GERD MEDICINE WITH ASK ABOUT DEXILANT THE ONLY PRESCRIPTION TWO RELEASES IN ONE PILL. Artistic rendition. Not an actual representation of granules.

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1 ASK ABOUT DEXILANT THE ONLY PRESCRIPTION GERD MEDICINE WITH TWO RELEASES IN ONE PILL Artistic rendition. Not an actual representation of granules. Granule 1 begins releasing medicine within an hour of taking a DEXILANT capsule. Granule 2 provides a second release of medicine around 4 5 hours later. The link between this information and therapeutic benefit is not known. Please see Important Safety Information on page 3.

2 DEXILANT HAS A SECOND RELEASE OF GERD MEDICINE THAT ARRIVES LATER IN THE DAY Granule 1 begins releasing medicine within an hour of taking a DEXILANT capsule. Granule 2 provides a second release of medicine around 4 5 hours later. The link between this information and therapeutic benefit is not known. 2

3 DEXILANT (dexlansoprazole) 30 mg and 60 mg delayed-release capsules Prescription DEXILANT capsules are used in children age 12 to 17 years for 4 weeks to treat heartburn related to GERD, for up to 8 weeks to heal acid-related damage to the lining of the esophagus (called erosive esophagitis or EE), and for up to 16 weeks to continue healing of EE and relief of heartburn. It is not known if DEXILANT is safe and effective in children under age 12 years. DEXILANT is not effective for symptoms of GERD in children under 1 year of age. In adults, persistent heartburn two or more days a week, despite treatment and diet changes, could be gastroesophageal reflux disease (GERD), also known as acid reflux disease (ARD). Prescription DEXILANT capsules are used in adults for 4 weeks to treat heartburn related to GERD, for up to 8 weeks to heal acid-related damage to the lining of the esophagus, and for up to 6 months to continue healing of EE and relief of heartburn. Most damage (erosions) heals in 4 8 weeks. Individual results may vary. Important Safety Information DEXILANT may not be right for everyone. Do not take DEXILANT if you are allergic to DEXILANT or any of its ingredients or taking a medicine that contains rilpivirine. Serious allergic reactions have been reported. Tell your doctor if you get any of the following symptoms with DEXILANT: rash, face swelling, throat tightness, or difficulty breathing. Symptom relief does not rule out other serious stomach conditions. A type of kidney problem called acute interstitial nephritis may develop at any time during treatment with proton pump inhibitor (PPI) medicines, including DEXILANT. Call your doctor right away if you have a decrease in the amount that you urinate or if you have blood in your urine. DEXILANT may increase your risk of getting severe diarrhea. Call your doctor right away if you have watery stool, stomach pain, and fever that does not go away. People who are taking multiple daily doses of PPI medicines for a long period of time (a year or longer) may have an increased risk of fractures of the hip, wrist, or spine. Some people who take PPIs may develop new or worsening of certain types of lupus erythematosus. Call your doctor right away if you have joint pain or rash on your cheeks or arms that gets worse in the sun. Talk with your doctor about the possibility of Vitamin B-12 deficiency if you have been on DEXILANT for a long time (more than 3 years). Low magnesium levels can happen in some people who take a PPI medicine. The most common side effects of DEXILANT in adults were diarrhea (4.8%), stomach pain (4.0%), nausea (2.9%), common cold (1.9%), vomiting (1.6%), and gas (1.6%). The most common side effects in children 12 to 17 years of age were headache, stomach pain, diarrhea, and pain or swelling (inflammation) in your mouth, nose or throat. DEXILANT and certain other medicines can affect each other. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your doctor if you are taking methotrexate, rilpivirine, atazanavir, nelfinavir, saquinavir, digoxin, product containing iron, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole, tacrolimus, St. John s Wort or rifampin. If you are taking DEXILANT with warfarin, you may need to be monitored because serious risks could occur. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call FDA Talk to your doctor or healthcare professional. Please see accompanying full Prescribing Information, including Medication Guide for DEXILANT. 3

4 TWO RELEASES. ONE PILL. HOW DEXILANT IS DIFFERENT DEXILANT is a GERD treatment that gives you two releases of medicine in one pill. The first release occurs within an hour of taking the pill; the second arrives around 4 5 hours later. Artistic rendition. Not an actual representation of granules. Please see Important Safety Information on page 3. 4

5 Talk to your doctor about GERD 1. I have heartburn or acid reflux symptoms days a week 2. I have been experiencing these symptoms for Less than 6 months 1 3 years 6 months 1 year 3+ years 3. I would describe my symptoms as Mild Severe Moderate 4. I usually have heartburn During the day After eating spicy foods 5. I experience nighttime heartburn 1 night or less per week 2 3 nights per week 4+ nights per week At night All of the above 6. I currently treat my heartburn with Antacids or over-the-counter (OTC) medication Prescription medication, such as a proton pump inhibitor (PPI) Prescription medication plus OTC medication at night Prescription medication that I take more than once a day I am not treating my condition 7. I treat my heartburn with a prescription and still experience symptoms 1 day or less per week 6 7 days per week 2 3 days per week Never 4 5 days per week Visit DEXILANT.com to try tools that can help you track your symptoms. Sign up for the DEXILANT Advantage Program for full access to these tools. Please see Important Safety Information on page 3. 5

6 How DEXILANT (dexlansoprazole) works DEXILANT is a gastroesophageal reflux disease (GERD) treatment that gives you two releases of medicine in one pill. DEXILANT begins to deliver the first release of medicine within an hour of taking your pill. Then, around 4 5 hours later, a second release of medicine arrives. Granule 1 Begins releasing medicine within an hour of taking it Granule 2 Provides a second release of medicine around 4 5 hours later Artistic rendition. Not an actual representation of granules. 6

7 DEXILANT PROVIDES UP TO 24 HOURS OF RELIEF FROM HEARTBURN DUE TO GERD Clinical studies show it. They also show that DEXILANT capsules heal erosions to the esophagus and keep them from coming back. Individual results may vary. Persistent heartburn two or more days a week, despite treatment and diet changes, could be gastroesophageal reflux disease (GERD). Important Safety Information DEXILANT may not be right for everyone. Do not take DEXILANT if you are allergic to DEXILANT or any of its ingredients or taking a medicine that contains rilpivirine. Serious allergic reactions have been reported. Tell your doctor if you get any of the following symptoms with DEXILANT: rash, face swelling, throat tightness, or difficulty breathing. Symptom relief does not rule out other serious stomach conditions. A type of kidney problem called acute interstitial nephritis may develop at any time during treatment with proton pump inhibitor (PPI) medicines, including DEXILANT. DEXILANT may increase your risk of getting severe diarrhea. Call your doctor right away if you have watery stool, stomach pain, and fever that does not go away. People who are taking multiple daily doses of PPI medicines for a long period of time (a year or longer) may have an increased risk of fractures of the hip, wrist, or spine. The most common side effects of DEXILANT in adults were diarrhea (4.8%), stomach pain (4.0%), nausea (2.9%), common cold (1.9%), vomiting (1.6%), and gas (1.6%). The most common side effects in children 12 to 17 years of age were headache, stomach pain, diarrhea, and pain or swelling (inflammation) in your mouth, nose or throat. Please see additional Important Safety Information on page 3. 7

8 What is GERD? Gastroesophageal reflux disease (GERD) occurs when stomach acid used for digestion repeatedly backs up, or refluxes, into the esophagus. GERD is also known as acid reflux disease. Heartburn, often described as pain or burning in the chest, is a common symptom of GERD. Inactive acid pumps Active acid pumps 8

9 What causes GERD? When you eat, millions of tiny pumps in your stomach produce the acid that helps you digest food. A valve called the LES (lower esophageal sphincter) between your esophagus and stomach allows food and liquids to enter the stomach. If the valve doesn t close all the way, or if it opens too often, stomach acid can move up into your esophagus and cause symptoms of GERD. What are the symptoms of GERD? Persistent heartburn Stomach acid rising Sour taste in the mouth Burning in the throat Pain or burning in the chest Burping Talk to your doctor about symptoms. With continued exposure to stomach acid, the esophagus may become irritated and possibly even damaged, a condition known as erosive esophagitis. Help take control of your GERD symptoms with the simple tips on page 12. 9

10 PATIENTS AGE APPROVED FOR 12 YEARS & OLDER Who can take DEXILANT (dexlansoprazole) DEXILANT capsules can be used in people 12 years of age and older for 4 weeks to treat heartburn related to GERD, for up to 8 weeks to heal acid-related damage to the lining of the esophagus (called erosive esophagitis or EE), and for up to 16 weeks in kids 12 to 17 years of age and up to 6 months in adults to continue healing of EE and relief of heartburn. It is not known if DEXILANT is safe and effective in kids under age 12 years. DEXILANT is not effective for symptoms of GERD in children under 1 year of age. Take DEXILANT capsules any time of day, with or without food Whenever taking DEXILANT capsules, remember: Swallow the capsules whole. Not an actual patient. If you have trouble swallowing DEXILANT capsules whole, it s OK to open the capsules and sprinkle the contents on a tablespoon of applesauce. Just be sure to swallow the applesauce mixture right away. Don t chew the applesauce mixture and don t store it for later use. Be sure to take DEXILANT capsules exactly as prescribed and for the full length of time. DEXILANT has a low occurrence of side effects Studies of more than 4500 adults showed that DEXILANT had a low occurrence of side effects. The most common side effects were diarrhea (4.8%), stomach pain (4.0%), nausea (2.9%), common cold (1.9%), vomiting (1.6%), and gas (1.6%). The most common side effects in children 12 to 17 years of age were headache, stomach pain, diarrhea, and pain or swelling (inflammation) in your mouth, nose or throat. Please see Important Safety Information on page 3. 10

11 PATIENTS ARE TALKING ABOUT DEXILANT (dexlansoprazole) 98% of patients said that DEXILANT was convenient to take.* 98% said that DEXILANT dosing fit into their daily schedule.* 94% would recommend that their friends or relatives with GERD ask their doctors about DEXILANT.* * Based on a January 2011 internet survey of 4013 adult users who were self-reported, physician-diagnosed, with GERD/Acid Reflux Disease/EE. Important Safety Information DEXILANT may not be right for everyone. Do not take DEXILANT if you are allergic to DEXILANT or any of its ingredients or taking a medicine that contains rilpivirine. Serious allergic reactions have been reported. Tell your doctor if you get any of the following symptoms with DEXILANT: rash, face swelling, throat tightness, or difficulty breathing. Please see additional Important Safety Information on page

12 Tips to manage GERD Avoid these potential trigger foods: Chocolate Peppermint and spearmint Tomato-based foods Coffee and other caffeinated drinks Spicy foods Onions Citrus fruits Alcohol Eat small, frequent meals. Avoid eating 2 3 hours before bedtime. If you currently smoke, try to quit. Raise the head of your bed 6 8 inches for sleeping. Watch your weight, and lose some if you re overweight. Wear loose-fitting clothes around your waist. Tools you can use to help fight heartburn Tracking symptoms. Keeping current with refills as directed by your doctor. Remembering to take your medication. They re all important parts of managing GERD effectively. And as a member of the DEXILANT Advantage Program, you ll have exclusive access to a variety of online tools to help you do just that. So, visit AboutDEXILANT.com/savings and sign up today. Please see Important Safety Information on page 3. DEXILANT and DEXILANT (with design) are trademarks of Takeda Pharmaceuticals U.S.A., Inc., registered in the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. All other trademarks are the property of their respective owners Takeda Pharmaceuticals U.S.A., Inc. USDDEX15/0102a(1)a(1)a 09/17 12

13 START SAVING NOW Patients pay $20* for their prescriptions and refills of DEXILANT Appropriate patients can get either a 30-day or a 90-day prescription and still pay no more than $20 Uninsured patients can save up to $55 for a 30-day prescription or up to $165 for a 90-day prescription here s how to start saving 1 Clip. Remove the Instant Savings Card below. 2 Activate. Visit DAPactivate.com or call to activate your card. 3 Save. Show the card to your pharmacist and pay $20 for DEXILANT. Visit AboutDEXILANT.com for more information Please see Important Safety Information on page 3. * Must meet Eligibility Requirements. For commercially insured patients, this savings card covers out-of-pocket expenses greater than $20, up to a maximum benefit of $55 for a 30-day prescription or $165 for a 90-day prescription. For uninsured patients, see Terms & Conditions. 13 Eligibility Requirements: This offer cannot be used if you are a beneficiary of, or any part of your prescription is covered by: (1) any federal or state healthcare program (Medicare, Medicaid, TriCARE, etc.), including a state pharmaceutical assistance program, (2) the Medicare Prescription Drug Program (Part D), or if you are currently in the coverage gap, or (3) insurance that is paying the entire cost of the prescription. Terms & Conditions: You must meet Eligibility Requirements. You agree to report your use of this offer to any Third Party that reimburses you or pays for any part of the prescription price. Use of this offer is confirmation that you are permitted, under the terms and conditions of the health benefit plan(s) covering your prescriptions, to take advantage of co-pay coverage programs. You additionally agree that you will not submit the cost of any portion of the product dispensed pursuant to this offer to a federal or state healthcare program for purposes of counting it toward your out-of-pocket expenses. For commercially insured patients, this savings card covers out-of-pocket expenses greater than $20, up to a maximum benefit of $55 for a 30-day prescription or $165 for a 90-day prescription. For uninsured patients, the amount of this offer is not to exceed $55 for a 30-day prescription or $165 for a 90-day prescription. This coupon is not valid with any other program, discount, or incentive involving DEXILANT (dexlansoprazole). This offer may be rescinded, revoked, or amended without notice. No reproductions. This offer is void where prohibited by law, taxed, or restricted. Limit one offer per purchase. Cash value of 1/100 of 1. For questions about this offer, call the Customer Service Center at Pharmacy Instructions: By submitting this offer for reimbursement to McKesson, you certify that: (1) you have dispensed DEXILANT to an eligible patient in accordance with the Eligibility Requirements of this offer and the accompanying prescription; (2) you have not submitted and will not submit a claim for reimbursement for the portion of the drug covered by this coupon to any payor; (3) your participation in this program is consistent with all applicable laws and any obligations, contractual or otherwise, that you may have as a pharmacy provider; and (4) submission of claims are subject to the LoyaltyScript program Terms and Conditions posted at For questions about processing, please call Takeda Pharmaceuticals U.S.A., Inc. USDDEX15/0102a(1)a(1)a 09/17

14 COVERAGE AND SAVINGS TO HELP ACCESS DEXILANT The majority of patients with commercial insurance have coverage for DEXILANT Patients pay $20* for 30-day or 90-day prescriptions, if appropriate The DEXILANT Advantage Program can help you save on your prescriptions and provide access to tools to help you track your symptoms. Enrollment is free, easy, and takes just a couple of minutes. See inside for details or visit AboutDEXILANT.com to register now * Must meet Eligibility Requirements. For commercially insured patients, this savings card covers out-of-pocket expenses greater than $20, up to a maximum benefit of $55 for a 30-day prescription or $165 for a 90-day prescription. For uninsured patients, see Terms & Conditions. Please see Important Safety Information on page 3. INSTANT SAVINGS CARD To activate this card go to or call PAY $20 * RxBIN: RxGRP: ID: XXXXXXXXX RxPCN: 1016 ISSUER: (80840) FOR YOUR PRESCRIPTION *Subject to maximum benefit. Must meet Eligibility Requirements.

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