9.01 Introduction to Neuroscience Fall 2007
|
|
|
- Diana Floyd
- 6 years ago
- Views:
Transcription
1 MIT OpenCourseWare Introduction to Neuroscience Fall 2007 For information about citing these materials or our Terms of Use, visit:
2 Declarative memory conscious, declared, explicit
3 Where is declarative memory? epilepsy electrical stimulation lesion
4 Temporal lobe epilepsy sensations feelings of familiarity or unfamiliarity recollections/flashbacks temporal cortex electrical stimulation causes the same effects Wilder Penfield medial part of temporal lobe
5 Bilateral medial temporal lobectomy Image removed due to copyright restrictions. Diagram comparing patient H.M.'s brain with normal brain. See Figure 24.8 in Bear, Mark F., Barry W. Connors, and Michael A. Paradiso. Neuroscience: Exploring the Brain. 3rd ed. Baltimore, MD: Lippincott Williams & Wilkins, 2007.
6 H.M. long-term memory anterograde amnesia partial retrograde amnesia short-term memory intact procedural memory intact
7 Short-term vs. long-term memory Short-term memory seconds to minutes Long-term memory up to a lifetime Consolidation conversion of STM to LTM
8 Medial temporal lobe lesion in monkeys Errors in delayed non-match to sample increase with time delay Image removed due to copyright restrictions. See Figure in Bear, Mark F., Barry W. Connors, and Michael A. Paradiso. Neuroscience: Exploring the Brain. 3rd ed. Baltimore, MD: Lippincott Williams & Wilkins, 2007.
9 Strongest effect from lesion of perirhinal cortex Image removed due to copyright restrictions. See Figure 24.9b in Bear, Mark F., Barry W. Connors, and Michael A. Paradiso. Neuroscience: Exploring the Brain. 3rd ed. Baltimore, MD: Lippincott Williams & Wilkins, weak effect from removal of hippocampus alone
10 Hypothesis: long-term memories are stored by synaptic modifications
11 Hebbian synaptic plasticity Neurons that fire together, wire together.
12 Brain slice preparation intracellular recording is easier than in vivo thickness: fraction of a millimeter used for studying intrinsic and synaptic conductances
13 Synaptic plasticity experiment Measure EPSP amplitude Induce synaptic modification Measure new EPSP amplitude Image removed due to copyright restrictions. See Figure 23.27a and b in Bear, Mark F., Barry W. Connors, and Michael A. Paradiso. Neuroscience: Exploring the Brain. 3rd ed. Baltimore, MD: Lippincott Williams & Wilkins, 2007.
14 Long-term potentiation (LTP) activity-dependent synaptic modification lasts for tens of minutes or longer induction high-frequency stimulation postsynaptic depolarization found in cortex, hippocampus, etc.
15 Long-term depression (LTD) Neurons that fire out of sync lose their link. induction: low-frequency stimulation
16 Glutamate receptor subtypes Presynaptic axon terminal Postsynaptic dendritic spine Glutamate Dendrite AMPA receptor Axon NMDA receptor Metabotropic glutamate receptor Figure by MIT OpenCourseWare. After Figure in Bear, Connors, and Paradiso. Neuroscience: Exploring the Brain. 3rd ed. Baltimore, MD: Lippincott Williams & Wilkins, 2007.
17 NMDA receptor transmitter-gated magnesium block: voltage-gated permeable to calcium
18 NMDA receptor as a coincidence detector (a) Postsynaptic membrane at resting potential (b) Postsynaptic membrane at depolarized potential Presynaptic glutamate release Mg 2+ Glutamate Presynaptic glutamate release Glutamate Mg 2+ AMPA receptor NMDA receptor AMPA receptor NMDA receptor Ca 2+ Na + Na + Na + Figure by MIT OpenCourseWare. After Figure in Bear, Connors, and Paradiso. Neuroscience: Exploring the Brain. 3rd ed. Baltimore, MD: Lippincott Williams & Wilkins, 2007.
19 The evidence NMDA receptor LTP is blocked by the antagonist AP5 Calcium chelators (such as EGTA) block LTP release of caged calcium mimics LTP
20 Morris water maze swimming pool with opaque water submerged platform measure time for rodent to swim to platform learning is impaired by AP5
21 NR1 knockout mouse NMDA-R has seven subunits NR1 knockout is lethal. Site-specific knockouts can be viable.
22 CA3 specific NR1 knockout no effect on Morris water maze performance if visual cues are reduced, then performance suffers
23 The central dogma STM Hebbian plasticity pattern completion LTM
24 Hebbian plasticity creates cell assemblies
25 Pattern completion
26 Interference How many memories can be stored?
Part 11: Mechanisms of Learning
Neurophysiology and Information: Theory of Brain Function Christopher Fiorillo BiS 527, Spring 2012 042 350 4326, fiorillo@kaist.ac.kr Part 11: Mechanisms of Learning Reading: Bear, Connors, and Paradiso,
Memory Systems II How Stored: Engram and LTP. Reading: BCP Chapter 25
Memory Systems II How Stored: Engram and LTP Reading: BCP Chapter 25 Memory Systems Learning is the acquisition of new knowledge or skills. Memory is the retention of learned information. Many different
Learning and Memory. The Case of H.M.
Learning and Memory Learning deals with how experience changes the brain Memory refers to how these changes are stored and later reactivated The Case of H.M. H.M. suffered from severe, intractable epilepsy
Introduction to Physiological Psychology Learning and Memory II
Introduction to Physiological Psychology Learning and Memory II ksweeney@cogsci.ucsd.edu cogsci.ucsd.edu/~ksweeney/psy260.html Memory Working Memory Long-term Memory Declarative Memory Procedural Memory
9.01 Introduction to Neuroscience Fall 2007
MIT OpenCourseWare http://ocw.mit.edu 9.01 Introduction to Neuroscience Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. Working memory short-term
BIPN 140 Problem Set 6
BIPN 140 Problem Set 6 1) The hippocampus is a cortical structure in the medial portion of the temporal lobe (medial temporal lobe in primates. a) What is the main function of the hippocampus? The hippocampus
BIPN 140 Problem Set 6
BIPN 140 Problem Set 6 1) Hippocampus is a cortical structure in the medial portion of the temporal lobe (medial temporal lobe in primates. a) What is the main function of the hippocampus? The hippocampus
Neuronal Plasticity, Learning and Memory. David Keays Institute of Molecular Pathology
Neuronal Plasticity, Learning and Memory David Keays Institute of Molecular Pathology http://keayslab.org Structure 1. What is learning and memory? 2. Anatomical basis 3. Cellular basis 4. Molecular
Synaptic plasticityhippocampus. Neur 8790 Topics in Neuroscience: Neuroplasticity. Outline. Synaptic plasticity hypothesis
Synaptic plasticityhippocampus Neur 8790 Topics in Neuroscience: Neuroplasticity Outline Synaptic plasticity hypothesis Long term potentiation in the hippocampus How it s measured What it looks like Mechanisms
Introduction to Physiological Psychology Review
Introduction to Physiological Psychology Review ksweeney@cogsci.ucsd.edu www.cogsci.ucsd.edu/~ksweeney/psy260.html n Learning and Memory n Human Communication n Emotion 1 What is memory? n Working Memory:
More dendritic spines, changes in shapes of dendritic spines More NT released by presynaptic membrane
LEARNING AND MEMORY (p.1) You are your learning and memory! (see movie Total Recall) L&M, two sides of the same coin learning refers more to the acquisition of new information & brain circuits (storage)
How Synapses Integrate Information and Change
How Synapses Integrate Information and Change Rachel Stewart class of 2016 http://neuroscience.uth.tmc.edu/s1/chapter06.html http://neuroscience.uth.tmc.edu/s1/chapter07.html Chris Cohan, Ph.D. Dept. of
Synap&c Plas&city. long-term plasticity (~30 min to lifetime) Long-term potentiation (LTP) / Long-term depression (LTD)
Synap&c Plas&city synaptic connectivity constantly changes in response to activity and other factors During development: provides the basic wiring of the brain s circuits Throughout rest of life: basis
How Synapses Integrate Information and Change
How Synapses Integrate Information and Change Rachel Stewart class of 2016 https://nba.uth.tmc.edu/neuroscience/s1/chapter06.html https://nba.uth.tmc.edu/neuroscience/s1/chapter07.html Chris Cohan, Ph.D.
Synaptic plasticity. Mark van Rossum. Institute for Adaptive and Neural Computation University of Edinburgh
Synaptic plasticity Mark van Rossum Institute for Adaptive and Neural Computation University of Edinburgh 1 Human memory systems 2 Psychologists have split up memory in: Declarative memory * Episodic memory
Synaptic plasticity and hippocampal memory
Synaptic plasticity and hippocampal memory Tobias Bast School of Psychology, University of Nottingham tobias.bast@nottingham.ac.uk Synaptic plasticity as the neurophysiological substrate of learning Hebb
CSE511 Brain & Memory Modeling Lect 22,24,25: Memory Systems
CSE511 Brain & Memory Modeling Lect 22,24,25: Memory Systems Compare Chap 31 of Purves et al., 5e Chap 24 of Bear et al., 3e Larry Wittie Computer Science, StonyBrook University http://www.cs.sunysb.edu/~cse511
Ch 8. Learning and Memory
Ch 8. Learning and Memory Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed., M. S. Gazzaniga, R. B. Ivry, and G. R. Mangun, Norton, 2002. Summarized by H.-S. Seok, K. Kim, and B.-T. Zhang Biointelligence
Systems Neuroscience November 29, Memory
Systems Neuroscience November 29, 2016 Memory Gabriela Michel http: www.ini.unizh.ch/~kiper/system_neurosci.html Forms of memory Different types of learning & memory rely on different brain structures
Ch 8. Learning and Memory
Ch 8. Learning and Memory Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed., M. S. Gazzaniga,, R. B. Ivry,, and G. R. Mangun,, Norton, 2002. Summarized by H.-S. Seok, K. Kim, and B.-T. Zhang Biointelligence
Theories of memory. Memory & brain Cellular bases of learning & memory. Epileptic patient Temporal lobectomy Amnesia
Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed., M. S. Gazzaniga, R. B. Ivry, and G. R. Mangun, Norton, 2002. Theories of Sensory, short-term & long-term memories Memory & brain Cellular bases
LONG TERM MEMORY. Learning Objective Topics. Retrieval and the Brain. Retrieval Neuroscience of Memory. LTP Brain areas Consolidation Reconsolidation
LONG TERM MEMORY Retrieval and the rain Learning Objective Topics Retrieval Neuroscience of Memory LTP rain areas onsolidation Reconsolidation 1 Long-term memory How does info become encoded/stored in
Chapter 23: Wiring the Brain
Chapter 23: Wiring the Brain Introduction Operation of the brain Precise interconnections among 100 billion neurons Brain development Begins as a tube Neurogenesis, synaptogenesis, pathway formation, connections
VS : Systemische Physiologie - Animalische Physiologie für Bioinformatiker. Neuronenmodelle III. Modelle synaptischer Kurz- und Langzeitplastizität
Bachelor Program Bioinformatics, FU Berlin VS : Systemische Physiologie - Animalische Physiologie für Bioinformatiker Synaptische Übertragung Neuronenmodelle III Modelle synaptischer Kurz- und Langzeitplastizität
Synaptic plasticity. Activity-dependent changes in synaptic strength. Changes in innervation patterns. New synapses or deterioration of synapses.
Synaptic plasticity Activity-dependent changes in synaptic strength. Changes in innervation patterns. New synapses or deterioration of synapses. Repair/changes in the nervous system after damage. MRC Centre
Summarized by. Biointelligence Laboratory, Seoul National University
Ch 8. Learning and Memory Cognitive Neuroscience: The Biology of the Mind, 3 rd Ed., M. S. Gazzaniga, R. B. Ivry, and G. R. Mangun, Norton, 2008. Summarized by H.-S. Seok, K. Kim, and db.-t. TZhang Biointelligence
Notes: Synapse. Overview. PSYC Summer Professor Claffey PDF. Conversion from an signal to a signal - electrical signal is the
PSYC 170 - Summer 2013 - Professor Claffey Notes: Synapse PDF Overview Conversion from an signal to a signal - electrical signal is the - chemical signal is the Presynaptic - refers to that sends/receives
Perceptual Learning. Motor Learning. Stimulus-Response Learning. Relational Learning
Introduction to Physiological Psychology Review ksweeney@cogsci.ucsd.edu www.cogsci.ucsd.edu/~ksweeney/psy260.html Learning and Memory Human Communication Emotion 1 Working Memory: What is memory? Limited
The synaptic Basis for Learning and Memory: a Theoretical approach
Theoretical Neuroscience II: Learning, Perception and Cognition The synaptic Basis for Learning and Memory: a Theoretical approach Harel Shouval Phone: 713-500-5708 Email: harel.shouval@uth.tmc.edu Course
Synapses and synaptic plasticity. Lubica Benuskova Lecture 8 How neurons communicate How do we learn and remember
Synapses and synaptic plasticity Lubica Benuskova Lecture 8 How neurons communicate How do we learn and remember 1 Brain is comprised of networks of neurons connected and communicating via synapses ~10
Supplementary Figure 1. Basic properties of compound EPSPs at
Supplementary Figure 1. Basic properties of compound EPSPs at hippocampal CA3 CA3 cell synapses. (a) EPSPs were evoked by extracellular stimulation of the recurrent collaterals and pharmacologically isolated
The Neurobiology of Learning and Memory
The Neurobiology of Learning and Memory JERRY W. RUDY University of Colorado, Boulder Sinauer Associates, Inc. Publishers Sunderland, Massachusetts 01375 Table of Contents CHAPTER 1 Introduction: Fundamental
memory Examples: Obama is president, PSYC 2 is in Price Center Theater, my 21st birthday was a disaster
PSYC 2: Biological Foundations - Fall 2012 - Professor Claffey Notes: Cognition 2 Version: 11/18/12 - original version Memory Classifications A note on memory classifications Definitions developed from
Why do we have a hippocampus? Short-term memory and consolidation
Why do we have a hippocampus? Short-term memory and consolidation So far we have talked about the hippocampus and: -coding of spatial locations in rats -declarative (explicit) memory -experimental evidence
Action potential. Definition: an all-or-none change in voltage that propagates itself down the axon
Action potential Definition: an all-or-none change in voltage that propagates itself down the axon Action potential Definition: an all-or-none change in voltage that propagates itself down the axon Naturally
BIPN140 Lecture 12: Synaptic Plasticity (II)
BIPN140 Lecture 12: Synaptic Plasticity (II) 1. Early v.s. Late LTP 2. Long-Term Depression 3. Molecular Mechanisms of Long-Term Depression: NMDA-R dependent 4. Molecular Mechanisms of Long-Term Depression:
Synaptic Plasticity and the NMDA Receptor
Synaptic Plasticity and the NMDA Receptor Lecture 4.2 David S. Touretzky November, 2015 Long Term Synaptic Plasticity Long Term Potentiation (LTP) Reversal of LTP Long Term Depression (LTD) Reversal of
Cellular Mechanisms of Learning and the Biological Basis of Individuality
The Study of Memory Has Two Parts: Cellular Mechanisms of Learning and the Biological Basis of Individuality (1) The Systems Problem of Memory: Where in the brain is memory stored? (2) The Molecular Problem
Feedback Education and Neuroscience. Pankaj Sah
Feedback Education and Neuroscience Pankaj Sah Science of Learning Learning The process of acquiring a skill or knowledge that leads to a change in behaviour Memory The ability to retain and recover information
BIOLOGICAL PROCESSES
BIOLOGICAL PROCESSES CHAPTER 3 1 LEARNING GOALS Discuss how the nervous system communicates internally. Describe the structure and function of neurons Describe how the neuron transmits information Describe
Exercising Our Minds: Effects of Exercise on Brain Structure & Function
Public Lecture Exercising Our Minds: Effects of Exercise on Brain Structure & Function Dr. Brian R. Christie Division of Medical Sciences, University of Victoria Cellular and Physiological Sciences, UBC
Psychology 320: Topics in Physiological Psychology Lecture Exam 2: March 19th, 2003
Psychology 320: Topics in Physiological Psychology Lecture Exam 2: March 19th, 2003 Name: Student #: BEFORE YOU BEGIN!!! 1) Count the number of pages in your exam. The exam is 8 pages long; if you do not
Lecture 22: A little Neurobiology
BIO 5099: Molecular Biology for Computer Scientists (et al) Lecture 22: A little Neurobiology http://compbio.uchsc.edu/hunter/bio5099 Larry.Hunter@uchsc.edu Nervous system development Part of the ectoderm
Synaptic Communication. Steven McLoon Department of Neuroscience University of Minnesota
Synaptic Communication Steven McLoon Department of Neuroscience University of Minnesota 1 Course News The first exam is next week on Friday! Be sure to checkout the sample exam on the course website. 2
Cellular mechanisms of information transfer: neuronal and synaptic plasticity
Cellular mechanisms of information transfer: neuronal and synaptic plasticity Ivan Pavlov (UCL Institute of Neurology, UK) Anton Chizhov (Ioffe Physical Technical Institute) Pavel Zykin (St.-Petersburg
COGNITIVE SCIENCE 107A. Hippocampus. Jaime A. Pineda, Ph.D.
COGNITIVE SCIENCE 107A Hippocampus Jaime A. Pineda, Ph.D. Common (Distributed) Model of Memory Processes Time Course of Memory Processes Long Term Memory DECLARATIVE NON-DECLARATIVE Semantic Episodic Skills
CASE 49. What type of memory is available for conscious retrieval? Which part of the brain stores semantic (factual) memories?
CASE 49 A 43-year-old woman is brought to her primary care physician by her family because of concerns about her forgetfulness. The patient has a history of Down syndrome but no other medical problems.
NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES 34.3
NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES 34.3 NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES Neurons communicate with other neurons or target cells at synapses. Chemical synapse: a very narrow
Beyond Vanilla LTP. Spike-timing-dependent-plasticity or STDP
Beyond Vanilla LTP Spike-timing-dependent-plasticity or STDP Hebbian learning rule asn W MN,aSN MN Δw ij = μ x j (v i - φ) learning threshold under which LTD can occur Stimulation electrode Recording electrode
Synaptic Integration
Synaptic Integration 3 rd January, 2017 Touqeer Ahmed PhD Atta-ur-Rahman School of Applied Biosciences National University of Sciences and Technology Excitatory Synaptic Actions Excitatory Synaptic Action
Basics of Computational Neuroscience: Neurons and Synapses to Networks
Basics of Computational Neuroscience: Neurons and Synapses to Networks Bruce Graham Mathematics School of Natural Sciences University of Stirling Scotland, U.K. Useful Book Authors: David Sterratt, Bruce
Cellular Neurobiology / BIPN 140
SECOND MIDTERM EXAMINATION Fall, 2015 GENERAL INSTRUCTIONS 1. Please write your name on ALL 6 pages. 2. Please answer each question IN THE SPACE ALLOTTED. 1) /10 pts 2) /10 pts 3) /15 pts 4) /15 pts 5)
Cellular and Molecular Mechanisms of Learning and Memory
Cellular/Molecular Mechanisms of Learning and Memory 27 Cellular and Molecular Mechanisms of Learning and Memory 2 Matthew Lattal and Ted Abel The nature of the cellular basis of learning and memory remains
SUPPLEMENTARY INFORMATION. Supplementary Figure 1
SUPPLEMENTARY INFORMATION Supplementary Figure 1 The supralinear events evoked in CA3 pyramidal cells fulfill the criteria for NMDA spikes, exhibiting a threshold, sensitivity to NMDAR blockade, and all-or-none
This Lecture: Psychology of Memory and Brain Areas Involved
Lecture 18 (Nov 24 th ): LEARNING & MEMORY #1 Lecture Outline This Lecture: Psychology of Memory and Brain Areas Involved Next lecture: Neural Mechanisms for Memory 1) Psychology of Memory: Short Term
QUIZ/TEST REVIEW NOTES SECTION 7 NEUROPHYSIOLOGY [THE SYNAPSE AND PHARMACOLOGY]
![QUIZ/TEST REVIEW NOTES SECTION 7 NEUROPHYSIOLOGY [THE SYNAPSE AND PHARMACOLOGY]](/thumbs/86/94924826.jpg "QUIZ/TEST REVIEW NOTES SECTION 7 NEUROPHYSIOLOGY [THE SYNAPSE AND PHARMACOLOGY]")
QUIZ/TEST REVIEW NOTES SECTION 7 NEUROPHYSIOLOGY [THE SYNAPSE AND PHARMACOLOGY] Learning Objectives: Explain how neurons communicate stimulus intensity Explain how action potentials are conducted along
Synaptic Plasticity and Memory
Synaptic Plasticity and Memory Properties and synaptic mechanisms underlying the induction of long-term potentiation (LTP) The role of calcium/calmodulin-dependent kinase II (CamKII) in the induction,
Long-Term Potentiation and Memory
Physiol Rev 84: 87 136, 2004; 10.1152/physrev.00014.2003. Long-Term Potentiation and Memory M. A. LYNCH Trinity College Institute of Neuroscience, Department of Physiology, Trinity College, Dublin, Ireland
Synapse. Structure & Function. Neurotransmitter Sequence. Integration. History: 10/4/12 original version
Synapse History: 10/4/12 original version Structure & Function (This content is covered in Sinjin's presentation, see link in calendar) Neurotransmitters Synaptic cleft Post-synaptic potential Excitation
Neuroscience 201A (2016) - Problems in Synaptic Physiology
Question 1: The record below in A shows an EPSC recorded from a cerebellar granule cell following stimulation (at the gap in the record) of a mossy fiber input. These responses are, then, evoked by stimulation.
Structure of a Neuron:
Structure of a Neuron: At the dendrite the incoming signals arrive (incoming currents) At the soma current are finally integrated. At the axon hillock action potential are generated if the potential crosses
SAMPLE EXAMINATION QUESTIONS
SAMPLE EXAMINATION QUESTIONS PLEASE NOTE, THE QUESTIONS BELOW SAMPLE THE ENTIRE LECTURE COURSE AND THEREORE INCLUDE QUESTIONS ABOUT TOPICS THAT WE HAVE NOT YET COVERED IN CLASS. 1. Which of the following
Astrocyte signaling controls spike timing-dependent depression at neocortical synapses
Supplementary Information Astrocyte signaling controls spike timing-dependent depression at neocortical synapses Rogier Min and Thomas Nevian Department of Physiology, University of Berne, Bern, Switzerland
Problem Set 3 - Answers. -70mV TBOA
Harvard-MIT Division of Health Sciences and Technology HST.131: Introduction to Neuroscience Course Director: Dr. David Corey HST 131/ Neuro 200 18 September 05 Explanation in text below graphs. Problem
Synaptic Transmission: Ionic and Metabotropic
Synaptic Transmission: Ionic and Metabotropic D. Purves et al. Neuroscience (Sinauer Assoc.) Chapters 5, 6, 7. C. Koch. Biophysics of Computation (Oxford) Chapter 4. J.G. Nicholls et al. From Neuron to
Ligand-Gated Ion Channels
Ligand-Gated Ion Channels The Other Machines That Make It Possible... Topics I Introduction & Electrochemical Gradients Passive Membrane Properties Action Potentials Voltage-Gated Ion Channels Topics II
9.01 Introduction to Neuroscience Fall 2007
MIT OpenCourseWare http://ocw.mit.edu 9.01 Introduction to Neuroscience Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. 9.01 Recitation (R02)
9.01 Introduction to Neuroscience Fall 2007
MIT OpenCourseWare http://ocw.mit.edu 9.01 Introduction to Neuroscience Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. Emotion Sebastian Seung
Chapter 6 subtitles postsynaptic integration
CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND Chapter 6 subtitles postsynaptic integration INTRODUCTION (1:56) This sixth and final chapter deals with the summation of presynaptic currents. Glutamate and
1) Drop off in the Bi 150 box outside Baxter 331 or to the head TA (jcolas).
Bi/CNS/NB 150 Problem Set 3 Due: Tuesday, Oct. 27, at 4:30 pm Instructions: 1) Drop off in the Bi 150 box outside Baxter 331 or e-mail to the head TA (jcolas). 2) Submit with this cover page. 3) Use a
Post stroke aphasia: recovery and reorganization
Post stroke aphasia: recovery and reorganization Gerard M Ribbers R o t t e r d a m N e u r o r e h a b i l i t a t i o n R e s e a r c h Context R o t t e r d a m N e u r o r e h a b i l i t a t i o n
Lisa M. Giocomo & Michael E. Hasselmo
Mol Neurobiol (2007) 36:184 200 DOI 10.1007/s12035-007-0032-z Neuromodulation by Glutamate and Acetylcholine can Change Circuit Dynamics by Regulating the Relative Influence of Afferent Input and Excitatory
Behavioral Neuroscience: Fear thou not. Rony Paz
Behavioral Neuroscience: Fear thou not Rony Paz Rony.paz@weizmann.ac.il Thoughts What is a reward? Learning is best motivated by threats to survival Threats are much better reinforcers Fear is a prime
A Model of Spike-Timing Dependent Plasticity: One or Two Coincidence Detectors?
RAPID COMMUNICATION J Neurophysiol 88: 507 513, 2002; 10.1152/jn.00909.2001. A Model of Spike-Timing Dependent Plasticity: One or Two Coincidence Detectors? UMA R. KARMARKAR AND DEAN V. BUONOMANO Departments
Biological Psychology 2012 Spring 2005 Patterson
Final Exam Biological Psychology 2012 Spring 2005 Patterson There are two versions of this exam. You have version A. Before starting the exam, mark A on question 60. MULTIPLE CHOICE. Choose the one alternative
Neurons. Pyramidal neurons in mouse cerebral cortex expressing green fluorescent protein. The red staining indicates GABAergic interneurons.
Neurons Pyramidal neurons in mouse cerebral cortex expressing green fluorescent protein. The red staining indicates GABAergic interneurons. MBL, Woods Hole R Cheung MSc Bioelectronics: PGEE11106 1 Neuron
Ube3a is required for experience-dependent maturation of the neocortex
Ube3a is required for experience-dependent maturation of the neocortex Koji Yashiro, Thorfinn T. Riday, Kathryn H. Condon, Adam C. Roberts, Danilo R. Bernardo, Rohit Prakash, Richard J. Weinberg, Michael
STDP between a Pair of Recurrently Connected Neurons with Asynchronous and Synchronous Stimulation AZADEH HASSANNEJAD NAZIR
STDP between a Pair of Recurrently Connected Neurons with Asynchronous and Synchronous Stimulation AZADEH HASSANNEJAD NAZIR Master of Science Thesis Stockholm, Sweden 2012 STDP between a Pair of Recurrently
BIOLOGY 12 NERVOUS SYSTEM PRACTICE
1 Name: BIOLOGY 12 NERVOUS SYSTEM PRACTICE Date: 1) Identify structures X, Y and Z and give one function of each. 2) Which processes are involved in the movement of molecule Y from point X to point Z?
Cell Responses in V4 Sparse Distributed Representation
Part 4B: Real Neurons Functions of Layers Input layer 4 from sensation or other areas 3. Neocortical Dynamics Hidden layers 2 & 3 Output layers 5 & 6 to motor systems or other areas 1 2 Hierarchical Categorical
TA Review. Neuronal Synapses. Steve-Felix Belinga Neuronal synapse & Muscle
TA Review Steve-Felix Belinga sbelinga@wustl.edu Neuronal synapse & Muscle Neuronal Synapses 1 Things you should know beyond the obvious stuff 1. Differences between ionotropic and metabotropic receptors.
Bioscience in the 21st century
Bioscience in the 21st century Neurons, Synapses, and Signaling Dr. Michael Burger Outline: 1. Why neuroscience? 2. The neuron 3. Action potentials 4. Synapses 5. Organization of the nervous system 6.
Ionotropic glutamate receptors (iglurs)
Ionotropic glutamate receptors (iglurs) GluA1 GluA2 GluA3 GluA4 GluN1 GluN2A GluN2B GluN2C GluN2D GluN3A GluN3B GluK1 GluK2 GluK3 GluK4 GluK5 The general architecture of receptor subunits Unique properties
3.E.2 Continued. This is the essential knowledge statement from the curriculum framework. Detect---process--- response
Nervous System: Part III What Happens at a Synapse? 3.E. Continued Animals have nervous systems that detect external and internal signals, transmit and integrate information, and produce responses. This
Neuroplasticity:. Happens in at least 3 ways: - - -
BRAIN PLASTICITY Neuroplasticity:. Happens in at least 3 ways: - - - Recently, it was found that new neurons and glial cells are born in specific brain regions - reorganization. Brain plasticity occurs
BRAIN PLASTICITY. Neuroplasticity:. Happens in at least 3 ways: - - -
BRAIN PLASTICITY Neuroplasticity:. Happens in at least 3 ways: - - - Recently, it was found that new neurons and glial cells are born in specific brain regions - reorganization. Brain plasticity occurs
(a) Gene for NMDA receptor subunit knocked out selectively in hippocampus No LTP in hippocampal region CA1, no water-maze learning by mouse.
7.29 J 9.09 Cellular Neurobiology Answers to 2009 Midterm Test Question 1. (a) Gene for NMDA receptor subunit knocked out selectively in hippocampus No LTP in hippocampal region CA1, no water-maze learning
LESSON 3.3 WORKBOOK. Why does applying pressure relieve pain?
Postsynaptic potentials small changes in voltage (membrane potential) due to the binding of neurotransmitter. Receptor-gated ion channels ion channels that open or close in response to the binding of a
Behavioral Neuroscience: Fear thou not. Rony Paz
Behavioral Neuroscience: Fear thou not Rony Paz Rony.paz@weizmann.ac.il Thoughts What is a reward? Learning is best motivated by threats to survival? Threats are much better reinforcers? Fear is a prime
Action Potentials and Synaptic Transmission. BIO 219 Napa Valley College Dr. Adam Ross
Action Potentials and Synaptic Transmission BIO 219 Napa Valley College Dr. Adam Ross Review of action potentials Nodes of Ranvier Nucleus Dendrites Cell body In saltatory conduction, the nerve impulses
QUIZ YOURSELF COLOSSAL NEURON ACTIVITY
QUIZ YOURSELF What are the factors that produce the resting potential? How is an action potential initiated and what is the subsequent flow of ions during the action potential? 1 COLOSSAL NEURON ACTIVITY
Investigation of Physiological Mechanism For Linking Field Synapses
Investigation of Physiological Mechanism For Linking Field Synapses Richard B. Wells 1, Nick Garrett 2, Tom Richner 3 Microelectronics Research and Communications Institute (MRCI) BEL 316 University of
Long-term synaptic plasticity. N500, 6 Sept., 2016
Long-term synaptic plasticity N500, 6 Sept., 2016 We just finished describing short-term synaptic changes What about long-term changes? How does the brain store information? Outline Origins of the synaptic
Neurobiology: The nerve cell. Principle and task To use a nerve function model to study the following aspects of a nerve cell:
Principle and task To use a nerve function model to study the following aspects of a nerve cell: INTRACELLULAR POTENTIAL AND ACTION POTENTIAL Comparison between low and high threshold levels Comparison
Section: Chapter 5: Multiple Choice. 1. The structure of synapses is best viewed with a(n):
Section: Chapter 5: Multiple Choice 1. The structure of synapses is best viewed with a(n): p.155 electron microscope. light microscope. confocal microscope. nissle-stained microscopic procedure. 2. Electron
Introduction to Neurobiology
Biology 240 General Zoology Introduction to Neurobiology Nervous System functions: communication of information via nerve signals integration and processing of information control of physiological and
Memory: Computation, Genetics, Physiology, and Behavior. James L. McClelland Stanford University
Memory: Computation, Genetics, Physiology, and Behavior James L. McClelland Stanford University A Playwright s Take on Memory What interests me a great deal is the mistiness of the past Harold Pinter,
Neurochemistry 2. Loewi s experiment
Neurochemistry 2 Loewi s experiment Cengage Learning 2016 AP reaches the axon terminal and activates voltage-gated Ca++ channels (3 major classes). Ca++ influx results in exocytosis of neurotransmitters
The role of phase synchronization in memory processes
The role of phase synchronization in memory processes Juergen Fell and Nikolai Axmacher Abstract In recent years, studies ranging from single-unit recordings in animals to electroencephalography and magnetoencephalography