Divisional Director of International Clinical Research Mood & Anxiety Disorders. Year Education Education institution
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1 Curriculum Vitae Torsten Meldgaard Madsen MD H. Lundbeck A/S Divisional Director of International Clinical Research Mood & Anxiety Disorders Education Year Education Education institution 1993 Diploma in Medical Research Arhus University 1996 Medical Doctor Copenhagen University 2000 Ph.d. Copenhagen University Professional Experience Period Position / Company / Major responsibilities Divisional Director / H. Lundbeck A/S / Mood & Anxiety Disorders Head of Department / H. Lundbeck A/S / Mood & Anxiety Disorders Resident physician / Arhus University Hospital / Psychiatry Postdoctoral Associate / Yale University / Dept of Molecular Psychiatry Clinical rotation / Herlev Hospital / Several Departments
2 Research Fellow / Rigs Hospital/ Psychiatric Department
3 Supplementary Education / Training Year Activity Organized by Psychotherapy Course Danish Psychiatry Society Course series for residents in psychiatry Danish Psychiatry Society Membership of Professional Societies Year 1996-present 1996-present 1996-present Society Danish Medical Association Society for Neuroscience Danish Society for Neuroscience 2003-present Danish Psychiatric Society (served as board member ) 2003-present Danish and World Society of Biological Psychiatry (Board member of the Danish Society 2004-present) 2007-present DIA (Global, multidisciplinary association of academicians and pharmaceutical industry) Publication / Presentation Year Publication Chen F, Madsen TM, Wegener G, Nyengaard JR. Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression. Hippocampus 2009;20(12): Chen F, Madsen TM, Wegener G, Nyengaard JR. Repeated electroconvulsive
4 seizures increase the total number of synapses in adult male rat hippocampus. Eur Neuropsychopharmacol 2009;19(5): Warner-Schmidt JL, Madsen TM, Duman RS. Electroconvulsive seizure restores neurogenesis and hippocampus-dependent fear memory after disruption by irradiation. Eur J Neurosci 2008;27(6): Chen F, Madsen TM, Wegener G, Nyengaard JR. Changes in rat hippocampal CA1 synapses following imipramine treatment. Hippocampus 2008;18(7): Bolwig TG, Madsen TM. Electroconvulsive therapy in melancholia: the role of hippocampal neurogenesis. Acta Psychiatr Scand Suppl 2007;(433): Madsen TM, Bolwig TG, Mikkelsen JD. Differential regulation of c-fos and FosB in the rat brain after amygdala kindling. Cell Mol Neurobiol 2006;26(1): Madsen TM, Yeh DD, Valentine GW, Duman RS. Electroconvulsive seizure treatment increases cell proliferation in rat frontal cortex. Neuropsychopharmacology 2005;30(1): Link WA, Ledo F, Torres B, Palczewska M, Madsen TM, Savignac M, et al. Day-night changes in downstream regulatory element antagonist modulator/potassium channel interacting protein activity contribute to circadian gene expression in pineal gland. J Neurosci 2004;24(23):
5 Chen J, Newton SS, Zeng L, Adams DH, Dow AL, Madsen TM, et al. Downregulation of the CCAAT-enhancer binding protein beta in deltafosb transgenic mice and by electroconvulsive seizures. Neuropsychopharmacology 2004;29(1): Madsen TM, Newton SS, Eaton ME, Russell DS, Duman RS. Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis. Biol Psychiatry 2003;54(10): Altar CA, Whitehead RE, Chen R, Wortwein G, Madsen TM. Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biological Psychiatry 2003;54(7): Madsen TM, Kristjansen PEG, Bolwig TG, Wortwein G. Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience 2003;119(3): Mikkelsen JD, Karle J, Madsen TM. Intrahippocampal infusion of antisense oligodeoxynucleotide to the GABA(A) receptor gamma2 subunit enhances neuropeptide Y gene expression. Brain Res Bulletin 2001;54:91-9. Madsen TM, Treschow A, Bengzon J, Bolwig TG, Lindvall O, Tingström A. Increased neurogenesis in a model of electroconvulsive therapy. Biol Psychiatry 2000;47(12):
6 Madsen TM, Greisen MH, Nielsen SM, Bolwig TG, Mikkelsen JD. Electroconvulsive stimuli enhance both neuropeptide Y receptor Y1 and Y2 messenger RNA expression and levels of binding in the rat hippocampus. Neuroscience 2000;98(1):33-9. Madsen TM, Woldbye DP, Bolwig TG, Mikkelsen JD. Kainic acid seizure suppression by neuropeptide Y is not correlated to immediate early gene mrna levels in rats. Neurosci Lett 1999;271(1):21-4. Ulrichsen J, Woldbye DP, Madsen TM, Clemmesen L, Haugbøl S, Olsen CH, et al. Electrical amygdala kindling in alcohol-withdrawal kindled rats. Alcohol Alcohol 1998;33(3): Woldbye DP, Klemp K, MadsenTM. Neuropeptide Y attenuates naloxone-precipitated morphine withdrawal via Y5-like receptors. J Pharmacol Exp Ther 1998;284(2): Woldbye DP, Larsen PJ, Mikkelsen JD, Klemp K, Madsen TM, Bolwig, TG. Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nat Med 1997;3(7) Woldbye DPD, Madsen TM, Larsen PJ, Mikkelsen JD, Bolwig TG. Neuropeptide Y inhibits hippocampal seizures and wet dog shakes. Brain Res 1996;737(1-2):162-8.
7 McNulty JA, Madsen TM, Tsai SY, Fox LM, Tonder N. Regulation of synaptic ribbons in rat pineal gland explants by norepinephrine and sympathetic neurons in a co-culture model. Cell Tissue Res 1996;283(1): McNulty JA, Tsai SY, Fox LM, Madsen TM, Silberman S, Tonder N. Neurotrophic effects of the pineal gland: role of non-neuronal cells in co-cultures of the pineal gland and superior cervical ganglia. J Pineal Res 1995;19(1):40-50.
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