imaging With Single-Photon Emission Computed Tomography Applies to all products administered or underwritten by Blue Cross and Blue Shield of Louisiana and its subsidiary, HMO Louisiana,
More informationNeuroGam Software Analysis in Epilepsy Diagnosis Using 99m Tc-ECD Brain Perfusion SPECT Imaging
e-issn 1643-3750 DOI: 10.12659/MSM.894566 Received: 2015.05.07 Accepted: 2015.06.01 Published: 2015.09.20 NeuroGam Software Analysis in Epilepsy Diagnosis Using 99m Tc-ECD Brain Perfusion SPECT Imaging
More informationPositron Emission Tomography: Tool to Facilitate Drug Development and to Study Pharmacokinetics
Positron Emission Tomography: Tool to Facilitate Drug Development and to Study Pharmacokinetics Robert B. Innis, MD, PhD Molecular Imaging Branch National Institute Mental Health 1 Outline of Talk 1. PET
More informationCEREBRAL BLOOD FLOW AND METABOLISM
Supported by: HURO/0901/069/2.3.1 HU-RO-DOCS CEREBRAL BLOOD FLOW AND METABOLISM Part 3 Modern imaging methods SPECT, PET, nmri History of Nuclear Medicine Starts with the invention of the X-ray 1946: radioactive
More informationOutline. SPECT/CT in Parathyroid Disease. Pathophysiology. Current guidelines. SPECT/CT the evidence. SPECT/CT in clinical scenarios
SPECT/CT in Parathyroid Disease Ann-Marie Quigley Nuclear Medicine Royal Free Hospital London Outline Pathophysiology Current guidelines SPECT/CT the evidence SPECT/CT in clinical scenarios MGD, Nodular
More informationPositron Emission Tomography: Tool to Facilitate Drug Development and to Study Pharmacokinetics
Positron Emission Tomography: Tool to Facilitate Drug Development and to Study Pharmacokinetics Robert B. Innis, MD, PhD Molecular Imaging Branch National Institute Mental Health 1 Outline of Talk 1. PET
More informationNuclear imaging of the human brain
Nuclear imaging of the human brain Steven Laureys Coma Science Group Cyclotron Research Centre & Neurology Dept. University of Liège, Belgium Neuroimaging structure function Neuroimaging: Modalities Structural
More informationFDOPA, C11Choline, C11 Methionine. Dr K.G.Kallur
FDOPA, C11Choline, C11 Methionine Dr K.G.Kallur Why? 11C Methionine scan Had undergone resection Earlier. Post op recurrent hypercalcemia C11 Methionine Unable to see in Sestamibi scan Brain Tumor After
More informationOutline. Primary Hyperparathyriodism. SPECT/CT in Parathyroid Localisation. Ann-Marie Quigley Nuclear Medicine Royal Free Hospital London
SPECT/CT in Parathyroid Localisation Ann-Marie Quigley Nuclear Medicine Royal Free Hospital London Outline Pathophysiology Current guidelines SPECT/CT the evidence SPECT/CT in clinical scenarios MGD, Nodular
More informationQuantitative Theranostics in Nuclear Medicine
Quantitative Theranostics in Nuclear Medicine M. Lassmann Klinik und Poliklinik für Nuklearmedizin Direktor: Prof. Dr. A. Buck Contents What is Theranostics? Potential Targets Basic Principles of Quantitative
More informationNuclear Medicine: Basics to therapy
Nuclear Medicine: Basics to therapy RCP Medical careers day Dr Sabina Dizdarevic MD MSc PhD FRCP Dr Deena Neriman MBBS FRCR Ms Charlotte Weston CEO BNMS On behalf of the British Nuclear Medicine Society
More informationSladkorna bolezen in kirurški poseg
Sladkorna bolezen in kirurški poseg Doc.dr.Vilma Urbančič, dr.med. UKC Ljubljana KO EDBP, Diabetološki oddelek 1.12.2010 10. Podiplomski tečaj iz hospitalne diabetologije Ljubljana, 24.11. -2.12.2010 Noordzij
More informationEffective Diagnosis of Alzheimer s Disease by means of Association Rules
Effective Diagnosis of Alzheimer s Disease by means of Association Rules Rosa Chaves (rosach@ugr.es) J. Ramírez, J.M. Górriz, M. López, D. Salas-Gonzalez, I. Illán, F. Segovia, P. Padilla Dpt. Theory of
More informationTHE SNM PRACTICE GUIDELINE FOR BRAIN DEATH SCINTIGRAPHY V2.0
THE SNM PRACTICE GUIDELINE FOR BRAIN DEATH SCINTIGRAPHY V2.0 Revised 2011 PREAMBLE These guidelines are an educational tool designed to assist practitioners in providing appropriate care for patients.
More informationNuclear medicine studies of the digestiv system. Zámbó Katalin Department of Nuclear Medicine
Nuclear medicine studies of the digestiv system Zámbó Katalin Department of Nuclear Medicine Imaging tehniques Anatomy Physiology Metabolism Molecular Rtg. / CT PET / SPECT MRI MR spectroscopy fmri Ultrasound
More information2019 Medicare Physician Fee Schedule -Final Relative Value Units and Payment Rates for Nuclear Cardiology Procedures
Myocardial Perfusion Imaging 0482T Absolute quant. Myocardial blood flow, PET PE Malpractice Total Conversion Factors $35.9996 $36.0391 78451-G SPECT MPI, single 1.38 8.5 0.10 9.98 $359.28 1.38 8.29 0.10
More informationDiagnostic Accuracy of Parkinson Disease by Support Vector Machine (SVM) Analysis of 123 I-FP-CIT Brain SPECT Data
Diagnostic Accuracy of Parkinson Disease by Support Vector Machine (SVM) Analysis of 123 I-FP-CIT Brain SPECT Data Implications of Putaminal Findings and Age Barbara Palumbo, MD, Mario Luca Fravolini,
More informationIntroduction Pediatric malignancies Changing trends & Radiation burden Radiation exposure from PET/CT Image gently PET & CT modification - PET/CT
Introduction Pediatric malignancies Changing trends & Radiation burden Radiation exposure from PET/CT Image gently PET & CT modification - PET/CT protocols Tips Leukaemia / lymphoma: ~ 35% acute lymphoblastic
More informationMeasures taken by the authority. to reduce extremity doses. in nuclear medicine facilities. in Switzerland
Measures taken by the authority to reduce extremity doses in nuclear medicine facilities in Switzerland Dr. phil nat Nicolas Stritt Swiss Federal Office of Public Health (SFOPH) Division Radioprotection
More informationGINKGO BILOBA IN MISELNE SPOSOBNOSTI. Avtorji: Jelena Raković, Božica Ljušanin Grbavac 18. modularna skupina April 2015
GINKGO BILOBA IN MISELNE SPOSOBNOSTI Avtorji: Jelena Raković, Božica Ljušanin Grbavac 18. modularna skupina April 2015 KLINIČNO VPRAŠANJE Ali uporaba standardiziranih pripravkov Ginkgo bilobe izboljšuje
More informationNUCLEAR MEDICINE. Keywords I-123-ioflupane. Attenuation correction. Chang. Contour delineation. Stereotactical normalization.
DOI 10.1007/s00330-015-3667-6 NUCLEAR MEDICINE Robust, fully automatic delineation of the head contour by stereotactical normalization for attenuation correction according to Chang in dopamine transporter
More informationGa68 Imaging. Roland HUSTINX Division of Nuclear Medicine and Oncologic Imaging Centre Hospitalier Universitaire de Liège Belgium
Ga68 Imaging Roland HUSTINX Division of Nuclear Medicine and Oncologic Imaging Centre Hospitalier Universitaire de Liège Belgium 68 Ga Produced by a 68 Ge/ 68 Ga generator Decays by positron emission
More informationAustin Radiological Association Nuclear Medicine Procedure BONE MINERAL STUDY (Tc-99m-MDP, Tc-99m-HMDP)
Austin Radiological Association Nuclear Medicine Procedure BONE MINERAL STUDY (Tc-99m-MDP, Tc-99m-HMDP) Overview The Bone Mineral Study, with either Tc-99m-MDP or Tc-99m-HMDP, depicts the distribution
More informationThe current diagnosis of idiopathic Parkinson s disease
Sensitivity and Specificity of Tc-TRODAT-1 SPECT Imaging in Differentiating Patients with Idiopathic Parkinson s Disease from Healthy Subjects Yi-Hsin Weng, MD 1 ; Tzu-Chen Yen, PhD 2 ; Min-Chi Chen, PhD
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
diagnosis and assessment bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published.
More informationDose Calibration for DaTscan
GE Healthcare Dose Calibration for DaTscan Please review the simple steps below to learn how to properly calibrate your dose of DaTscan. 1 2 3 4 5 6 7 8 9 Reading DaTscan in the Dose Calibrator 1. Place
More informationNuclear Medicine Head and Neck Region. Bán Zsuzsanna, MD University of Pécs, Department of Nuclear Medicine
Nuclear Medicine Head and Neck Region Bán Zsuzsanna, MD University of Pécs, Department of Nuclear Medicine Thyroid scintigraphy Parathyroid scintigraphy F18-FDG PET examinations in head and neck cancer
More informationPriporočila za zdravljenje primarne imunske trombocitopenije. Barbara Skopec
Priporočila za zdravljenje primarne imunske trombocitopenije Barbara Skopec ITP = Idiopatična trombocitopenična purpura ITP = primarna imunska trombocitopenija Rodeghiero F, et al. Blood 2009;113:2386
More informationStandardization of Radiopharmaceutical Dosimetry
Standardization of Radiopharmaceutical Dosimetry Jonathon A. Nye, PhD Department of Radiology and Imaging Sciences Emory University SEAAPM 2011 Myrtle Beach, SC Review of Dosimetry Nomenclature Dose Gray
More informationROUTINE MRI PROTOCOLS: I. Abdomen Plus Post Gadolinium Screening Pelvis
ROUTINE MRI PROTOCOLS: I. Abdomen Plus Post Gadolinium Screening Pelvis Sequence Coverage Slice/Gap Notes COR T2 ssfse 32-40 6/-1 Coverage from all sequences is above the liver dome, through the kidneys.
More informationOptimized PET/CT protocols: how much CT is needed? Increasing use of PET-CT. Imaging in Lymphoma
BVS/ABR Workshop 2011 on dose related to multimodality imaging Optimized PET/CT protocols: how much CT is needed? 2008 Mean medical radiation exposure/head Belgium= 2.42 msv The Netherlands= 0.8 msv Belgium
More informationversion 2.0, approved February 7, 1999 I. Purpose Background Information and Definitions III. Common Indications IV. Procedure
Society of Nuclear Medicine Procedure Guideline for Brain Perfusion Single Photon Emission Computed Tomography (SPECT) Using Tc-99m Radiopharmaceuticals version 2.0, approved February 7, 1999 A u t h o
More informationPET/MR:Techniques, Indications and Applications
PET/MR:Techniques, Indications and Applications Franz Wolfgang Hirsch Professor and Head of the Department of Pediatric Radiology University Hospital Leipzig / Germany Children s Hospital University Leipzig
More informationJ of Nuclear Medicine Technology, first published online January 24, 2014 as doi: /jnmt
J of Nuclear Medicine Technology, first published online January 24, 2014 as doi:10.2967/jnmt.113.133736 Effects of Pacemaker, Implantable Cardioverter Defibrillator, and Left Ventricular Leads on CT-Based
More information