PICU Therapeutic Hypothermia Post Cardiac Arrest Re Warming Phase

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1 Arrest Re Warming Phase Weight Allergies Patient Care ***After 24 hours initiate re warming (or after 72 hours for an infant less than one month old)*** PICU Re Warming Protocol ***See Reference Text*** Communication Seizure Precautions Monitor for Seizure Activity Medications Medication sentences are per dose. You will need to calculate a total daily dose if needed. Loading Dose PHENobarbital (PHENobarbital pediatric) 10 mg/kg, IVPush, inj, ONE TIME, PRN seizure activity Recommended maximum dose = 1000 mg. Suggested rate NOT TO EXCEED 1 mg/kg/min (max: 30 mg/min). 20 mg/kg, IVPush, inj, ONE TIME, PRN seizure activity Recommended maximum dose = 1000 mg. Suggested rate NOT TO EXCEED 1 mg/kg/min (max: 30 mg/min). levetiracetam (levetiracetam pediatric) 20 mg/kg, IVPB, inj, ONE TIME, PRN seizure activity Recommended maximum dose = 2500 mg. Suggested to infuse over 15 minutes. fosphenytoin (fosphenytoin pediatric) 10 mgpe/kg, IVPush, inj, ONE TIME, PRN seizure activity Recommended maximum dose = 1000 mg. Suggested infusion rate of 1 3 mgpe/kg/min (max of 150 mgpe/min). 20 mgpe/kg, IVPush, inj, ONE TIME, PRN seizure activity Recommended maximum dose = 1000 mg. Suggested infusion rate of 1 3 mgpe/kg/min (max of 150 mgpe/min). Maintenance Dose PHENobarbital (PHENobarbital pediatric) 3 mg/kg, IVPush, inj, q12h Recommended maximum dose = 1000 mg. Suggested rate NOT TO EXCEED 1 mg/kg/min (max: 30 mg/min). levetiracetam (levetiracetam pediatric) 10 mg/kg, IVPB, inj, q12h Recommended maximum dose = 2500 mg. Suggested to infuse over 15 minutes. fosphenytoin (fosphenytoin pediatric) 2 mgpe/kg, IVPush, inj, q8h Recommended maximum dose = 1000 mg. Suggested infusion rate of 1 3 mgpe/kg/min (max of 150 mgpe/min). Laboratory CBC Routine, T;N, q6h for 2 days Prothrombin Time with INR Page: 1 Arrest Version: 1 Effective on: 08/13/13

2 Arrest Re Warming Phase PTT Comprehensive Metabolic Panel Arterial Blood Gas Routine, Additional Tests: Lactate, q6h For 2 days Phenobarbital Level Phenytoin Level Free Phenytoin Level Total Culture Blood Blood, Routine, T;N, q24h for 1 days Culture Urine Urine, Routine, T;N Culture Sputum with Gram Stain Sputum, Routine, T;N Page: 2 Arrest Version: 1 Effective on: 08/13/13

3 Arrest Initial Phase Patient Care PICU Therapeutic Hypothermia Guidelines ***Required to continue with ordering Plan.*** Vital Signs Per Unit Standards, Continous monitoring and record q1h q1h Strict Intake and Output Per Unit Standards Set Up for Arterial Line Placement Set Up for Central Line Placement Insert Gastric Tube Nasogastric NG Orogastric OG If patient has existing NG/OG tube: Maintain Gastric Tube Insert Urinary Catheter Foley, with CBT Monitor. Criticore, with CBT Monitor. Monitoring Core Body Temperature Monitoring Utilize Bladder, Trans Esophageal, or Rectal Thermometers for CBT. End Tidal CO2 Monitoring Laboratory Baseline Labs CBC with Differential Comprehensive Metabolic Panel DIC Panel Arterial Blood Gas, Additional Tests: Lactate Amylase Level Lipase Level Diagnostic Tests DX Chest Portable Consults/Referrals Page: 3 Arrest Version: 1 Effective on: 08/13/13

4 Arrest Initial Phase Consult MD Service: Pedi Neurosurgery...Additional Orders Page: 4 Arrest Version: 1 Effective on: 08/13/13

5 Arrest Initial Phase PICU Continuous Med Infusion Plan IV Solutions Standard Concentration DOBUTamine 100 mg/50 ml D5W (NI/PI) IVsyr Final concentration = 2 mg/ml (2000 mcg/ml) Range is 2 20 mcg/kg/min Start at rate: mcg/kg/min This patient is allergic to morphine. EPINEPHrine 1.25 mg/50 ml D5W (Pedi) milrinone 5 mg/50 ml NS (Pedi) IVsyr Final concentration 0.1 mg/ml (100 mcg/ml). Mixed in syringe. Usual Dose Range is mcg/kg/min. Notify physician if administered dose (rate) is greater than the usual dose range. Start at rate: mcg/kg/min isoproterenol 1.6 mg/50 ml NS (Pedi) lidocaine 200 mg/50 ml NS (PICU) nitroprusside 5 mg/50 ml D5W (NICU) norepinephrine 0.8 mg/50 ml NS (Pedi) Maximum Concentration DOBUTamine 200 mg/50 ml D5W (NI/PI) EPINEPHrine 2.5 mg/50 ml D5W (Pedi) milrinone 10 mg/50 ml NS (Pedi) isoproterenol 3.2 mg/50 ml NS (Pedi) lidocaine 400 mg/50 ml NS (PICU) nitroprusside 10 mg/50 ml D5W (NICU) norepinephrine 1.6 mg/50 ml NS (Pedi) Minimum Concentration Page: 5 Arrest Version: 1 Effective on: 08/13/13

6 Arrest Initial Phase PICU Continuous Med Infusion Plan DOBUTamine 50 mg/50 ml D5W (NI/PI) DOPamine 40 mg/50 ml D5W (NI/PI) IVsyr Final concentration= 0.8 mg/ml (800 mcg/ml). Mixed in syringe. Dose range is 2 20 mcg/kg/min. Titrate to desired effect. Start at rate: mcg/kg/min EPINEPHrine 0.5 mg/50 ml D5W (Pedi) isoproterenol 0.8 mg/50 ml NS (Pedi) Page: 6 Arrest Version: 1 Effective on: 08/13/13

7 Arrest Initial Phase PICU Mechanical Ventilation Plan Patient Care Patient Activity Bedrest, HOB elevation degrees Obtain Specialty Bed Order: Rotorest Perform Oral Care Per Unit Standards Per Unit Standards, Assess and brush teeth within 2 hours of admission. Then brush teeth every 12 hours q4h q4h, Assess and brush teeth within 2 hours of admission. Then brush teeth every 12 hours Suction Patient Per VAP Protocol Perform Neurological Checks q1h q1h, until NMBA infusion rate has not changed for 4 hours, then q2h. q2h Insert Gastric Tube Nasogastric NG Dobhoff Tube Monitoring Brain Function Monitoring (Apply Brain Function Monitor) Type: Brain Z Type: 5 Lead EEG Type: SEDline Protocol VAP Prevention Protocol Neuromuscular Blocking Agent Protocol Peripheral Nerve Stimulator Protocol Medications Medication sentences are per dose. You will need to calculate a total daily dose if needed. ocular lubricant (Lacri Lube S.O.P. ophthalmic ointment) 1 app, both eyes, ophth oint, As Needed, PRN dry eyes Paralytic Titrate Train of Four to be 2/4 twitches. Perform Train of Four (TOF) every 30 minutes during initiation until desired TOF is reached and every 4 hours throughout duration of therapy to maintain ordered TOF. ***Do not perform wake up trials while patient is on paralytic*** Page: 7 Arrest Version: 1 Effective on: 08/13/13

8 Arrest Initial Phase PICU Mechanical Ventilation Plan vecuronium 0.05 mg/kg, IVPush, inj, ONE TIME 0.08 mg/kg, IVPush, inj, ONE TIME 0.1 mg/kg, IVPush, inj, ONE TIME vecuronium 30 mg/30 ml NS (Pedi) IVsyr Final Concentration = 1 mg/ml (1000 mcg/ml). Mixed in syringe. Dose range is mg/kg/hr. Titrate to desired effect. Start at rate: mg/kg/hr rocuronium 0.3 mg/kg, IVPush, inj, ONE TIME 0.45 mg/kg, IVPush, inj, ONE TIME 0.6 mg/kg, IVPush, inj, ONE TIME 1.2 mg/kg, IVPush, inj, ONE TIME rocuronium 30 mg/30 ml NS (Pedi) IVsyr Final concentration 1 mg/ml. Usual dose range is mg/kg/hr Start at rate: mg/kg/hr Respiratory Ventilator Settings Ventilator Settings APRV Ventilator Settings HFOV CPAP BiPAP SiPAP Arterial Blood Gas End Tidal CO2 Monitoring Weaning Parameters Page: 8 Arrest Version: 1 Effective on: 08/13/13

9 Arrest Initial Phase PICU Procedural Sedation Med Plan IV Solutions NS IV, ml/hr Medications Medication sentences are per dose. You will need to calculate a total daily dose if needed. midazolam (midazolam pediatric) 10 mg, IVPush, inj, ONE TIME Vial to bedside. fentanyl (fentanyl pediatric) 250 mcg, IVPush, inj, ONE TIME Vial to bedside. propofol 200 mg, IVPush, inj, ONE TIME Vial to bedside. ketamine (ketamine pediatric) 200 mg, IVPush, inj, ONE TIME Vial to bedside. lidocaine topical (lidocaine 4% topical solution) 2 ml, inhalation, soln, ONE TIME To bedside. Dilute in 3 ml NSS. lidocaine (lidocaine 1% preservative free injectable solution) 5 ml, locally, inj, ONE TIME Vial to bedside. lidocaine topical (lidocaine 2% topical gel with applicator) 1 app, topical, jelly, ONE TIME ranitidine (ranitidine pediatric) 0.67 mg/kg, IVsyr, syringe, ONE TIME Diluent NS. Infuse over 30 min. Dose + 3 ml overfill. 1 mg/kg, IVsyr, syringe, ONE TIME Diluent NS. Infuse over 30 min. Dose + 3 ml overfill mg/kg, IVsyr, syringe, ONE TIME Diluent NS. Infuse over 30 min. Dose + 3 ml overfill. metoclopramide (metoclopramide pediatric) 0.1 mg/kg, IVPush, inj, ONE TIME Page: 9 Arrest Version: 1 Effective on: 08/13/13

10 Arrest Cooling Phase Patient Care ***At 24 hours from time the time of cooling induction, advance to and initiate Re Warming Phase. Except in infants less than 1 month old where cooling is maintained for 72 hours.*** PICU Cooling Induction and Maintenance P (PICU Cooling Induction and Maintenance Protocol) ***See Reference Text*** Apply K Thermia (Cooling) Cooling Measures For Induction (T > 34C) set blanket to 6 degrees Celcius. For Maintaince (T 32 34C) set to automatic mode at 33 degrees Celcius. If temp <32 degrees Celcius turn off blanket. K Thermia, Without Pads Apply Ice To: Head, Torso, and Extremities, until Temp Degrees Celcius then remove. Laboratory CBC Routine, T;N, q6h for 2 days Prothrombin Time with INR PTT Comprehensive Metabolic Panel Arterial Blood Gas Routine, Additional Tests: Lactate, q6h For 2 days Culture Blood Blood, Routine, T;N, q24h for 1 days Culture Urine Urine, Routine, T;N Culture Sputum with Gram Stain Sputum, Routine, T;N Diagnostic Tests EEG Request Page: 10 Arrest Version: 1 Effective on: 08/13/13

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