BULLETIN # 50. Manitoba Drug Benefits and Interchangeability Formulary Amendments. The following amendments will take effect on March 13, 2006.

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1 BULLETIN # 50 Manitoba Drug Benefits and Interchangeability Formulary Amendments The following amendments will take effect on March 13, The amended Manitoba Specified Drug Regulation and Drug Interchangeability Formulary Regulation will be available on the Manitoba Health website on the effective date of March 13, Bulletin 50 is currently available for download: Inside This Issue Part 1 Additions Page 1 Part 2 Deletions Page 1 Part 3 Additions Page 1-4 New Interchangeable Product Page 4 Category Deletions Page 4 Interchangeable Product Price Changes Page 4-7

2 Part 1 Addition Bulletin # Rhoxal-lovastatin lovastatin 20 mg Tablet RXP Part 2 Deletions Apo-Omeprazole HP-PAC omeprazole 20 mg Capsules APX lansoprazole/ amoxicillin 30 mg/ 500 mg/ 500 mg Capsule/ Capsule ABB Losec omeprazole 20 mg Delayed Release Losec omeprazole 20 mg Capsules -- Losec A omeprazole/ amoxicillin 20 mg/ 500 mg/ 1000 mg Capsule Losec M Pantoloc Pariet Prevacid omeprazole/ metronidazole 20 mg/ 250 mg/ 500 mg pantoprazole 40 mg rabeprazole lansoprazole 10 mg 20 mg 15 mg 30 mg Tablet Enteric Coated Enteric Coated Release Capsules SOL JAN ABB Part 3 The following products will be considered for Pharmacare reimbursement upon an individual prescriber/patient request basis Apo-Omeprazole omeprazole 20 mg Capsules APX 1 of 7

3 History of peptic or duodenal ulcer (d) For PPIs in Zollinger-Ellison Syndrome and Barrett s Esophagus Bulletin # HP-PAC - For H. pylori eradication. lansoprazole/ amoxicillin 30 mg/ 500 mg/ 500 mg Capsule/ Capsule ABB -- Losec A - For H. pylori eradication. omeprazole/ amoxicillin 20 mg/ 500 mg/ 1000 mg Capsule -- Losec M - For H. pylori eradication. omeprazole/ metronidazole 20 mg/ 250 mg/ 500 mg Tablet Losec (20 mg moved from Part 2) omeprazole 10 mg 20 mg 10 mg 20 mg / Capsules History of peptic or duodenal ulcer (d) For H. pylori Eradication (The PPI may be approved for a 7-14 day treatment course.) (e) For PPIs in Zollinger-Ellison Syndrome and Barrett s Esophagus 2 of 7

4 Pantoloc Enteric Coated pantoprazole 40 mg (40 mg moved from Part 2) History of peptic or duodenal ulcer (d) For H. pylori Eradication (The PPI may be approved for a 7-14 day treatment course.) (e) For PPIs in Zollinger-Ellison Syndrome and Barrett s Esophagus Note: Omeprazole and rabeprazole must have been tried and failed or not tolerated. SOL Pariet 10 mg Enteric Coated rabeprazole 20 mg History of peptic or duodenal ulcer (d) For H. pylori Eradication (The PPI may be approved for a 7-14 day treatment course.) (e) For PPIs in Zollinger-Ellison Syndrome and Barrett s Esophagus JAN Prevacid lansoprazole 15 mg 30 mg Release Capsules ABB 3 of 7

5 History of peptic or duodenal ulcer (d) For H. pylori Eradication (The PPI may be approved for a 7-14 day treatment course.) (e) For PPIs in Zollinger-Ellison Syndrome and Barrett s Esophagus Note: Omeprazole and raberprazole must have been tried and failed or not tolerated. New Interchangeable Product The following product has been added to an existing interchangeable drug category: Lovastatin - 20 mg - $ Rhoxal-lovastatin RXP Folic Acid - 5 mg - Category Deletions Interchangeable Product Price Changes The following changes in prices have occurred: ($) Anuzinc zinc sulfate 10 mg Suppositories Arava leflunomide 10 mg Arava leflunomide 20 mg Calcimar calcitonin 200 IU/mL Injection Coumadin warfarin 1 mg Coumadin warfarin 2 mg Coumadin warfarin 2.5 mg Coumadin warfarin 3 mg Coumadin warfarin 4 mg Coumadin warfarin 5 mg Coumadin warfarin 10 mg Cytoxan cyclophosamide 25 mg Cytoxan cyclophosamide 50 mg Diabeta glyburide 2.5 mg Diabeta glyburide 5 mg Didronel etidronate disodium 200 mg of 7

6 Endocet oxycodone HCl/ acetaminophen 5 mg/325 mg Estradot estradiol 17B/estrogen 50 mcg Transdermal Patch Estradot estradiol 17B/estrogen 75 mcg Transdermal Patch Estradot estradiol 17B/estrogen 100 mcg Transdermal Patch Glucophage metformin 500 mg Glucophage metformin 850 mg Hycort hydrocortisone 100 mg/60 ml Enema Imovane zopiclone 7.5 mg Kayexalate sodium polystyrene sulfonate 454 g Oral Powder Lamisil terbinafine 250 mg Lasix furosemide 20 mg Lasix furosemide 40 mg Librax chlordiazepoxide HCl/clindium bromide 5 mg/2.5 mg Capsules Lioresal baclofen 10 mg Lioresal D.S. baclofen 20 mg Lipidil Micro fenofibrate 200 mg Capsules Lopressor metoprolol 50 mg Lopressor metoprolol 100 mg Megace megestrol acetate 160 mg Miacalcin NS calcitonin (salmon synthetic) 200 IU Nasal Spray Mogadon nitrazepam 5 mg Mogadon nitrazepam 10 mg Monopril fosinopril 10 mg Monopril fosinopril 20 mg M.O.S morphine hydrochloride 5 mg/ml Syrup M.O.S morphine hydrochloride 20 mg/ml Syrup Myochrysine sodium aurothiomalate 10 mg/ml Injection Myochrysine sodium aurothiomalate 50 mg/ml Injection Nitrazadon nitrazepam 10 mg Novo-Ampicillin ampicillin 250 mg Capsules Novo-Ampicillin ampicillin 500 mg Capsules Novo-Clopate clorazepate 3.75 mg Capsules Novo-Clopate clorazepate 7.5 mg Capsules Novo-Clopate clorazepate 15 mg Capsules Novo-Diflunasal diflunisal 250 mg Novo-Diflunasal diflunisal 500 mg Novo-Doxepin doxepin 25 mg Capsules Novo-Doxepin doxepin 50 mg Capsules Novo-Doxepin doxepin 75 mg Capsules Novo-Doxepin doxepin 100 mg Capsules Novo-Doxepin doxepin 150 mg Capsules Novo-Hylazin hydralazine 10 mg Novo-Hylazin hydralazine 25 mg Novo-Hylazin hydralazine 50 mg Novo-Hydroxyzin hydroxyzine 10 mg Capsules Novo-Hydroxyzin hydroxyzine 25 mg Capsules Novo-Hydroxyzin hydroxyzine 50 mg Capsules Novo-Prazin prazosin 1 mg of 7

7 Novo-Prazin prazosin 2 mg Novo-Prazin prazosin 5 mg Novo-Purol allopurinol 100 mg Novo-Purol allopurinol 200 mg Novo-Purol allopurinol 300 mg Novo-Timol timolol maleate 5 mg Novo-Timol timolol maleate 10 mg Novo-Triamzide triamterene/ hydrochlorothiazide 50 mg/25 mg Os-Cal calcium carbonate 500 mg Planquenil hydroxychloroquine sulfate 200 mg pms-hydromorphone hydromorphone 1 mg/ml Oral Liquid pms-metoclopramide metoclopramide 5 mg/5 ml Oral Solution Pravachol pravastatin sodium 10 mg Pravachol pravastatin sodium 20 mg Pravachol pravastatin sodium 40 mg ratio-atenolol atenolol 50 mg ratio-ciprofloxacin ciprofloxacin 250 mg ** ratio-ciprofloxacin ciprofloxacin 500 mg ** ratio-ciprofloxacin ciprofloxacin 750 mg ** ratio-ipra Sal UVD ipratropium 0.2 mg/ bromide/salbutamol 1 mg/ml Unit Dose Vial Rifadin rifampin 150 mg Capsules Rifadin rifampin 300 mg Capsules Ritalin methylphenidate 10 mg Ritalin methylphenidate 20 mg Sandoz dexamethasone 0.1% Ophthalmic/ Dexamethasone Otic Solution Sectral acebutalol 100 mg Sectral acebutalol 200 mg Sectral acebutalol 400 mg Sinemet CR levodopa/carbidopa 200 mg/50 mg Sofracort framycetin sulfate/ gramicidin/ 5 mg/ 0.05 mg/ Otic/ Ophthalmic dexamethasone 0.5 mg/ml Solution Surgam tiaprofenic acid 300 mg Tegretol carbamazepine 200 mg Tegretol carbamazepine 100 mg Chewable Tegretol carbamazepine 200 mg Chewable Tegretol CR carbamazepine 200 mg Release Tegretol CR carbamazepine 400 mg Release Trental pentoxifylline 400 mg Visken pindolol 5 mg Visken pindolol 10 mg Visken pindolol 15 mg Vitamin B12 cyanocobalamin 1 mg/ml Injection Voltaren diclofenac sodium 50 mg Suppositories Voltaren diclofenac sodium 100 mg Suppositories of 7

8 Voltaren diclofenac sodium 50 mg Voltaren Rapide diclofenac potassium 50 mg Voltaren SR diclofenac sodium 75 mg Slow Release Voltaren SR diclofenac sodium 100 mg Slow Release Sectral acebutalol 200 mg Sectral acebutalol 400 mg Sinemet CR levodopa/carbidopa 200 mg/50 mg Sofracort framycetin sulfate/ gramicidin/ 5 mg/ 0.05 mg/ Otic/ Ophthalmic dexamethasone 0.5 mg/ml Solution Surgam tiaprofenic acid 300 mg Tegretol carbamazepine 200 mg Tegretol carbamazepine 100 mg Chewable Tegretol carbamazepine 200 mg Chewable Tegretol CR carbamazepine 200 mg Release Tegretol CR carbamazepine 400 mg Release Trental pentoxifylline 400 mg Tryptan L-tryptophan 500 mg Capsules Tryptan L-tryptophan 500 mg Tryptan L-tryptophan 1 g Visken pindolol 5 mg Visken pindolol 10 mg Visken pindolol 15 mg Vitamin B12 cyanocobalamin 1 mg/ml Injection ** (0.3410) Voltaren diclofenac sodium 50 mg Suppositories Voltaren diclofenac sodium 100 mg Suppositories Voltaren diclofenac sodium 50 mg Voltaren Rapide diclofenac potassium 50 mg Voltaren SR diclofenac sodium 75 mg Slow Release Voltaren SR diclofenac sodium 100 mg Slow Release Winpred prednisone 1 mg ** The price change has resulted in a change to the lowest price in the category. ( ) Denotes the price of the lowest generic product in the product category. 7 of 7

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