Boehringer Ingelheim and investment in R&D. Volker Barkmann
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1 Boehringer Ingelheim and investment in R&D Volker Barkmann
2 I. Our Corporation
3 Boehringer Ingelheim in brief Boehringer Ingelheim Center Our headquarters in Ingelheim, Germany Family-owned global corporation Founded 1885 in Ingelheim, Germany Focus on: Human Pharmaceuticals, Animal Health and Biopharmaceuticals Employees worldwide more than 47,000 R&D worldwide at five sites Expenses for R&D: EUR 2,743 million 16 production facilities in 11 countries Total net sales: EUR 14,065 million Affiliated companies: 142 worldwide Investment in tangible assets: EUR 558 million Corporate Standard Presentation 2014 Boehringer Ingelheim 3
4 Net sales development affected by exchange rate effects Net sales Net sales by region In EUR million 14,691 14,065 Asia, Australia, Africa Europe 24% 30% 46% Americas Americas region continues to be the most important sales market Net sales by country Japan Growth +1.4% (currency-adjusted) In euro terms -4.3% Other 43% 13% 7% 37% USA Germany Top 3 countries: ~60% of total net sales Corporate Standard Presentation 2014 Boehringer Ingelheim 4
5 Ten years of sustained positive performance in EUR billion R&D- Expenditure Net sales and operating income almost doubled R&D expenditure more than doubled 7.4 Productivity significantly increased Net Sales Operating Income Employees 34,221 37,406 39,800 41,534 44,094 47,492 Sales/Employee (in thousands of EUR) Corporate Standard Presentation 2014 Boehringer Ingelheim 5
6 II. Our Research & Development
7 Our Research & Development drive Employees in R&D More than 7,700 employees in R&D+Medicine globally 250 new positions in 2013 Overall R&D Investment EUR billion spent in total for R&D in 2013 Independent basic research Continued commitment to basic research represented by the Research Institute of Molecular Pathology, Vienna, Austria Boehringer Ingelheim Venture Fund Investments and active role in biotechnology companies Broadening our access to emerging therapeutic concepts and novel technology platforms Fund volume: EUR 100 million Corporate Standard Presentation 2014 Boehringer Ingelheim 7
8 Our global research and development sites Ridgefield, USA 2 Biberach/ Ingelheim, Germany 3 Vienna, Austria 4 Milan, Italy 5 Kobe, Japan Corporate Standard Presentation 2014 Boehringer Ingelheim 8
9 Focus on six therapeutic areas in R&D+Medicine Our worldwide sites focus on six major therapeutic areas: Respiratory diseases Cardiovascular diseases Metabolic diseases Oncology Diseases of the central nervous system Immunology Corporate Standard Presentation 2014 Boehringer Ingelheim 9
10 Research and development successes in projects submitted for international registration, including: nintedanib for non-small cell lung cancer tiotropium for asthma empagliflozin for type 2 diabetes 3 product launches: gilotrif for non-small cell lung cancer pradaxa for the prevention and treatment of deep vein thrombosis and pulmonary embolism striverdi respimat for COPD Positive feedback from authorities: Fast Track designation for nintedanib for idiopathic pulmonary fibrosis (IPF) Breakthrough Therapy status for volasertib for acute myeloid leukaemia (AML) Corporate Standard Presentation 2014 Boehringer Ingelheim 10
11 Products from our own R&D pipeline Active ingredient Product name Indication First launch Olodaterol striverdi Chronic obstructive pulmonary disease 2014 Afatinib gilotrif Non-small cell lung cancer (NSCLC) 2013 Linagliptin tradjenta jentadueto Type 2 diabetes 2011 Dabigatran etexilate pradaxa Prevention and treatment of deep vein thrombosis Tiotropium Telmisartan plus amlodipine spiriva respimat Soft Mist Inhaler spiriva Pulmonary embolism Stroke Prevention in patients with Atrial Fibrillation (SPAF) Prevention of venous thromboembolic events Chronic Obstructive Pulmonary Disease (COPD) twynsta Essential hypertension 2009 Corporate Standard Presentation 2014 Boehringer Ingelheim 11
12 III. What drives R&D investments in the pharmaceutical industry?
13 What drives R&D decisions in the research based pharmaceutical industry? Science Clusters Expertise R&D investment Markets Patient needs IP
14 EU market vs. US market EU EU wide marketing authorisation 28 different healthcare systems Market access delays - in some countries several years Different Health technology assessments on national and regional levels No 2 global market regulated prices Parallel Trade & Reference Pricing USA US wide marketing authorisation One healthcare system Immediate market access - No 1 global market prices negotiated -
15 Your decision If you had to choose where would you first want to market and therefore mainly develop your new medicine?
16 Thank you!
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