Learning and Memory. The Case of H.M.

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1 Learning and Memory Learning deals with how experience changes the brain Memory refers to how these changes are stored and later reactivated The Case of H.M. H.M. suffered from severe, intractable epilepsy He apparently had epileptic foci in both medial temporal lobes Unilateral medial temporal lobectomy (removal of a portion of the lobe) had proven successful in patients with one epileptic focus Bilateral medial temporal lobectomy was prescribed for H.M.; this included removal of the hippocampus and amygdala 1

2 The Case of H.M. Results of the Surgery: H.M. s convulsions were reduced in severity and frequency His measurable I.Q. increased from about 104 to 118 He remained an emotionally stable individual H.M. suffered from devastating amnesia 2

3 Forms of Amnesia: Anterograde: Amnesia for events that occur after some disturbance to the brain, such as head injury or certain degenerative brain diseases. Retrograde: Amnesia for events that preceded some disturbance to the brain, such as a head injury or electroconvulsive shock. Copyright Allyn and Bacon

4 H.M. s Memory Deficits H.M. has minor retrograde amnesia for the events of the 2 years preceding the surgery He has normal memory for events in the remote past and normal shortterm memory However, he has severe anterograde amnesia he cannot form longterm memories for most events that occurred after his surgery Spared Learning Abilities Shortterm memory: Immediate memory for events, most of which are not consolidated into longterm memory. Longterm memories: Relatively stable memory of events that occurred in the more distant past, as opposed to shortterm memory. 4

5 Copyright Allyn and Bacon 2004 H.M. s specific problem appears to be a difficulty with memory consolidation the transfer of shortterm memories to longterm storage 5

6 At first, it was assumed that H.M. could not form longterm memories at all. However, extensive testing revealed that H.M. can retain information about certain types of tasks. demonstrated by his improved performance of these tasks over time despite improved performance, H.M. has no conscious recollection of previously practiced the tasks Copyright Allyn and Bacon 2004 H.M. s task was to draw a line within the boundaries of a starshaped target by watching his hand in a mirror. H.M. was asked to trace the star 10 times on each of 3 consecutive days. His performance improved over time, despite his having no conscious recollection of having performed the task before. 6

7 H.M. s memory for the items on the test was indicated by his ability to recognize the more fragmented versions of them when he was retested. Pavlovian conditioning Tones and a puff of air to the eye were presented to H.M.; he blinked in response Two years later, he retained this conditioned pairing almost perfectly, though he had no conscious awareness of his previous training 7

8 Impact of H.M. s Case Showed that the medial temporal lobes are important for forming and organizing memory Challenged the view that mnemonic (memoryrelated) functions are diffusely distributed throughout the brain Renewed efforts to relate specific brain structures to specific mnemonic processes Supported the theory that there are different modes of storage for shortterm and longterm memories Provided the first evidence that implicit (without conscious awareness) memory could survive in the absence of explicit (conscious) memory Divisions of Longterm Memory Copyright by Houghton Mifflin Company 8

9 Medial Temporal Lobe Amnesia The ability to form implicit longterm memories, coupled with difficulty forming explicit longterm memories, is often seen in cases of medial temporal lobe amnesia. Research on these amnesics has suggested that some kinds of explicit longterm memories are more likely to be disrupted. Problems with episodic memory ( memories for the events of one s own life) are more common than problems with semantic memory (memories for general facts or information) Patients who have experienced cerebral ischemia (disruption of blood flow) often suffer from medial temporal lobe amnesia Copyright Allyn and Bacon 2004 Patient R.B. suffered ischemic damage to his brain during heart surgery. He had pattern of amnesia similar to H.M. s, though his was not as severe. Obvious brain damage was restricted to the CA1 region of the hippocampus (supported the idea that the hippocampus was particularly important for some forms of memory) 9

10 Korsakoff s Amnesia Korsakoff s syndrome: Brain damage resulting from malnutrition associated with chronic alcoholism. Severe anterograde amnesia Severe retrograde amnesia» Most severe for recent memories» Also affects memories of events from years before (remote events) Amnesia believed to be associated (in part) with damage to the mediodorsal nuclei of the thalamus Activity Is Reduced In The Frontal Lobes Of Patients With Korsakoff s Syndrome PET scans from a normal patient (larger image) and a patient suffering from Korsakoff s syndrome (the inset) Red and yellow represent areas of high metabolic activity 10

11 Korsakoff s Syndrome Confabulation: The reporting of memories of events that did not take place without the intention to deceive; seen in people with Korsakoff s syndrome. Alzheimer s Disease A major cause of amnesia; first symptom is often a mild loss of memory In addition to both anterograde and retrograde amnesia, patients often display deficits in shortterm memory and some forms of implicit memory (those involving verbal or perceptual material, but not those involving sensorimotor learning) 11

12 Posttraumatic Amnesia Blows to the head can lead to a disturbance of consciousness (concussion), a complete loss of consciousness (coma), and amnesia Patients with posttraumatic amnesia generally have both anterograde and retrograde amnesia The retrograde amnesia seen after concussion or coma is typically worse for most recent memories this led to the suggestion that older memories are stored in a more permanent form through the process of consolidation Animal Models Of Amnesia (Similar to H.M. s) Medial temporal lobe damage makes this task very difficult if there is any kind of delay between the presentation of the sample object and the presentation of the two objects during the test run 12

13 Delayed NonmatchingtoSample Task Work with animal models of amnesia (delayed nonmatchingtosample task = DNMS) suggests that the hippocampus is important for some, but not all, forms of memory The DNMS task requires the ability to form longterm memories. The Hippocampus and Memory for Spatial Location The hippocampus plays a particularly important role in spatial memory Two tasks are widely used to test spatial memory in rodents Morris Water Maze Radial Arm Maze 13

14 Morris Water Maze Requires rats to learn the location of an invisible stationary platform and find it when swimming in opaque (milky) water Rats with hippocampal lesions have great difficulty Control rats easily learn the task Radial Arm Maze Test There is a central chamber with as many as 8 arms radiating from it. During each test, a few of the arms are baited with some kind of reward; rodents with an intact hippocampus learn to visit only the baited arms. 14

15 Hippocampal Place Cells Animals need to know where they are at all times, so they can hunt, explore new territories and find their way home Additional evidence for the importance of the hippocampus in spatial memory comes from the existence of place cells Each hippocampal place cell is activated when an animal is in a certain region in its environment A place cell that fires when an animal is in one position will stop firing when the animal moves to a different place Place Cell Firing Patterns From Mechanisms of Memory 15

16 Place cells fire in corresponding location in larger round chamber In animals and humans, spatial memories are first formed in the hippocampus Humans also use the hippocampus to acquire and store socalled declarative memories, involving all the events with which a person is involved during waking hours. Most scientists believe that the hippocampus is essential for processing and consolidating new memories 16

17 How Are Memories Formed? Memories can be formed by strengthening the connections between existing neurons to improve the effectiveness of their communication. LongTerm Potentiation (LTP) is an enduring increase in synaptic strength (efficacy) resulting from prior activity (experience) at the synapse LTP is an important model for studying the type of mechanisms that may underlie memory LongTerm Potentiation (LTP) is the kind of change postulated by Donald Hebb to underlie memory: It can persist for a long time (weeks in vivo) It occurs only when the both the presynaptic and postsynaptic neurons are simultaneously active = cells that fire together wire together Hebbian Theory: In general, synapses are strengthened when the pre and postsynaptic neurons are simultaniously active and weakened when their activity is not synchronized. Hebb first suggested the importance of correlated activity in strengthening synapses (1940s) 17

18 Evidence That LTP Is Related To The Neural Basis Of Learning And Memory LTP can be produced by patterns of electrical stimulation that mimic normal brain activity LTP is most prominent in brain structures that are implicated in learning and memory Behavioral conditioning can produce LTPlike changes in the hippocampus Many drugs that influence learning and memory have parallel effects on LTP Mutant mice that display little hippocampal LTP have difficulty learning the Morris water maze LTP Is Often Studied In The Rodent Hippocampal Slice Preparation 18

19 LTP Is Often Studied In The Rodent Hippocampal Slice Preparation Stimulating Electrode Recording Electrode From Mechanisms of Memory 19

20 LTP Is Often Studied In The Rodent Hippocampal Slice Preparation LongTerm Potentiation (LTP) fepsp Slope (% of Baseline) Tetanus No Tetanus 50 The slope of the field excitatory postsynaptic potential (fepsp) is a good measure of synaptic efficiency Time (min) 20

21 LongTerm Potentiation (LTP) fepsp Slope (% of Baseline) Tetanus No Tetanus 50 The slope of the field excitatory postsynaptic potential (fepsp) is a good measure of synaptic efficiency. It increases in response to a burst of intense stimulation Time (min) Many Forms of LTP Depend on Changes at Glutamate Synapses The brain has several types of receptors for glutamate AMPA receptors and NMDA receptors are both ionotrophic receptors (they open an ion channel in the postsynaptic cell) AMPA receptors open sodium channels if many AMPA receptors are activated, the postsynaptic membrane becomes significantly depolarized The NMDA receptor channel opens (and sodium and calcium pass through) only when the membrane is already significantly depolarized This requirement for cooccurrence of activity provides further support for Hebb s postulate and the putative role of LTP in learning 21

22 Coincidence Detection by the NMDA Receptor Thomson & Wadsworth, 2004 Coincidence Detection by the NMDA Receptor Synaptic Cleft Ca Gly Cytoplasm Ca Synaptic Cleft Gly Cytoplasm Mg Ca Glu Synaptic Glutamate Alone Mg From Mechanisms of Memory Glu Glutamate plus Membrane Depolarization 22

23 Understanding the molecular basis of LTP may help us understand the biochemistry of learning This may enable us to understand what impairs, and what may improve, memory Mice with genes that cause abnormalities in the NMDA receptor learn slowly mice with enhanced NMDA receptor function (nicknamed Doogie mice ) have better than normal memory for some types of tasks 23

24 Understanding the molecular basis of LTP may help us understand the biochemistry of learning This may enable us to understand what impairs, and what may improve, memory Mice with genes that cause abnormalities in the NMDA receptor learn slowly mice with enhanced NMDA receptor function (nicknamed Doogie mice ) have better than normal memory for some types of tasks Mice lacking AMPA receptors also have defects in both LTP and memory LTP experiments have helped to identify many of the putative memory enhancing drugs currently being studied as possible components of memory systems What about other types of drugs that might improve memory? Many memory boasting supplements increase blood flow to the brain Ex. Ginko biloba dilates blood vessels, and may have other effects on the brain as well Sometimes produces small improvements when given to Alzheimer s patients or other people with memory problems Results currently more equivocal for younger, normal brains 24

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