Position: Associate Professor, Department of Molecular and Integrative Physiology

Transcription

1 Principal Investigator Name: Dr. Paige C. Geiger Position: Associate Professor, Department of Molecular and Integrative Physiology Education: B.A.; Chemistry; University of Kansas; 1995 B.A.; English; University of Kansas; 1995 Ph.D.; Physiology; Mayo Graduate School; 2001 Previous Positions: Graduate Research Assistant, Applied Physiology Laboratory (Dr. Gary C. Sieck, PI), Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN National Science Foundation Postdoctoral Fellow, Muscle Physiology Laboratory (Prof. Giovanni Cecchi, PI), Department of Physiology, University of Florence, Florence, Italy Postdoctoral Fellow, Applied Physiology Laboratory (Dr. John O. Holloszy, PI), Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO Assistant Professor, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 2011-present Other Experience: 2001-present 2000-present 2004-present Associate Professor, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS Member, American Physiological Society Member, Biophysical Society Member, American College of Sports Medicine Conference Committee, American Physiological Society Honors: National Science Foundation International Postdoctoral Fellowship 2001 American Physiological Society Proctor and Gamble Professional Opportunity Award

2 Research Interests: Dr. Paige Geiger is an Associate Professor in the Department of Molecular and Integrative Physiology at the University of Kansas Medical Center. She did her graduate training with Dr. Gary Sieck at the Mayo Clinic in Rochester, MN and postdoctoral training with Dr. John Holloszy at Washington University School of Medicine in St. Louis, MO. She also completed a National Science Foundation Postdoctoral Fellowship under Professor Giovanni Cecchi at the University of Florence, Italy. Her research group studies physiological and molecular mechanisms that link abnormal insulin signaling with the development of whole body and skeletal muscle insulin resistance. Her integrative research approach combines whole animal, muscle, and muscle cell culture techniques with cellular and molecular biology. The three main research projects in the laboratory are 1) heat shock protein-mediated protection against insulin resistance; 2) the role of estrogen receptors in skeletal muscle insulin resistance; and 3) mechanisms of brain insulin resistance associated with neurodegeneration and Parkinson s Disease. Collaborative projects include examining the effect of oxidative stress on diabetic peripheral neuropathy and the impact of skeletal muscle metabolism on the pathology of ALS. Peer-reviewed Publications: 1. Morris, J.K., H. Zhang, A.A. Gupte, G.L. Bomhoff, J.A. Stanford, and P.C. Geiger. (2008) Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson s Disease. In Press, Brain Research. 2. Gupte, A.A., G.L. Bomhoff, and P.C. Geiger. (2008) Age-related differences in skeletal muscle insulin signaling: the role of stress kinases and heat shock proteins. In press, J Appl Physiol. 3. Wright, D.C., P.C. Geiger, D.H. Han, T.E. Jones, and J.O. Holloszy. (2007) Calcium induces increases in peroxisome proliferator-activated receptor γ coactivator-1α and mitochondrial biogenesis by a pathway leading to p38 mitogen activated protein kinase activation. J Biol Chem 282(26): Geiger, P.C., C. Hancock, D.C. Wright, D.H. Han, and J.O. Holloszy. (2007) IL-6 increases muscle insulin sensitivity only at super-physiological levels. Am J Physiol Endocrinol Metabl 292(6):E Wright, D.C., D.H. Han, P.M. Garcia-Roves, P.C. Geiger, T.E. Jones, and J.O. Holloszy. (2007) Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1a expression. J Biol Chem 282(1): , Geiger, P.C., J.F. Bailey, C.B. Mantilla, W.Z. Zhan, and G.C. Sieck. (2006) Changes in myosin heavy chain expression during postnatal development of rat diaphragm muscle. J Appl Physiol 101(6): Editorials directly highlighting this manuscript: Lewis, Michael I. (2006) Mechanism Underlying Myogenesis: Complex and Likely to Become More So! J Appl Physiol. 101(6): And Dempsey, Jerry (2006) Highlights from the Literature. Physiology, Vol

3 7. Geiger, P.C., D.C. Wright, D.H. Han, and J.O. Holloszy. (2006) How muscle insulin sensitivity is regulated: Testing of an hypothesis Am J Physiol Endocrinol Metab 291(6): E Wright, D.C., P.C. Geiger, D.H. Han, and J.O. Holloszy. (2006) Are tyrosine kinases involved in mediating contraction-stimulated muscle glucose uptake? Am J Physiol Endocrinol Metab, 290(1): E Wright, D.C., P.C. Geiger, J.O. Holloszy, and D.H. Han. (2005) Contraction-and hypoxiamediated glucose transport is mediated by a Ca 2+ dependent mechanism in slow-twitch rat soleus muscle. Am J Physiol Endocrinol Metab, 288(6):E Geiger, P.C., D.C. Wright, D.H. Han, and J.O. Holloszy. (2005) Activation of p38map kinase enhances sensitivity of muscle glucose transport to insulin. Am J Physiol Endocrinol Metab, 288: E Wright, D.C., P.C. Geiger, D.H. Han, and J.O. Holloszy. (2004) Phorbol Esters Effect Skeletal Muscle Glucose Transport in a Fiber Type Specific Manner. Am J Physiol Endocrinol Metab, 287:E Bagni, M.A., B. Colombini, P.C. Geiger, R. Berlinguer Palmini, and G. Cecchi. (2004) A non cross-bridge calcium-dependent stiffness in frog muscle fibers. Am J Physiol Cell Physiol, 286(6): C Bagni, M.A., B. Colombini, F. Colomo, P. Geiger, R.B. Palmini, G. Cecchi. (2003)Force response to stretches in activated frog muscle fibres at low tension. Adv Exp Med Biol, 538: ; discussion Geiger, P.C., J.P. Bailey, W.Z. Zhan, C.B. Mantilla, and G.C. Sieck. (2003) Denervationinduced changes in myosin heavy chain expression in the rat diaphragm muscle. J Appl Physiol, 95: Han, Y.S., P.C. Geiger, M.J. Cody, R.L. Macken, and G.C. Sieck. (2003) ATP Consumption rate per cross bridge depends on myosin heavy chain isoform. J Appl Physiol, 94: Sieck, G.C., Y.S. Prakash, Y.S. Han, Y.H. Fang, P.C. Geiger, and W.Z. Zhan. (2003) Changes in actomyosin ATP consumption rate in rat diaphragm muscle fibers during postnatal development. J Appl Physiol 94(5): Geiger, P.C., M.J. Cody, Y.S. Han, L.W. Hunter, W.Z. Zhan, and G.C. Sieck. (2002) Effects of hypothyroidism on maximum specific force in rat diaphragm muscle fibers. J Appl Physiol 92(4):

4 18. Heunks, L.M.A., M.J. Cody, P.C. Geiger, P.N.R. Dekhuijzen, and G.C. Sieck. (2001) Nitric oxide impairs calcium activation and slows cross-bridge cycling kinetics in skeletal muscle. J Appl Physiol 91: Geiger, P.C., M.J. Cody, R.L. Macken, and G.C. Sieck.(2001) Effect of unilateral denervation on maximum specific force in rat diaphragm muscle fibers. J Appl Physiol 90(4): Han, Y.S., D.N. Proctor, P.C. Geiger, and G.C. Sieck.(2001) Reserve capacity for ATP consumption during isometric contraction in human skeletal muscle fibers. J Appl Physiol 90(2): Geiger, P.C., M.J. Cody, R.L. Macken, M.E. Bayrd, Y.H. Fang, and G.C. Sieck. (2001) Selected Contribution: Mechanisms underlying increased force generation by rat diaphragm muscle fibers during development. J Appl Physiol 90(1): Geiger, P.C., M.J. Cody, R.L. Macken, and G.C. Sieck. (2000) Maximum specific force depends on myosin heavy chain content in rat diaphragm muscle fibers. J Appl Physiol 89(2): Geiger, P.C., M.J. Cody, and G.C. Sieck. (1999) Force-Calcium relationship depends on myosin heavy chain and troponin isoforms in rat diaphragm muscle fibers. J Appl Physiol 87(5): Abstracts/Presentations: Morris, J.K., Zhang, H., Gupte, A.A., Bomhoff, G.L., Geiger, P.C., and Stanford, J.A. Measures of insulin resistance in a 6-OHDA model of Parkinson s disease. Society for Neuroscience National Meeting, November Gupte, A.A., Bomhoff, G.L., and Geiger, P.C. Weekly Heat Therapy Restores Glucose Uptake in Insulin-resistant Skeletal Muscle: Role of Heat Shock Proteins and Stress Kinases. American Physiological Society Intersociety Meeting, Hilton Head, SC, September Gorres, B.K., Bomhoff, G.L., Gupte, A.A., and Geiger, P.C. Estrogen Receptor α: A potential player in glucose regulation. American Physiological Society Intersociety Meeting, Hilton Head, SC, September Morris, J.K., Gupte, A.A., Bomhoff, G.L., Stanford, J.A., and Geiger, P.C. High fat diet influences oxidative capacity and decreases striatal dopamine turnover: implications for diabetes and Parkinson s disease. American Physiological Society Intersociety Meeting, Hilton Head, SC, September Gupte, A.A., Bomhoff, G.L., Morris, J.K., Gorres, B.K., and Geiger, P.C. Mechanisms by which lipoic acid prevents high fat diet-induced insulin resestance in skeletal muscle. Oral and poster presentation at Experimental Biology, San Diego, CA, April 2008.

5 Gorres, B.K., Bomhoff, G.L., Gupte, A.A., and Geiger, P.C. Insulin Resistance in Females: The impact of estrogen and high fat diet Student Research Forum Presentation. 10 th place overall (out of 100). Gupte, A., Bomhoff, G.L., Touchberry, C.D., Dollerschell, J.T., and Geiger, P.C. Heat shock mediated JNK inactivation improves insulin signaling in skeletal muscle. Poster presented at the Experimental Biology meeting (FASEB), Washington DC, April Gorres, B.K. and Geiger, P.C. In Vivo Model for Visualizing GLUT4 Translocation in Skeletal Muscle. Student Research Forum Presentation, Gupte, A., Bomhoff, G.L., and Geiger, P.C. Heat shock mediated JNK inactivation improves insulin signaling in skeletal muscle. Poster and oral presentation, Student Research Forum, KUMC, 12th April 2007.